Sex and Age Differences in Telomere Length and Susceptibility to COVID-19

Manar Ahmed Kamal*; Kareem Reda Alamiry; Mahmoud Zaki

**Manar Ahmed Kamal*, Kareem Reda Alamiry and Mahmoud Zaki**

Volume1-Issue7
Dates: Received: 2020-10-09 | Accepted: 2020-11-11 | Published: 2020-11-12
Pages: 303-310

Abstract

Background: Telomeres are the ends of a chromosome and play a fundamental role as vanguards contra the chromosomal decay. Due to the inability of DNA polymerase to replicate chromosomal ends, a reduction in telomeres length happens after each cell division. The existence of shorter telomeres in older people is related to diminish immune functions. Viral infections able to stimulate remodeling of cells, stress responses, and telomere shortening. Moreover, telomere shortening can be caused by extrinsic environmental variables which induce oxidative stress under conditions of inflammation.

Aim: To identify the correlation between telomere shortening and susceptibility to Novel Coronavirus Disease 2019 (COVID-19). In addition to clarifying changes in telomere length according to the viral infection, the effect of sex and age differences in telomere length in confirmed positive COVID-19 cases are also reviewed.

Conclusion: There is a correlation between telomere length and COVID-19 infection with higher susceptibly of elderly patients and males due to shortening in their telomere length. Approximately 53% of (111,428) infected cases (≥ 50) years old are males, and 47% of (111,428) infected cases (≥ 50) years old are females.

FullText HTML FullText PDF DOI: 10.37871/jbres1159

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How to cite this article

Kamal MA, Alamiry KR, Zaki M. Sex and Age Differences in Telomere Length and Susceptibility to COVID-19. J Biomed Res Environ Sci. 2020 Nov 12; 1(7): 303-310. doi: 10.37871/jbres1159, Article ID: jbres1159

Subject area(s)

Genetics

Infectious Diseases

Virology

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