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How a Plant-Based Diet and Ultra-Low LDL Levels Can Reverse Atherosclerosis and Prevent Restenosis: A Breakthrough in Heart Health

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Open Access
Article Type Perspective
Subject Medicine Group
OCLC JBRES Record
Dasaad Mulijono*
Issue: Volume6-Issue4
Pages: 368-372
Received: 2025-04-08
Accepted: 2025-04-23
Published: 2025-04-24

Abstract

Low-Density Lipoprotein Cholesterol (LDL-C) remains a key target in preventing and treating cardiovascular disease. Recent data and expert consensus increasingly support aggressive LDL-C lowering strategies, with emerging evidence suggesting that levels below 30 mg/dL (ultralow/ UL) may provide significant clinical benefits, including atherosclerosis regression and reduced rates of restenosis post-intervention.

At our cardiology centre at Bethsaida Hospital in Indonesia, directed by Prof. Dasaad Mulijono, we have successfully implemented a comprehensive approach that combines a Plant-Based Diet (PBD) with high-intensity lipid-lowering therapy (excluding PCSK9 inhibitors) to achieve sustained UL-LDL-C in patients with Coronary Artery Disease (CAD). This strategy has resulted in a restenosis rate of approximately 2%, compared to rates as high as 10-20% in other centres. Furthermore, Computed Tomography Coronary Angiography (CTCA), angiographic, and clinical follow-up data suggest signs of halted or regressed atherosclerotic progression.

These findings support the hypothesis that integrating a PBD with intensive lipid management may represent an effective and sustainable model for secondary prevention in high-risk cardiovascular populations. Future guidelines may consider more aggressive LDL-C targets and lifestyle-based interventions to optimize patient outcomes.

FullText HTML FullText PDF DOI: 10.37871/jbres2091 Crossmark

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© 2025 Mulijono D. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Mulijono D. How a Plant-Based Diet and Ultra-Low LDL Levels Can Reverse Atherosclerosis and Prevent Restenosis: A Breakthrough in Heart Health. J Biomed Res Environ Sci. 2025 Apr 24; 6(4): 368-372. doi: 10.37871/jbres2091, Article ID: JBRES2091, Available at: https://www.jelsciences.com/articles/jbres2091.pdf

Subject area(s)

Vascular MedicineNutritionClinical Cardiology

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