Covid-19 Research

Open Access
Research Article
OCLC 8886944244

Ginger (Zingiber officinale) and its Bioactive Components with Protective and Therapeutic Potential against Cancer Google Scholar

Read • Cite • Share — permanent Open Access hosting with DOI tracking
Medicine Group
TherapeuticsPharmacology
Article Submission Portal

Volume1-Issue5
Dates: Received: 2020-08-14 | Accepted: 2020-09-11 | Published: 2020-09-15
Pages: 144-149

Abstract

Ginger can be an important complementary medicine for prevention and treatment of different types of cancers, owing to its natural origin, safety, and low cost relative to synthetic cancer drugs. Ginger contains volatile oils, anthocyanins, tannins, phenolic compounds and sesquiterpenes anticancer effects of ginger may arise from the ability to induce changes in a number of cellular processes, including cell division, apoptosis and differentiation. In this study, anticancer activity of ginger extract against various cancer cells both in vitro and in vivo were investigated. The evidence in this review suggests that ginger and its compounds in diet may lower cancer risk and affect tumor behavior.

FullText HTML FullText PDF DOI: 10.37871/jbres1133

Certificate of Publication

Copyright

© 2020 Sibi G, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Bobde MV, Yadav S, Sibi G. Ginger (Zingiber officinale) and its Bioactive Components with Protective and Therapeutic Potential against Cancer. J Biomed Res Environ Sci. 2020 Sep 15; 1(5): 144-149. doi: 10.37871/jbres1133, Article ID: jbres1133

Subject area(s)

Therapeutics
Pharmacology

University/Institute

Bharathiar University

References

  1. Semwal RB, Semwal DK, Combrinck S, Viljoen AM. Gingerols and shogaols:
  2. Important nutraceutical principles from ginger. Phytochemistry. 2015
  3. Sep;117:554-568. doi: 10.1016/j.phytochem.2015.07.012. Epub 2015 Jul 27. PMID:
  5. Langner E, Greifenberg S, Gruenwald J. Ginger: history and use. Adv
  6. Ther. 1998 Jan-Feb;15(1):25-44. PMID: 10178636.
  7. Ault A. On food and cooking. The science and lore of the kitchen by
  8. Harold McGee. Scribner, New York. 2003; pp. 425-426
  9. Wilson R, Haniadka R, Sandhya P, Palatty PL, Baliga MS. Ginger (
  10. Zingiber
  11. officinale
  12. Roscoe) the dietary agent in skin care: A Review. In bioactive
  13. dietary factors and plant extracts in dermatology. Edited by: Watson RR, Zibadi
  14. S. Karnataska: Humana Press. 2013: 103-111.
  15. Ali BH, Blunden G, Tanira MO, Nemmar A. Some phytochemical,
  16. pharmacological and toxicological properties of ginger (
  17. Zingiber officinale
  18. Roscoe):
  19. a review of recent research. Food Chem Toxicol. 2008 Feb;46(2):409-20. doi:
  20. 1016/j.fct.2007.09.085. Epub 2007 Sep 18. PMID: 17950516.
  21. Wang B, Sun J, Ma Y, Wu G, Tian Y, Shi Y, Le G. Resveratrol preserves
  22. mitochondrial function, stimulates mitochondrial biogenesis, and attenuates
  23. oxidative stress in regulatory T cells of mice fed a high-fat diet. J Food Sci.
  24. 2014 Sep;79(9):H1823-31. doi: 10.1111/1750-3841.12555. Epub 2014 Aug 23. PMID:
  26. Wang S, Sun X, Jiang L, Liu X, Chen M, Yao X, Sun Q, Yang G. 6-Gingerol
  27. induces autophagy to protect HUVECs survival from apoptosis. Chem Biol
  28. Interact. 2016 Aug 25;256:249-56. doi: 10.1016/j.cbi.2016.07.020. Epub 2016 Jul
  29. PMID: 27451028.
  30. Liu CM, Kao CL, Tseng YT, Lo YC, Chen CY. Ginger Phytochemicals Inhibit
  31. Cell Growth and Modulate Drug Resistance Factors in Docetaxel Resistant
  32. Prostate Cancer Cell. Molecules. 2017 Sep 5;22(9):1477. doi: 10.3390/molecules22091477.
  33. PMID: 28872603; PMCID: PMC6151784.
  34. Tahir AA, Sani NF, Murad NA, Makpol S, Ngah WZ, Yusof YA. Combined
  35. ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in
  36. colon cancer HT29 cells. Nutr J. 2015 Apr 1;14:31. doi: 10.1186/s12937-015-0015-2.
  37. PMID: 25889965; PMCID: PMC4390091.
  38. Lee SH, Cekanova M, Baek SJ. Multiple mechanisms are involved in
  39. 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer
  40. cells. Mol Carcinog. 2008 Mar;47(3):197-208. doi: 10.1002/mc.20374. PMID:
  41. 18058799; PMCID: PMC2430145.
  42. Poltronieri J, Becceneri AB, Fuzer AM, Filho JC, Martin AC, Vieira PC,
  43. Pouliot N, Cominetti MR. [6]-gingerol as a cancer chemopreventive agent: a
  44. review of its activity on different steps of the metastatic process. Mini Rev
  45. Med Chem. 2014 Apr;14(4):313-21. doi: 10.2174/1389557514666140219095510. PMID:
  47. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A.
  48. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108. doi:
  49. 3322/caac.21262. Epub 2015 Feb 4. PMID: 25651787.
  50. Lee HS, Seo EY, Kang NE, Kim WK. [6]-Gingerol inhibits metastasis of
  51. MDA-MB-231 human breast cancer cells. J Nutr Biochem. 2008 May;19(5):313-9.
  52. doi: 10.1016/j.jnutbio.2007.05.008. Epub 2007 Aug 1. PMID: 17683926.
  53. Ling H, Yang H, Tan SH, Chui WK, Chew EH. 6-Shogaol, an active
  54. constituent of ginger, inhibits breast cancer cell invasion by reducing matrix
  55. metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br
