Daigo Hirao, Subrina Jesmin*, Adil Maqbool, Takehito Sugasaw, AKM Shaharul Islam, Yui Haruguchi, Arifur Rahman, Farzana Sohael, Chishimba Mowa and Nobutake Shimojo
Volume5-Issue11
Dates: Received: 2024-10-17 | Accepted: 2024-11-14 | Published: 2024-11-18
Pages: 1469-1478
Abstract
Osteosarcoma, a primary malignant bone tumor, predominantly affects children and young adults, with a high incidence during puberty. Early diagnosis is critical due to the rapid tumor growth. Neoadjuvant chemotherapy has improved outcomes slightly, but prognosis remains poor in South Asia. Socioeconomic challenges and limited access to advanced therapies hinder effective treatment in this region. Despite global advancements in chemotherapy and surgical techniques, outcomes in low- and middle-income countries remain suboptimal. This review highlights the epidemiological challenges, diagnostic obstacles, and treatment barriers faced in South Asia, emphasizing the need for more accessible therapeutic approaches and improved healthcare systems.
FullText HTML
FullText PDF
DOI: 10.37871/jbres2035
Certificate of Publication

Copyright
© 2024 Hirao D, et al. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Hirao D, Jesmin S, Maqbool A, Sugasawa T, Shaharul Islam AKM, Haruguchi Y, Rahman A, Sohael F, Mowa C, Shimojo N. Osteosarcoma in South Asia: A Brief Overview. J Biomed Res Environ Sci. 2024 Nov 10; 5(11): 1469-1478. doi: 10.37871/ jbres2035, Article ID: JBRES2035, Available at: https://www.jelsciences.com/articles/jbres2035.pdf
Subject area(s)
References
- Bleyer A, O'Leary M, Barr R. Ries L. Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000. National Cancer Institute. 2006.
- Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives. Pathologica. 2021 Apr;113(2):70-84. doi: 10.32074/1591-951X-213. Epub 2020 Nov 3. PMID: 33179614; PMCID: PMC8167394.
- Hornicek F, Bahrami A, Baldini E. Epidemiology, pathology and molecular genetics of Ewing sarcoma. Medilib ir. 2022.
- Bajpai J, Jaffe N. Perspectives of the role of chemotherapy in the management of osteosarcoma. Scientific Research. 2012;3(6):1191-1203. doi: 10.4236/jct.2012.36154.
- Czarnecka AM, Synoradzki K, Firlej W, Bartnik E, Sobczuk P, Fiedorowicz M, Grieb P, Rutkowski P. Molecular Biology of Osteosarcoma. Cancers (Basel). 2020 Jul 31;12(8):2130. doi: 10.3390/cancers12082130. PMID: 32751922; PMCID: PMC7463657.
- Rojas GA, Hubbard AK, Diessner BJ, Ribeiro KB, Spector LG. International trends in incidence of osteosarcoma (1988-2012). Int J Cancer. 2021 Sep 1;149(5):1044-1053. doi: 10.1002/ijc.33673. Epub 2021 May 17. PMID: 33963769; PMCID: PMC9137041.
- Hossain MS, Begum M, Mian MM, Ferdous S, Kabir S, Sarker HK, Karim S, Choudhury S, Khan A, Khan ZJ, Karim-Kos HE. Epidemiology of childhood and adolescent cancer in Bangladesh, 2001-2014. BMC Cancer. 2016 Feb 15;16:104. doi: 10.1186/s12885-016-2161-0. PMID: 26879701; PMCID: PMC4754803.
- Swaminathan S. Consensus document for management on soft tissue sarcoma and osteosarcoma. Indian Council of Medical Journal. 2016.
- Riza M, Salimo H, Wasita B, Idulhaq M, Saputra E, Widyaningsih V, Wayanshakty J. Survival and prognostic factors in pediatric osteosarcoma: A 5-year single-center experience in Central Java, Indonesia. Paediatrica Indonesiana. 2024;64(1):10. doi: 10.14238/pi64.1.2024.10-6.
- Zhao X, Wu Q, Gong X, Liu J, Ma Y. Osteosarcoma: a review of current and future therapeutic approaches. Biomed Eng Online. 2021 Mar 2;20(1):24. doi: 10.1186/s12938-021-00860-0. PMID: 33653371; PMCID: PMC7923306.
- Dahan M, Anract P, Babinet A, Larousserie F, Biau D. Proximal femoral osteosarcoma: Diagnostic challenges translate into delayed and inappropriate management. Orthop Traumatol Surg Res. 2017 Nov;103(7):1011-1015. doi: 10.1016/j.otsr.2017.05.019. Epub 2017 Jun 21. PMID: 28647623.
- Mittal A, Pushpam D, Ganguly S, Kumar VS, Khan SA, Bakhshi S. Controversies and Challenges in the Management of Osteosarcoma-an Indian Perspective. Indian J Surg Oncol. 2022 Dec;13(4):939-955. doi: 10.1007/s13193-021-01486-3. Epub 2022 Jan 9. PMID: 36687236; PMCID: PMC9845467.
- Sharma S, Zapatero-Rodríguez J, Estrela P, O'Kennedy R. Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics. Biosensors (Basel). 2015 Aug 13;5(3):577-601. doi: 10.3390/bios5030577. PMID: 26287254; PMCID: PMC4600173.
- Jiang ZY, Liu JB, Wang XF, Ma YS, Fu D. Current Status and Prospects of Clinical Treatment of Osteosarcoma. Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221124696. doi: 10.1177/15330338221124696. PMID: 36128851; PMCID: PMC9500272.
- Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M. Recent advances in nanotechnology-based diagnosis and treatments of human osteosarcoma. 2021;11(2):55. doi: 10.3390/bios11020055.
- Pruksakorn D, Phanphaisarn A, Arpornchayanon O, Uttamo N, Leerapun T, Settakorn J. Survival rate and prognostic factors of conventional osteosarcoma in Northern Thailand: A series from Chiang Mai University Hospital. Cancer Epidemiol. 2015 Dec;39(6):956-63. doi: 10.1016/j.canep.2015.10.016. Epub 2015 Nov 9. PMID: 26540607.
- Xin S, Wei G. Prognostic factors in osteosarcoma: A study level meta-analysis and systematic review of current practice. J Bone Oncol. 2020 Feb 21;21:100281. doi: 10.1016/j.jbo.2020.100281. PMID: 32140401; PMCID: PMC7047183.
- Monsereenusorn C, Alcasabas AP, Loh AHP, Soh SY, Leung KWP, Dhamne C, Blair S, Lam C, Rujkijyanont P, Traivaree C, Photia A, Veerapan P, Puhaindran ME, Oh BLZ, Wang E, Rodriguez-Galindo C. Predictors and Treatment Outcomes of Pediatric Osteosarcoma in Diverse Socioeconomic Backgrounds in Southeast Asia: A Retrospective Multicenter Study. Asian Pac J Cancer Prev. 2022 Feb 1;23(2):631-640. doi: 10.31557/APJCP.2022.23.2.631. PMID: 35225476; PMCID: PMC9272642.
- Chintapally N, Nuwayhid M, Arroju V, Muddu VK, Gao P, Reddy BY, Sunkavalli C. State of cancer care in India and opportunities for innovation. Future Oncol. 2023 Dec;19(39):2593-2606. doi: 10.2217/fon-2023-0047. Epub 2023 Sep 7. PMID: 37675499.
- Ebrahimi A, Hosseini S, Shahabi S, Ashkani-Esfahani S, Lozano-Calderon S. The Impact of Social Determinants of Health on the Prognosis of Primary Bone Tumors: A Systematic Review. JBJS Rev. 2024 Sep 3;12(9). doi: 10.2106/JBJS.RVW.24.00071. PMID: 39226393.
