Efficacy and Safety of a Food Containing Active Diamine Oxidase (DAO) in Patients with Chronic Urticaria: A Single-Center, Single-Arm, Open-Label Exploratory Study

doi:10.37871/jbres2292

Volume7-Issue4
Dates: Received: 2025-12-24 | Accepted: 2026-04-18 | Published: 2026-04-21
Pages: 1-10

Abstract

Chronic Urticaria (CU) poses a significant therapeutic challenge, as conventional antihistamines are ineffective for about 40% of patients. This treatment gap is linked to key pathological drivers: impaired histamine metabolism due to low Diamine Oxidase (DAO) activity, immune dysregulation, and vitamin D deficiency. Addressing this need, our study evaluated NatureU Yan, a functional food designed to simultaneously target these pathways with active DAO, vitamin D, and Bifidobacterium longum BB536. In a 28-day trial involving 19 CU patients, this multi-targeted intervention led to striking clinical benefits. Patients exhibited a 170.71% improvement in disease control (UCT), an 80.82% reduction in symptom severity (UAS7), and an 88.24% enhancement in quality of life (DLQI), with an excellent safety profile. These findings position NatureU Yan as a promising, safe, and mechanistically grounded complementary option for CU management.

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How to cite this article

Luo L, Law L, Yu M, Zhang N, Yang M. Effi cacy and Safety of a Food Containing Active Diamine Oxidase (DAO) in Patients with Chronic Urticaria: A Single-Center, Single-Arm, Open- Label Exploratory Study. J Biomed Res Environ Sci. 2026 Apr 21; 7(4): 10. Doi: 10.37872/jbres2292

Subject area(s)

Biology

Biomedical Engineering

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