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Effectiveness of ALPHABAN 40 WP (Cypermethrin) insecticide in Blattella germanica and Aedes aegypti control in Cuba

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Domingo Montada Dorta*, Maureen Leyva Silva, Julio Duquesne Reyes, Alexis Brito, Rafael Lizano and Jose A de la Paz

Volume6-Issue6
Dates: Received: 2025-02-12 | Accepted: 2025-06-15 | Published: 2025-06-16
Pages: 695-703

Abstract

Disease vector control in Cuba is carried out primarily with chemical insecticides, with those based on cypermethrin being the most commonly used .In Cuba there are 30 registered formulations whose active ingredient is the cypermethrin molecule. ALPHABAN 40 WP (cypermethrin) formulation from PELGAR INTERNATIONAL LTD, UNIT 13 NEWMAN LANE, ALTON, HAMPSHIRE, GU34 2QR. UK is a high-potency wettable powder containing the potent synthetic pyrethroid. Cypermethrin is has excellent insecticidal qualities and a good knockdown effect. Before starting the field evaluation, the susceptibility status to cypermethrin was evaluated using the impregnated bottle methodology on a population of Aedes aegypti mosquitoes in the selected area, which was resistant (90% mortality). In the following study, we set ourselves the objective of evaluating the effectiveness of ALPHABAN 40 WP in Aedes aegypti control through surface bioassays and in Blattella. Germanic through residual treatment. The residual effect on different surfaces in tile, concrete and wood was evaluated with the mosquito strain collected for 10 weeks. Mortality fluctuated from the first weeks (, but remained high > 80%), on all surfaces until week 6. The highest mortality rates occurred on plastic and metal during the 10 weeks (100%). In the case of Blattella germanica, sticky traps (Insect Trap and Monitor) were used to monitor the infestation index in cockroaches, the results of which show up to a 95% reduction in the eighth week.

FullText HTML FullText PDF DOI: 10.37871/jbres2123


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© 2025 Dorta DM, et al, Distributed under Creative Commons CC-BY 4.0

How to cite this article

Dorta DM, Silva ML, Reyes JD, Brito A, Lizano R, de la Paz JA. Effectiveness of ALPHABAN 40 WP (Cypermethrin) insecticide in Blattella germanica and Aedes aegypti control in Cuba. J Biomed Res Environ Sci. 2025 Jun 16; 6(6): 695-703. doi: 10.37871/jbres2123, Article ID: JBRES2123, Available at: https://www.jelsciences.com/articles/jbres2123.pdf


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References


  1. Cypermethrin. Environmental health criteria. 1989;82.
  2. Rodríguez MM, Crespo A, Hurtado D, Fuentes I, Rey J, Bisset JA. Diagnostic doses of insecticides for adult aedes aegypti to assess insecticide resistance in Cuba. J Am Mosq Control Assoc. 2017 Jun;33(2):142-144. doi: 10.2987/16-6593.1. PMID: 28590216.
  3. WHO. Manual for indoor residual spraying: application of residual sprays for vector control. Geneva. World Health Organization. 2007.
  4. WHO. Evaluación de los depósitos de insecticidas en las paredes OMS/CDS/NTD/WHOPES/GCDPP. 2006.
  5. Abbott WS. A method for computing the effectiveness of an insecticide. Journal Economic Entomology. 1925;18:265-267. doi: 10.1093/jee/18.2.265a.
  6. Polson KA, Brogdon WG, Rawlins SC, Chadee DD. Characterization of insecticide resistance in Trinidadian strains of Aedes aegypti mosquitoes. Acta Trop. 2011 Jan;117(1):31-8. doi: 10.1016/j.actatropica.2010.09.005. Epub 2010 Sep 19. PMID: 20858454.
  7. Fatta D, Canna-Michaelidou S, Michael C, Demetriou Georgiou E, Christodoulidou M, Achilleos A, Vasquez M. Organochlorine and organophosphoric insecticides, herbicides and heavy metals residue in industrial wastewaters in Cyprus. J Hazard Mater. 2007 Jun 25;145(1-2):169-79. doi: 10.1016/j.jhazmat.2006.11.009. Epub 2006 Nov 10. PMID: 17174026.
  8. Williams PL, James RC, Roberts SM. Principles of toxicology: Environmental and industrial applications. 2nd ed. New York; 2000.
  9. Klaassen CC. Doull´s toxicology: The basic science of poisons. 5th ed. Nueva York. Mc Graw Hill; 1996.
  10. Marcombe S, Poupardin R, Darriet F, Reynaud S, Bonnet J, Strode C, Brengues C, Yébakima A, Ranson H, Corbel V, David JP. Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies). BMC Genomics. 2009 Oct 26;10:494. doi: 10.1186/1471-2164-10-494. PMID: 19857255; PMCID: PMC2770535.
  11. Vazquez-Prokopec GM, Medina-Barreiro A, Che-Mendoza A, Dzul-Manzanilla F, Correa-Morales F, Guillermo-May G, Bibiano-Marín W, Uc-Puc V, Geded-Moreno E, Vadillo-Sánchez J, Palacio-Vargas J, Ritchie SA, Lenhart A, Manrique-Saide P. Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico. PLoS Negl Trop Dis. 2017 Jun 12;11(6):e0005656. doi: 10.1371/journal.pntd.0005656. PMID: 28604781; PMCID: PMC5481028.
  12. Montada Dorta D, Leyva Silva M, Castex Rodriguez M, Silva Leyva Y. Eficacia de los tratamientos intradomiciliarios con cipermetrina, lambdacialotrina y clorpirifos en el control de Aedes aegypti en Ciudad de La Habana [Efficacy of indoor treatment with cypermethrin, lambda-cyhalothrin and chlorpyrifos for the regulation of Aedes aegypti in the City of Havana]. Rev Cubana Med Trop. 2010 Sep-Dec;62(3):230-6. Spanish. PMID: 23437554.
  13. Bisset JA, Rodríguez MM, Hurtado D, Hernández H, Valdés V, Fuentes I. Resistencia a insecticidas y sus mecanismos bioquímicos en Aedes aegypti del municipio Boyeros en los años 2010 y 2012. Revista Cubana Medicina Tropical. 2016;68(1).
  14. Rodríguez MMJ, Bisset ADH, Montada D, Leyva M, Castex M, Hernández H, Fuentes I. Estudio sobre la susceptibilidad a insecticidas en Aedes aegypti del Área de Salud Raúl Sánchez, Pinar del Río. Revista Cubana Medicina Tropical. 2016;68(2).
  15. Montada Dorta D, Castex Rodríguez M, Suárez Delgado S, Figueredo Sánchez D, Leyva Silva M. Estado de la resistencia a insecticidas en adultos del mosquito Aedes aegypti del municipio Playa, Ciudad de La Habana, Cuba [State of the resistance to insecticides in adult Aedes aegypti mosquitoes from playa municipality, Havana City, Cuba]. Rev Cubana Med Trop. 2005 May-Aug;57(2):137-42. Spanish. PMID: 17966584.
  16. Montada Dorta D, Calderón Morales I, Leyva Silva M, Figueredo Sánchez D. Niveles de susceptibilidad de una cepa de Aedes aegypti procedente de Santiago de Cuba ante los insecticidas lambdacialotrina, cipermetrina y clorpirifos [Levels of susceptibility of an Aedes aegyptistrain from Santiago de Cuba to lambda-cyhalothrin, cypermethrin, and chlorpyrifos]. Rev Cubana Med Trop. 2007 Jan-Apr;59(1):40-5. Spanish. PMID: 23427417.
  17. Montada, D, Leyva M, Silva Y, Marquetti MC, Castex M. Susceptibilidad de 3 cepas de Aedes aegypti asociada con la aplicación de 3 insecticidas. Revista Cubana de Medicina Tropical. 2009;61(2):150-160.
  18. Bisset JA, Rodriguez MM, Hemingway J, Diaz C, Small GJ, Ortiz E. Malathion and pyrethroid resistance in Culex quinquefasciatus from Cuba: efficacy of pirimiphos-methyl in the presence of at least three resistance mechanisms. Med Vet Entomol. 1991 Apr;5(2):223-8. doi: 10.1111/j.1365-2915.1991.tb00544.x. PMID: 1768912.
  19. Bisset J, Rodriguez M, Soca A, Pasteur N, Raymond M. Cross-resistance to pyrethroid and organophosphorus insecticides in the southern house mosquito (Diptera:Culicidae) from Cuba. J Med Entomol. 1997 Mar;34(2):244-6. doi: 10.1093/jmedent/34.2.244. PMID: 9103771.
  20. Montada Dorta D, Zaldívar de Zayas J, Figueredo Sánchez D, Suárez Delgado S, Leyva Silva M. Eficacia de los tratamientos intradomiciliarios con los insecticidas cipermetrina, lambdacialotrina y clorpirifos en una cepa de Aedes aegypti [Efficacy of the intradomiciliary treatments with cypermethrin, lambda-cyhalothrin and chlorpyrifos insecticides in an Aedes aegypti strain]. Rev Cubana Med Trop. 2006;58(2):148-53. Spanish. PMID: 23427434.
  21. Montada D, Calderón I, Figueredo D, Soto E, Leyva M. Eficiencia del Galgotrin 25 EC, Terfos 48 EC, Lambdacihalotrina 2,5 EC e Icon 2,5 EC en el control del mosquito Aedes aegypti en el municipio Santiago de Cuba, Cuba. Revista Cubana Medicina Tropical. 2008;60:55-61.
  22. Castex M, Montada D, González I, Estévez S, San Blas O, González R. Efectividad del tratamiento perifocal con Ficam (Bendiocarb) 80 WP en el control de Aedes aegypti en Santa Clara, Cuba. Revista Cubana Medicina Tropical. 2008;60:92-94.
  23. Montada D, Bisset JA, Lazcano D, Castex M, Leyva M, San Blas O. Efectividad del Sipertrin en el control de Aedes aegypti en Santa Clara, Villa Clara. Revista Cubana Medicina Tropical. 2013;65(3):350-60.
  24. Montada D, Toledo ME, Castex M, Leyva M, Gonzalez K, Vanlerbeghe V. The use of deltamethrin as a control strategy against Aedes aegypti (Culicidae) in Santiago de Cuba City. Journal of Pesticides and Biofertilizers. 2018;1:10002.
  25. Duquesne J, Leyva M, Montada D, Brito A, Bofill LM, Duarte FR. Effectiveness of K-Othrine Polyzone 62.5 SC (Deltamethrin) in the Control of Aedes (St.) aegypti (Diptera: Culicidae) in Cárdenas, Matanzas, Cuba. International Journal of Zoology and Animal Biology. 2022;5(6):000417. doi:10.23880/izab-16000417.
  26. Stoddard ST, Forshey BM, Morrison AC, Paz-Soldan VA, Vazquez-Prokopec GM, Astete H, Reiner RC Jr, Vilcarromero S, Elder JP, Halsey ES, Kochel TJ, Kitron U, Scott TW. House-to-house human movement drives dengue virus transmission. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):994-9. doi: 10.1073/pnas.1213349110. Epub 2012 Dec 31. PMID: 23277539; PMCID: PMC3549073..
  27. Dzul-Manzanilla F, Ibarra-López J, Bibiano Marín W, Martini-Jaimes A, Leyva JT, Correa-Morales F, Huerta H, Manrique-Saide P, Vazquez-Prokopec GM. Indoor Resting Behavior of Aedes aegypti (Diptera: Culicidae) in Acapulco, Mexico. J Med Entomol. 2017 Mar 1;54(2):501-504. doi: 10.1093/jme/tjw203. Erratum in: J Med Entomol. 2017 May 1;54(3):804. doi: 10.1093/jme/tjx035. PMID: 28011725..
  28. Esu E, Lenhart A, Smith L, Horstick O. Effectiveness of peridomestic space spraying with insecticide on dengue transmission; systematic review. Trop Med Int Health. 2010 May;15(5):619-31. doi: 10.1111/j.1365-3156.2010.02489.x. Epub 2010 Mar 8. PMID: 20214764..
  29. Vythilingam I, Wan-Yusoff WS. Dengue vector control in Malaysia: Are we moving in the right direction? Trop Biomed. 2017 Dec 1;34(4):746-758. PMID: 33592944..
  30. Samuel M, Maoz D, Manrique P, Ward T, Runge-Ranzinger S, Toledo J, Boyce R, Horstick O. Community effectiveness of indoor spraying as a dengue vector control method: A systematic review. PLoS Negl Trop Dis. 2017 Aug 31;11(8):e0005837. doi: 10.1371/journal.pntd.0005837. PMID: 28859087; PMCID: PMC5578493.
  31. Dunbar MW, Correa-Morales F, Dzul-Manzanilla F, Medina-Barreiro A, Bibiano-Marín W, Morales-Ríos E, Vadillo-Sánchez J, López-Monroy B, Ritchie SA, Lenhart A, Manrique-Saide P, Vazquez-Prokopec GM. Efficacy of novel indoor residual spraying methods targeting pyrethroid-resistant Aedes aegypti within experimental houses. PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007203. doi: 10.1371/journal.pntd.0007203. PMID: 30817759; PMCID: PMC6394901.
  32. Bowman LR, Donegan S, McCall PJ. Is Dengue Vector Control Deficient in Effectiveness or Evidence?: Systematic Review and Meta-analysis. PLoS Negl Trop Dis. 2016 Mar 17;10(3):e0004551. doi: 10.1371/journal.pntd.0004551. PMID: 26986468; PMCID: PMC4795802.
  33. Sreehari U, Raghavendra K, Tiwari SN, Sreedharan S, Ghosh SK, Valecha N. Small-scale (Phase II) evaluation of the efficacy and residual activity of SumiShield® 50 WG (clothianidin 50%, w/w) for indoor residual spraying in comparison to deltamethrin, bendiocarb and pirimiphos-methyl for malaria vector control in Karnataka state, India. J Vector Borne Dis. 2018 Apr-Jun;55(2):122-129. doi: 10.4103/0972-9062.242559. PMID: 30280710.
  34. Dzib Florez SA. Evaluación de la aplicación de insecticidas comerciales residuales, para el control de Aedes aegypti en Yucatán. Facultad de Ciencias Biológicas Doctorado thesis. Universidad Autónoma de Nuevo León. 2019.
  35. Galardo AKR, Galardo CD. Relatório técnico sobre o Estudo da Eficácia de Redes Impregnadas com Inseticidas e do uso de Fendona em borrifações domiciliares para o controle de Anopheles sp. em bioensaios de campo e laboratório no estado do Amapá-Brasil. Macapá. Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá. 2009. doi: 10.23880/izab-16000460.
  36. Ab Hamid NN, Mohd Noor S, Saadatian-Elahi M, Isa NR, Ruslan R, Balqis. Residual spray for the control of Aedes vectors in dengue outbreak residential areas. Advances in Entomology. 2019;7:105-123. doi: 10.4236/ae.2019.74009.
  37. Ab Hamid N, Mohd Noor SN, Susubi J, Isa NR, Md Rodzay R, Bachtiar Effendi AM, Hafisool AA, Azman FA, Abdullah SF, Kamarul Zaman MK, Wasi Ahmad N, Lee HL. Semi-field evaluation of the bio-efficacy of two different deltamethrin formulations against Aedes species in an outdoor residual spraying study. Heliyon. 2020 Jan 22;6(1):e03230. doi: 10.1016/j.heliyon.2020.e03230. PMID: 31993521; PMCID: PMC6976940.
  38. Ibrahim KT, Popoola KO, Akure KO. Laboratory Evaluation of Residual Efficacy of Actellic 300 CS (Pirimiphos-Methyl) and K-Othrine WG 250 (Deltamethrin) on Different Indoor Surfaces. Int J Insect Sci. 2017 Nov 2;9:1179543317732989. doi: 10.1177/1179543317732989. PMID: 29147079; PMCID: PMC5672989.
  39. Corrêa APSA, Galardo AKR, Lima LA, Câmara DCP, Müller JN, Barroso JFS, Lapouble OMM, Rodovalho CM, Ribeiro KAN, Lima JBP. Efficacy of insecticides used in indoor residual spraying for malaria control: an experimental trial on various surfaces in a "test house". Malar J. 2019 Oct 10;18(1):345. doi: 10.1186/s12936-019-2969-6. PMID: 31601226; PMCID: PMC6785876.
  40. Gliniewicz A, Krzemińska A, Sawicka B. Oporność prusaków Blattella germanica L. odłowionych w szpitalach na wybrane insektycydy pyretroidowe i karbaminianowe [Susceptibility of cockroaches Blattella germanica L. collected from hospitals to selected pyrethroid and carbamate insecticides]. Rocz Panstw Zakl Hig. 1996;47(3):333-41. Polish. PMID: 9026900.
  41. Diaz Pantoja C, Perez MG, Calvo E, Rodriguez MM, Bisset JA. Insecticide resistance studies on Blattella germanica (Dictyoptera:Blattellidae) from Cuba. Ann N Y Acad Sci. 2000;916:628-34. doi: 10.1111/j.1749-6632.2000.tb05349.x. PMID: 11193688.
  42. Zayas F de. Entomofauna Cubana, T3 La Habana: Editorial Científico Técnica; 1974. p.128.


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