Volume7-Issue3
Dates: Received: 2026-03-10 | Accepted: 2026-03-17 | Published: 2026-03-20
Pages: 1-4
Abstract
Background: Takayasu arteritis, rheumatoid arthritis, and autoimmune hypothyroidism are immune-mediated disorders that rarely coexist in a single patient. Their concurrence represents an important example of polyautoimmunity and may create diagnostic and therapeutic challenges.
Case presentation: A 45-year-old Sudanese woman presented with acute gastrointestinal symptoms and a history of chronic symmetrical inflammatory arthritis affecting the small joints of both upper limbs. Physical examination revealed absent upper-limb pulses, carotid bruits, and diffuse goiter. Laboratory testing demonstrated positive anti-cyclic citrullinated peptide antibodies consistent with rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria. Thyroid function tests revealed markedly elevated TSH and low T4 levels consistent with autoimmune hypothyroidism. Computed tomography angiography showed inflammatory thickening of the aortic arch with occlusion and stenosis of major branches fulfilling the American College of Rheumatology (ACR) criteria for Takayasu arteritis.
Conclusion: This case highlights the importance of recognizing polyautoimmunity and emphasizes the need for multidisciplinary evaluation when vascular, rheumatologic, and endocrine manifestations coexist.
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DOI: 10.37871/jbres2281
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© 2026 Abdallah TM, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Abdallah TM, Karar AH, Awad M, Okud IO, Elsheikh AM, Musa MA, Adam MS, Almutasim AM, Mohammeddin HA. Coexistence of Takayasu Arteritis, Rheumatoid Arthritis and Autoimmune Hypothyroidism: A Case Report. J Biomed Res Environ Sci. 2026 Mar 20; 7(3): 4. Doi: 10.37872/jbres2281
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References
- Ghosh S. Polyautoimmunity: Updated review. Autoimmun Rev. 2022;21(5):103057.
- Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS. Takayasu arteritis. Ann Intern Med. 1994 Jun 1;120(11):919-29. doi: 10.7326/0003-4819-120-11-199406010-00004. PMID: 7909656.
- Johnston SL, Lock RJ, Gompels MM. Takayasu arteritis: a review. J Clin Pathol. 2002 Jul;55(7):481-6. doi: 10.1136/jcp.55.7.481. PMID: 12101189; PMCID: PMC1769710.
- Numano F. The story of Takayasu arteritis. Rheumatology (Oxford). 2002 Jan;41(1):103-6. doi: 10.1093/rheumatology/41.1.103. PMID: 11792888.
- Weyand CM, Goronzy JJ. Medium- and large-vessel vasculitis. N Engl J Med. 2003 Jul 10;349(2):160-9. doi: 10.1056/NEJMra022694. PMID: 12853590.
- Koster MJ, Matteson EL, Warrington KJ. Large?vessel vasculitis. Rheum Dis Clin North Am. 2015;41(1):15-28.
- de Souza AWS, de Carvalho JF. Advances in Takayasu arteritis. Lancet Rheumatol. 2021;3:e537-e546.
- Liang KP, Nannini C, Crowson CS. Autoimmune thyroid disease and RA. Curr Rheumatol Rep. 2007;9(5):389-394.
- Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014 Apr-May;13(4-5):391-7. doi: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13. PMID: 24434360.
- Rai P, Aggarwal A, Misra R. Autoimmune thyroid disease in RA. Clin Rheumatol. 2022;41:317-324.
- Arend WP, Michel BA, Bloch DA. ACR criteria for Takayasu arteritis. Arthritis Rheum. 1990;33(8):1129-1134.
- Nasu T, Kurita D, Kuwana M. Coexistence of Takayasu arteritis and rheumatoid arthritis. Mod Rheumatol. 2013;23(2):472-478.
- Misra DP, Khan A, Agarwal V. Recent advances in takayasu arteritis. Int J Rheum Dis. 2021;24(1):12-20.
- Lee YJ, Kim HJ, Lee SW. Interleukin pathways in TAK and RA. Front Immunol. 2023;14:1187385.
- Maksimowicz?McKinnon K, Clark TM, Hoffman GS. Disease progression in Takayasu arteritis. Arthritis Rheum. 2007;56(3):1000-1009.
- Ungprasert P, Crowson CS, Koster MJ, Matteson EL. Epidemiology of Takayasu arteritis. Rheumatology. 2020;59(9):2366-2375.