Covid-19 Research

Review Article

Mushrooms Natural Products Cosmetic Weapons as Anti-Hair Loss, Anti-Ageing Skin and Future Prospect

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access
Article Type Review Article
Subject Medicine Group
OCLC JBRES Record
Waill Elkhateeb*, Atsushi Ishihara and Ghoson Daba
Issue: Volume6-Issue2
Pages: 180-190
Received: 2025-01-27
Accepted: 2025-02-19
Published: 2025-02-28

Abstract

Throughout old history, mushrooms are considered a rich source of many important phytonutrients such as polysaccharides and other nutrients, in addition to many essential amino acids, which are building blocks of vital proteins. In overall, mushrooms offer a wide range of health benefits with a large spectrum of pharmacological properties, including antidiabetic, antioxidative, antiviral, antibacterial, nephroprotective, hepatoprotective and others. Both wild edible and medicinal mushrooms possess strong therapeutic and biological activities. The multifunctional activities of the mushroom extracts and the targeted potential of each of the compounds in the extracts have a wide-ranging of applications, especially in anti-hair loss and anti-ageing skin. This review aims to provide a clear insight on mushrooms natural bioactive compounds, and their extracts are whichever presently used or original to be used as cosmetics products for their antioxidant, anti-aging, anti-wrinkle, skin whitening, moisturizing effects and anti-Hair loss. Future outlook and prospective challenges.

FullText HTML FullText PDF DOI: 10.37871/jbres2070 Crossmark

Certificate of Publication

Certificate of Publication

Copyright

© 2025 Elkhateeb W, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Elkhateeb W, Ishihara A, Daba G. Mushrooms Natural Products Cosmetic Weapons as Anti-Hair Loss, Anti-Ageing Skin and Future Prospect. J Biomed Res Environ Sci. 2025 Feb 28; 6(2): 180-190. doi: 10.37871/ jbres2070, Article ID: JBRES2070, Available at: https://www.jelsciences.com/articles/jbres2070.pdf

Subject area(s)

PharmacologyDermatology

References

  1. Bhambri A, Srivastava M, Mahale VG, Mahale S, Karn SK. Mushrooms as Potential Sources of Active Metabolites and Medicines. Front Microbiol. 2022 Apr 26;13:837266. doi: 10.3389/fmicb.2022.837266. PMID: 35558110; PMCID: PMC9090473.
  2. Miles PG, Chang ST. Mushrooms: Cultivation, nutritional value, medicinal effect, and environmental impact. 2nd ed. Boca Raton: CRC press; 2004. doi: 10.1201/9780203492086 .
  3. Elkhateeb WA, Zaghlol GM, El-Garawani IM, Ahmed EF, Rateb ME, Abdel Moneim AE. Ganoderma applanatum secondary metabolites induced apoptosis through different pathways: In vivo and in vitro anticancer studies. Biomed Pharmacother. 2018 May;101:264-277. doi: 10.1016/j.biopha.2018.02.058. Epub 2018 Feb 27. PMID: 29494964.
  4. Elkhateeb WA, Daba GM, Elmahdy EM, Thomas PW, Wen TC, Mohamed N. Antiviral potential of mushrooms in the light of their biological active compounds. ARC J Pharmac Sci. 2019;5:8-12. doi: 10.20431/2455-1538.0502003.
  5. Elkhateeb WA, Daba GM, Thomas PW, Wen TC. Medicinal mushrooms as a new source of natural therapeutic bioactive compounds. Egypt Pharmaceu Journal. 2019;18(2):88101. doi: 88-101. 10.4103/epj.epj_17_19.
  6. Elkhateeb WA, Elnahas MO, Thomas PW, Daba GM. To heal or not to heal? Medicinal mushrooms wound healing capacities. ARC Journal of Pharmaceutical Sciences. 2019;5(4):28-35. doi: 10.20431/2455-1538.0504004.
  7. Elkhateeb WA. What medicinal mushroom can do? Chem Res J. 2020;5(1):106-118.
  8. Elkhateeb WA, Elnahas MO, Thomas PW, Daba GM. Trametes versicolor and dictyophora indusiata champions of medicinal mushrooms. Open Access Journal of Pharmaceutical Research. 2020;4(1):1-7. doi: 10.23880/oajpr-16000192.
  9. Elkhateeb WA, Daba G. The endless nutritional and pharmaceutical benefits of the Himalayan gold, Cordyceps; Current knowledge and prospective potentials. Biofarmasi Journal of Natural Product Biochemistry. 2020;18(2):1-10. doi: 10.13057/biofar/f180204.
  10. Elkhateeb W, Elnahas MO, Paul W, Daba GM. Fomes fomentarius and Polyporus squamosus models of marvel medicinal mushrooms. Biomed Res Rev. 2020;3:119. doi: 10.31021/brr.20203119.
  11. Daba GM, Elkhateeb W, ELDien AN, Fadl E, Elhagrasi A, Fayad W, Wen TC. Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities. Biodiversitas Journal of Biological Diversity. 2020;21(6):1-10. doi: 10.13057/biodiv/d210615.
  12. Elkhateeb WA, Daba GM, Elnahas M, Thomas P, Emam M. Metabolic profile and skin-related bioactivities of Cerioporus squamosus hydromethanolic extract. Biodiversitas Journal Biological Div. 2020;21(10). doi: 10.13057/biodiv/d211037.
  13. Elkhateeb WA, El Ghwas D, Gundoju N, Somasekhar T, Akram M, Daba GM. Chicken of the Woods Laetiporus sulphureus and Schizophyllum Commune treasure of medicinal mushrooms. Open Access Journal of Microbiology & Biotechnology. 2021;6(3):1-7. doi: 10.23880/oajmb-16000201.
  14. Elkhateeb W, Thomas P, Elnahas M, Daba G. Hypogeous and epigeous mushrooms in human health. In Advances in Macrofungi CRC Press; 2021. p.7-19. doi: 10.1201/9781003191278-2.
  15. Elkhateeb W, Elnahas M, Daba G. Infrequent current and potential applications of mushrooms. CRC Press. 2021. p. 70-81. doi: 10.1201/9781003096818-7.
  16. Elkhateeb WA, Daba GM. Mycotherapy of the good and the tasty medicinal mushrooms Lentinus, Pleurotus, and Tremella. Journal of Pharmaceutics and Pharmacology Research. 2021;4(3):1-6. doi: 10.31579/2693-7247/29.
  17. Elkhateeb WA, Daba GM. The fascinating bird’s nest mushroom, secondary metabolites and biological activities. International Journal of Pharma Research and Health Sciences. 2021;9(1):3265-3269. doi: 10.21276/ijprhs.2021.01.01.
  18. Elkhateeb WA, Daba GM. Highlights on unique orange pore cap mushroom Favolaschia Sp. and beech orange mushroom Cyttaria sp. and their biological activities. Open Access Journal of Pharmaceutical Research. 2021;5(3):1-6. doi: 10.23880/oajpr-16000246.
  19. Elkhateeb WA, Daba GM. Highlights on the wood blue-leg mushroom Clitocybe Nuda and blue-milk mushroom Lactarius Indigo ecology and biological activities. Open Access Journal of Pharmaceutical Research. 2021;5(3):1-6. doi: 10.23880/oajpr-16000249.
  20. Elkhateeb WA, Daba GM. Highlights on the golden mushroom cantharellus cibarius and unique shaggy ink cap mushroom coprinus comatus and smoky bracket mushroom bjerkandera adusta ecology and biological activities. Open Access Journal of Mycology & Mycological Sciences. 2021;4(2):1-8. doi: 10.23880/oajmms-16000143.
  21. Elkhateeb WA, Daba GM. The coral mushrooms Ramaria and Clavaria. Studies in Fungi. 2021;6(1):495-506. doi 10.5943/sif/6/1/39.
  22. Elkhateeb WA, Daba GM. Medicinal mushroom: What should we know? International Journal of Pharmaceutical Chemistry and Analysis. 2022;9(1):1-19. doi: 10.18231/j.ijpca.2022.001.
  23. Elkhateeb WA, Daba GM. The wild non edible mushrooms, what should we know so far? International Journal of Advanced Biochemistry Research. 2022;6(1):43-50. doi: 10.33545/26174693.2022.v6.i1a.83.
  24. Elkhateeb WA, Daba GM. Vitamin D enriched edible mushrooms: A review. Open Access Journal of Mycology & Mycological Sciences. 2023;6(1):1-6. doi: 10.23880/oajmms-16000170.
  25. Elkhateeb WA, El-Ghwas DE, Daba GM. Mushrooms and lichens the factory of important secondary metabolites. Journal of Biomedical Research and Environmental Sciences. 2023;4(6):1072-1082. doi: 10.37871/jbres1770.
  26. Elkhateeb WA, El-Ghwas DE, Daba GM. Anti-inflammatory agents from mushrooms: A Review. Open Access Journal of Pharmaceutical Research. 2023;7(1):1-7. doi: 10.23880/oajpr-16000278.
  27. Elkhateeb WA, Galappaththi MC, El-Ghwas DE, Daba G. The anti-diabetic potential of mushrooms: A review. Current Trends in Biotechnology and Pharmacy. 2023;17(4):1415-1424. doi: 10.5530/ctbp.2023.4.77.
  28. Elkhateeb WA, Soliman AA, Shaheen MN, Elmahdy EM, Daba GM. Bioactive potentials of the truffle mushrooms Tirmania nivea, Tirmania pinoyi and Tuber indicum. Egyptian Pharmaceutical Journal. 2024;23(1):94-102. doi: 10.4103/epj.epj_204_23.
  29. Elkhateeb W, Daba G, Somasekhar T, Gundoju NR. The Precious Truffles: Bioactive compounds as a source of various biological activities. Environmental Science. 2024;3(2):40. doi: 10.5281/zenodo.12625345.
  30. Chopra H, Mishra AK, Baig AA, Mohanta TK, Mohanta YK, Baek KH. Narrative Review: Bioactive Potential of Various Mushrooms as the Treasure of Versatile Therapeutic Natural Product. J Fungi (Basel). 2021 Sep 6;7(9):728. doi: 10.3390/jof7090728. PMID: 34575766; PMCID: PMC8466349.‏
  31. Seo S, Kang G, Ha JW, Kim JC. In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions. Journal of Industrial and Engineering Chemistry. 2013;19(4):1331-1339. doi: 10.1016/j.jiec.2012.12.037.
  32. Chen F, Zhang Q, Wu P, Zhao Y, Suo X, Xiao A, Ke M, He X, Tong Z, Chen Y. Green fabrication of seedbed-like Flammulina velutipes polysaccharides-derived scaffolds accelerating full-thickness skin wound healing accompanied by hair follicle regeneration. Int J Biol Macromol. 2021 Jan 15;167:117-129. doi: 10.1016/j.ijbiomac.2020.11.154. Epub 2020 Nov 26. PMID: 33249152.‏
