A Comprehensive Review of IgG4 Related Disease Unraveling the Role of B and T Lymphocytes in the Pathogenesis of the Disease

Gaia Mancuso*

Gaia Mancuso*

Volume5-Issue11
Dates: Received: 2024-07-29 | Accepted: 2024-10-30 | Published: 2024-11-10
Pages: 1430-1453

Abstract

IgG4-RD is a chronic fibro inflammatory disease characterized by a significant elevation of serum IgG4 concentration and marked infiltration of IgG4-positive plasma cells in the affected organs. A dense lymphoplasmacytic infiltrate and the formation of ectopic lymphoid structures are characteristic histopathological findings in an IgG4-RD lesions. These findings strongly suggest the preferential involvement of T and B lymphocytes in the development of this disease. We want to sum up the last evidences regarding the IgG4-RD with a focus on the role of the involvement of CD4+T-cell subsets and B lymphocytes.

FullText HTML FullText PDF DOI: 10.37871/jbres2032

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How to cite this article

Mancuso G. A Comprehensive Review of IgG4 Related Disease Unraveling the Role of B and T Lymphocytes in the Pathogenesis of the Disease. J Biomed Res Environ Sci. 2024 Nov 10; 5(11): 1430-1453. doi: 10.37871/jbres2032, Article ID: JBRES2032, Available at: https://www.jelsciences.com/articles/jbres2032.pdf

Subject area(s)

Rheumatology

Immunology

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