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Combining Whole Food Plant-Based Diet and Intermittent Fasting: A Synergistic Strategy to Combat Chronic Diseases

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Article Type: Perspective Published: 2025-11-12 Volume/Issue: 6 / 11 Pages: 1682-1690

Combining Whole Food Plant-Based Diet and Intermittent Fasting: A Synergistic Strategy to Combat Chronic Diseases

Mulijono D
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Public Health Nutrition
Combining Whole Food Plant-Based Diet and Intermittent Fasting: A Synergistic Strategy to Combat Chronic Diseases
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Abstract

<p>The escalating burden of chronic Non-Communicable Diseases (NCDs)-including Cardiovascular Disease (CVD), Type 2 Diabetes Mellitus (T2DM), obesity, hypertension, and cancer-highlights the failure of symptom-based medicine to address root causes. Lifestyle medicine now stands as a transformative alternative, with two proven interventions-Whole-Food Plant-Based Diets (WFPBD) and Intermittent Fasting (IF)-showing powerful metabolic and anti-inflammatory benefits.<br>When combined, WFPBD and IF yield synergistic physiological effects, enhancing insulin sensitivity, lipid regulation, autophagy, and inflammation control while promoting sustainable weight loss and cellular repair. This integration addresses both the quality and timing of nutrition, targeting the molecular roots of chronic disease.<br>At Bethsaida Hospital (Indonesia), under the leadership of Prof. Dasaad Mulijono, this combined WFPBD+IF protocol has been implemented for nearly seven years in thousands of patients with advanced cardiometabolic disorders. The program demonstrated measurable success, including the reversal of Coronary Artery Disease (CAD), remission of T2DM &amp; hypertension, reduction in medication use, normalisation of lipid and inflammatory markers, improved renal function, and sustained weight loss.<br>This low-cost, scalable, and clinically validated model demonstrates that integrating nutrition and fasting offers a replicable blueprint for global metabolic restoration and long-term disease reversal.<br></p>

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