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Cell-Free Therapy Based on Adipose Stem Cell-Derived Exosomes to Inhibit Scar Formation Proactively: Mechanisms and Clinical Targeting Applications

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Open Access
Article Type Review Article
Subject Biology Group
OCLC JBRES Record
Xinhao Cheng, Haijiang Dong, Yu Li, Shuying Yu, Guangren Yue and Ximei Wang*
Issue: Volume6-Issue1
Pages: 031-055
Received: 2024-12-08
Accepted: 2025-01-18
Published: 2025-01-20

Abstract

This review provides an in-depth analysis of the potential benefits of cell-free therapy based on adipose-derived exosomes (ADSC-Exos) in inhibiting scar formation. The review highlights the advantages of using ADSC-Exos. It also explores the complex mechanisms by which ADSC-Exos inhibit scar formation, including their role in hemostasis, inflammation, cell proliferation, tissue remodeling, and their regulation of critical molecules (platelets, inflammatory factors, extracellular matrix molecules, collagen molecules) and crucial cells (macrophages, endothelial cells, fibroblasts), as well as their modulation of epithelial-mesenchymal transition. Additionally, the article examines different delivery methods and engineering approaches for optimizing the targeting of adipose stem cell-derived exosomes in traumatic scarring. It points out the potential of using liposomes to construct molecular-targeted exosomes in precision medicine. Finally, the review summarizes current research and provides insights into the future development of exosomes in scar treatment. In conclusion, this article reveals the potential of cell-free therapy based on ADSC-Exos as a promising treatment for inhibiting scar formation.

FullText HTML FullText PDF DOI: 10.37871/jbres2055 Crossmark

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© 2025 Cheng X, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Cheng X, Dong H, Li Y, Yu S, Yue G, Wang X. Cell-Free Therapy Based on Adipose Stem Cell- Derived Exosomes to Inhibit Scar Formation Proactively: Mechanisms and Clinical Targeting Applications. J Biomed Res Environ Sci. 2025 Jan 20; 6(1): 031-055. doi: 10.37871/jbres2055, Article ID: JBRES2055, Available at: https:// www.jelsciences.com/articles/jbres2055.pdf

Subject area(s)

Stem CellsBioengineeringBiology

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