- Ilcisin L, Han R, Krailo M, Shulman DS, Weil BR, Weldon CB, Umaretiya P, Aziz-Bose R, Greenzang KA, Gorlick R, Reed DR, Randall RL, Nadel H, Binitie O, Dubois SG, Janeway KA, Bona K. Poverty, race, ethnicity, and survival in pediatric nonmetastatic osteosarcoma: a Children's Oncology Group report. J Natl Cancer Inst. 2024 Oct 1;116(10):1664-1674. doi: 10.1093/jnci/djae103. PMID: 38926133.
- Halalsheh H, Abu-Hijlih R, Ismael T, Shehadeh A, Salaymeh KJ, Boheisi M, Sultan I. Doxorubicin Dose Deintensification in Pediatric Osteosarcoma, Is Less Better? South Asian J Cancer. 2023 Apr 10;12(3):290-296. doi: 10.1055/s-0042-1760203. PMID: 38047045; PMCID: PMC10691917.
- Narayanan G, Thambi S, Kattoor J, Sugath B, Nair S. Telangiectatic osteosarcoma—A single-center experience. Thieme. 2023. doi: 10.1055/s-0043-1771386.
- Yin C, Chokkakula S, Li J, Li W, Yang W, Chong S, Zhou W, Wu H, Wang C. Unveiling research trends in the prognosis of osteosarcoma: A bibliometric analysis from 2000 to 2022. Heliyon. 2024 Mar 7;10(6):e27566. doi: 10.1016/j.heliyon.2024.e27566. PMID: 38515706; PMCID: PMC10955242.
- Xu P, Hu L, Yu C, Yang W, Kang F, Zhang M, Wang J. Unsymmetrical cyanine dye via in vivo hitchhiking endogenous albumin affords high-performance NIR-II/photoacoustic imaging and photothermal therapy. Springer Nature. 2021. doi: 10.1186/s12951-021-01075-0.
- Tian H, Wu R, Feng N, Zhang J, Zuo J. Recent advances in hydrogels-based osteosarcoma therapy. Frontiers in Bioengineering and Biotechnology. 2022. doi: 10.3389/fbioe.2022.1042625.
- De Guzman B, Cabaya N, Ting F, Tan J. Factor’s influencing treatment decisions among breast cancer patients in the Philippine general hospital cancer institute: Medical oncology outpatient clinic. 2020. doi: 10.1093/annonc/mdz430.009.
- Ahmadnia S, Ghalibaf AK, Kamkar S, Mohamadzadeh Z, Ghalibafian M. Survivor and parent engagement in childhood cancer treatment in Iran. Ecancermedicalscience. 2021 Apr 19;15:1220. doi: 10.3332/ecancer.2021.1220. PMID: 34158824; PMCID: PMC8183647.
- Agyemang LS, Foster C, McLean C, Fenlon D, Wagland R. The cultural and structural influences that 'hide' information from women diagnosed with breast cancer in Ghana: an ethnography. BMC Womens Health. 2021 Oct 15;21(1):364. doi: 10.1186/s12905-021-01502-2. PMID: 34654413; PMCID: PMC8518148.
- Salek M, Silverstein A, Tilly A, Gassant PY, Gunasekera S, Hordofa DF, Hesson D, Duffy C, Malik N, McNeil M, Force LM, Bhakta N, Rodin D, Kaye EC. Factors influencing treatment decision-making for cancer patients in low- and middle-income countries: A scoping review. Cancer Med. 2023 Sep;12(17):18133-18152. doi: 10.1002/cam4.6375. Epub 2023 Aug 1. PMID: 37526041; PMCID: PMC10524036.
- Memon S, Mangi F, Memon F, Sushel C, Shaikh A, Shaikh T. The pattern of musculoskeletal cancers in Pakistan. Journal of Liaquat University of Medical & Health Sciences. 2022. doi: 10.22442/jlumhs.2021.00870.
- Ramaswamy A, Rekhi B, Bakhshi S, Hingmire S, Agarwal M. Indian data on bone and soft tissue sarcomas: A summary of published study results. South Asian J Cancer. 2016 Jul-Sep;5(3):138-45. doi: 10.4103/2278-330X.187587. PMID: 27606300; PMCID: PMC4991135.