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Combining Whole Food Plant-Based Diet and Intermittent Fasting: A Synergistic Strategy to Combat Chronic Diseases

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

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Open Access
Article Type Perspective
Subject Medicine Group
OCLC JBRES Record
Mulijono D
Issue: Volume6-Issue11
Pages: 1682-1690
Received: 2025-08-29
Accepted: 2025-11-11
Published: 2025-11-12

Abstract

The escalating burden of chronic Non-Communicable Diseases (NCDs)-including Cardiovascular Disease (CVD), Type 2 Diabetes Mellitus (T2DM), obesity, hypertension, and cancer-highlights the failure of symptom-based medicine to address root causes. Lifestyle medicine now stands as a transformative alternative, with two proven interventions-Whole-Food Plant-Based Diets (WFPBD) and Intermittent Fasting (IF)-showing powerful metabolic and anti-inflammatory benefits.
When combined, WFPBD and IF yield synergistic physiological effects, enhancing insulin sensitivity, lipid regulation, autophagy, and inflammation control while promoting sustainable weight loss and cellular repair. This integration addresses both the quality and timing of nutrition, targeting the molecular roots of chronic disease.
At Bethsaida Hospital (Indonesia), under the leadership of Prof. Dasaad Mulijono, this combined WFPBD+IF protocol has been implemented for nearly seven years in thousands of patients with advanced cardiometabolic disorders. The program demonstrated measurable success, including the reversal of Coronary Artery Disease (CAD), remission of T2DM & hypertension, reduction in medication use, normalisation of lipid and inflammatory markers, improved renal function, and sustained weight loss.
This low-cost, scalable, and clinically validated model demonstrates that integrating nutrition and fasting offers a replicable blueprint for global metabolic restoration and long-term disease reversal.

FullText HTML FullText PDF DOI: 10.37871/jbres2221 Crossmark

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© 2025 Mulijono D, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Mulijono D. Combining Whole Food Plant-Based Diet and Intermittent Fasting: A Synergistic Strategy to Combat Chronic Diseases. J Biomed Res Environ Sci. 2025 Nov 11; 6(11): 1682-1690. doi: 10.37871/ jbres2221, Article ID: JBRES2221, Available at: https://www.jelsciences.com/articles/jbres2221.pdf

Subject area(s)

Public HealthNutrition

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