Longevity Technology Transfer: From Laboratory to Marketplace

References

1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: An expanding universe. Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. PMID: 36599349.
2. DePinho R. Advancing therapeutic strategies for age-related diseases. Cell. 2024;187(3):565-580.
3. Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10. PMID: 31292558; PMCID: PMC7205183.
4. Longevity and anti-senescence market report. Business Research Insights. 2024.
5. Deloitte. The future of health: How innovation will blur traditional healthcare boundaries. 2024.
6. Papapetrou E, Tsalaporta P. Macroeconomic implications of demographic aging: A global perspective. International Monetary Fund Working Paper. 2020.
7. Amaglobeli D, Chai H, Dabla NE, Dybczak K, Soto M, Tieman A. The future of saving: The role of pension system design in an aging world. IMF Staff Discussion Note. 2019.
8. Grand View Research. Longevity and anti-aging products market size report. 2024.
9. Partridge L, Fuentealba M, Kennedy BK. The quest to slow ageing through drug discovery. Nat Rev Drug Discov. 2020 Aug;19(8):513-532. doi: 10.1038/s41573-020-0067-7. Epub 2020 May 28. PMID: 32467649.
10. Global longevity investment hits $5.2 billion in 2022. Longevity Tech. 2022.
11. Andreessen H. Aging research investments portfolio. 2024.
12. Anti-aging market size, share & trends analysis report. Grand View Research. 2021.
13. Longevity and anti-aging market outlook. Future Market Insights. 2024.
14. Unity biotechnology announces 12-week data from UBX0101 Phase 2 clinical study. Unity Biotechnology. 2020.
15. Max Planck institute for biology of ageing. 2024.
16. National innovation challenge on active and confident aging. National Research Foundation Singapore. 2024.
17. Innovation task force annual report. European Medicines Agency (EMA). 2022.
18. University of California, Berkeley, and max Planck institute for demographic research. Human Mortality Database.
19. Barzilai N, Cuervo AM, Austad S. Aging as a Biological Target for Prevention and Therapy. JAMA. 2018 Oct 2;320(13):1321-1322. doi: 10.1001/jama.2018.9562. PMID: 30242337.
20. Marks P, Gottlieb S. Balancing Safety and Innovation for Cell-Based Regenerative Medicine. N Engl J Med. 2018 Mar 8;378(10):954-959. doi: 10.1056/NEJMsr1715626. PMID: 29514023.
21. Dror DM. Investors in Longevity: Big capital and the future of extending life. Literary Letters: Geneva, Switzerland. 2024.
22. Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA. Metformin as a Tool to Target Aging. Cell Metab. 2016 Jun 14;23(6):1060-1065. doi: 10.1016/j.cmet.2016.05.011. PMID: 27304507; PMCID: PMC5943638.
23. Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020 Nov;288(5):518-536. doi: 10.1111/joim.13141. Epub 2020 Aug 4. PMID: 32686219; PMCID: PMC7405395.
24. Justice JN, Nambiar AM, Tchkonia T, LeBrasseur NK, Pascual R, Hashmi SK, Prata L, Masternak MM, Kritchevsky SB, Musi N, Kirkland JL. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine. 2019 Feb;40:554-563. doi: 10.1016/j.ebiom.2018.12.052. Epub 2019 Jan 5. PMID: 30616998; PMCID: PMC6412088.
25. Longevity technology market size, share & trends analysis report. Grand View Research. 2023.
26. Sierra F. Moving geroscience from bench to bedside: New targets, biomarkers, and clinical trials. Geroscience. 2020;42(1):1-3.
27. Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018 Jun;19(6):371-384. doi: 10.1038/s41576-018-0004-3. PMID: 29643443.
28. Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414. PMID: 29676998; PMCID: PMC5940111.
29. Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N. Strategies and Challenges in Clinical Trials Targeting Human Aging. J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1424-1434. doi: 10.1093/gerona/glw149. Epub 2016 Aug 16. PMID: 27535968; PMCID: PMC5055653.
30. Shift bioscience secures $16M seed funding for AI cell simulation platform. Lab Biotech. 2024.
31. Digital health 150: The digital health companies transforming healthcare. CB Insights. 2023.
32. Deming TJ. Biotech's long road from innovation to impact. Nature Biotechnology. 2020;38:1280-1283.
33. SAKIGAKE designation system. PMDA (Pharmaceuticals and Medical Devices Agency). Japan. 2014.
34. Fishburn CS. Why senescence is a hard sell. SciBX: Science-Business eXchange. 2019;12(9):254-255.
35. Tse HF, Ho JC, Choi SW, Lee YK, Butler AW, Ng KM, Siu CW, Simpson MA, Lai WH, Chan YC, Au KW, Zhang J, Lay KW, Esteban MA, Nicholls JM, Colman A, Sham PC. Patient-specific induced-pluripotent stem cells-derived cardiomyocytes recapitulate the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing. Hum Mol Genet. 2013 Apr 1;22(7):1395-403. doi: 10.1093/hmg/dds556. Epub 2013 Jan 8. Erratum in: Hum Mol Genet. 2014 Apr 15;23(8):2332-3. PMID: 23300193.
36. Translational Research Partnerships. Buck Institute for Research on Aging. 2021.
37. Age Science initiative launched with the Astera Institute. Salk Institute for Biological Studies. 2022.
38. Kennedy BK, Pennypacker JK. Drugs that modulate aging: the promising yet difficult path ahead. Transl Res. 2014 May;163(5):456-65. doi: 10.1016/j.trsl.2013.11.007. Epub 2013 Nov 20. PMID: 24316383; PMCID: PMC4004650.
39. Company Overview. Juvenescence Ltd. 2023.
40. Company Overview. Cambrian Biopharma. 2024.
41. Bradley SR, Hayter CS, Link AN. Models and methods of university technology transfer. Foundations and Trends in Entrepreneurship. 2013;9(6):571-650.
42. Innovation Task Force Annual Report. European Medicines Agency. 2022
43. Mowery DC, Nelson RR, Sampat BN, Ziedonis AA. Ivory tower and industrial innovation: University-industry technology transfer before and after the Bayh-Dole Act. Stanford University Press; 2015.
44. Olshansky SJ. From Lifespan to Healthspan. JAMA. 2018 Oct 2;320(13):1323-1324. doi: 10.1001/jama.2018.12621. PMID: 30242384.
45. Rothaermel FT, Agung SD, Jiang L. University entrepreneurship: A taxonomy of the literature. Industrial and Corporate Change. 2007;16(4):691-791.
46. Aging research investments tracking. Khosla Ventures. 2024.
47. Company overview. Altos Labs. 2024.
48. Anti-aging treatments and personalized medicine. Juvenescence Ltd. 2024.
49. Blue Rock Therapeutics. 2024.
50. Calico & AbbVie. Partnership details. 2024.
51. Biomarker qualification program: Qualified biomarkers. U.S. Food and Drug Administration. 2023.
52. Longevity industry: Financial industry report. Aging Analytics Agency Ltd. 2022.