  33. Vetvicka V, Vetvickova J. Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med. 2014 Feb;2(2):14. doi: 10.3978/j.issn.2305-5839.2014.01.05. PMID: 25332990; PMCID: PMC4202470.‏
  34. Sagayama K, Tanaka N, Fukumoto T, Kashiwada Y. Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. Journal of natural medicines. 2019;73:597-601. doi: 10.1007/s11418-019-01280-0.‏
  35. Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. Anti-androgenic activities of Ganoderma lucidum. J Ethnopharmacol. 2005 Oct 31;102(1):107-12. doi: 10.1016/j.jep.2005.05.041. PMID: 16029938.
  36. Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF. Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 9. PMID: 22593926.
  37. Liu J, Tamura S, Kurashiki K, Shimizu K, Noda K, Konishi F, Kumamoto S, Kondo R. Anti-androgen effects of extracts and compounds from Ganoderma lucidum. Chem Biodivers. 2009 Feb;6(2):231-43. doi: 10.1002/cbdv.200800019. PMID: 19235153.
  38. Kim JE, Lee KW. Molecular Targets of Phytochemicals for Skin Inflammation. Curr Pharm Des. 2018;24(14):1533-1550. doi: 10.2174/1381612824666180426113247. PMID: 29701147.
  39. Albuquerque PBS, de Oliveira WF, Dos Santos Silva PM, Dos Santos Correia MT, Kennedy JF, Coelho LCBB. Skincare application of medicinal plant polysaccharides - A review. Carbohydr Polym. 2022 Feb 1;277:118824. doi: 10.1016/j.carbpol.2021.118824. Epub 2021 Oct 28. PMID: 34893241.
  40. Yao Y, Xu B. Skin health promoting effects of natural polysaccharides and their potential application in the cosmetic industry. Polysaccharides. 2022;3(4):818-830.‏ doi: 10.3390/polysaccharides3040048.
  41. Luo J, Ganesan K, Xu B. Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms. J Fungi (Basel). 2024 Mar 14;10(3):215. doi: 10.3390/jof10030215. PMID: 38535223; PMCID: PMC10970926.
  42. Apparoo Y, Wei Phan C, Rani Kuppusamy U, Chan EWC. Potential role of ergothioneine rich mushroom as anti-aging candidate through elimination of neuronal senescent cells. Brain Res. 2024 Feb 1;1824:148693. doi: 10.1016/j.brainres.2023.148693. Epub 2023 Nov 29. PMID: 38036238.
  43. Khondka P. Composition and partial structure characterization of tremella polysaccharides. Mycobiology. 2009 Dec;37(4):286-94. doi: 10.4489/MYCO.2009.37.4.286. Epub 2009 Dec 31. PMID: 23983549; PMCID: PMC3749419.
  44. Shen T, Duan C, Chen B, Li M, Ruan Y, Xu D, Shi D, Yu D, Li J, Wang C. Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1. Mol Med Rep. 2017 Aug;16(2):1340-1346. doi: 10.3892/mmr.2017.6754. Epub 2017 Jun 12. PMID: 28627707; PMCID: PMC5561887.
  45. Luo L, Wang Y, Zhang S, Guo L, Jia G, Lin W, Gao Z, Gao Y, Sun T. Preparation and characterization of selenium-rich polysaccharide from Phellinus igniarius and its effects on wound healing. Carbohydr Polym. 2021 Jul 15;264:117982. doi: 10.1016/j.carbpol.2021.117982. Epub 2021 Mar 24. PMID: 33910711.
  46. Teja K, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A potential option in the management of deficiency and diseases in humans. Journal of Pure & Applied Microbiology. 2023;17(2). doi: 10.22207/JPAM.17.2.55.
  47. Thomas PW, Elkhateeb WA, Daba GM. Chaga (Inonotus obliquus): A medical marvel but a conservation dilemma? Sydowia. 2020;72:123-130.
  48. De Silva D, Rapior S, Sudarman E, Stadler M, Jianchu Xu, Aisyah A, Kevin D. Bioactive metabolites from macrofungi: Ethnopharmacology, biological activities and chemistry. Fungal Diversity. 2013;62(1):1-40.
