Application of UV-C Technology in Managing the Monkeypox Epidemic: Surface, Air, and PPE Decontamination

Mustafa Kosea; Cagri Kaan Akkanb; Huseyin Karabacakc; Ahmet Kolumand*

Mustafa Kosea, Cagri Kaan Akkanb, Huseyin Karabacakc and Ahmet Kolumand*

Volume5-Issue10
Dates: Received: 2024-10-04 | Accepted: 2024-10-21 | Published: 2024-10-25
Pages: 1358-1370

Abstract

The outbreak of monkeypox, a zoonotic viral disease, necessitates effective strategies for infection control and decontamination. Ultraviolet-C (UV-C) radiation, with its germicidal properties, has long been utilized for sterilization in various settings. This paper explores the potential of UV-C technology in managing the monkeypox epidemic, focusing on its applications for surface, air, and Personal Protective Equipment (PPE) decontamination. Traditional UV-C methods have demonstrated effectiveness in reducing viral loads on surfaces and in the air, potentially mitigating the spread of monkeypox. Additionally, UV-C can aid in the sterilization of PPE, crucial for protecting healthcare workers and managing supply shortages. The paper also addresses environmental considerations, including the energy consumption and water footprint associated with UV-C systems. The transition to energy-efficient UV-C LEDs and sustainable practices is highlighted as a means to balance efficacy with environmental impact. By integrating UV-C technology with other infection control measures, healthcare facilities and high-risk environments can enhance their response to the monkeypox epidemic while minimizing ecological concerns.

FullText HTML FullText PDF DOI: 10.37871/jbres2024

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How to cite this article

Kösea M, Akkanb ÇK, Karabacakc H, Kolumand A. Application of UV-C Technology in Managing the Monkeypox Epidemic: Surface, Air, and PPE Decontamination. J Biomed Res Environ Sci. 2024 Oct 25; 5(10): 1358-1370. doi: 10.37871/jbres2024, Article ID: JBRES2024, Available at: https://www.jelsciences.com/articles/jbres2024.pdf

Subject area(s)

Biology

Infectious Diseases

Virology

References

Truong CS, Muthukutty P, Jang HK, Kim YH, Lee DH, Yoo SY. Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection. Viruses. 2023 Jun 28;15(7):1463. doi: 10.3390/v15071463. PMID: 37515151; PMCID: PMC10385069.
Mitjà O, Ogoina D, Titanji BK, Galvan C, Muyembe JJ, Marks M, Orkin CM. Monkeypox. Lancet. 2023 Jan 7;401(10370):60-74. doi: 10.1016/S0140-6736(22)02075-X. Epub 2022 Nov 17. Erratum in: Lancet. 2022 Dec 3;400(10367):1926. doi: 10.1016/S0140-6736(22)02414-X. PMID: 36403582; PMCID: PMC9671644.
Khattak S, Rauf MA, Ali Y, Yousaf MT, Liu Z, Wu DD, Ji XY. The monkeypox diagnosis, treatments and prevention: A review. Front Cell Infect Microbiol. 2023 Feb 6;12:1088471. doi: 10.3389/fcimb.2022.1088471. PMID: 36814644; PMCID: PMC9939471.
Kang Y, Yu Y, Xu S. Human monkeypox infection threat: A comprehensive overview. PLoS Negl Trop Dis. 2023 Apr 20;17(4):e0011246. doi: 10.1371/journal.pntd.0011246. PMID: 37079486; PMCID: PMC10118097.
Lim EY, Whitehorn J, Rivett L. Monkeypox: a review of the 2022 outbreak. Br Med Bull. 2023 Apr 5;145(1):17-29. doi: 10.1093/bmb/ldad002. PMID: 36751952.
Ragan IK, Hartson LM, Sullivan EJ, Bowen RA, Goodrich RP. Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV light. PLoS One. 2023 Jan 20;18(1):e0278862. doi: 10.1371/journal.pone.0278862. PMID: 36662705; PMCID: PMC9857991.
Mariotti D, Bettini A, Meschi S, Notari S, Francalancia M, Tartaglia E, Lapa D, Specchiarello E, Girardi E, Matusali G, Maggi F. Effect of chemical and physical agents on monkeypox virus infectivity and downstream research applications. Virology. 2024 Apr;592:109993. doi: 10.1016/j.virol.2024.109993. Epub 2024 Jan 16. PMID: 38244323.
de Almeida MTG, de Almeida BG, Siqueira JPZ, Byzynski Soares G, Sigari Morais V, Mitsue Yasuoka FM, Ghiglieno F. Ultraviolet-C Light-emitting Device Against Microorganisms in Beauty Salons. Pathog Immun. 2022 Jun 16;7(1):49-59. doi: 10.20411/pai.v7i1.497. PMID: 35795726; PMCID: PMC9249058.
Santos TD, de Castro LF. Evaluation of a portable Ultraviolet C (UV-C) device for hospital surface decontamination. Photodiagnosis Photodyn Ther. 2021 Mar;33:102161. doi: 10.1016/j.pdpdt.2020.102161. Epub 2020 Dec 26. PMID: 33373741; PMCID: PMC7764389.
Ramos CCR, Roque JLA, Sarmiento DB, Suarez LEG, Sunio JTP, Tabungar KIB, Tengco GSC, Rio PC, Hilario AL. Use of ultraviolet-C in environmental sterilization in hospitals: A systematic review on efficacy and safety. Int J Health Sci (Qassim). 2020 Nov-Dec;14(6):52-65. PMID: 33192232; PMCID: PMC7644456.
Carlisle MG, Rutala WA, Cadnum JL, Wilson BM, Deshpande A, Donskey CJ. A randomized trial of ultraviolet-C (UV-C) light versus sodium hypochlorite delivered by an electrostatic sprayer for adjunctive decontamination of hospital rooms. Infect Control Hosp Epidemiol. 2023 Jun;44(6):1025-1028. doi: 10.1017/ice.2022.132. Epub 2022 Jun 6. PMID: 35659791.
Boyce JM, Donskey CJ. Understanding ultraviolet light surface decontamination in hospital rooms: A primer. Infect Control Hosp Epidemiol. 2019 Sep;40(9):1030-1035. doi: 10.1017/ice.2019.161. Epub 2019 Jun 18. PMID: 31210119.
Koutras C, Wade R. Rapid inactivation of vaccinia, a surrogate virus for monkeypox and smallpox, using ultraviolet-C disinfection. bioRxiv. 2002. doi: 10.1101/2022.10.04.510918.
Ragan IK, Hartson LM, Sullivan EJ, Bowen RA, Goodrich RP. Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV light. PLoS One. 2023 Jan 20;18(1):e0278862. doi: 10.1371/journal.pone.0278862. PMID: 36662705; PMCID: PMC9857991.
Ackora-Prah J, Okyere S, Bonyah E, Adebanji A, Boateng Y. Optimal control model of human-to-human transmission of monkeypox virus. F1000Research. 2023. doi: 10.12688/f1000research.130276.1.
Sudarmaji N, Kifli N, Hermansyah A, Yeoh SF, Goh BH, Ming LC. Prevention and Treatment of Monkeypox: A Systematic Review of Preclinical Studies. Viruses. 2022 Nov 11;14(11):2496. doi: 10.3390/v14112496. PMID: 36423105; PMCID: PMC9699130.
Gedam R, Srivastava A. Sterilization using Germicidal UV Light. CSVTU Research Journal on Engineering and Technology. 2021. doi: 10.30732/csvturj.20211001002.
Sharma P, Chen P, Han S, Chung P, Chen J, Tseng J, Han C. Design Considerations for a Surface Disinfection Device Using Ultraviolet-C Light-Emitting Diodes. J Res Natl Inst Stand Technol. 2022 Feb 16;126:126045. doi: 10.6028/jres.126.045. PMID: 36475088; PMCID: PMC9707634.
Lulli LG, Baldassarre A, Mucci N, Arcangeli G. Prevention, Risk Exposure, and Knowledge of Monkeypox in Occupational Settings: A Scoping Review. Trop Med Infect Dis. 2022 Sep 29;7(10):276. doi: 10.3390/tropicalmed7100276. PMID: 36288017; PMCID: PMC9608671.
Chiappa F, Frascella B, Vigezzi GP, Moro M, Diamanti L, Gentile L, Lago P, Clementi N, Signorelli C, Mancini N, Odone A. The efficacy of ultraviolet light-emitting technology against coronaviruses: a systematic review. J Hosp Infect. 2021 Aug;114:63-78. doi: 10.1016/j.jhin.2021.05.005. Epub 2021 May 21. PMID: 34029626; PMCID: PMC8139389.
Weaver DT, McElvany BD, Gopalakrishnan V, Card KJ, Crozier D, Dhawan A, Dinh MN, Dolson E, Farrokhian N, Hitomi M, Ho E, Jagdish T, King ES, Cadnum JL, Donskey CJ, Krishnan N, Kuzmin G, Li J, Maltas J, Mo J, Pelesko J, Scarborough JA, Sedor G, Tian E, An GC, Diehl SA, Scott JG. UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic. PLoS One. 2021 Jul 26;16(7):e0241734. doi: 10.1371/journal.pone.0241734. PMID: 34310599; PMCID: PMC8312969.
Padrão J, Nicolau T, Felgueiras HP, Calçada C, Veiga MI, Osório NS, Martins MS, Dourado N, Taveira-Gomes A, Ferreira F, Zille A. Development of an Ultraviolet-C Irradiation Room in a Public Portuguese Hospital for Safe Re-Utilization of Personal Protective Respirators. Int J Environ Res Public Health. 2022 Apr 16;19(8):4854. doi: 10.3390/ijerph19084854. PMID: 35457722; PMCID: PMC9026523.
Cadnum JL, Li DF, Redmond SN, John AR, Pearlmutter B, Donskey CJ. Effectiveness of Ultraviolet-C Light and a High-Level Disinfection Cabinet for Decontamination of N95 Respirators. Pathog Immun. 2020 Apr 20;5(1):52-67. doi: 10.20411/pai.v5i1.372. PMID: 32363254; PMCID: PMC7192214.
Li X, Blatchley E. Validation of In-Room UV-C-Based Air Cleaners. Indoor Air. 2023. doi: 10.1155/2023/5510449.
Martínez de Alba AE, Rubio MB, Morán-Diez ME, Bernabéu C, Hermosa R, Monte E. Microbiological Evaluation of the Disinfecting Potential of UV-C and UV-C Plus Ozone Generating Robots. Microorganisms. 2021 Jan 15;9(1):172. doi: 10.3390/microorganisms9010172. PMID: 33467428; PMCID: PMC7830970.
Hemati S, Mohammadi-Moghadam F. A systematic review on environmental perspectives of monkeypox virus. Reviews on Environmental Health. 2023. doi: 10.1515/reveh-2022-0221.
Brown K, Leggat PA. Human Monkeypox: Current State of Knowledge and Implications for the Future. Trop Med Infect Dis. 2016 Dec 20;1(1):8. doi: 10.3390/tropicalmed1010008. PMID: 30270859; PMCID: PMC6082047.
Yamano N, Kunisada M, Nishiaki-Sawada A, Ohashi H, Igarashi T, Nishigori C. Evaluation of Acute Reactions on Mouse Skin Irradiated with 222 and 235 nm UV-C. Photochem Photobiol. 2021 Jul;97(4):770-777. doi: 10.1111/php.13384. Epub 2021 Feb 5. PMID: 33480023; PMCID: PMC8359381.
Sandri A, Tessari A, Giannetti D, Cetti A, Lleo MM, Boschi F. UV-A Radiation: Safe Human Exposure and Antibacterial Activity. Int J Mol Sci. 2023 May 5;24(9):8331. doi: 10.3390/ijms24098331. PMID: 37176038; PMCID: PMC10179708.
Sliney DH, Stuck BE. A Need to Revise Human Exposure Limits for Ultraviolet UV-C Radiation†. Photochem Photobiol. 2021 May;97(3):485-492. doi: 10.1111/php.13402. Epub 2021 Mar 25. PMID: 33590879; PMCID: PMC8252557.
Welch D, Kleiman NJ, Arden PC, Kuryla CL, Buonanno M, Ponnaiya B, Wu X, Brenner DJ. No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long-Term (66 week) Chronic Exposure to 222-nm Far-UVC Radiation. Photochem Photobiol. 2023 Jan;99(1):168-175. doi: 10.1111/php.13656. Epub 2022 Jun 8. PMID: 35614842; PMCID: PMC9691791.
Köse M. Biyolojik tehditlere karşı koruyucu maske ve UV dekontaminasyon kutusu tasarımı (Master's thesis, Pamukkale University).Design of protective mask and UV decontamination box against biological threats.2024.
Astrid F, Beata Z, Van den Nest Miriam, Julia E, Elisabeth P, Magda DE. The use of a UV-C disinfection robot in the routine cleaning process: a field study in an Academic hospital. Antimicrob Resist Infect Control. 2021 May 29;10(1):84. doi: 10.1186/s13756-021-00945-4. PMID: 34051861; PMCID: PMC8164075.
Napolitano NA, Mahapatra T, Tang W. The effectiveness of UV-C radiation for facility-wide environmental disinfection to reduce health care-acquired infections. Am J Infect Control. 2015 Dec 1;43(12):1342-6. doi: 10.1016/j.ajic.2015.07.006. Epub 2015 Aug 12. PMID: 26277574.
Yinda CK, Morris DH, Fischer RJ, Gallogly S, Weishampel ZA, Port JR, Bushmaker T, Schulz JE, Bibby K, van Doremalen N, Lloyd-Smith JO, Munster VJ. Stability of Monkeypox Virus in Body Fluids and Wastewater. Emerg Infect Dis. 2023 Oct;29(10):2065-2072. doi: 10.3201/eid2910.230824. PMID: 37735747; PMCID: PMC10521604.
Smolle C, Huss F, Lindblad M, Reischies F, Tano E. Effectiveness of automated ultraviolet-C light for decontamination of textiles inoculated with Enterococcus faecium. J Hosp Infect. 2018 Jan;98(1):102-104. doi: 10.1016/j.jhin.2017.07.034. Epub 2017 Aug 4. PMID: 28827192.
Hockaday SL, Schulte J, McCallum E, Schwartz R, Esparza R, Swienton R, Fowler R. Investigation and Decontamination of an Urban Monkeypox Occurrence. Disaster Med Public Health Prep. 2023 Aug 23;17:e460. doi: 10.1017/dmp.2023.116. PMID: 37609843.
Vaughan A, Aarons E, Astbury J, Brooks T, Chand M, Flegg P, Hardman A, Harper N, Jarvis R, Mawdsley S, McGivern M, Morgan D, Morris G, Nixon G, O'Connor C, Palmer R, Phin N, Price DA, Russell K, Said B, Schmid ML, Vivancos R, Walsh A, Welfare W, Wilburn J, Dunning J. Human-to-Human Transmission of Monkeypox Virus, United Kingdom, October 2018. Emerg Infect Dis. 2020 Apr;26(4):782-785. doi: 10.3201/eid2604.191164. Epub 2020 Apr 17. PMID: 32023204; PMCID: PMC7101111.
