Selin Akturk Esen*, Oznur Bal, Efnan Algin, Yusuf Acu0131kgoz, Merve Dirikoc, Gokhan Ucar1, Lale Damgaci, Yakup Ergun, Irfan Esen3, Hurrem Bodur and Dogan Uncu
Volume1-Issue5
Dates: Received: 2020-09-15 | Accepted: 2020-09-29 | Published: 2020-09-30
Pages: 186-189
Abstract
At the end of 2019, a new coronavirus pneumonia turned into an epidemic in China and then spread to other countries around the world. This disease was identified as the COVID-19 (SARS-CoV-2) disease. SARS-CoV-2 RNA is detected by Reverse-Transcription Polymerase Chain Reaction (RT-PCR). A positive test for SARS-CoV-2 may confirm the diagnosis of COVID-19, but the results of false negativity and false positivity can be confusing. This article describes the negative COVID-19 RNA RT-PCR test results of four cancer patients with symptoms/clinical findings suggestive of COVID-19 and also computed tomography findings consistent with viral pneumonia.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1141
Certificate of Publication
Copyright
© 2020 Esen SA, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Esen SA, Bal Ö, Algın E, Açıkgöz Y, Dirikoç M, Uçar G, Damgacı L, Ergun Y, Esen İ, Bodur H, Uncu D. The Negative RT-PCR Test is Enough to Rule Out Covıd-19 in Cancer Patients or Not? Covıd-19 or Not? J Biomed Res Environ Sci. 2020 Sep 30; 1(5): 186-189. doi: 10.37871/jbres1141, Article ID: jbres1141
Subject area(s)
University/Institute
References
- Organization WH. Director-General’s remarks at the media briefing on 2019-nCoV on 2020. 2020 February 11.
- Wong HYF, Lam HYS, Fong AH, Leung ST, Chin TW, Lo CSY, Lui MM, Lee JCY, Chiu KW, Chung TW, Lee EYP, Wan EYF, Hung IFN, Lam TPW, Kuo MD, Ng MY. Frequency and Distribution of Chest Radiographic Findings in Patients Positive for COVID-19. Radiology. 2020 Aug;296(2):E72-E78. doi: 10.1148/radiol.2020201160. Epub 2020 Mar 27. PMID: 32216717; PMCID: PMC7233401.
- Li Y, Yao L, Li J, Chen L, Song Y, Cai Z, Yang C. Stability issues of RT-PCR testing of SARS-CoV-2 for hospitalized patients clinically diagnosed with COVID-19. J Med Virol. 2020 Jul;92(7):903-908. doi: 10.1002/jmv.25786. Epub 2020 Apr 5. PMID: 32219885; PMCID: PMC7228231.
- Yu F, Yan L, Wang N, Yang S, Wang L, Tang Y, Gao G, Wang S, Ma C, Xie R, Wang F, Tan C, Zhu L, Guo Y, Zhang F. Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients. Clin Infect Dis. 2020 Jul 28;71(15):793-798. doi: 10.1093/cid/ciaa345. PMID: 32221523; PMCID: PMC7184442.
- Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, Tan W. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA. 2020 May 12;323(18):1843-1844. doi: 10.1001/jama.2020.3786. PMID: 32159775; PMCID: PMC7066521.
- Organization WH. Coronavirus disease (COVID-19) technical guidance: Surveillance and case definitions. 2020 February 28.
- Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 February 28;8:475-481. doi: 10.1016/S2213-2600(20)30079-5.
- Sefers S PZ, Tang YW. False positives and false negatives encountered in diagnostic molecular microbiology. Reviews in Medical Microbiology. 2005; 16:59-67.
- Parissenti AM, Guo B, Pritzker LB, Pritzker KP, Wang X, Zhu M, Shepherd LE, Trudeau ME. Tumor RNA disruption predicts survival benefit from breast cancer chemotherapy. Breast Cancer Res Treat. 2015 Aug;153(1):135-44. doi: 10.1007/s10549-015-3498-9. Epub 2015 Jul 25. PMID: 26208483.
