A patient with Intestinal Aspergillosis caused by Endoscopic Submucosal Dissection operation

Tingting Lou; Mengjia Zhang; Tingting Liu; Xueling Fang

Tingting Lou, Mengjia Zhang, Tingting Liu and Xueling Fang

Volume6-Issue8
Dates: Received: 2025-08-10 | Accepted: 2025-08-25 | Published: 2025-08-30
Pages: 157-1163

Abstract

Gastrointestinal Aspergillosis (GA) is rarely invasive aspergillosis. We describe the first case of primary invasive gastric aspergillosis arising after endoscopic submucosal dissection in an immunocompetent diabetic patient, apparently triggered by routine home cleaning, and progressing rapidly to fatal systemic dissemination.

FullText HTML FullText PDF DOI: 10.37871/jbres2173

Certificate of Publication

Copyright

How to cite this article

Lou T, Zhang M, Liu T, Fang X. A patient with Intestinal Aspergillosis caused by Endoscopic Submucosal Dissection operation. J Biomed Res Environ Sci. 2025 Aug 30; 6(8): 1157-1163. doi: 10.37871/jbres2173, Article ID: JBRES2173, Available at: https://www.jelsciences.com/articles/jbres2173.pdf

Subject area(s)

Public Health

Gastroenterology

Surgery

References

Karaman I, Karaman A, Boduroğlu EC, Erdoğan D, Tanır G. Invasive Aspergillus infection localized to the gastric wall: report of a case. Surg Today. 2013 Jun;43(6):682-4. doi: 10.1007/s00595-012-0255-0. Epub 2012 Aug 3. PMID: 22864935; PMCID: PMC7101927.
Kazan E, Maertens J, Herbrecht R, Weisser M, Gachot B, Vekhoff A, Caillot D, Raffoux E, Fagot T, Reman O, Isnard F, Thiebaut A, Bretagne S, Cordonnier C. A retrospective series of gut aspergillosis in haematology patients. Clin Microbiol Infect. 2011 Apr;17(4):588-94. doi: 10.1111/j.1469-0691.2010.03310.x. PMID: 20636423.
Eggimann P, Chevrolet JC, Starobinski M, Majno P, Totsch M, Chapuis B, Pittet D. Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature. Infection. 2006 Dec;34(6):333-8. doi: 10.1007/s15010-006-5660-0. PMID: 17180588; PMCID: PMC2779002.
Karaman I, Karaman A, Boduroğlu EC, Erdoğan D, Tanır G. Invasive Aspergillus infection localized to the gastric wall: report of a case. Surg Today. 2013 Jun;43(6):682-4. doi: 10.1007/s00595-012-0255-0. Epub 2012 Aug 3. PMID: 22864935; PMCID: PMC7101927.
Verweij PE, Brandt ME. Aspergillus, Fusarium, and other opportunistic moniliaceous fungi. In: Manual of Clinical Microbiology. Murray PR, Baron EJ, Landry ML, Jorgenesen JH, editors. Washington DC, ASM Press; 2007. p.1802.
P Ramírez P, Garnacho-Montero J. Aspergilosis invasiva en el paciente crítico [Invasive aspergillosis in critically ill patients]. Rev Iberoam Micol. 2018 Oct-Dec;35(4):210-216. Spanish. doi: 10.1016/j.riam.2018.07.001. PMID: 30554674.
Gavalda J, Len O, San Juan R, Aguado JM, Fortun J, Lumbreras C, Moreno A, Munoz P, Blanes M, Ramos A, Rufi G, Gurgui M, Torre-Cisneros J, Montejo M, Cuenca-Estrella M, Rodriguez-Tudela JL, Pahissa A; RESITRA (Spanish Network for Research on Infection in Transplantation). Risk factors for invasive aspergillosis in solid-organ transplant recipients: a case-control study. Clin Infect Dis. 2005 Jul 1;41(1):52-9. doi: 10.1086/430602. Epub 2005 May 26. PMID: 15937763.
Marr KA, Carter RA, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin Infect Dis. 2002 Apr 1;34(7):909-17. doi: 10.1086/339202. Epub 2002 Feb 26. PMID: 11880955.
Pagano L, Fianchi L, Leone G. Fungal pneumonia due to molds in patients with hematological malignancies. J Chemother. 2006 Aug;18(4):339-52. doi: 10.1179/joc.2006.18.4.339. PMID: 17024788.
Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med. 1997 Jan;14(1):29-34. doi: 10.1002/(SICI)1096-9136(199701)14:1<29::AID-DIA300>3.0.CO;2-V. PMID: 9017350.
Graham PL 3rd, Lin SX, Larson EL. A U.S. population-based survey of Staphylococcus aureus colonization. Ann Intern Med. 2006 Mar 7;144(5):318-25. doi: 10.7326/0003-4819-144-5-200603070-00006. PMID: 16520472.
Eggimann P, Chevrolet JC, Starobinski M, Majno P, Totsch M, Chapuis B, Pittet D. Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature. Infection. 2006 Dec;34(6):333-8. doi: 10.1007/s15010-006-5660-0. PMID: 17180588; PMCID: PMC2779002.
Kazan E, Maertens J, Herbrecht R, Weisser M, Gachot B, Vekhoff A, Caillot D, Raffoux E, Fagot T, Reman O, Isnard F, Thiebaut A, Bretagne S, Cordonnier C. A retrospective series of gut aspergillosis in haematology patients. Clin Microbiol Infect. 2011 Apr;17(4):588-94. doi: 10.1111/j.1469-0691.2010.03310.x. PMID: 20636423..
De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, Pappas PG, Maertens J, Lortholary O, Kauffman CA, Denning DW, Patterson TF, Maschmeyer G, Bille J, Dismukes WE, Herbrecht R, Hope WW, Kibbler CC, Kullberg BJ, Marr KA, Muñoz P, Odds FC, Perfect JR, Restrepo A, Ruhnke M, Segal BH, Sobel JD, Sorrell TC, Viscoli C, Wingard JR, Zaoutis T, Bennett JE; European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group; National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis. 2008 Jun 15;46(12):1813-21. doi: 10.1086/588660. PMID: 18462102; PMCID: PMC2671227.
Talento AF, Dunne K, Joyce EA, Palmer M, Johnson E, White PL, Springer J, Loeffler J, Ryan T, Collins D, Rogers TR. A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit. J Crit Care. 2017 Aug;40:119-127. doi: 10.1016/j.jcrc.2017.03.025. Epub 2017 Mar 30. PMID: 28384600.
Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, de Pauw B; Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillus Study Group. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med. 2002 Aug 8;347(6):408-15. doi: 10.1056/NEJMoa020191. PMID: 12167683.
Herbrecht R, Denning DW, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern WV, Marr KA, Ribaud P, Lortholary O, Sylvester R, Rubin RH, Wingard JR, Stark P, Durand C, Caillot D, Thiel E, Chandrasekar PH, Hodges MR, Schlamm HT, Troke PF, de Pauw B; Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillus Study Group. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med. 2002 Aug 8;347(6):408-15. doi: 10.1056/NEJMoa020191. PMID: 12167683.
Maertens J, Raad I, Petrikkos G, Boogaerts M, Selleslag D, Petersen FB, Sable CA, Kartsonis NA, Ngai A, Taylor A, Patterson TF, Denning DW, Walsh TJ; Caspofungin Salvage Aspergillosis Study Group. Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin Infect Dis. 2004 Dec 1;39(11):1563-71. doi: 10.1086/423381. Epub 2004 Nov 9. PMID: 15578352.
Viscoli C, Herbrecht R, Akan H, Baila L, Sonet A, Gallamini A, Giagounidis A, Marchetti O, Martino R, Meert L, Paesmans M, Ameye L, Shivaprakash M, Ullmann AJ, Maertens J; Infectious Disease Group of the EORTC. An EORTC Phase II study of caspofungin as first-line therapy of invasive aspergillosis in haematological patients. J Antimicrob Chemother. 2009 Dec;64(6):1274-81. doi: 10.1093/jac/dkp355. Epub 2009 Oct 19. PMID: 19841031.
Patterson TF, Thompson GR 3rd, Denning DW. Practice guidelines for the diagnosis and management of aspergillosis: 2022 Update by the infectious diseases society of America. Clin Infect Dis. 2022;75(2):e33-e64. doi: 10.1093/cid/ciac118.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline. Clin Microbiol Infect. 2018 May;24 Suppl 1:e1-e38. doi: 10.1016/j.cmi.2018.01.002. Epub 2018 Mar 12. PMID: 29544767.