Covid-19 Research

Special Issue

Gut–Liver Axis: Modern Hepatology and Digestive Disease Insights

A JBRES Special Issue dedicated to rigorous, outcome-oriented research on the gut-liver axis—linking microbiome dysbiosis, microbial metabolites, intestinal barrier integrity, and immune mechanisms to advance understanding and management of hepatobiliary and digestive diseases.

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JBRES Special Issue • Gastroenterology & Hepatic Disorders
Special Issue Title

Gut–Liver Axis: Modern Hepatology and Digestive Disease Insights

This Special Issue of the Journal of Biomedical Research & Environmental Sciences (JBRES) invites high-quality submissions that strengthen the evidence base for the gut-liver axis in modern hepatology. We welcome work that elucidates microbiome-metabolite interactions, clarifies barrier & immune mechanisms, and demonstrates clinical & therapeutic effectiveness across liver diseases, metabolic disorders, and digestive pathologies.

Microbiome & Metabolites
Dysbiosis patterns, SCFAs, bile acids, LPS/endotoxemia, TMAO, secondary metabolites, and their roles in hepatic inflammation and fibrosis.
Barrier & Immune Insights
Intestinal permeability, leaky gut, immune cell trafficking, innate/adaptive responses, and bidirectional signaling in MASLD/MASH, cirrhosis, and beyond.
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About this Special Issue

Hepatology and digestive disease research is strongest when it connects microbiome insights with hepatic pathophysiology and practical outcomes. This Special Issue focuses on the gut-liver axis—from microbial dysbiosis and metabolite signaling to barrier dysfunction, immune dysregulation, and translational interventions. We especially welcome submissions that report transparent methods, robust endpoints, and insights that can improve diagnosis, prevention, equity, and long-term management of liver and gut-related disorders.

Preference is given to studies with clear outcomes (liver enzymes, fibrosis scores, metabolic markers, inflammation), robust analysis, and a concise “What this changes in practice” statement.

Topics of interest

Submissions may address (but are not limited to):

Gut Microbiome Dysbiosis Patterns Microbial Metabolites (SCFAs, Bile Acids) Intestinal Barrier Dysfunction Endotoxemia & LPS Signaling MASLD/MASH Pathogenesis Gut-Liver Immune Crosstalk Cirrhosis & Portal Hypertension Hepatocellular Carcinoma Links Fecal Microbiota Transplantation Probiotics, Prebiotics & Postbiotics Bile Acid Modulators & Therapies Translational & Clinical Interventions

Article types accepted

  • Original Research Articles
  • Clinical Trials & Intervention Studies
  • Observational & Population Studies
  • Review Articles
  • Systematic Reviews & Meta-Analyses
  • Mini-Reviews
  • Short Communications
  • Case Studies (where appropriate)
Tip: Include (1) primary/secondary outcomes, (2) a brief methods transparency note (preregistration/data availability if applicable), and (3) a “Clinical/Community Relevance” paragraph.

Why submit to this Special Issue?

  • Axis-forward visibility: your work is presented alongside leading gut-liver axis and hepatology research.
  • Efficient editorial pathway: JBRES targets rapid peer review (7–14 days where applicable).
  • Permanent DOI: accepted articles receive DOI for strong citation continuity.
  • Open access reach: broad discoverability for clinicians, researchers, and gastroenterology/hepatology teams.
  • Author support: clear guidance through review, proofing, and publication.
Ready to submit?
Submit online, or share an abstract for an editorial scope check (methods + outcomes summary preferred).
Submit Manuscript Email Abstract
Submission Portal Submission Instructions Aims & Scope Archive
Alternative submission emails: support@jelsciences.com | editor.review@scireslit.us
License (upon publication): Creative Commons CC BY 4.0
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
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