Covid-19 Research

Perspective

Music as Medicine: Transforming Cardiac Interventions with Physiological and Neurochemical Benefits

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Perspective
Subject Medicine Group
OCLC JBRES Record
Dasaad Mulijono*
Issue: Volume7-Issue2
Pages: 1-6
Received: 2025-12-26
Accepted: 2026-02-26
Published: 2026-02-27

Abstract

Music, deeply embedded in human culture, profoundly influences physiological and psychological states, showcasing remarkable potential within clinical environments, notably the catheterization laboratory (Cath Lab). This article offers an in-depth examination of music's crucial role in interventional cardiology from both physiological and neurochemical perspectives. Music effectively modulates stress responses, enhancing parasympathetic activity and reducing heart rate, blood pressure, and cortisol levels, thereby promoting a state of calmness and relaxation critical for optimal procedural outcomes. Neurochemically, music stimulates the release of dopamine, serotonin, oxytocin, and endorphins, crucial neurochemicals associated with mood enhancement, emotional stability, teamwork facilitation, and pain relief. These effects collectively enhance cognitive performance, procedural precision, and patient comfort, resulting in reduced anxiety, decreased reliance on medication, and shorter recovery times. Highlighting practical implementation, Bethsaida Hospital—under the leadership of Prof. Dasaad Mulijono (DM)—exemplifies the integration of music through advanced, personalized audio experiences within a compassionate and spiritually mindful environment, underscoring the significance of music as an indispensable adjunctive therapeutic modality in interventional cardiology.

FullText HTML FullText PDF DOI: 10.37871/jbres2275 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2026 Mulijono D. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Mulijono D.Music as Medicine: Transforming Cardiac Interventions with Physiological and Neurochemical Benefi ts. J Biomed Res Environ Sci. 2026 Feb 27; 7(2): 6. Doi: 10.37872/ jbres2275

Subject area(s)

