Covid-19 Research

Research Article

Efficacy and Safety of a Food Containing Active Diamine Oxidase (DAO) in Patients with Chronic Urticaria: A Single-Center, Single-Arm, Open-Label Exploratory Study

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Research Article
Subject Biology Group
OCLC JBRES Record
Lorry Luo*, Luke Law*, Ming Yu, Naining Zhang and Miexin Yang
Issue: Volume7-Issue4
Pages: 1-10
Received: 2025-12-24
Accepted: 2026-04-18
Published: 2026-04-21

Abstract

Chronic Urticaria (CU) poses a significant therapeutic challenge, as conventional antihistamines are ineffective for about 40% of patients. This treatment gap is linked to key pathological drivers: impaired histamine metabolism due to low Diamine Oxidase (DAO) activity, immune dysregulation, and vitamin D deficiency. Addressing this need, our study evaluated NatureU Yan, a functional food designed to simultaneously target these pathways with active DAO, vitamin D, and Bifidobacterium longum BB536. In a 28-day trial involving 19 CU patients, this multi-targeted intervention led to striking clinical benefits. Patients exhibited a 170.71% improvement in disease control (UCT), an 80.82% reduction in symptom severity (UAS7), and an 88.24% enhancement in quality of life (DLQI), with an excellent safety profile. These findings position NatureU Yan as a promising, safe, and mechanistically grounded complementary option for CU management.

FullText HTML FullText PDF DOI: 10.37871/jbres2292 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2026 Luo L, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Luo L, Law L, Yu M, Zhang N, Yang M. Effi cacy and Safety of a Food Containing Active Diamine Oxidase (DAO) in Patients with Chronic Urticaria: A Single-Center, Single-Arm, Open- Label Exploratory Study. J Biomed Res Environ Sci. 2026 Apr 21; 7(4): 10. Doi: 10.37872/jbres2292

Subject area(s)

BiologyBiomedical Engineering

References

  1. Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, Bernstein JA, Bindslev-Jensen C, Brzoza Z, Buense Bedrikow R, et al. The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018;73(7):1393-1414. doi:10.1111/all.13397.
  2. Ma S, Wang Z, Zhang Y, Jiang G. Analysis of quality of life and economic burden in patients with chronic urticaria: a comparative study of spontaneous and induced urticaria and its effects on cognition of biologics. J Dermatolog Treat. 2025;36(1). doi:10.1080/09546634.2025.2506672.
  3. Yang S, Chen L, Zhang H, Song Y, Wang W, Hu Z, Wang S, Huang L, Wang Y, Wu S, et al. Beyond the itch: the complex interplay of immune, neurological, and psychological factors in chronic urticaria. J Neuroinflammation. 2025;22(1). doi:10.1186/s12974-025-03397-4.
  4. Wang J, He L, Yi W, Liang Q, Jiang L, Tan Y, Zhang G, Su Y, Xiao R, Lu Q, et al. Consecutive injections of low-dose interleukin-2 improve symptoms and disease control in patients with chronic spontaneous urticaria. Clin Immunol. 2023;247:109247. doi:10.1016/j.clim.2023.109247.
  5. Suwa E, Yamaura K, Oda M, Namiki T, Ueno K. Histamine H4 receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model. Eur J Pharmacol. 2011;667(1-3):383-388. doi:10.1016/j.ejphar.2011.05.037.
  6. Gao S, Liu K, Ku W, Wang D, Wake H, Qiao H, Teshigawara K, Nishibori M. Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor. Front Immunol. 2022;13:930683. doi:10.3389/fimmu.2022.930683.
  7. Alemany-Fornés M, Bori J, Muguerza B, Suárez M. Diamine oxidase deficiency implications for health, current management, and future directions in the treatment of histamine intolerance: a review. Int J Biol Macromol. 2025;327:147130. doi:10.1016/j.ijbiomac.2025.147130.
  8. Yacoub MR, Ramirez GA, Berti A, Mercurio G, Breda D, Saporiti N, Burastero S, Dagna L, Colombo G. Diamine oxidase supplementation in chronic spontaneous urticaria: a randomized, double-blind placebo-controlled study. Int Arch Allergy Immunol. 2018;176(3-4):268-271. doi:10.1159/000488142.
  9. Siddiqui A, Bai A, Kumar H, Mandhwani YR, Bai A, Bai P, Kumar N, Muskan FN, Jatoi S, Ali Z, et al. Chronic urticaria and vitamin D supplementations: a systematic review. Eur J Med Res. 2025;30(1). doi:10.1186/s40001-025-02852-5.
  10. Sassi F, Tamone C, D’Amelio P. Vitamin D: nutrient, hormone, and immunomodulator. Nutrients. 2018;10(11):1656. doi:10.3390/nu10111656.
  11. Rorie A, Goldner WS, Lyden E, Poole JA. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. Ann Allergy Asthma Immunol. 2014;112(4):376-382. doi:10.1016/j.anai.2014.01.010.
  12. Xiao JZ, Kondo S, Yanagisawa N, Miyaji K, Enomoto K, Sakoda T, Iwatsuki K, Enomoto T. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol Int. 2007;56(1):67-75. doi:10.2332/allergolint.O-06-455.
  13. Cavaliere G, Costanzi E, Cenci-Goga B, Misuraca M, Traina G. Potential role of probiotic strain Lactiplantibacillus plantarum in control of histamine metabolism. Biology (Basel). 2025;14(6). doi:10.3390/biology14060734.
  14. Schnedl WJ, Schenk M, Lackner S, Enko D, Mangge H, Forster F. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019;28(6):1779-1784. doi:10.1007/s10068-019-00627-3.
  15. Oguz Topal I, Kocaturk E, Gungor S, Durmuscan M, Sucu V, Y?ld?rmak S. Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria? J Dermatolog Treat. 2016;27(2):163-166. doi:10.3109/09546634.2015.1079297.
  16. Tuchinda P, Kulthanan K, Chularojanamontri L, Arunkajohnsak S, Sriussadaporn S. Relationship between vitamin D and chronic spontaneous urticaria: a systematic review. Clin Transl Allergy. 2018;8:51. doi:10.1186/s13601-018-0234-7.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership