Knowledge Attitude and Practice to awards Food Drug Interaction among Health Care Providers at Public Primary Hospitals of Southern Ethiopia

Hassen Alambo Tona; Haileyesus Worku Fankasho*; Amanuel Kora Moliso; Fitsum Getachew Guche

**Hassen Alambo Tona, Haileyesus Worku Fankasho*, Amanuel Kora Moliso and Fitsum Getachew Guche**

Volume6-Issue9
Dates: Received: 2025-09-22 | Accepted: 2025-09-29 | Published: 2025-09-30
Pages: 1380-1392

Abstract

Background: Interactions between food and medications can greatly impact patient adherence and the overall effectiveness of drug therapy. In healthcare settings, Food-Drug Interactions (FDIs) are an increasing concern. Various studies have reported FDI rates ranging from 3% to 30%. Despite clear evidence of the harmful effects linked to many FDIs, there is limited information about the factors that influence healthcare providers’ knowledge, attitudes, and practices regarding these interactions.

Objective: To assess the knowledge, attitude, and practice of healthcare providers towards fooddrug interactions and their associated factors at the public primary hospitals in Wolaita Zone.

Methods: A cross-sectional study was carried out among healthcare providers in primary hospitals within the Wolaita Zone, South Ethiopia. A total of 337 healthcare providers were selected using single population proportion formulas, population correction methods, and a multi-stage sampling technique to choose the facilities. Data collection was done using standardized, self-administered questionnaires. The collected data were entered into Epi-Data version 4.6.0.2 and then exported to SPSS version 25.0 for further analysis. The mean score was used as the threshold to categorize outcome variables. Descriptive statistics, including frequencies and percentages, were used to summarize the data. Bivariate analysis was performed to identify potential associated variables, with those having a p-value less than 0.25 considered for multivariable analysis. Statistical significance was determined at a p-value of less than 0.05 using binary logistic regression.

Result: Out of 337 respondents, 316 (94%) participated in the study, and the rest, 21 (6%), were not enrolled due to exclusion. Overall knowledge level was 89%, with 82% positive perception, despite poor practice (60%). Sex and profession were independent factors associated with knowledge. Work experience and profession were independent factors associated with attitude. The profession was associated with practice.

Conclusion: Healthcare providers demonstrated a generally good level of knowledge regarding food-drug interactions. Among the factors examined-sex, work experience, and profession— only experience and profession were found to have a significant influence on their knowledge, attitudes, and practices related to food-drug interactions.

FullText HTML FullText PDF DOI: 10.37871/jbres2193

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Tona HA, Fankasho HW, Moliso AK and Guche FG. Knowledge Attitude and Practice to awards Food Drug Interaction among Health Care Providers at Public Primary Hospitals of Southern Ethiopia. J Biomed Res Environ Sci. 2025 Sept 30; 6(9): 1380-1392. doi: 10.37871/jbres2193, Article ID: JBRES2193, Available at: https://www.jelsciences.com/articles/jbres2193.pdf

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References

Bushra R, Aslam N, Khan AY. Food-drug interactions. Oman Med J. 2011 Mar;26(2):77-83. doi: 10.5001/omj.2011.21. PMID: 22043389; PMCID: PMC3191675.
Aman SF, Hassan F, Naqvi BS, Hasan SM. Studies of food drug interactions. Pak J Pharm Sci. 2010 Jul;23(3):313-20. PMID: 20566446.
Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: an updated systematic review. Drugs. 2009;69(13):1777-98. doi: 10.2165/11317010-000000000-00000. PMID: 19719333.
Grześk G, Rogowicz D, Wołowiec Ł, Ratajczak A, Gilewski W, Chudzińska M, Sinkiewicz A, Banach J. The Clinical Significance of Drug-Food Interactions of Direct Oral Anticoagulants. Int J Mol Sci. 2021 Aug 8;22(16):8531. doi: 10.3390/ijms22168531. PMID: 34445237; PMCID: PMC8395160.
Bland SE, Vermeulen L. Drug-food interactions. Journal of Pharmacy Society. 2012;1:97-105.
Sajid SA, Sultana R, Masaratunnisa M, Naaz S, Adil MS. A questionnaire study of food– drug interactions to assess knowledge of health professionals from diverse backgrounds. Asian Journal of Medicine and Health. 2017;5(2):1-9. doi: 10.9734/AJMAH/2017/33682.
Enwerem NM, Okunji P. Knowledge, Attitudes and awareness of food and drug interactions among nurses with different levels of experience. Int J Nurs. 2015;2(1):1-9. doi: 10.15640/ijn.v2n1a1.
Radwan A, Sweileh A, Shraim W, Hroub A, Elaraj J, Shraim N. Evaluation of community pharmacists' knowledge and awareness of food-drug interactions in Palestine. Int J Clin Pharm. 2018 Jun;40(3):668-675. doi: 10.1007/s11096-018-0640-x. Epub 2018 May 2. PMID: 29721737.
Chen M, Zhou SY, Fabriaga E, Zhang PH, Zhou Q. Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review. J Food Drug Anal. 2018 Apr;26(2S):S61-S71. doi: 10.1016/j.jfda.2018.01.009. Epub 2018 Feb 15. PMID: 29703387; PMCID: PMC9326888.
Petric Z, Žuntar I, Putnik P, Bursać Kovačević D. Food-Drug Interactions with Fruit Juices. Foods. 2020 Dec 24;10(1):33. doi: 10.3390/foods10010033. PMID: 33374399; PMCID: PMC7823305.
Pápai K, Budai M, Ludányi K, Antal I, Klebovich I. In vitro food-drug interaction study: Which milk component has a decreasing effect on the bioavailability of ciprofloxacin? J Pharm Biomed Anal. 2010 May 1;52(1):37-42. doi: 10.1016/j.jpba.2009.12.003. Epub 2009 Dec 6. PMID: 20053516.
Paśko P, Rodacki T, Domagała-Rodacka R, Owczarek D. A short review of drug-food interactions of medicines treating overactive bladder syndrome. Int J Clin Pharm. 2016 Dec;38(6):1350-1356. doi: 10.1007/s11096-016-0383-5. Epub 2016 Oct 13. PMID: 27738922; PMCID: PMC5124029.
López-Yerena A, Perez M, Vallverdú-Queralt A, Escribano-Ferrer E. Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions. Pharmaceutics. 2020 Nov 21;12(11):1123. doi: 10.3390/pharmaceutics12111123. PMID: 33233356; PMCID: PMC7700232.
Osuala EC, Ojewole EB. Knowledge, attitudes and practices of healthcare professionals regarding drug-food interactions: a scoping review. Int J Pharm Pract. 2021 Oct 18;29(5):406-415. doi: 10.1093/ijpp/riab049. PMID: 34355752.
Tokka ASA. Assessment of the awareness, knowledge, attitude, and practice of Sudanese community pharmacists, in Khartoum State, about drug interactions. WJPR. 2017;409-426. doi: 10.20959/WJPR20174-8257.
Emiru YK, Belay YB, Bizuneh GK, Tegegn HG. Community Pharmacists’ knowledge, attitude, and professional practice behaviors towards dietary supplements: results from multi- center survey in Ethiopia. Nutr Diet Suppl. 2019;11;59-68. doi: 10.2147/NDS.S222114.
Najim DAl, Sahhaf HAl, Bunaian NARAl. Knowledge and attitude on common food and drug interactions among primary health care physicians in Dammam,Al-Khobar,and Qatif,kingdom of SaudiArabia. International Journal of scientific research. 2018;7(7).
Füredi P, Pápai K, Budai M, Ludányi K, Antal I, Klebovich I. Fluorokinolonok in vivo étel-interakciós vizsgálatai [In vivo effect of food on absorption of fluoroquinolones]. Acta Pharm Hung. 2009;79(2):81-7. Hungarian. PMID: 19634639.
Angamo MT, Chalmers L, Curtain CM, Bereznicki LR. Adverse-Drug-Reaction-Related Hospitalisations in Developed and Developing Countries: A Review of Prevalence and Contributing Factors. Drug Saf. 2016 Sep;39(9):847-57. doi: 10.1007/s40264-016-0444-7. PMID: 27449638.
Kathiria JM, Sattigeri BM, Desai PM, Patel SP. A study of adverse drug reactions in patients admitted to intensive care unit of a tertiary care teaching rural hospital. Int J Pharm Pharm Sci. 2013;5(1):160-163.
Tokka ASA, Idris KAMA. Assessment of the awareness, knowledge, attitude, and practice of Sudanese community pharmacists, in Khartoum State, about drug interactions. WJPR. 2017;6(4):409-426. doi: 10.20959/wjpr20174-8257.
Koziolek M, Alcaro S, Augustijns P, Basit AW, Grimm M, Hens B, Hoad CL, Jedamzik P, Madla CM, Maliepaard M, Marciani L, Maruca A, Parrott N, Pávek P, Porter CJH, Reppas C, van Riet-Nales D, Rubbens J, Statelova M, Trevaskis NL, Valentová K, Vertzoni M, Čepo DV, Corsetti M. The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group. Eur J Pharm Sci. 2019 Jun 15;134:31-59. doi: 10.1016/j.ejps.2019.04.003. Epub 2019 Apr 8. PMID: 30974173.
Deng J, Zhu X, Chen Z, Fan CH, Kwan HS, Wong CH, Shek KY, Zuo Z, Lam TN. A Review of Food-Drug Interactions on Oral Drug Absorption. Drugs. 2017 Nov;77(17):1833-1855. doi: 10.1007/s40265-017-0832-z. PMID: 29076109.
Ased S, Wells J, Morrow LE, Malesker MA. Clinically Significant Food-Drug Interactions. Consult Pharm. 2018 Nov 1;33(11):649-657. doi: 10.4140/TCP.n.2018.649.. PMID: 30458907.
Osuala EC, Tlou B, Ojewole EB. Assessment of knowledge of drug-food interactions among healthcare professionals in public sector hospitals in eThekwini, KwaZulu-Natal. PLoS One. 2021 Nov 3;16(11):e0259402. doi: 10.1371/journal.pone.0259402. PMID: 34731227; PMCID: PMC8565720.
Benni JM, Jayanthi MK, Tubaki BR, Renuka M. Knowledge and awareness of food and drug interactions (FDI): a survey among health care professionals. Inter J Pharmaco Clin Scin. 2012;1(4):97-105.
Abdel-Latif MM, Abdel-Wahab BA. Knowledge and awareness of adverse drug reactions and pharmacovigilance practices among healthcare professionals in Al-Madinah Al-Munawwarah, Kingdom of Saudi Arabia. Saudi Pharm J. 2015 Apr;23(2):154-61. doi: 10.1016/j.jsps.2014.07.005. Epub 2014 Jul 9. PMID: 25972735; PMCID: PMC4420988.
Williams L, Hill DP Jr, Davis JA, Lowenthal DT. The influence of food on the absorption and metabolism of drugs: an update. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):201-11. doi: 10.1007/BF03189714. PMID: 8980916.
Bertrand B, Livingston-Bowen C, Duffrin C, Mann A. ACE inhibitors and potassium foods--nurses' knowledge. Int J Health Care Qual Assur. 2014;27(1):54-64. doi: 10.1108/IJHCQA-06-2012-0057. PMID: 24660518.
Zawiah M, Yousef AM, Khan AH, Al-Ashwal FY, Matar A, ALKhawaldeh B, Nassar R, Abduljabbar R, Abdo Ahmed AA. Food-drug interactions: Knowledge among pharmacists in Jordan. PLoS One. 2020 Jun 17;15(6):e0234779. doi: 10.1371/journal.pone.0234779. PMID: 32555684; PMCID: PMC7299397.