Synergy of Ergothioneine and Tyrosine-Arginine Peptide to boost β-Endorphin Generation to Alleviate Stress-Induced Dermatological Disorders

Fangru Jiang; Zhe Liu*

Fangru Jiang and Zhe Liu*

Volume6-Issue4
Dates: Received: 2025-03-17 | Accepted: 2025-04-08 | Published: 2025-04-09
Pages: 312-319

Abstract

Objective: This study aimed to investigate the synergistic effects of Ergothioneine (EGT) and Tyrosine-Arginine Peptide (TAP) in promoting β-endorphin production in the skin, aiming to alleviate stress-induced dermatological disorders.

Method: An optimal ratio between EGT and TAP for β-endorphin stimulation was ascertained through cell experiments using human dermal fibroblasts and immortalized human keratinocytes. These cells were treated with cortisol to induce stress-related conditions. β-endorphin content was measured following treatment with various EGT-TAP ratios. Additional gene expression analysis was conducted to observe the regulatory effects of the combination on key skin health indicators, using specific primers and qPCR methods.

Results: The combination of EGT and TAP displayed a significant synergistic effect on β-endorphin production, with the optimal ratio identified as 9:1. This ratio resulted in a 175.75% and 190.20% increase in β-endorphin generation compared to individual EGT and TAP treatments, respectively. The EGT-TAP combination also mitigated cortisol-induced disruptions in gene expression, positively affecting the expression of extracellular matrix proteins and mitigating the negative effects of stress on skin cell models.

Conclusion: The combined administration of EGT and TAP at a 9:1 ratio significantly boosts β-endorphin levels and beneficially regulates gene expression under stress-induced conditions in skin cells. This synergy presents a novel and effective approach to enhance skin health and counteract the detrimental impacts of stress, offering a promising avenue for the development of advanced dermatological treatments.

FullText HTML FullText PDF DOI: 10.37871/jbres2086

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How to cite this article

Jiang F, Liu Z. Synergy of Ergothioneine and Tyrosine-Arginine Peptide to boost β-Endorphin Generation to Alleviate Stress-Induced Dermatological Disorders. J Biomed Res Environ Sci. 2025 Apr 09; 6(4): 312- 319. doi: 10.37871/jbres2086, Article ID: JBRES2086, Available at: https://www.jelsciences.com/articles/jbres2086.pdf

Subject area(s)

Dermatology

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