Public HealthPhysiologyCardiovascular Diseases

References

  1. Alex J, Patel H, Zughaib MT, Aggarwal A, Kommineni A, et al. Burnout of support personnel in the cardiac catheterization laboratory. Cardiol Res. 2022 Oct;13(5):283-288. doi:10.14740/cr1439. Epub 2022 Oct 25. PMID: 36405231; PMCID: PMC9635780.
  2. Block A, Bonaventura K, Grahn P, Bestgen F, Wippert PM. Stress management in pre- and postoperative care amongst practitioners and patients in cardiac catheterization laboratory: a study protocol. Front Cardiovasc Med. 2022 Jul 1;9:830256. doi:10.3389/fcvm.2022.830256. PMID: 35845056; PMCID: PMC9285119.
  3. Bumgarner B. Cath lab credentialing ... it's not just for nurses anymore! J Cardiovasc Manag. 1994 Jan-Feb;5(1):28-31. PMID: 10132429.
  4. Bejar MA, Mzoughi K, Sta M, Naser AB, Abdallah SB, et al. Anxiety in the cardiac catheter laboratory: importance of the education. Arch Cardiovasc Dis Suppl. 2021;13(2):195. doi:10.1016/j.acvdsp.2021.04.116.
  5. Annachhatre AS, Janbure N, Gaddam N, Shinde D, Annachhatre S. Anesthesiologists and job satisfaction in cardiac cath lab: do we need guidelines? Ann Card Anaesth. 2020 Apr-Jun;23(2):116-121. doi:10.4103/aca.ACA_164_18. PMID: 32275022; PMCID: PMC7336964.
  6. Iwanaga M, Moroki Y. Subjective and physiological responses to music stimuli controlled over activity and preference. J Music Ther. 1999;36(1):26-38. doi:10.1093/jmt/36.1.26. PMID: 10519843.
  7. Schäfer T, Sedlmeier P, Städtler C, Huron D. The psychological functions of music listening. Front Psychol. 2013 Aug 13;4:511. doi:10.3389/fpsyg.2013.00511. PMID: 23964257; PMCID: PMC3741536.
  8. Lee HP, Liu YC, Lin MF. Effects of different genres of music on the psycho-physiological responses of undergraduates. Hu Li Za Zhi. 2016 Dec;63(6):77-88. Chinese. doi:10.6224/JN.63.6.77. PMID: 27900748.
  9. Watkins GR. Music therapy: proposed physiological mechanisms and clinical implications. Clin Nurse Spec. 1997 Mar;11(2):43-50. doi:10.1097/00002800-199703000-00003. PMID: 9233140.
  10. Filho RAA, Oliveira JJG, Zovico PVC, Rica RL, Barbosa WA, Machado AF, Evangelista AL, Costa EC, Bergamin M, Baker JS, Bocalini DS. Effects of music on psychophysiological responses during high intensity interval training using body weight exercises. Physiol Behav. 2022 Oct 15;255:113931. doi:10.1016/j.physbeh.2022.113931. Epub 2022 Jul 28. PMID: 35907471.
  11. T Zaatar M, Alhakim K, Enayeh M, Tamer R. The transformative power of music: insights into neuroplasticity, health, and disease. Brain Behav Immun Health. 2023 Dec 12;35:100716. doi:10.1016/j.bbih.2023.100716. PMID: 38178844; PMCID: PMC10765015.
  12. Speranza L, Pulcrano S, Perrone-Capano C, di Porzio U, Volpicelli F. Music affects functional brain connectivity and is effective in the treatment of neurological disorders. Rev Neurosci. 2022 Mar 24;33(7):789-801. doi:10.1515/revneuro-2021-0135. PMID: 35325516.
  13. Arnold CA, Bagg MK, Harvey AR. The psychophysiology of music-based interventions and the experience of pain. Front Psychol. 2024 May 10;15:1361857. doi:10.3389/fpsyg.2024.1361857. PMID: 38800683; PMCID: PMC11122921.
  14. Keeler JR, Roth EA, Neuser BL, Spitsbergen JM, Waters DJ, et al. The neurochemistry and social flow of singing: bonding and oxytocin. Front Hum Neurosci. 2015 Sep 23;9:518. doi:10.3389/fnhum.2015.00518. PMID: 26441614; PMCID: PMC4585277.
  15. Ferreri L, Mas-Herrero E, Zatorre RJ, Ripollés P, Gomez-Andres A, et al. Dopamine modulates the reward experiences elicited by music. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3793-3798. doi:10.1073/pnas.1811878116. Epub 2019 Jan 22. PMID: 30670642; PMCID: PMC6397525.
  16. Reybrouck M, Van Dyck E. Is music a drug? How music listening may trigger neurochemical responses in the brain. Musicae Sci. 2024;28(4):649-674. doi:10.1177/10298649241236770.
  17. Thoma MV, La Marca R, Brönnimann R, Finkel L, Ehlert U, et al. The effect of music on the human stress response. PLoS One. 2013 Aug 5;8(8):e70156. doi:10.1371/journal.pone.0070156. PMID: 23940541; PMCID: PMC3734071.
  18. Fukui H, Toyoshima K. Influence of music on steroid hormones and the relationship between receptor polymorphisms and musical ability: a pilot study. Front Psychol. 2013 Dec 3;4:910. doi:10.3389/fpsyg.2013.00910. PMID: 24348454; PMCID: PMC3848314.
  19. Chanda ML, Levitin DJ. The neurochemistry of music. Trends Cogn Sci. 2013 Apr;17(4):179-193. doi:10.1016/j.tics.2013.02.007. PMID: 23541122.
  20. Fukui H, Yamashita M. The effects of music and visual stress on testosterone and cortisol in men and women. Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):173-180. PMID: 14523353.
  21. Bleibel M, El Cheikh A, Sadier NS, Abou-Abbas L. The effect of music therapy on cognitive functions in patients with Alzheimer's disease: a systematic review of randomized controlled trials. Alzheimers Res Ther. 2023 Mar 27;15(1):65. doi:10.1186/s13195-023-01214-9. PMID: 36973733; PMCID: PMC10041788.
  22. Jordan C, Lawlor B, Loughrey D. A systematic review of music interventions for the cognitive and behavioural symptoms of mild cognitive impairment (non-dementia). J Psychiatr Res. 2022 Jul;151:382-390. doi:10.1016/j.jpsychires.2022.04.028. Epub 2022 Apr 25. PMID: 35576664.
  23. Alashram AR, Janada Q, Ghrear T, Annino G. Role of music therapy in improving cognitive function post-traumatic brain injury: a systematic review. Appl Neuropsychol Adult. 2023 Jun 30:1-10. doi:10.1080/23279095.2023.2228951. Epub ahead of print. PMID: 37389826.
  24. Taheri S, Razeghi M, Choobineh A, Kazemi R, Rasipisheh P, et al. Investigating the effect of background music on cognitive and skill performance: a cross-sectional study. Work. 2022;71(4):871-879. doi:10.3233/WOR-213631. PMID: 35253719.
  25. Raglio A, Figini C, Bencivenni A, Grossi F, Boschetti F, Manera MR. Cognitive stimulation with music in older adults with cognitive impairment: a scoping review. Brain Sci. 2024 Aug 22;14(8):842. doi:10.3390/brainsci14080842. PMID: 39199533; PMCID: PMC11352551.
  26. Santiváñez-Acosta R, Tapia-López ELN, Santero M. Music therapy in pain and anxiety management during labor: a systematic review and meta-analysis. Medicina (Kaunas). 2020 Oct 10;56(10):526. doi:10.3390/medicina56100526. PMID: 33050409; PMCID: PMC7599829.
  27. Hunter AR, Heiderscheit A, Galbally M, Gravina D, Mutwalli H, et al. The effects of music-based interventions for pain and anxiety management during vaginal labour and caesarean delivery: a systematic review and narrative synthesis of randomised controlled trials. Int J Environ Res Public Health. 2023 Nov 29;20(23):7120. doi:10.3390/ijerph20237120. PMID: 38063550; PMCID: PMC10706633.
  28. Ortega A, Gauna F, Munoz D, Oberreuter G, Breinbauer HA, et al. Music therapy for pain and anxiety management in nasal bone fracture reduction: randomized controlled clinical trial. Otolaryngol Head Neck Surg. 2019 Oct;161(4):613-619. doi:10.1177/0194599819856604. Epub 2019 Jun 11. PMID: 31184266.
  29. Park S, Lee S, Howard S, Yi J. Technology-based music interventions to reduce anxiety and pain among patients undergoing surgery or procedures: systematic review of the literature. JMIR Mhealth Uhealth. 2024 Jul 8;12:e48802. doi:10.2196/48802. PMID: 38976863; PMCID: PMC11263896.
  30. Akba? Uysal D, ?enuzun Aykar F, Uyar M. The effects of aromatherapy and music on pain, anxiety, and stress levels in palliative care patients. Support Care Cancer. 2024 Sep 4;32(10):632. doi:10.1007/s00520-024-08837-0. PMID: 39230757.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership