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Molecular Investigation of Cytochrome P-450 Enzymes Inductors

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

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Open Access
Article Type Original Article
Subject Medicine Group
OCLC JBRES Record
Terzulum G* and Andrei Ivanovich K
Issue: Volume6-Issue7
Pages: 976-983
Received: 2025-07-18
Accepted: 2025-07-26
Published: 2025-07-28

Abstract

Cytochrome P-450 enzymes play a critical role in xenobiotic metabolism and homeostasis, with their induction offering therapeutic potential for liver diseases and metabolic disorders. Using molecular docking and statistical analyses, the research examines the binding affinities and structural features of 46 known inducers, classifying them into Type I (affecting apo-protein expression) and Type II (directly influencing the heme center). Linear Discriminant Analysis (LDA) achieved an 87% accuracy in classifying these inducers, with key interactions identified at amino acid residues Glu301, Phe115, and Ser294. Compounds such as 3,5-difluoromethylurea and 3,4-dichlorophenylmethylurea demonstrated strong binding, highlighting their potential as effective inducers. The study also developed Quantitative Structure-Activity Relationship (QSAR) models to predict binding constants, providing insights into the structural determinants of induction. These findings advance the understanding of cytochrome P-450 induction mechanisms and lay the groundwork for designing safer, more selective drugs.

FullText HTML FullText PDF DOI: 10.37871/jbres2152 Crossmark

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Copyright

© 2025 Terzulum G, et al., Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Terzulum G, Andrei IK, Molecular Investigation of Cytochrome P-450 Enzymes Inductors. J Biomed Res Environ Sci. 2025 Jul 28; 6(7): 976-983. doi: 10.37871/jbres2152, Article ID: JBRES2152, Available at: https://www.jelsciences. com/articles/jbres2152.pdf

Subject area(s)

PharmacologyMetabolism

References

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