Gerhard A Coetzee*
Volume5-Issue10
Dates: Received: 2024-10-08 | Accepted: 2024-10-11 | Published: 2024-10-11
Pages: 1288-1290
Abstract
Modern biological science depends on hypotheses generation, which can best be obtained without pre-conceptions, and by collective teamwork and individual brilliance. Therefore, ‘open’ searches can lead to informative hypotheses generation that in turn can be framed, delved into and tested, ultimately leading to novel mechanistic insights and translation into informative diagnostics and therapeutics.
FullText HTML
FullText PDF
DOI: 10.37871/jbres2016
Certificate of Publication

Copyright
© 2024 Coetzee GA. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Coetzee GA. Hypotheses Generation through Team Science or Fishing Expedition. J Biomed Res Environ Sci. 2024 Oct 11; 5(10): 1288-1290. doi: 10.37871/jbres2016, Article ID: JBRES2016, Available at: https://www.jelsciences.com/articles/ jbres2016.pdf
Subject area(s)
References
- Kondratyev NV, Alfimova MV, Golov AK, Golimbet VE. Bench Research Informed by GWAS Results. Cells. 2021 Nov 15;10(11):3184. doi: 10.3390/cells10113184. PMID: 34831407; PMCID: PMC8623533.
- Dermitzakis ET. Genome-sequencing anniversary. Genome literacy. Science. 2011 Feb 11;331(6018):689-90. doi: 10.1126/science.1203237. PMID: 21310993.
- Via M, Gignoux C, Burchard EG. The 1000 Genomes Project: new opportunities for research and social challenges. Genome Med. 2010 Jan 21;2(1):3. doi: 10.1186/gm124. PMID: 20193048; PMCID: PMC2829928.
- Pierce SE, Booms A, Prahl J, van der Schans EJC, Tyson T, Coetzee GA. Post-GWAS knowledge gap: the how, where, and when. NPJ Parkinsons Dis. 2020 Sep 9;6:23. doi: 10.1038/s41531-020-00125-y. PMID: 32964108; PMCID: PMC7481221.
- Ecker JR, Bickmore WA, Barroso I, Pritchard JK, Gilad Y, Segal E. Genomics: ENCODE explained. Nature. 2012 Sep 6;489(7414):52-5. doi: 10.1038/489052a. PMID: 22955614.
- Nusinovich Y. Decoding the Brain. Science. 2024;384(6698):858-859.
- Cancer Genome Atlas Research Network; Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct;45(10):1113-20. doi: 10.1038/ng.2764. PMID: 24071849; PMCID: PMC3919969.
- Bressan E, Reed X, Bansal V, Hutchins E, Cobb MM, Webb MG, Alsop E, Grenn FP, Illarionova A, Savytska N, Violich I, Broeer S, Fernandes N, Sivakumar R, Beilina A, Billingsley KJ, Berghausen J, Pantazis CB, Pitz V, Patel D, Daida K, Meechoovet B, Reiman R, Courtright-Lim A, Logemann A, Antone J, Barch M, Kitchen R, Li Y, Dalgard CL; American Genome Center; Rizzu P, Hernandez DG, Hjelm BE, Nalls M, Gibbs JR, Finkbeiner S, Cookson MR, Van Keuren-Jensen K, Craig DW, Singleton AB, Heutink P, Blauwendraat C. The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism. Cell Genom. 2023 Feb 6;3(3):100261. doi: 10.1016/j.xgen.2023.100261. PMID: 36950378; PMCID: PMC10025424.
- Rigden DJ, Fernández XM. The 2024 Nucleic Acids Research database issue and the online molecular biology database collection. Nucleic Acids Res. 2024 Jan 5;52(D1):D1-D9. doi: 10.1093/nar/gkad1173. PMID: 38035367; PMCID: PMC10767945.
- Messeri L, Crockett MJ. Artificial intelligence and illusions of understanding in scientific research. Nature. 2024 Mar;627(8002):49-58. doi: 10.1038/s41586-024-07146-0. Epub 2024 Mar 6. PMID: 38448693.