Covid-19 Research

Original Article

Potential Use of Quercetin as Protective Agent against Hydroxychloroquine Induced Cardiotoxicity

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

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Open Access
Article Type Original Article
Subject Medicine Group
OCLC 8979505266
Mona G Amer* and Nader M. Mohamed
Issue: Volume2-Issue3
Pages: 185-192
Received: 2021-03-07
Accepted: 2021-03-17
Published: 2021-03-18

Abstract

The aim of this study is to investigate the protective effects of Quercetin (QCT) on Hydroxychloquine (HCQ)-induced myocardial affection in rats. HCQ has been found to produce toxic effects including cardiac manifestation. Adding QCT to HCQ ameliorates its effects and prevents cardiac manifestations. For this purpose, eighty adult male rats were divided into four groups (n = 20). Group 1 (control) and group 2 (QCT-treated). Group 3 (HCQ treated) received 20 mg/kg of HCQ and group 4 (QCT + HCQ treated) received quercetin (50 mg/kg; orally) combined with HCQ for 4 weeks. Cardiac troponin-I and oxidative markers (Malondialdehyde (MDA), and total serum antioxidant) were estimated in serum. In addition, histopathological and morphometric changes of the rat heart were assessed. The HCQ treated group showed increased serum levels of cardiac troponin-I, MDA and decreased serum levels of total antioxidant. Pathological picture of myocardial hypertrophy and degeneration together with depleted cardiac tissue expression of troponin T were also observed. The characteristic features were presence of whorled myelin bodies and curvilinear bodies by EM examination. These parameters improved better in the group receiving combination of QCT together with HCQ. So, Adding QCT to HCQ could be prophylactic measure against its cardiotoxic effect compared with HCQ treatment alone.

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© 2021 Amer MG, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Amer MG, Mohamed NM. Potential Use of Quercetin as Protective Agent against Hydroxychloroquine Induced Cardiotoxicity. J Biomed Res Environ Sci. 2021 Mar 18; 2(3): 185-192. doi: 10.37871/jbres1208, Article ID: jbres1208

Subject area(s)

AnatomyClinical Cardiology

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