  56. J Pharmacol. 2010 Dec;161(8):1763-77. doi: 10.1111/j.1476-5381.2010.00991.x. PMID:
  57. 20718733; PMCID: PMC3010581.
  58. Elkady AI, Abuzinadah OA, Baeshen NA, Rahmy TR. Differential control of
  59. growth, apoptotic activity, and gene expression in human breast cancer cells by
  60. extracts derived from medicinal herbs Zingiber officinale. J Biomed Biotechnol.
  61. 2012;2012:614356. doi: 10.1155/2012/614356. Epub 2012 Aug 26. PMID: 22969274;
  62. PMCID: PMC3433172.
  63. Joo JH, Hong SS, Cho YR, Seo DW. 10-Gingerol inhibits proliferation and
  64. invasion of MDA-MB-231 breast cancer cells through suppression of Akt and p38MAPK
  65. activity. Oncol Rep. 2016 Feb;35(2):779-84. doi: 10.3892/or.2015.4405. Epub
  66. 2015 Nov 9. PMID: 26554741.
  67. Bernard MM, McConnery JR, Hoskin DW. [10]-Gingerol, a major phenolic
  68. constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative
  69. breast cancer cells. Exp Mol Pathol. 2017 Apr;102(2):370-376. doi:
  70. 1016/j.yexmp.2017.03.006. Epub 2017 Mar 16. PMID: 28315687.
  71. Kaewtunjai N, Wongpoomchai R, Imsumran A, Pompimon W, Athipornchai A,
  72. Suksamrarn A, Lee TR, Tuntiwechapikul W. Ginger Extract Promotes Telomere
  73. Shortening and Cellular Senescence in A549 Lung Cancer Cells. ACS Omega. 2018
  74. Dec 27;3(12):18572-18581. doi: 10.1021/acsomega.8b02853. PMID: 32010796; PMCID:
  75. PMC6988994.
  76. Yusof YA, Ahmad N, Das S, Sulaiman S, Murad NA. Chemopreventive
  77. efficacy of ginger (
  78. Zingiber officinale
  79. ) in ethionine induced rat
  80. hepatocarcinogenesis. Afr J Tradit Complement Altern Med. 2008 Oct
  81. 25;6(1):87-93. doi: 10.4314/ajtcam.v6i1.57078. PMID: 20162046; PMCID:
  82. PMC2816532.
  83. Wang Y, Wang S, Song R, Cai J, Xu J, Tang X, Li N. Ginger
  84. polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular
  85. carcinoma HepG2 cells. Int J Biol Macromol. 2019 Feb 15;123:81-90. doi:
  86. 1016/j.ijbiomac.2018.10.169. Epub 2018 Nov 8. PMID: 30414900.
  87. Habib SH, Makpol S, Abdul Hamid NA, Das S, Ngah WZ, Yusof YA. Ginger
  88. extract (Zingiber officinale) has anti-cancer and anti-inflammatory effects on
  89. ethionine-induced hepatoma rats. Clinics (Sao Paulo). 2008 Dec;63(6):807-13.
  90. doi: 10.1590/s1807-59322008000600017. PMID: 19061005; PMCID: PMC2664283.
  91. Weng CJ, Wu CF, Huang HW, Ho CT, Yen GC. Anti-invasion effects of
  92. 6-shogaol and 6-gingerol, two active components in ginger, on human
  93. hepatocarcinoma cells. Mol Nutr Food Res. 2010 Nov;54(11):1618-27. doi:
  94. 1002/mnfr.201000108. PMID: 20521273.
  95. Weng CJ, Chou CP, Ho CT, Yen GC. Molecular mechanism inhibiting human
  96. hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. Mol Nutr Food Res.
  97. 2012 Aug;56(8):1304-14. doi: 10.1002/mnfr.201200173. Epub 2012 Jun 20. PMID:
  99. Chakraborty D, Bishayee K, Ghosh S, Biswas R, Mandal SK, Khuda-Bukhsh
  100. AR. [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer
  101. cells: drug-DNA interaction and expression of certain signal genes in HeLa
  102. cells. Eur J Pharmacol. 2012 Nov 5;694(1-3):20-9. doi:
  103. 1016/j.ejphar.2012.08.001. Epub 2012 Aug 24. PMID: 22939973.
  104. Zhang F, Zhang JG, Qu J, Zhang Q, Prasad C, Wei ZJ. Assessment of
  105. anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy
  106. with drugs on human cervical adenocarcinoma cells. Food Chem Toxicol. 2017
  107. Nov;109(Pt 2):910-922. doi: 10.1016/j.fct.2017.02.038. Epub 2017 Feb 27. PMID:
  109. Zhang F, Thakur K, Hu F, Zhang JG, Wei ZJ. 10-Gingerol, a Phytochemical
