Ginger (Zingiber officinale) and its Bioactive Components with Protective and Therapeutic Potential against Cancer

Meeneri Vilas Bobde; Saroj Yadav; Sibi G*

Meeneri Vilas Bobde, Saroj Yadav and Sibi G*

Volume1-Issue5
Dates: Received: 2020-08-14 | Accepted: 2020-09-11 | Published: 2020-09-15
Pages: 144-149

Abstract

Ginger can be an important complementary medicine for prevention and treatment of different types of cancers, owing to its natural origin, safety, and low cost relative to synthetic cancer drugs. Ginger contains volatile oils, anthocyanins, tannins, phenolic compounds and sesquiterpenes anticancer effects of ginger may arise from the ability to induce changes in a number of cellular processes, including cell division, apoptosis and differentiation. In this study, anticancer activity of ginger extract against various cancer cells both in vitro and in vivo were investigated. The evidence in this review suggests that ginger and its compounds in diet may lower cancer risk and affect tumor behavior.

FullText HTML FullText PDF DOI: 10.37871/jbres1133

Certificate of Publication

Copyright

How to cite this article

Bobde MV, Yadav S, Sibi G. Ginger (Zingiber officinale) and its Bioactive Components with Protective and Therapeutic Potential against Cancer. J Biomed Res Environ Sci. 2020 Sep 15; 1(5): 144-149. doi: 10.37871/jbres1133, Article ID: jbres1133

Subject area(s)

Therapeutics

Pharmacology

University/Institute

Bharathiar University

References

Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry. 2015 Sep;117:554-568. doi: 10.1016/j.phytochem.2015.07.012. Epub 2015 Jul 27. PMID: 26228533.
Langner E, Greifenberg S, Gruenwald J. Ginger: history and use. Adv Ther. 1998 Jan-Feb;15(1):25-44. PMID: 10178636.
Ault A. On food and cooking. The science and lore of the kitchen by Harold McGee. Scribner, New York. 2003; pp. 425-426
Wilson R, Haniadka R, Sandhya P, Palatty PL, Baliga MS. Ginger (Zingiber officinale Roscoe) the dietary agent in skin care: A Review. In bioactive dietary factors and plant extracts in dermatology. Edited by: Watson RR, Zibadi S. Karnataska: Humana Press. 2013: 103-111.
Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol. 2008 Feb;46(2):409-20. doi: 10.1016/j.fct.2007.09.085. Epub 2007 Sep 18. PMID: 17950516.
Wang B, Sun J, Ma Y, Wu G, Tian Y, Shi Y, Le G. Resveratrol preserves mitochondrial function, stimulates mitochondrial biogenesis, and attenuates oxidative stress in regulatory T cells of mice fed a high-fat diet. J Food Sci. 2014 Sep;79(9):H1823-31. doi: 10.1111/1750-3841.12555. Epub 2014 Aug 23. PMID: 25156660.
Wang S, Sun X, Jiang L, Liu X, Chen M, Yao X, Sun Q, Yang G. 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chem Biol Interact. 2016 Aug 25;256:249-56. doi: 10.1016/j.cbi.2016.07.020. Epub 2016 Jul 20. PMID: 27451028.
Liu CM, Kao CL, Tseng YT, Lo YC, Chen CY. Ginger Phytochemicals Inhibit Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant Prostate Cancer Cell. Molecules. 2017 Sep 5;22(9):1477. doi: 10.3390/molecules22091477. PMID: 28872603; PMCID: PMC6151784.
Tahir AA, Sani NF, Murad NA, Makpol S, Ngah WZ, Yusof YA. Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells. Nutr J. 2015 Apr 1;14:31. doi: 10.1186/s12937-015-0015-2. PMID: 25889965; PMCID: PMC4390091.
Lee SH, Cekanova M, Baek SJ. Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Mol Carcinog. 2008 Mar;47(3):197-208. doi: 10.1002/mc.20374. PMID: 18058799; PMCID: PMC2430145.
Poltronieri J, Becceneri AB, Fuzer AM, Filho JC, Martin AC, Vieira PC, Pouliot N, Cominetti MR. [6]-gingerol as a cancer chemopreventive agent: a review of its activity on different steps of the metastatic process. Mini Rev Med Chem. 2014 Apr;14(4):313-21. doi: 10.2174/1389557514666140219095510. PMID: 24552266.
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4. PMID: 25651787.
Lee HS, Seo EY, Kang NE, Kim WK. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem. 2008 May;19(5):313-9. doi: 10.1016/j.jnutbio.2007.05.008. Epub 2007 Aug 1. PMID: 17683926.
Ling H, Yang H, Tan SH, Chui WK, Chew EH. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br J Pharmacol. 2010 Dec;161(8):1763-77. doi: 10.1111/j.1476-5381.2010.00991.x. PMID: 20718733; PMCID: PMC3010581.
Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR. Differential control of growth, apoptotic activity, and gene expression in human breast cancer cells by extracts derived from medicinal herbs Zingiber officinale. J Biomed Biotechnol. 2012;2012:614356. doi: 10.1155/2012/614356. Epub 2012 Aug 26. PMID: 22969274; PMCID: PMC3433172.
Joo JH, Hong SS, Cho YR, Seo DW. 10-Gingerol inhibits proliferation and invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK activity. Oncol Rep. 2016 Feb;35(2):779-84. doi: 10.3892/or.2015.4405. Epub 2015 Nov 9. PMID: 26554741.
Bernard MM, McConnery JR, Hoskin DW. [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells. Exp Mol Pathol. 2017 Apr;102(2):370-376. doi: 10.1016/j.yexmp.2017.03.006. Epub 2017 Mar 16. PMID: 28315687.
Kaewtunjai N, Wongpoomchai R, Imsumran A, Pompimon W, Athipornchai A, Suksamrarn A, Lee TR, Tuntiwechapikul W. Ginger Extract Promotes Telomere Shortening and Cellular Senescence in A549 Lung Cancer Cells. ACS Omega. 2018 Dec 27;3(12):18572-18581. doi: 10.1021/acsomega.8b02853. PMID: 32010796; PMCID: PMC6988994.
Yusof YA, Ahmad N, Das S, Sulaiman S, Murad NA. Chemopreventive efficacy of ginger (Zingiber officinale) in ethionine induced rat hepatocarcinogenesis. Afr J Tradit Complement Altern Med. 2008 Oct 25;6(1):87-93. doi: 10.4314/ajtcam.v6i1.57078. PMID: 20162046; PMCID: PMC2816532.
Wang Y, Wang S, Song R, Cai J, Xu J, Tang X, Li N. Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Int J Biol Macromol. 2019 Feb 15;123:81-90. doi: 10.1016/j.ijbiomac.2018.10.169. Epub 2018 Nov 8. PMID: 30414900.
Habib SH, Makpol S, Abdul Hamid NA, Das S, Ngah WZ, Yusof YA. Ginger extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats. Clinics (Sao Paulo). 2008 Dec;63(6):807-13. doi: 10.1590/s1807-59322008000600017. PMID: 19061005; PMCID: PMC2664283.
Weng CJ, Wu CF, Huang HW, Ho CT, Yen GC. Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Mol Nutr Food Res. 2010 Nov;54(11):1618-27. doi: 10.1002/mnfr.201000108. PMID: 20521273.
Weng CJ, Chou CP, Ho CT, Yen GC. Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. Mol Nutr Food Res. 2012 Aug;56(8):1304-14. doi: 10.1002/mnfr.201200173. Epub 2012 Jun 20. PMID: 22714996.
Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh AR. [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells. Eur J Pharmacol. 2012 Nov 5;694(1-3):20-9. doi: 10.1016/j.ejphar.2012.08.001. Epub 2012 Aug 24. PMID: 22939973.
Zhang F, Zhang JG, Qu J, Zhang Q, Prasad C, Wei ZJ. Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells. Food Chem Toxicol. 2017 Nov;109(Pt 2):910-922. doi: 10.1016/j.fct.2017.02.038. Epub 2017 Feb 27. PMID: 28249781.
Zhang F, Thakur K, Hu F, Zhang JG, Wei ZJ. 10-Gingerol, a Phytochemical Derivative from “Tongling White Ginger”, Inhibits Cervical Cancer: Insights into the Molecular Mechanism and Inhibitory Targets. J Agric Food Chem. 2017 Mar 15;65(10):2089-2099. doi: 10.1021/acs.jafc.7b00095. Epub 2017 Mar 1. PMID: 28230361.
Rastogi N, Duggal S, Singh SK, Porwal K, Srivastava VK, Maurya R, Bhatt ML, Mishra DP. Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells. Oncotarget. 2015 Dec 22;6(41):43310-25. doi: 10.18632/oncotarget.6383. PMID: 26621832; PMCID: PMC4791234.
Ansari JA, Ahmad MK, Khan AR, Fatima N, Khan HJ, Rastogi N, Mishra DP, Mahdi AA. Anticancer and Antioxidant activity of Zingiber officinale Roscoe rhizome. Indian J Exp Biol. 2016 Nov;54(11):767-773. PMID: 30179422.
Lin CB, Lin CC, Tsay GJ. 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest. Evid Based Complement Alternat Med. 2012;2012:326096. doi: 10.1155/2012/326096. Epub 2012 Jun 7. PMID: 22719783; PMCID: PMC3375166.
Su P, Veeraraghavan VP, Krishna Mohan S, Lu W. A ginger derivative, zingerone-a phenolic compound-induces ROS-mediated apoptosis in colon cancer cells (HCT-116). J Biochem Mol Toxicol. 2019 Dec;33(12):e22403. doi: 10.1002/jbt.22403. Epub 2019 Nov 12. PMID: 31714660.
Abdullah S, Abidin SAZ, Murad NA, Makpol S, Ngah WZW, Yusof YAM. Ginger extract (Zingiber offi cinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. Afr J Biochem Res. 2010; 4: 134-142. https://rb.gy/3ipnnc
Liu Y, Whelan RJ, Pattnaik BR, Ludwig K, Subudhi E, Rowland H, Claussen N, Zucker N, Uppal S, Kushner DM, Felder M, Patankar MS, Kapur A. Terpenoids from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells through the activation of p53. PLoS One. 2012;7(12):e53178. doi: 10.1371/journal.pone.0053178. Epub 2012 Dec 31. PMID: 23300887; PMCID: PMC3534047.
Qi LW, Zhang Z, Zhang CF, Anderson S, Liu Q, Yuan CS, Wang CZ. Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk. Am J Chin Med. 2015;43(4):743-56. doi: 10.1142/S0192415X15500469. Epub 2015 Jun 28. PMID: 26119958.
Elkady AI, Hussein RA, Abu-Zinadah OA. Effects of crude extracts from medicinal herbs Rhazya stricta and Zingiber officinale on growth and proliferation of human brain cancer cell line in vitro. Biomed Res Int. 2014;2014:260210. doi: 10.1155/2014/260210. Epub 2014 Jul 22. PMID: 25136570; PMCID: PMC4130191.
Park GH, Park JH, Song HM, Eo HJ, Kim MK, Lee JW, Lee MH, Cho KH, Lee JR, Cho HJ, Jeong JB. Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells. BMC Complement Altern Med. 2014 Oct 23;14:408. doi: 10.1186/1472-6882-14-408. PMID: 25338635; PMCID: PMC4210498.
Danciu C, Vlaia L, Fetea F, Hancianu M, Coricovac DE, Ciurlea SA, Şoica CM, Marincu I, Vlaia V, Dehelean CA, Trandafirescu C. Evaluation of phenolic profile, antioxidant and anticancer potential of two main representants of Zingiberaceae family against B164A5 murine melanoma cells. Biol Res. 2015 Jan 12;48(1):1. doi: 10.1186/0717-6287-48-1. PMID: 25654588; PMCID: PMC4417255.
Huang HC, Chiu SH, Chang TM. Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action. Biosci Biotechnol Biochem. 2011;75(6):1067-72. doi: 10.1271/bbb.100851. Epub 2011 Jun 13. PMID: 21670536.
Huang HC, Chou YC, Wu CY, Chang TM. [8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways. Biochem Biophys Res Commun. 2013 Aug 23;438(2):375-81. doi: 10.1016/j.bbrc.2013.07.079. Epub 2013 Jul 25. PMID: 23892040.
Cojocaru SI, Stan M, Stoian G, Dinischiotu A. EFFECTS OF ZINGIBER OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN FIBROBLASTS. Rev Med Chir Soc Med Nat Iasi. 2015 Apr-Jun;119(2):592-6. PMID: 26204672.
Yao C, Oh JH, Oh IG, Park CH, Chung JH. [6]-Shogaol inhibits melanogenesis in B16 mouse melanoma cells through activation of the ERK pathway. Acta Pharmacol Sin. 2013 Feb;34(2):289-94. doi: 10.1038/aps.2012.134. Epub 2012 Nov 5. PMID: 23123645; PMCID: PMC4011614.
Park YJ, Wen J, Bang S, Park SW, Song SY. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei Med J. 2006 Oct 31;47(5):688-97. doi: 10.3349/ymj.2006.47.5.688. PMID: 17066513; PMCID: PMC2687755.
Kim SO, Kim MR. [6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- κ B/Snail Signal Transduction Pathway. Evid Based Complement Alternat Med. 2013;2013:761852. doi: 10.1155/2013/761852. Epub 2013 Sep 24. PMID: 24204396; PMCID: PMC3800596.
Shamoto T, Matsuo Y, Shibata T, Tsuboi K, Nagasaki T, Takahashi H, Funahashi H, Okada Y, Takeyama H. Zerumbone inhibits angiogenesis by blocking NF-κB activity in pancreatic cancer. Pancreas. 2014 Apr;43(3):396-404. doi: 10.1097/MPA.0000000000000039. PMID: 24622069.
Zhang S, Liu Q, Liu Y, Qiao H, Liu Y. Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway. Evid Based Complement Alternat Med. 2012;2012:936030. doi: 10.1155/2012/936030. Epub 2012 Jan 29. PMID: 22454691; PMCID: PMC3290912.
Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K. Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death. PLoS One. 2015 May 11;10(5):e0126605. doi: 10.1371/journal.pone.0126605. PMID: 25961833; PMCID: PMC4427290.
Zhou L, Qi L, Jiang L, Zhou P, Ma J, Xu X, Li P. Antitumor activity of gemcitabine can be potentiated in pancreatic cancer through modulation of TLR4/NF-κB signaling by 6-shogaol. AAPS J. 2014 Mar;16(2):246-57. doi: 10.1208/s12248-013-9558-3. Epub 2014 Jan 15. PMID: 24424498; PMCID: PMC3933586.
Karna P, Chagani S, Gundala SR, Rida PC, Asif G, Sharma V, Gupta MV, Aneja R. Benefits of whole ginger extract in prostate cancer. Br J Nutr. 2012 Feb;107(4):473-84. doi: 10.1017/S0007114511003308. Epub 2011 Aug 18. PMID: 21849094; PMCID: PMC3426621.
Saha A, Blando J, Silver E, Beltran L, Sessler J, DiGiovanni J. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in vitro and in vivo through inhibition of STAT3 and NF-κB signaling. Cancer Prev Res (Phila). 2014 Jun;7(6):627-38. doi: 10.1158/1940-6207.CAPR-13-0420. Epub 2014 Apr 1. PMID: 24691500.