Covid-19 Research

Research Article

Cord Blood Haematological Parameters Reference Range Difference in Urban and Rural Population of West Bengal as Compared to Global Scenario

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Research Article
Subject Medicine Group
OCLC 9041196484
Sayak Manna, Indranil Dhar, Tapan Kumar Naskar and Sujata Law*
Issue: Volume2-Issue3
Pages: 206-212
Received: 2021-03-15
Accepted: 2021-03-23
Published: 2021-03-24

Abstract

Background: Human umbilical cord blood is often discarded as a biomedical waste. We aimed to standardise a local cord blood reference range for the West Bengal population. The cord blood haematological values differ depending on ethnic, regional and genealogical groups, so we primarily focussed our study on the international and intra-national differences of cord blood parameters. Comparison between the cord blood values of urban and the rural population along with normal and caesarean deliveries was not recorded before.

Methods: Umbilical cord blood was procured from consenting mothers (average age: 26.1 and 38-40 weeks gestation period), post-delivery at Medical College, Kolkata. Cord blood parameters were divided into two major groups: urban and rural population, each group was further divided into two sub-groups depending on the mode of delivery: normal and caesarean delivery. Comparison was also drawn on the basis of other international groups having different ethnic backgrounds and inter-state individuals having similar ethnic background.

Results: Our results showed West Bengal’s cord blood WBC value was higher and monocyte count was much lesser when compared globally. The neutrophil value was higher in rural as compared to urban and both the lymphocyte and platelet values of urban were recorded more than rural. Slight differences were recorded among urban-normal, urban-caesarean, rural normal and rural caesarean groups.

Conclusion: A new angle in terms of urban and rural population study is introduced in cord blood analysis. The standardisation of cord blood reference range for the West Bengal population is a new step for neonatal studies.

FullText HTML FullText PDF DOI: 10.37871/jbres1212 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2021 Manna S, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Manna S, Dhar I, Naskar TK, Law S. Cord Blood Haematological Parameters Reference Range Difference in Urban and Rural Population of West Bengal as Compared to Global Scenario. J Biomed Res Environ Sci. 2021 Mar 24; 2(3): 206-212. doi: 10.37871/jbres1212, Article ID: jbres1212

Subject area(s)

Stem CellsHematologyCellular BiologyBlood Disorders

References

  1. Mayani H, Lansdorp PM. Biology of human umbilical cord blood-derived hematopoietic stem/progenitor cells. Stem Cells. 1998;16(3):153-65. doi: 10.1002/stem.160153. PMID: 9617891.
  2. Rocha V, Sanz G, Gluckman E. Umbilical cord blood transplantation. Current Opinion in Hematology. 2004. doi: 10.1097/01.moh.0000145933.36985.eb.
  3. Chalmers IM, Janossy G, Contreras M, Navarrete C. Intracellular cytokine profile of cord and adult blood lymphocytes. Blood. 1998 Jul 1;92(1):11-8. PMID: 9639493.
  4. Lu L, Xiao M, Shen RN, Grigsby S, Broxmeyer HE. Enrichment, characterization, and responsiveness of single primitive CD34 human umbilical cord blood hematopoietic progenitors with high proliferative and replating potential. Blood. 1993 Jan 1;81(1):41-8. PMID: 7678069.
  5. Mahla RS. Stem Cells Applications in Regenerative Medicine and Disease Therapeutics. Int J Cell Biol. 2016;2016:6940283. doi: 10.1155/2016/6940283. Epub 2016 Jul 19. PMID: 27516776; PMCID: PMC4969512.
  6. Weiss ML, Troyer DL. Stem cells in the umbilical cord. Stem Cell Rev. 2006;2(2):155-62. doi: 10.1007/s12015-006-0022-y. PMID: 17237554; PMCID: PMC3753204.
  7. Tse W, Laughlin MJ. Umbilical cord blood transplantation: a new alternative option. Hematology Am Soc Hematol Educ Program. 2005:377-83. doi: 10.1182/asheducation-2005.1.377. PMID: 16304407.
  8. Costakos DT, Walden J, Rinzel MT, Dahlen L. Painless blood testing to prevent neonatal sepsis. WMJ. 2009 Sep;108(6):321-2. PMID: 19813501.
  9. Lanfranchi A, Porta F, Chirico G. Stem cells and the frontiers of neonatology. Early Hum Dev. 2009 Oct;85(10 Suppl):S15-8. doi: 10.1016/j.earlhumdev.2009.08.005. PMID: 19836907.
  10. Carroll PD, Nankervis CA, Iams J, Kelleher K. Umbilical cord blood as a replacement source for admission complete blood count in premature infants. J Perinatol. 2012 Feb;32(2):97-102. doi: 10.1038/jp.2011.60. Epub 2011 May 12. PMID: 21566570; PMCID: PMC3891501.
  11. Hansen A, Forbes P, Buck R. Potential substitution of cord blood for infant blood in the neonatal sepsis evaluation. Biol Neonate. 2005;88(1):12-8. doi: 10.1159/000083946. Epub 2005 Feb 10. PMID: 15711036.
  12. Walka MM, Sonntag J, Kage A, Dudenhausen JW, Obladen M. Complete blood counts from umbilical cords of healthy term newborns by two automated cytometers. Acta Haematol. 1998;100(4):167-73. doi: 10.1159/000040898. PMID: 9973637.
  13. Pranke P, Failace RR, Allebrandt WF, Steibel G, Schmidt F, Nardi NB. Hematologic and immunophenotypic characterization of human umbilical cord blood. Acta Haematol. 2001;105(2):71-6. doi: 10.1159/000046537. Erratum in: Acta Haematol 2001;105(4):251. PMID: 11408707.
  14. Forestier F, Daffos F, Catherine N, Renard M, Andreux JP. Developmental hematopoiesis in normal human fetal blood. Blood. 1991 Jun 1;77(11):2360-3. PMID: 2039818.
  15. Noguera NI, Detarsio G, Pérez SM, Bragós IM, Lanza O, Rodríguez JH, Acosta I, Davoli R, Milani AC. Hematologic study of newborn umbilical cord blood. Medicina (B Aires). 1999;59(5 Pt 1):446-8. PMID: 10684163.
  16. Redźko S, Przepieść J, Zak J, Urban J, Wysocka J. Influence of perinatal factors on hematological variables in umbilical cord blood. J Perinat Med. 2005;33(1):42-5. doi: 10.1515/JPM.2005.007. PMID: 15841613.
  17. Lee HR, Shin S, Yoon JH, Kim BJ, Hwang KR, Kim JJ, Roh EY. [Complete blood count reference values of donated cord blood from Korean neonates]. Korean J Lab Med. 2009 Jun;29(3):179-84. Korean. doi: 10.3343/kjlm.2009.29.3.179. PMID: 19571613.
  18. Jan RH, Wen SH, Shih WL, Chang YH, Chen SH. Evaluation of biological features of cord blood units in different Taiwan ethnics. Acta Paediatr Taiwan. 2007 Mar-Apr;48(2):57-61. PMID: 17626603.
  19. Bieback K, Kern S, Klüter H, Eichler H. Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood. Stem Cells. 2004;22(4):625-34. doi: 10.1634/stemcells.22-4-625. PMID: 15277708.
  20. Glasser L, Sutton N, Schmeling M, Machan JT. A comprehensive study of umbilical cord blood cell developmental changes and reference ranges by gestation, gender and mode of delivery. J Perinatol. 2015 Jul;35(7):469-75. doi: 10.1038/jp.2014.241. Epub 2015 Jan 29. PMID: 25634517.
  21. Adewumi A, Titilope A A, Akinsegun AA, Abidoye G, Ebele U, Sulaimon AA. Cord blood full blood count parameters in Lagos, Nigeria. Pan Afr Med J. 2014 Mar 13;17:192. doi: 10.11604/pamj.2014.17.192.3680. PMID: 25396018; PMCID: PMC4228999.
  22. Al-Marzoki JM, Al-Maaroof ZW, Kadhum AH. Determination of reference ranges for full blood count parameters in neonatal cord plasma in Hilla, Babil, Iraq. J Blood Med. 2012;3:113-8. doi: 10.2147/JBM.S35895. Epub 2012 Oct 1. PMID: 23055785; PMCID: PMC3464059.
  23. Qaiser DH, Sandila MP, Ahmed ST, Kazmi T. Haematological reference values for full-term, healthy, newborns of Karachi, Pakistan. J Pak Med Assoc. 2009 Sep;59(9):618-22. PMID: 19750858.
  24. Basnet S, Singh SK, Sathian B, Mishra R. Reference ranges for hematological values in umbilical cord blood in Pokhara, Nepal. J Nepal Paediatr Soc. 2016;36(2):160-164. doi: 10.3126/jnps.v36i2.15605.
  25. Suman FR, Raj RS, Priyathersini N, Rajendran R, Rajendran R, Ramadoss U. Biological Reference Interval for Hematological Profile of Umbilical Cord Blood: A Study Conducted at A Tertiary Care Centre in South India. J Clin Diagn Res. 2015 Oct;9(10):SC07-9. doi: 10.7860/JCDR/2015/14713.6675. Epub 2015 Oct 1. PMID: 26557584; PMCID: PMC4625303.
  26. Marwaha N, Marwaha RK, Narang A, Thusu K, Garewal G, Bhakoo ON. Routine hematological values in term newborns. Indian Pediatr. 1992 Sep;29(9):1095-9. PMID: 1452304.
  27. Katsares V, Paparidis Z, Nikolaidou E, Karvounidou I, Ardelean KA, Drossas N, Grigoriadis N, Grigoriadis J. Reference ranges for umbilical cord blood hematological values. Lab Med. 2009;40(7):437-439. doi: 10.1309/LMWCY2YGYCF9EEMQ.
  28. Chang YH, Yang SH, Wang TF, Lin TY, Yang KL, Chen SH. Complete blood count reference values of cord blood in Taiwan and the influence of gender and delivery route on them. Pediatr Neonatol. 2011 Jun;52(3):155-60. doi: 10.1016/j.pedneo.2011.03.007. Epub 2011 May 6. PMID: 21703558.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership