Covid-19 Research

Article Figures

A Mutational Pathway Leading to Thyroid Tumors During Medication for Feline Hyperthyroidism

View article figures, article metadata, topics, DOI, abstract, and related articles from the JBRES article record.

View Abstract Article Library
Article Type: Original Article Published: 2025-07-28 Volume/Issue: 6 / 7 Pages: 986-993

A Mutational Pathway Leading to Thyroid Tumors During Medication for Feline Hyperthyroidism

Ryunosuke Kikuchi1,3*, Yumiko Kagawa2 and Rosario Placido Roberto da Costa3
Abstract FullText HTML PDF DOI
Veterinary Science Biology
A Mutational Pathway Leading to Thyroid Tumors During Medication for Feline Hyperthyroidism
jbres2154-g001.webp

Article Figures

Abstract

<p>Over 350 million cats worldwide live in homes with their human companions. An inexplicable phenomenon is affecting domestic cats (felis catus) - the global prevalence of feline hyperthyroidism has been increasing since the late 1970s. Feline hyperthyroidism is the result of a malignant thyroid carcinoma in ~2% and a benign functional thyroid adenoma in ~98% of diagnosed cases. Thyroid tumors remain palpable in cats after medication (e.g., methimazole, carbimazole), but few studies have reported such remaining tumors. Hence, we pathologically examined tissues that were sampled from 206 cats by thyroidectomy after such medication at 65 veterinary hospitals. Our results show carcinoma in 11.2% and adenoma in 83.4% of samples. Based on an increase in the carcinoma rate from ~2% at the diagnosis stage to 11.2% at the post-treatment stage, it can be inferred that a thyroid adenoma transforms into a thyroid carcinoma in a hyperthyroid cat through a multistep mutational pathway like the human adenoma-carcinoma sequence. It remains for future study to assess whether this feline phenomenon is somehow related to the human one in terms of the One Health approach; e.g., the incidence rate of thyroid cancers has been increasing in humans since the early 1980s (cf. this tendency cannot be explained only by over-diagnosis and detection technology).<br></p>

Similar Topic Articles

  • Prevalence and Molecular Confirmation of Corynebacterium pseudotuberculosis in Sheep Populations of Argentine Patagonia: Implications for Wildlife Conservation and One Health
    Diaz Lucia M*, Cortes Carla A, Pujana, Matias, Alvarez, Laura A, Randazzo Viviana R and Gallardo, Adriana A
    Published: 2026-03-27
    Abstract PDF DOI
  • Tail Biting in Pigs Behavioral Signs Welfare Impact Risk Factors and Prevention Strategies
    Ishaya UG*, Vanessa AM, Yolanda D, Rutendo PM, Methun CD, Abdullateef AI, Chidiebere NA, Michael Idowu B and Samuel UE
    Published: 2025-09-20
    Abstract FullText HTML PDF DOI
  • Development of a Fluorescence Isothermal Recombinase Polymerase Amplification Assay for Rapid Detection of Feline Calicivirus
    Yujun Zhu, Shuzhou Huang, Bihong Huang, Yuexiao Lian, Tongyuan Zhang, Feng Cong*, and Miaoli Wu*
    Published: 2025-08-25
    Abstract FullText HTML PDF DOI
  • Valuing the Relative Importance of Goat Farmers Trait Preferences: Implication for Designing Community Based Breeding Program
    Kefelegn Kebede* and Ahmed Usman
    Published: 2023-10-11
    Abstract FullText HTML PDF DOI
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership