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Potential Use of Immunological Indices as Predictors of Bacterial Infections Following Cardiopulmonary Bypass Surgery in Elderly Patients

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Article Type Research Article
Subject Medicine Group
OCLC JBRES Record
Piotr Sindera, Barbara Zawidlak-Wegrzynska* and Ewa Kucewicz-Czech
Issue: Volume6-Issue3
Pages: 297-308
Received: 2025-03-23
Accepted: 2025-03-25
Published: 2025-03-28

Abstract

Cardiac surgery with Cardiopulmonary Bypass (CPB) induces postoperative immunological responses in patients. We aimed to determine changes in various immunological parameters in patients during and after cardiac surgery supported by CPB and to search for possible reliable predictors of postoperative bacterial infections. CD4, CD8, CD3, CD19, CD45, CD16+56+ and CD3+HLA-DR+ lymphocytes and CD14 monocytes were counted by flow cytometry in blood samples taken from 36 patients (21 women and 15 men divided into 3 age groups), three of whom were diagnosed with postoperative infections (fourth group). An increased percentage of B lymphocytes and a reduced percentage of cells with CD4 receptors (T-helper cells) were observed on the first postoperative day. These changes during this period correlated with the onset of bacterial infections.

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© 2025 Sindera P, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Sindera P, Zawidlak-Wegrzynska B, Kucewicz-Czech E. Potential use of Immunological Indices as Predictors of Bacterial Infections Following Cardiopulmonary Bypass Surgery in Elderly Patients. J Biomed Res Environ Sci. 2025 Mar 28; 6(3): 297-308. doi: 10.37871/jbres2084, Article ID: JBRES2084, Available at: https://www. jelsciences.com/articles/jbres2084.pdf

Subject area(s)

ImmunologyCardiovascular DiseasesSurgery

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