  110. Derivative from “Tongling White Ginger”, Inhibits Cervical Cancer: Insights
  111. into the Molecular Mechanism and Inhibitory Targets. J Agric Food Chem. 2017
  112. Mar 15;65(10):2089-2099. doi: 10.1021/acs.jafc.7b00095. Epub 2017 Mar 1. PMID:
  114. Rastogi N, Duggal S, Singh SK, Porwal K, Srivastava VK, Maurya R, Bhatt
  115. ML, Mishra DP. Proteasome inhibition mediates p53 reactivation and anti-cancer
  116. activity of 6-gingerol in cervical cancer cells. Oncotarget. 2015 Dec
  117. 22;6(41):43310-25. doi: 10.18632/oncotarget.6383. PMID: 26621832; PMCID:
  118. PMC4791234.
  119. Ansari JA, Ahmad MK, Khan AR, Fatima N, Khan HJ, Rastogi N, Mishra DP,
  120. Mahdi AA. Anticancer and Antioxidant activity of
  121. Zingiber officinale
  122. Roscoe
  123. rhizome. Indian J Exp Biol. 2016 Nov;54(11):767-773. PMID: 30179422.
  124. Lin CB, Lin CC, Tsay GJ. 6-Gingerol Inhibits Growth of Colon Cancer
  125. Cell LoVo via Induction of G2/M Arrest. Evid Based Complement Alternat Med.
  126. 2012;2012:326096. doi: 10.1155/2012/326096. Epub 2012 Jun 7. PMID: 22719783;
  127. PMCID: PMC3375166.
  128. Su P, Veeraraghavan VP, Krishna Mohan S, Lu W. A ginger derivative, zingerone-a
  129. phenolic compound-induces ROS-mediated apoptosis in colon cancer cells
  130. (HCT-116). J Biochem Mol Toxicol. 2019 Dec;33(12):e22403. doi:
  131. 1002/jbt.22403. Epub 2019 Nov 12. PMID: 31714660.
  132. Abdullah S, Abidin SAZ, Murad NA, Makpol S, Ngah WZW, Yusof YAM. Ginger
  133. extract (
  134. Zingiber offi cinale
  135. ) triggers apoptosis and G0/G1 cells arrest
  136. in HCT 116 and HT 29 colon cancer cell lines. Afr J Biochem Res. 2010; 4:
  137. 134-142.
  138. https://rb.gy/3ipnnc
  139. Liu Y, Whelan RJ, Pattnaik BR, Ludwig K, Subudhi E, Rowland H, Claussen
  140. N, Zucker N, Uppal S, Kushner DM, Felder M, Patankar MS, Kapur A. Terpenoids
  141. from Zingiber officinale (Ginger) induce apoptosis in endometrial cancer cells
  142. through the activation of p53. PLoS One. 2012;7(12):e53178. doi:
  143. 1371/journal.pone.0053178. Epub 2012 Dec 31. PMID: 23300887; PMCID:
  144. PMC3534047.
  145. Qi LW, Zhang Z, Zhang CF, Anderson S, Liu Q, Yuan CS, Wang CZ.
  146. Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by
  147. p53/p21-cdc2/cdc25A Crosstalk. Am J Chin Med. 2015;43(4):743-56. doi:
  148. 1142/S0192415X15500469. Epub 2015 Jun 28. PMID: 26119958.
  149. Elkady AI, Hussein RA, Abu-Zinadah OA. Effects of crude extracts from
  150. medicinal herbs Rhazya stricta and Zingiber officinale on growth and
  151. proliferation of human brain cancer cell line in vitro. Biomed Res Int.
  152. 2014;2014:260210. doi: 10.1155/2014/260210. Epub 2014 Jul 22. PMID: 25136570;
  153. PMCID: PMC4130191.
  154. Park GH, Park JH, Song HM, Eo HJ, Kim MK, Lee JW, Lee MH, Cho KH, Lee
  155. JR, Cho HJ, Jeong JB. Anti-cancer activity of Ginger (Zingiber officinale) leaf
  156. through the expression of activating transcription factor 3 in human colorectal
  157. cancer cells. BMC Complement Altern Med. 2014 Oct 23;14:408. doi:
  158. 1186/1472-6882-14-408. PMID: 25338635; PMCID: PMC4210498.
  159. Danciu C, Vlaia L, Fetea F, Hancianu M, Coricovac DE, Ciurlea SA, Åžoica
  160. CM, Marincu I, Vlaia V, Dehelean CA, Trandafirescu C. Evaluation of phenolic
  161. profile, antioxidant and anticancer potential of two main representants of
  162. Zingiberaceae family against B164A5 murine melanoma cells. Biol Res. 2015 Jan
  163. 12;48(1):1. doi: 10.1186/0717-6287-48-1. PMID: 25654588; PMCID: PMC4417255.
  164. Huang HC, Chiu SH, Chang TM. Inhibitory effect of [6]-gingerol on