Ackora-Prah J, Okyere S, Bonyah E, Adebanji A., & Boateng, Y. (2023). Optimal control model of human-to-human transmission of monkeypox virus. F1000Research. 2023;12:326. doi: 10.12688/f1000research.130276.1.
Rangel K, Cabral FO, Lechuga GC, Villas-Bôas MHS, Midlej V, De-Simone SG. Effectiveness Evaluation of a UV-C-Photoinactivator against Selected ESKAPE-E Pathogens. Int J Environ Res Public Health. 2022 Dec 9;19(24):16559. doi: 10.3390/ijerph192416559. PMID: 36554438; PMCID: PMC9778679.
Guimera D, Trzil J, Joyner J, Hysmith ND. Effectiveness of a shielded ultraviolet C air disinfection system in an inpatient pharmacy of a tertiary care children's hospital. Am J Infect Control. 2018 Feb;46(2):223-225. doi: 10.1016/j.ajic.2017.07.026. Epub 2017 Aug 31. PMID: 28865936.
Lombini M, Diolaiti E, De Rosa A, Lessio L, Pareschi G, Bianco A, Cortecchia F, Fiorini M, Fiorini G, Malaguti G, Zanutta A. Design of optical cavity for air sanification through ultraviolet germicidal irradiation. Opt Express. 2021 Jun 7;29(12):18688-18704. doi: 10.1364/OE.422437. PMID: 34154120.
Li P, Koziel JA, Macedo N, Zimmerman JJ, Wrzesinski D, Sobotka E, Balderas M, Walz WB, Paris RV, Lee M, Liu D, Yedilbayev B, Ramirez BC, Jenks WS. Evaluation of an Air Cleaning Device Equipped with Filtration and UV: Comparison of Removal Efficiency on Particulate Matter and Viable Airborne Bacteria in the Inlet and Treated Air. Int J Environ Res Public Health. 2022 Dec 2;19(23):16135. doi: 10.3390/ijerph192316135. PMID: 36498208; PMCID: PMC9735963.
Song BM, Lee GH, Han HJ, Yang JH, Lee EG, Gu H, Park HK, Ryu K, Kim J, Kang SM, Tark D. Ultraviolet-C light at 222 nm has a high disinfecting spectrum in environments contaminated by infectious pathogens, including SARS-CoV-2. PLoS One. 2023 Nov 28;18(11):e0294427. doi: 10.1371/journal.pone.0294427. PMID: 38015931; PMCID: PMC10684113.
Bartolomeu M, Braz M, Costa P, Duarte J, Pereira C, Almeida A. Evaluation of UV-C Radiation Efficiency in the Decontamination of Inanimate Surfaces and Personal Protective Equipment Contaminated with Phage ϕ6. Microorganisms. 2022 Mar 9;10(3):593. doi: 10.3390/microorganisms10030593. PMID: 35336168; PMCID: PMC8954440.
Bhardwaj SK, Singh H, Deep A, Khatri M, Bhaumik J, Kim KH, Bhardwaj N. UVC-based photoinactivation as an efficient tool to control the transmission of coronaviruses. Sci Total Environ. 2021 Oct 20;792:148548. doi: 10.1016/j.scitotenv.2021.148548. Epub 2021 Jun 16. PMID: 34465056; PMCID: PMC8238411.
Guridi A, Sevillano E, de la Fuente I, Mateo E, Eraso E, Quindós G. Disinfectant Activity of A Portable Ultraviolet C Equipment. Int J Environ Res Public Health. 2019 Nov 27;16(23):4747. doi: 10.3390/ijerph16234747. PMID: 31783593; PMCID: PMC6926820.
She R, Chen D, Pak P, Armani D, Schubert A, Armani, A. Build-at-home UV-C disinfection system for healthcare settings. arXiv: Medical Physics. 2020 Mar 29. doi: doi.org/10.48550/arXiv.2003.12916
Harapan H, Ophinni Y, Megawati D, Frediansyah A, Mamada SS, Salampe M, Bin Emran T, Winardi W, Fathima R, Sirinam S, Sittikul P, Stoian AM, Nainu F, Sallam M. Monkeypox: A Comprehensive Review. Viruses. 2022 Sep 29;14(10):2155. doi: 10.3390/v14102155. PMID: 36298710; PMCID: PMC9612348.
McCarthy MW. Therapeutic strategies to address monkeypox. Expert Rev Anti Infect Ther. 2022 Oct;20(10):1249-1252. doi: 10.1080/14787210.2022.2113058. Epub 2022 Aug 17. PMID: 35953443; PMCID: PMC9491133.