Volume2-Issue1
Dates: Received: 2021-01-27 | Accepted: 2021-01-29 | Published: 2021-01-29
Pages: 030-033
Abstract
It has been widely reported that infections caused by coronaviruses, especially SARS-CoV-2 (Covid-19), can result in cytokine storm syndrome, one of the causes of acute cerebrovascular disease and ‘kounis syndrome’. An 87-year-old male patient, who did not have any chronic diseases apart from hypertensions, was admitted to our emergency department with mental fog and right-sided weakness in the absence of the typical symptoms of Covid-19 (such as fever, cough). In addition to evidence of left middle cerebral artery infarction in Computerized Tomography (CT) of the brain, there were infiltrative findings compatible with Covid-19 in thorax CT. Here, we discuss this case in the light of the literature, assuming that inflammation (cytokine storm) and hypercoagulopathy induced by Covid-19 may have presented with large vessel occlusion and kounis syndrome as a result of increased risk of arterial thrombosis.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1183
Certificate of Publication

Copyright
© 2021 Ertekin A. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Ertekin A. Triggered by Covid-19? Large Vascular Occlusion Resulting in Cytokine Storm Syndrome and Kounis Syndrome: A Case Report1. J Biomed Res Environ Sci. 2021 Jan 29; 2(1): 030-033. doi: 10.37871/jbres1183, Article ID: jbres1183
Subject area(s)
References
- Wang HY, Li
- XL, Yan ZR, Sun XP, Han J, Zhang BW. Potential neurological symptoms of
- COVID-19. Ther Adv Neurol Disord. 2020 Mar 28;13:1756286420917830. doi:
- 1177/1756286420917830. PMID: 32284735; PMCID: PMC7119227.
- Mao L, Jin H,
- Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu
- B. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease
- 2019 in Wuhan, China. JAMA Neurol. 2020 Jun 1;77(6):683-690. doi:
- 1001/jamaneurol.2020.1127. PMID: 32275288; PMCID: PMC7149362.
- D’Anna L, Kwan
- J, Brown Z, Halse O, Jamil S, Kalladka D, Venter M, Banerjee S. Characteristics
- and clinical course of Covid-19 patients admitted with acute stroke. J Neurol.
- 2020 Nov;267(11):3161-3165. doi: 10.1007/s00415-020-10012-4. Epub 2020 Jun 24.
- PMID: 32583054; PMCID: PMC7313245.
- Mahboob S,
- Boppana SH, Rose NB, Beutler BD, Tabaac BJ. Large vessel stroke and COVID-19:
- Case report and literature review. eNeurologicalSci. 2020 Jun 16;20:100250.
- doi: 10.1016/j.ensci.2020.100250. PMID: 32632380; PMCID: PMC7297179.
- Wu Y, Xu X,
- Chen Z, Duan J, Hashimoto K, Yang L, Liu C, Yang C. Nervous system involvement
- after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020
- Jul;87:18-22. doi: 10.1016/j.bbi.2020.03.031. Epub 2020 Mar 30. PMID: 32240762;
- PMCID: PMC7146689.
- Saba L, Gerosa
- C, Wintermark M, Hedin U, Fanni D, Suri JS, Balestrieri A, Faa G. Can COVID19
- trigger the plaque vulnerability-a Kounis syndrome warning for “asymptomatic
- subjectsâ€. Cardiovasc Diagn Ther. 2020 Oct;10(5):1352-1355. doi:
- 21037/cdt-20-561. PMID: 33224760; PMCID: PMC7666923.
- Wang T, Du Z,
- Zhu F, Cao Z, An Y, Gao Y, Jiang B. Comorbidities and multi-organ injuries in
- the treatment of COVID-19. Lancet. 2020 Mar 21;395(10228):e52. doi:
- 1016/S0140-6736(20)30558-4. Epub 2020 Mar 11. PMID: 32171074; PMCID:
- PMC7270177.
- Yin CH, Wang
- C, Tang Z, Wen Y, Zhang SW, Wang BE. [Clinical analysis of multiple organ
- dysfunction syndrome in patients suffering from SARS]. Zhongguo Wei Zhong Bing
- Ji Jiu Yi Xue. 2004 Nov;16(11):646-50. Chinese. PMID: 15535894.
- Wang Y, Wang
- Y, Chen Y, Qin Q. Unique epidemiological and clinical features of the emerging
- 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures.
- J Med Virol. 2020 Jun;92(6):568-576. doi: 10.1002/jmv.25748. Epub 2020 Mar 29.
- PMID: 32134116; PMCID: PMC7228347.
- Nagel MA, Mahalingam R, Cohrs RJ, Gilden
- D. Virus vasculopathy and stroke: an under-recognized cause and treatment
- target. Infect Disord Drug Targets. 2010 Apr;10(2):105-11. doi:
- 2174/187152610790963537. PMID: 20166970; PMCID: PMC2909030.