  165. melanogenesis in B16F10 melanoma cells and a possible mechanism of action.
  166. Biosci Biotechnol Biochem. 2011;75(6):1067-72. doi: 10.1271/bbb.100851. Epub
  167. 2011 Jun 13. PMID: 21670536.
  168. Huang HC, Chou YC, Wu CY, Chang TM. [8]-Gingerol inhibits melanogenesis
  169. in murine melanoma cells through down-regulation of the MAPK and PKA signal
  170. pathways. Biochem Biophys Res Commun. 2013 Aug 23;438(2):375-81. doi:
  171. 1016/j.bbrc.2013.07.079. Epub 2013 Jul 25. PMID: 23892040.
  172. Cojocaru SI, Stan M, Stoian G, Dinischiotu A. EFFECTS OF ZINGIBER
  173. OFFICINALE ROSCOE FRESH EXTRACT ON AMELANOTIC MELANOMA AND NORMAL SKIN
  174. FIBROBLASTS. Rev Med Chir Soc Med Nat Iasi. 2015 Apr-Jun;119(2):592-6. PMID:
  176. Yao C, Oh JH, Oh IG, Park CH, Chung JH. [6]-Shogaol inhibits
  177. melanogenesis in B16 mouse melanoma cells through activation of the ERK
  178. pathway. Acta Pharmacol Sin. 2013 Feb;34(2):289-94. doi: 10.1038/aps.2012.134.
  179. Epub 2012 Nov 5. PMID: 23123645; PMCID: PMC4011614.
  180. Park YJ, Wen J, Bang S, Park SW, Song SY. [6]-Gingerol induces cell
  181. cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells.
  182. Yonsei Med J. 2006 Oct 31;47(5):688-97. doi: 10.3349/ymj.2006.47.5.688. PMID:
  183. 17066513; PMCID: PMC2687755.
  184. Kim SO, Kim MR. [6]-Gingerol Prevents Disassembly of Cell Junctions and
  185. Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- κ
  186. B/Snail Signal Transduction Pathway. Evid Based Complement Alternat Med.
  187. 2013;2013:761852. doi: 10.1155/2013/761852. Epub 2013 Sep 24. PMID: 24204396;
  188. PMCID: PMC3800596.
  189. Shamoto T, Matsuo Y, Shibata T, Tsuboi K, Nagasaki T, Takahashi H,
  190. Funahashi H, Okada Y, Takeyama H. Zerumbone inhibits angiogenesis by blocking
  191. NF-κB activity in pancreatic cancer. Pancreas. 2014 Apr;43(3):396-404. doi:
  192. 1097/MPA.0000000000000039. PMID: 24622069.
  193. Zhang S, Liu Q, Liu Y, Qiao H, Liu Y. Zerumbone, a Southeast Asian
  194. Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through
  195. p53 Signaling Pathway. Evid Based Complement Alternat Med. 2012;2012:936030.
  196. doi: 10.1155/2012/936030. Epub 2012 Jan 29. PMID: 22454691; PMCID: PMC3290912.
  197. Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K. Anticancer
  198. Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through
  199. Reactive Oxygen Species-Mediated Autotic Cell Death. PLoS One. 2015 May
  200. 11;10(5):e0126605. doi: 10.1371/journal.pone.0126605. PMID: 25961833; PMCID:
  201. PMC4427290.
  202. Zhou L, Qi L, Jiang L, Zhou P, Ma J, Xu X, Li P. Antitumor activity of
  203. gemcitabine can be potentiated in pancreatic cancer through modulation of
  204. TLR4/NF-κB signaling by 6-shogaol. AAPS J. 2014 Mar;16(2):246-57. doi:
  205. 1208/s12248-013-9558-3. Epub 2014 Jan 15. PMID: 24424498; PMCID: PMC3933586.
  206. Karna P, Chagani S, Gundala SR, Rida PC, Asif G, Sharma V, Gupta MV,
  207. Aneja R. Benefits of whole ginger extract in prostate cancer. Br J Nutr. 2012
  208. Feb;107(4):473-84. doi: 10.1017/S0007114511003308. Epub 2011 Aug 18. PMID:
  209. 21849094; PMCID: PMC3426621.
  210. Saha A, Blando J, Silver E, Beltran L, Sessler J, DiGiovanni J.
  211. 6-Shogaol from dried ginger inhibits growth of prostate cancer cells both in
  212. vitro and in vivo through inhibition of STAT3 and NF-κB signaling. Cancer Prev
  213. Res (Phila). 2014 Jun;7(6):627-38. doi: 10.1158/1940-6207.CAPR-13-0420. Epub
  214. 2014 Apr 1. PMID: 24691500.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership