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Prevalence and Patterns of Herbal Medicine Use among Type 2 Diabetes Mellitus Patients at the University Teaching Hospitals in Lusaka

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Open Access
Article Type Research Article
Subject Medicine Group
OCLC 9427634369
Christabel Nangandu Hikaambo*, Yvonne Namutambo, Martin Kampamba, Webrod Mufwambi, Reagan Kabuka, Martha Chulu, Namuchindo Nanyangwe, Michelo Banda, Tadious Chimombe, Lungwani Tyson Muungo and Steward Mudenda
Issue: Volume3-Issue1
Pages: 074-081
Received: 2022-01-10
Accepted: 2022-01-18
Published: 2022-01-20

Abstract

Background: In 2015, Zambia reported 218,200 instances of Diabetes Mellitus (DM) with 8,232 diabetes-related fatalities. Insulin therapy and oral antidiabetic medications are two pharmacological therapies used to treat diabetes mellitus. Herbal medicine, on the other hand, has a lengthy history and is an easily accessible and economical therapeutic option. Patients with Type 2 Diabetes Mellitus (T2DM) are increasingly turning to herbal therapies as keeping to conventional regimens becomes more challenging.

Aim: We aimed to assess the prevalence and patterns of herbal medicine use among Type 2 diabetes mellitus patients at the University Teaching Hospital.

Methods: This cross-sectional study was conducted on 101 T2DM patients using a self-administered questionnaire from August to October 2021. Data were analysed using Statistical Package for Social Science (SPSS) version 26.

Results: Of the 101 participants, (n = 93, 92.1%) used herbal medicines. Garlic (Allium sativum) was the most widely used herbal medication (58.4%), followed by Moringa (Moringa oleifera) at 42.6%, and mule (Myrrh) at 5%. The need to treat diabetes and other medical problems (n = 47, 50.5%) was the main reason for herbal medicines use, followed by family tradition or culture 36 (38.7%). The primary source of information about herbal medicines use was friends (n = 46, 45.5%), followed by family members (n = 38, 37.6%). The majority (n = 83, 82.2%) of the participants reported not having any adverse events from herbal medicines, and only (n = 10, 9.9%) had experienced side effects.

Conclusion: There was a high use of herbal medicines among T2DM patients, particularly those aged between 45 and 76 years. From the standpoint of high prevalence and low disclosure rate, it is imperative for healthcare providers to strongly educate patients regarding the use of herbal medicines. In addition, the public need to be educated on pharmacovigilance so that they know the report of adverse events even those that may be associated with herbal medicines.

FullText HTML FullText PDF DOI: 10.37871/jbres1402 Crossmark

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Copyright

© 2022 Hikaambo CN, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Hikaambo CN, Namutambo Y, Kampamba M, Mufwambi W, Kabuka R, Chulu M, Nanyangwe N, Banda M, Chimombe T, Muungo LT, Mudenda S. Prevalence and Patterns of Herbal Medicine Use among Type 2 Diabetes Mellitus Patients at the University Teaching Hospitals in Lusaka. J Biomed Res Environ Sci. 2022 Jan 20; 3(1): 074-081. doi: 10.37871/jbres1402, Article ID: JBRES1402, Available at: https://www.jelsciences.com/articles/jbres1402.pdf

Subject area(s)

Alternative MedicineDiabetesClinical Endocrinology

University/Institute

University of Zambia

References

  1. Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: a pathophysiologic approach. Ed. McGraw-Hill Medical, New York; 2014.
  2. Dilworth L, Facey A, Omoruyi F. Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues. Int J Mol Sci. 2021 Jul 16;22(14):7644. doi: 10.3390/ijms22147644. PMID: 34299261; PMCID: PMC8305176.
  3. Sun Y, Ma C, Sun H, Wang H, Peng W, Zhou Z, Wang H, Pi C, Shi Y, He X. Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer's Disease. J Diabetes Res. 2020 Jan 29;2020:4981814. doi: 10.1155/2020/4981814. PMID: 32083135; PMCID: PMC7011481.
  4. Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes. 2015 Jun 25;6(6):850-67. doi: 10.4239/wjd.v6.i6.850. PMID: 26131326; PMCID: PMC4478580.
  5. Ritter JM, Rang HP, Flower RJ, Henderson G. Rang & Dale's Pharmacology E-Book: with STUDENT CONSULT Online Access: Elsevier Health Sciences; 2014.
  6. Tan SY, Mei Wong JL, Sim YJ, Wong SS, Mohamed Elhassan SA, Tan SH, Ling Lim GP, Rong Tay NW, Annan NC, Bhattamisra SK, Candasamy M. Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention. Diabetes Metab Syndr. 2019 Jan-Feb;13(1):364-372. doi: 10.1016/j.dsx.2018.10.008. Epub 2018 Oct 10. PMID: 30641727.
  7. Toklu HZ. Herbal medicine use among diabetes mellitus patients in Northern Cyprus. Journal of Medicinal Plants Research. 2013;7(22):1652-1664. doi: 10.5897/JMPR12.1207.
  8. Benzie IFF W-GS. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. CRC Press/Taylor & Francis; 2011.
  9. Tag H, Kalita P, Dwivedi P, Das AK, Namsa ND. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, northeast, India. J Ethnopharmacol. 2012 Jun 14;141(3):786-95. doi: 10.1016/j.jep.2012.03.007. Epub 2012 Mar 13. PMID: 22433536.
  10. WHO. World Health Organization General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. WHO: Geneva. 2000.
  11. Bent S. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med. 2008 Jun;23(6):854-9. doi: 10.1007/s11606-008-0632-y. Epub 2008 Apr 16. PMID: 18415652; PMCID: PMC2517879.
  12. Saxena M, Saxena J, Nema R, Singh D, Gupta A. Phytochemistry of medicinal plants. Journal of pharmacognosy and phytochemistry. 2013;1(6).
  13. https://bit.ly/34MsLv4
  14. Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine. 1995 Oct;2(2):137-89. doi: 10.1016/S0944-7113(11)80059-0. PMID: 23196156.
  15. Moreira DdL, Teixeira SS, Monteiro MHD, De-Oliveira ACA, Paumgartten FJ. Erratum on" Traditional use and safety of herbal medicines". Revista Brasileira de Farmacognosia. 2014;24:502-3.
  16. George P. Concerns regarding the safety and toxicity of medicinal plants-An overview. Journal of applied pharmaceutical science. 2011;1(6):40-4.
  17. https://bit.ly/3I2vT4u
  18. Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014 Jan 10;4:177. doi: 10.3389/fphar.2013.00177. PMID: 24454289; PMCID: PMC3887317.
  19. Bailey SL, Ayles H, Beyers N, Godfrey-Faussett P, Muyoyeta M, du Toit E, Yudkin JS, Floyd S. Diabetes mellitus in Zambia and the Western Cape province of South Africa: Prevalence, risk factors, diagnosis and management. Diabetes Res Clin Pract. 2016 Aug;118:1-11. doi: 10.1016/j.diabres.2016.05.001. Epub 2016 May 7. PMID: 27485851; PMCID: PMC4994576.
  20. Animaw W, Seyoum Y. Increasing prevalence of diabetes mellitus in a developing country and its related factors. PLoS One. 2017 Nov 7;12(11):e0187670. doi: 10.1371/journal.pone.0187670. PMID: 29112962; PMCID: PMC5675402.
  21. Godman B, Basu D, Pillay Y, Mwita JC, Rwegerera GM, Anand Paramadhas BD, Tiroyakgosi C, Okwen PM, Niba LL, Nonvignon J, Sefah I, Oluka M, Guantai AN, Kibuule D, Kalemeera F, Mubita M, Fadare J, Ogunleye OO, Distiller LA, Rampamba EM, Wing J, Mueller D, Alfadl A, Amu AA, Matsebula Z, Kalungia A, Zaranyika T, Masuka N, Wale J, Hill R, Kurdi A, Timoney A, Campbell S, Meyer JC. Review of Ongoing Activities and Challenges to Improve the Care of Patients With Type 2 Diabetes Across Africa and the Implications for the Future. Front Pharmacol. 2020 Mar 20;11:108. doi: 10.3389/fphar.2020.00108. PMID: 32265688; PMCID: PMC7098994.
  22. Atlas D. International diabetes federation. IDF Diabetes Atlas, 7th ed. Brussels, Belgium: International Diabetes Federation. 2015.
  23. Al-Rowais NA. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J. 2002 Nov;23(11):1327-31. PMID: 12506289.
  24. Ali BAM, Mahfouz MS. Herbal medicine use among patients with type 2 diabetes in North Sudan. Annual Research & Review in Biology. 2014:1827-38.
  25. https://bit.ly/3qv1vcZ
  26. Iglay K, Hannachi H, Joseph Howie P, Xu J, Li X, Engel SS, Moore LM, Rajpathak S. Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus. Curr Med Res Opin. 2016 Jul;32(7):1243-52. doi: 10.1185/03007995.2016.1168291. Epub 2016 Apr 4. PMID: 26986190.
  27. Mekuria AB, Belachew SA, Tegegn HG, Ali DS, Netere AK, Lemlemu E, Erku DA. Prevalence and correlates of herbal medicine use among type 2 diabetic patients in Teaching Hospital in Ethiopia: a cross-sectional study. BMC Complement Altern Med. 2018 Mar 9;18(1):85. doi: 10.1186/s12906-018-2147-3. PMID: 29523120; PMCID: PMC5845232.
  28. Kasole R, Martin HD, Kimiywe J. Traditional Medicine and Its Role in the Management of Diabetes Mellitus: "Patients' and Herbalists' Perspectives". Evid Based Complement Alternat Med. 2019 Jul 4;2019:2835691. doi: 10.1155/2019/2835691. PMID: 31354852; PMCID: PMC6637672.
  29. Coulter ID, Willis EM. The rise and rise of complementary and alternative medicine: a sociological perspective. Med J Aust. 2004 Jun 7;180(11):587-9. doi: 10.5694/j.1326-5377.2004.tb06099.x. PMID: 15174992.
  30. Kifle ZD, Bayleyegn B, Yimer Tadesse T, Woldeyohanins AE. Prevalence and associated factors of herbal medicine use among adult diabetes mellitus patients at government hospital, Ethiopia: An institutional-based cross-sectional study. Metabol Open. 2021 Aug 26;11:100120. doi: 10.1016/j.metop.2021.100120. PMID: 34485891; PMCID: PMC8403751.
  31. Adeniyi O, Washington L, Glenn CJ, Franklin SG, Scott A, Aung M, Niranjan SJ, Jolly PE. The use of complementary and alternative medicine among hypertensive and type 2 diabetic patients in Western Jamaica: A mixed methods study. PLoS One. 2021 Feb 8;16(2):e0245163. doi: 10.1371/journal.pone.0245163. PMID: 33556053; PMCID: PMC7870151.
  32. Nur N. Knowledge and behaviours related to herbal remedies: a cross-sectional epidemiological study in adults in Middle Anatolia, Turkey. Health Soc Care Community. 2010 Jul;18(4):389-95. doi: 10.1111/j.1365-2524.2010.00911.x. Epub 2010 Mar 15. PMID: 20345888.
  33. Peltzer K, Nguyen Huu T, Bach Ngoc N, Pengpid S. The use of herbal remedies and supplementary products among chronic disease patients in Vietnam. Studies on Ethno-Medicine. 2017;11(2):137-45. doi: 10.1080/09735070.2017.1305230
  34. Alqathama A, Alluhiabi G, Baghdadi H, Aljahani L, Khan O, Jabal S, Makkawi S, Alhomoud F. Herbal medicine from the perspective of type II diabetic patients and physicians: what is the relationship? BMC Complement Med Ther. 2020 Feb 28;20(1):65. doi: 10.1186/s12906-020-2854-4. PMID: 32111222; PMCID: PMC7076897.
  35. Lunyera J, Wang D, Maro V, Karia F, Boyd D, Omolo J, Patel UD, Stanifer JW; Comprehensive Kidney Disease Assessment For Risk factors, epidemiology, Knowledge, and Attitudes (CKD AFRiKA) Study. Traditional medicine practices among community members with diabetes mellitus in Northern Tanzania: an ethnomedical survey. BMC Complement Altern Med. 2016 Aug 11;16(1):282. doi: 10.1186/s12906-016-1262-2. PMID: 27514380; PMCID: PMC4982437.
  36. Amaeze OU, Aderemi-Williams RI, Ayo-Vaughan MA, Ogundemuren DA, Ogunmola DS, Anyika EN. Herbal medicine use among Type 2 diabetes mellitus patients in Nigeria: understanding the magnitude and predictors of use. Int J Clin Pharm. 2018 Jun;40(3):580-588. doi: 10.1007/s11096-018-0648-2. Epub 2018 May 2. PMID: 29721742.
  37. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care. 2003 Apr;26(4):1277-94. doi: 10.2337/diacare.26.4.1277. PMID: 12663610.
  38. Alsanad S, Aboushanab T, Khalil M, Alkhamees OA. A Descriptive Review of the Prevalence and Usage of Traditional and Complementary Medicine among Saudi Diabetic Patients. Scientifica (Cairo). 2018 Aug 29;2018:6303190. doi: 10.1155/2018/6303190. PMID: 30228928; PMCID: PMC6136479.
  39. Başer T, Aypak C, Görpelioğlu S. Use of Herbal Products in Type 2 Diabetes Mellitus Patients. Family Medicine and Care. 2018. doi: 10.15761/FMC.1000106.
  40. Azizi-Fini I, Adib-Hajbaghery M, Gharehboghlou Z. Herbal medicine use among patients with type 2 diabetes in Kashan, Iran, 2015. European Journal of Integrative Medicine. 2016;8(4):570-5. doi: 10.1016/j.eujim.2016.04.003.
  41. Kiefer D, Tellez-Girón P, Bradbury EJ. A pilot study of herbal medicine use in a Midwest Latino population. WMJ. 2014 Apr;113(2):64-71. PMID: 24908901; PMCID: PMC4212979.
  42. Jayaprasad B, Thamayandhi D, Sharavanan PS. Traditionally using antidiabetic medicinal plants in Tamil Nadu. International Journal of Research in Pharmaceutical and Biosciences. 2012;2(1):1-8.
  43. https://bit.ly/33qcGuS
  44. Rao MU, Sreenivasulu M, Chengaiah B, Reddy KJ, Chetty CM. Herbal medicines for diabetes mellitus: a review. Int J PharmTech Res. 2010;2(3):1883-92.
  45. https://bit.ly/3nyAKlZ
  46. Nair SS, Kavrekar V, Mishra A. In vitro studies on alpha-amylase and alpha-glucosidase inhibitory activities of selected plant extracts. European Journal of Experimental Biology. 2013;3(1):128-32.
  47. Girón MD, Sevillano N, Salto R, Haidour A, Manzano M, Jiménez ML, Rueda R, López-Pedrosa JM. Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin. Clin Nutr. 2009 Oct;28(5):565-74. doi: 10.1016/j.clnu.2009.04.018. Epub 2009 May 23. PMID: 19477051.
  48. Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H. [Polyphenol constituents from Salacia species: quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities]. Yakugaku Zasshi. 2001 May;121(5):371-8. Japanese. doi: 10.1248/yakushi.121.371. PMID: 11360491.
  49. Mujawdiya PK, Kapur S. Mangiferin: A potential natural molecule for management of metabolic syndrome. Int J Pharm Pharm Sci. 2015;7:9-13.
  50. https://bit.ly/3tzcKTx
  51. Díaz-de-Cerio E, Verardo V, Gómez-Caravaca AM, Fernández-Gutiérrez A, Segura-Carretero A. Health Effects of Psidium guajava L. Leaves: An Overview of the Last Decade. Int J Mol Sci. 2017 Apr 24;18(4):897. doi: 10.3390/ijms18040897. PMID: 28441777; PMCID: PMC5412476.
  52. Tumelo Akapelwa Muyenga DM, Michael Chigunta. Ethnobotanical Survey of Medical Plants Used in Treatment of Diabetes in Chipulukusu Compound, Ndola District, Zambia. Journal of Preventive and Rehabilitative Medicine. 2018;1(1):39-44. doi: : 10.21617/jprm.2018.0101.5
  53. Dahlgren JP, Ostergård H, Ehrlén J. Local environment and density-dependent feedbacks determine population growth in a forest herb. Oecologia. 2014 Dec;176(4):1023-32. doi: 10.1007/s00442-014-3073-9. Epub 2014 Sep 17. PMID: 25224800.
  54. Ching SM, Zakaria ZA, Paimin F, Jalalian M. Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia. BMC Complement Altern Med. 2013 Jun 26;13:148. doi: 10.1186/1472-6882-13-148. PMID: 23802882; PMCID: PMC3701537.
  55. Khalil SH, Zaki A, Ibrahim AM, El-Moughazi AM, Khater AM, Youssef AM, El-Sa'ed AT, Rashed EM. Pattern of use of complementary and alternative medicine among type 2 diabetes mellitus patients in Alexandria, Egypt. J Egypt Public Health Assoc. 2013 Dec;88(3):137-42. doi: 10.1097/01.EPX.0000440994.89503.45. PMID: 24374946.
  56. ALAlami U, A Saeed K, A Khan M. Prevalence and Pattern of Traditional and Complementary Alternative Medicine Use in Diabetic Patients in Dubai, UAE. Arab Journal of Nutrition and Exercise (AJNE). 2017;2:118.
  57. Naja F, Mousa D, Alameddine M, Shoaib H, Itani L, Mourad Y. Prevalence and correlates of complementary and alternative medicine use among diabetic patients in Beirut, Lebanon: a cross-sectional study. BMC Complement Altern Med. 2014 Jun 6;14:185. doi: 10.1186/1472-6882-14-185. PMID: 24906634; PMCID: PMC4074134.
  58. Shikov AN, Narkevich IA, Akamova AV, Nemyatykh OD, Flisyuk EV, Luzhanin VG, Povydysh MN, Mikhailova IV, Pozharitskaya ON. Medical Species Used in Russia for the Management of Diabetes and Related Disorders. Front Pharmacol. 2021 Jul 20;12:697411. doi: 10.3389/fphar.2021.697411. PMID: 34354589; PMCID: PMC8330883.
  59. Talaei B, Asghari G, Mirmiran P, Azizi F, Bahreini S. Knowledge, Attitude, and Practice of Diabetic Patients toward Herbal Products in Iran: A Cross-sectional Study. Journal of Nutrition and Food Security. 2019;4(3). doi: 10.18502/jnfs.v4i3.1307
  60. Kelak JA, Cheah WL, Safii R. Patient's Decision to Disclose the Use of Traditional and Complementary Medicine to Medical Doctor: A Descriptive Phenomenology Study. Evid Based Complement Alternat Med. 2018 Feb 14;2018:4735234. doi: 10.1155/2018/4735234. PMID: 29636778; PMCID: PMC5832099.
  61. Jang S, Kim KH, Sun SH, Go HY, Lee EK, Jang BH, Shin YC, Ko SG. Characteristics of Herbal Medicine Users and Adverse Events Experienced in South Korea: A Survey Study. Evid Based Complement Alternat Med. 2017;2017:4089019. doi: 10.1155/2017/4089019. Epub 2017 Apr 10. PMID: 28491107; PMCID: PMC5402245.
  62. Shaw D, Graeme L, Pierre D, Elizabeth W, Kelvin C. Pharmacovigilance of herbal medicine. J Ethnopharmacol. 2012 Apr 10;140(3):513-8. doi: 10.1016/j.jep.2012.01.051. Epub 2012 Feb 9. PMID: 22342381.
  63. Larizgoitia I, Bouesseau MC, Kelley E. WHO Efforts to Promote Reporting of Adverse Events and Global Learning. J Public Health Res. 2013 Dec 1;2(3):e29. doi: 10.4081/jphr.2013.e29. PMID: 25170500; PMCID: PMC4147748.
  64. Toki T, Ono S. Spontaneous Reporting on Adverse Events by Consumers in the United States: An Analysis of the Food and Drug Administration Adverse Event Reporting System Database. Drugs Real World Outcomes. 2018 Jun;5(2):117-128. doi: 10.1007/s40801-018-0134-0. PMID: 29725886; PMCID: PMC5984610.
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