Crystal Induced Colitis Mimicking Crohns Disease

Davi Viana Ramos; Eloy Vianey Carvalho de Franca; David Ramos da Silva; Alexandre de Sousa Carlos*

doi:10.37871/jbres1977

Case Report

Crystal Induced Colitis Mimicking Crohns Disease

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

View DOI Submit Manuscript

News & Press

Publish academic announcements

Share institutional updates, conference announcements, research highlights, and education/science initiatives on JBRES.

Free OptionsSponsored Banner

View Page Submit by Email

Publish Smarter

Quick reasons scholars choose us

Speed + clarity

Decision in 7–14 days

Double-blind review with actionable feedback and clear next steps.

Fast ReviewFair Process

Visibility

DOI + discovery support

Crossref DOI registration and discovery-focused publishing for global reach.

Crossref DOIDiscoverability

Author support

Responsive editorial help

Quick communication, formatting guidance, and proof support until publication.

SupportProof Help

Impact proof

Monthly reach updates

After publishing, we can share visibility signals (views, downloads, discoverability).

Reach ReportMetrics

Trust

Ethical, transparent publishing

Clear policies, COI handling, and publication ethics that protect your work.

EthicsTransparency

Ownership

You keep your rights

Open access publishing with author-friendly licensing and long-term availability.

Author RightsOpen Access

Quality polish

Editing + layout support

Cleaner formatting, better readability, and publication-ready presentation.

EditingProfessional Layout

Time saver

Clear submission guidance

Simple steps, helpful templates, and quick checks to reduce back-and-forth.

Easy SubmitLess Delay

Priority

Returning authors get faster handling

If you’ve published with us, we prioritize communication and processing.

PriorityReturning Authors

Visibility tools

Share-ready links and citations

DOI links, citation-ready details, and share options to amplify your paper.

Citation ReadyShare Tools

Article Details

Publication record, authors, dates, abstract, and full text access.

Open Access

Article Type Case Report

Subject Medicine Group

OCLC JBRES Record

Davi Viana Ramos, Eloy Vianey Carvalho de Franca, David Ramos da Silva and Alexandre de Sousa Carlos*

Issue: Volume5-Issue8

Pages: 980-982

Received: 2024-07-08

Accepted: 2024-08-07

Published: 2024-08-12

Abstract

Crystal-induced colitis, a rare complication of sevelamer therapy in Chronic Kidney Disease (CKD) patients, presents diagnostic challenges. We report a case of a 39-year-old man with severe lower gastrointestinal bleeding attributed to sevelamer-induced colonic ulcers. Despite initial suspicion of Crohn's disease, histopathological analysis revealed crystalline material suggestive of sevelamer-associated colitis. Discontinuation of sevelamer led to the cessation of bleeding and stabilization of the patient's condition. This case highlights the importance of considering medication-induced gastrointestinal complications in CKD patients.

FullText HTML FullText PDF DOI: 10.37871/jbres1977

Certificate of Publication

Copyright

How to cite this article

Ramos DV, de Franca EVC, da Silva DR, de Sousa Carlos A. Crystal Induced Colitis Mimicking Crohns Disease. J Biomed Res Environ Sci. 2024 Aug 12; 5(8): 980-982. doi: 10.37871/jbres1977, Article ID: JBRES1977, Available at: https://www. jelsciences.com/articles/jbres1977.pdf

Subject area(s)

Pathology Gastroenterology

References

Barna MM, Kapoian T, O'Mara NB. Sevelamer carbonate. Ann Pharmacother. 2010 Jan;44(1):127-34. doi: 10.1345/aph.1M291. Epub 2009 Dec 2. PMID: 19955298.
Desai M, Reiprich A, Khov N, Yang Z, Mathew A, Levenick J. Crystal-Associated Colitis with Ulceration Leading to Hematochezia and Abdominal Pain. Case Rep Gastroenterol. 2016 Jun 27;10(2):332-7. doi: 10.1159/000446575. PMID: 27482192; PMCID: PMC4945809.
Madan P, Bhayana S, Chandra P, Hughes JI. Lower gastrointestinal bleeding: association with Sevelamer use. World J Gastroenterol. 2008 Apr 28;14(16):2615-6. doi: 10.3748/wjg.14.2615. PMID: 18442219; PMCID: PMC2708383.
Swanson BJ, Limketkai BN, Liu TC, Montgomery E, Nazari K, Park JY, Santangelo WC, Torbenson MS, Voltaggio L, Yearsley MM, Arnold CA. Sevelamer crystals in the gastrointestinal tract (GIT): a new entity associated with mucosal injury. Am J Surg Pathol. 2013 Nov;37(11):1686-93. doi: 10.1097/PAS.0b013e3182999d8d. PMID: 24061514.
Lee ZJ, Chia C, Busmani I, Wong WK. A rare cause of ischemic gut: A case report. Int J Surg Case Rep. 2016;20:114-7. doi: 10.1016/j.ijscr.2016.01.018. Epub 2016 Jan 22. PMID: 26852360; PMCID: PMC4818320.
Chintamaneni P, Das R, Kuan SF, Kermanshahi TR, Hashash JG. Hematochezia Associated with Sevalamer-Induced Mucosal Injury. ACG Case Rep J. 2014 Apr 4;1(3):145-7. doi: 10.14309/crj.2014.32. PMID: 26157856; PMCID: PMC4435309.
Yamaguchi T, Ohyama S, Furukawa H, Sato N, Ohnishi I, Kasashima S, Kawashima A, Kayahara M. Sigmoid colon diverticula perforation associated with sevelamer hydrochloride administration: A case report. Ann Med Surg (Lond). 2016 Aug 2;10:57-60. doi: 10.1016/j.amsu.2016.07.020. PMID: 27547398; PMCID: PMC4983137.
Keri KC, Veitla V, Samji NS. Ischemic Colitis in Association with Sevelamer Crystals. Indian J Nephrol. 2019 May-Jun;29(3):191-193. doi: 10.4103/ijn.IJN_80_18. PMID: 31142966; PMCID: PMC6521773.
Fistrek Prlic M, Jelakovic M, Brinar M, Grgic D, Romic I, Marusic Z, Ivandic E, Jelakovic B, Vukovic Brinar I, Krznaric Z. Case report: Sevelamer-associated colitis-a cause of pseudotumor formation with colon perforation and life-threatening bleeding. Front Med (Lausanne). 2023 Apr 27;10:1097469. doi: 10.3389/fmed.2023.1097469. PMID: 37181355; PMCID: PMC10174228.
Nambiar S, Pillai UK, Devasahayam J, Oliver T, Karippot A. Colonic Mucosal Ulceration and Gastrointestinal Bleeding Associated with Sevelamer Crystal Deposition in a Patient with End Stage Renal Disease. Case Rep Nephrol. 2018 Feb 28;2018:4708068. doi: 10.1155/2018/4708068. PMID: 29682371; PMCID: PMC5851163.