  49. Choi SY, Hur SJ, An CS, Jeon YH, Jeoung YJ, Bak JP, Lim BO. Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate. J Biomed Biotechnol. 2010;2010:943516. doi: 10.1155/2010/943516. Epub 2010 Mar 10. PMID: 20300439; PMCID: PMC2840610.
  50. Park J, Nguyen TMN, Park HA, Nguyen MTT, Lee NY, Ban SY, Park KB, Lee CK, Kim J, Park JT. Protective Effects of Lanostane Triterpenoids from Chaga Mushroom in Human Keratinocytes, HaCaT Cells, against Inflammatory and Oxidative Stresses. Int J Mol Sci. 2023 Aug 15;24(16):12803. doi: 10.3390/ijms241612803. PMID: 37628993; PMCID: PMC10454022.
  51. Pippola E, Kotiranta H. The genus tremella (Basidiomycota, Tremellales) in Finland. In Annales Botanici Fennici. 2008;45(6):40-434.
  52. Zhu H, Sun SJ. Inhibition of bacterial quorum sensing-regulated behaviors by Tremella fuciformis extract. Curr Microbiol. 2008 Nov;57(5):418-22. doi: 10.1007/s00284-008-9215-8. Epub 2008 Jul 26. PMID: 18661179.
  53. Ma SY, He L, Yao LF. Research advances on structural characteristics and bioactivity of Tremella fuciformis polysaccharides. Food Sci. 2010;23:411-416.
  54. Ma X, Yang M, He Y, Zhai C, Li C. A review on the production, structure, bioactivities and applications of Tremella polysaccharides. Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211000541. doi: 10.1177/20587384211000541. PMID: 33858263; PMCID: PMC8172338.
  55. Lourith N, Pungprom S, Kanlayavattanakul M. Formulation and efficacy evaluation of the safe and efficient moisturizing snow mushroom hand sanitizer. J Cosmet Dermatol. 2021 Feb;20(2):554-560. doi: 10.1111/jocd.13543. Epub 2020 Jul 2. PMID: 32531816; PMCID: PMC7323351.
  56. Wu Y, Choi MH, Li J, Yang H, Shin HJ. Mushroom cosmetics: The present and future. Cosmetics. 2016;3(3):22. doi: 10.3390/cosmetics3030022.
  57. Kim D, Park J, Kim J, Han C, Yoon J, Kim N, Seo J, Lee C. Flavonoids as mushroom tyrosinase inhibitors: a fluorescence quenching study. J Agric Food Chem. 2006 Feb 8;54(3):935-41. doi: 10.1021/jf0521855. PMID: 16448205.
  58. Usman M, Murtaza G, Ditta A. Nutritional, medicinal, and cosmetic value of bioactive compounds in button mushroom (Agaricus bisporus): A review. Applied Sciences. 2021;11(13):5943.‏ doi: 10.3390/app11135943.
  59. Miyake M, Yamamoto S, Sano O, Fujii M, Kohno K, Ushio S, Iwaki K, Fukuda S. Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line. Biosci Biotechnol Biochem. 2010;74(4):753-8. doi: 10.1271/bbb.90795. PMID: 20445320.
  60. Taofiq O, Gonzalez-Paramas AM, Martins A, Barreiro MF, Ferreira IC. Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics—A review. Ind Crops Prod. 2016;90:38-48. doi: 10.1016/j.indcrop.2016.06.012.
  61. Kim MY, Seguin P, Ahn JK, Kim JJ, Chun SC, Kim EH, Seo SH, Kang EY, Kim SL, Park YJ, Ro HM, Chung IM. Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J Agric Food Chem. 2008 Aug 27;56(16):7265-70. doi: 10.1021/jf8008553. Epub 2008 Jul 11. PMID: 18616260.
  62. Deepalakshmi K, Mirunalini S. Therapeutic properties and current medical usage of medicinal mushroom: Ganoderma lucidum. International Journal of Pharmaceutical Sciences and Research. 2011;2(8):1922-1929.‏ doi: 10.13040/IJPSR.0975-8232.2(8).1922-29.
  63. Ogra Y, Ishiwata K, Ruiz Encinar J, Łobiński R, Suzuki KT. Speciation of selenium in selenium-enriched shiitake mushroom, Lentinula edodes. Anal Bioanal Chem. 2004 Jul;379(5-6):861-6. doi: 10.1007/s00216-004-2670-6. Epub 2004 Jun 17. PMID: 15205868.
Publish with JBRES — Peer-reviewed, multidisciplinary Open Access with rapid review, DOI, and global visibility.
Double-Blind CrossRef DOI Discoverable
Submit Manuscript Membership