Pokhrel N and Paudyal S
Volume6-Issue12
Dates: Received: 2025-11-21 | Accepted: 2025-12-15 | Published: 2025-12-16
Pages: 1897-1901
Abstract
Kikuchi-Fujimoto Disease is a rare, benign, self-limiting cause of lymphadenopathy, typically characterized by fever and tender cervical lymph nodes, affecting mostly young women. Clinicians should consider Kikuchi disease in the differential diagnosis of causes of lymphadenopathy to avoid misdiagnosis as lymphoma, systemic lupus erythematosus, tuberculosis or infectious mononucleosis, thereby preventing unnecessary aggressive treatments.
FullText HTML
FullText PDF
DOI: 10.37871/jbres2238
Certificate of Publication
Copyright
© 2025 Pokhrel N, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Pokhrel N, Paudyal S. A Rare Case of Kikuchi-Fujimoto Disease. J Biomed Res Environ Sci. 2025 Dec 16; 6(12): 1897-1901. doi: 10.37871/jbres2238, Article ID: JBRES2238, Available at: https://www.jelsciences.com/articles/jbres2238.pdf
Subject area(s)
References
- Masab M, Surmachevska N, Farooq H. Kikuchi-Fujimoto Disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
- Al-Maghrabi J, Kanaan H. Histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease) in Saudi Arabia: clinicopathology and immunohistochemistry. Ann Saudi Med. 2005 Jul-Aug;25(4):319-23. doi: 10.5144/0256-4947.2005.319. PMID: 16212126; PMCID: PMC6148025.
- Perry AM, Choi SM. Kikuchi-Fujimoto Disease: A Review. Arch Pathol Lab Med. 2018 Nov;142(11):1341-1346. doi: 10.5858/arpa.2018-0219-RA. PMID: 30407860.
- Seo JH, Lee JS, Lee EJ, Lee JH, Kim JP, Woo SH, Ahn SK, Kwon OJ, Hwa JS, Park JJ. Comparison of clinical features and EBV expression in histiocytic necrotizing lymphadenitis of children and adults. Int J Pediatr Otorhinolaryngol. 2014 May;78(5):748-52. doi: 10.1016/j.ijporl.2014.02.001. Epub 2014 Feb 10. PMID: 24594231.
- Quadir A, Peacock K, Hsu P, Singh-Grewal D, Alexander S. A familial case of Kikuchi-Fujimoto disease in dizygotic twins. Pediatr Rheumatol Online J. 2020 Aug 10;18(1):62. doi: 10.1186/s12969-020-00457-2. PMID: 32778173; PMCID: PMC7418326.
- Al-Allaf AW, Yahia YM. Kikuchi-Fujimoto Disease Associated with Sjögren's Syndrome: A Case Report. Eur J Case Rep Intern Med. 2018 May 25;5(5):000856. doi: 10.12890/2018_000856. PMID: 30756036; PMCID: PMC6346929.
- Kellner D, Temelkovska T, Greeley A, Saito A. Kikuchi-Fujimoto Disease: A Case Report of Fever and Lymphadenopathy in a Young White Man. Fed Pract. 2023 Jan;40(1):22-27. doi: 10.12788/fp.0347. Epub 2023 Jan 16. PMID: 37223239; PMCID: PMC10201941.
- AlShieban S, Masuadi E, Alghamdi R, Alshalfan A, Alessa S, Alqarni AK, Alotaibe Z, Bamefleh H. Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia. Cureus. 2023 Jan 12;15(1):e33683. doi: 10.7759/cureus.33683. PMID: 36643080; PMCID: PMC9835018.
- Rodríguez-Ferreras A, Maray I, Coya-Fernández C, Octavio-Bocigas MM, Fernández-Del Río MF, Casares-López S, Ruiz-Salazar J. Kikuchi-Fujimoto Disease: a rare type of lymphadenopathy and its plausible relationship with human papillomavirus vaccines. Rev Esp Quimioter. 2023 Aug;36(4):429-431. doi: 10.37201/req/140.2022. Epub 2023 May 3. PMID: 37130334; PMCID: PMC10336308.
- Asano S, Akaike Y, Jinnouchi H, Muramatsu T, Wakasa H. Necrotizing lymphadenitis: a review of clinicopathological, immunohistochemical and ultrastructural studies. Hematol Oncol. 1990 Sep-Oct;8(5):251-60. doi: 10.1002/hon.2900080503. PMID: 2249796.
- Song JY, Cheong HJ, Kee SY, Lee J, Sohn JW, Kim MJ, Seo SI, Kim IS, Kim WJ. Disease spectrum of cervical lymphadenitis: analysis based on ultrasound-guided core-needle gun biopsy. J Infect. 2007 Oct;55(4):310-6. doi: 10.1016/j.jinf.2007.06.004. Epub 2007 Aug 13. PMID: 17697715.
- Kucukardali Y, Solmazgul E, Kunter E, Oncul O, Yildirim S, Kaplan M. Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin Rheumatol. 2007 Jan;26(1):50-4. doi: 10.1007/s10067-006-0230-5. Epub 2006 Mar 15. PMID: 16538388.
- Kuo TT. Kikuchi's disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995 Jul;19(7):798-809. doi: 10.1097/00000478-199507000-00008. PMID: 7793478.
- Ahmed Z, Quadir H, Hakobyan K, Gaddam M, Kannan A, Ojinnaka U, Mostafa JA. Kikuchi-Fujimoto Disease: A Rare Cause of Cervical Lymphadenopathy. Cureus. 2021 Aug 9;13(8):e17021. doi: 10.7759/cureus.17021. PMID: 34522502; PMCID: PMC8425500.
- Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol. 2000 Sep;114(9):709-11. doi: 10.1258/0022215001906561. PMID: 11091837.
- Lin DY, Villegas MS, Tan PL, Wang S, Shek LP. Severe Kikuchi's disease responsive to immune modulation. Singapore Med J. 2010 Jan;51(1):e18-21. PMID: 20200761.
- Sousa Ade A, Soares JM, Sá Santos MH, Martins MP, Salles JM. Kikuchi-Fujimoto disease: three case reports. Sao Paulo Med J. 2010 Jul;128(4):232-5. doi: 10.1590/s1516-31802010000400011. PMID: 21120436; PMCID: PMC10938983.
