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OCLC Number/Unique Identifier: 9010241208

Importance the Type 1 (CR1) and Type 3 (CR3) Complement Receptors in the Infectious Disease

Biology Group    Start Submission

Cassio Marinho Campelo*

Dates: Received: 2021-03-16 | Accepted: 2021-03-30 | Published: 2021-03-31
Pages: 216-217


The complement system is one of the host’s primary defence mechanisms against pathogens. Its activation involves proteolytic cascades of enzymatic reactions that result in products with effector functions and recognition of molecules on the surface of microorganisms [1,2].

FullText HTML FullText PDF DOI: 10.37871/jbres1214

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© 2021 Campelo CM. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Campelo CM. Importance the Type 1 (CR1) and Type 3 (CR3) Complement Receptors in the Infectious Disease. J Biomed ResEnviron Sci. 2021 Mar 31; 2(3): 216-217. doi: 10.37871/jbres1214, Article ID: jbres1214

Subject area(s)


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  4. Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010 Sep;11(9):785-97. doi: 10.1038/ni.1923. Epub 2010 Aug 19. PMID: 20720586; PMCID: PMC2924908.
  5. Ross GD, Yount WJ, Walport MJ, Winfield JB, Parker CJ, Fuller CR, Taylor RP, Myones BL, Lachmann PJ. Disease-associated loss of erythrocyte complement receptors (CR1, C3b receptors) in patients with systemic lupus erythematosus and other diseases involving autoantibodies and/or complement activation. J Immunol. 1985 Sep;135(3):2005-14. PMID: 4020137.
  6. Kumar A, Malaviya AN, Srivastava LM. Lowered expression of C3b receptor (CR1) on erythrocytes of rheumatoid arthritis patients. Immunobiology. 1994 Aug;191(1):9-20. doi: 10.1016/S0171-2985(11)80264-0. PMID: 7806259.
  7. Mouhoub A, Delibrias CC, Fischer E, Boyer V, Kazatchkine MD. Ligation of CR1 (C3b receptor, CD35) on CD4+ T lymphocytes enhances viral replication in HIV-infected cells. Clin Exp Immunol. 1996 Nov;106(2):297-303. doi: 10.1046/j.1365-2249.1996.d01-844.x. PMID: 8918576; PMCID: PMC2200595.
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  9. Ueno N, Wilson ME. Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival. Trends Parasitol. 2012 Aug;28(8):335-44. doi: 10.1016/ Epub 2012 Jun 21. PMID: 22726697; PMCID: PMC3399048.
  10. Campelo CM, Pinheiro IC, de Melo Tavares B, Alves de Lima Henn G, Fernandes C, Albuquerque-Pinto LC, Carneiro Câmara LM. Modulation in the expression of type 1 (CR1/CD35) and type 3 (CR3/CD11b) complement receptors on leukocytes from patients with Visceral leishmaniasis. Exp Parasitol. 2020 Nov;218:107970. doi: 10.1016/j.exppara.2020.107970. Epub 2020 Aug 21. PMID: 32828829.


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