Covid-19 Research

Review Article

OCLC Number/Unique Identifier:

Plants from South America: A Systematic Review of Their Antiplasmodial and Antimalarial Activities Based on Ethnopharmacological Use

Medicine Group
Pharmacology
   Start Submission

Isabela Penna Ceravolo*, Rita de Cassia Cardoso Arcas# and Antoniana Ursine Krettli#

Volume5-Issue8
Dates: Received: 2024-07-29 | Accepted: 2024-08-09 | Published: 2024-08-10
Pages: 921-948

Abstract

Malaria remains one of the most important diseases in the world, being lethal to 610 thousand individuals annually. The widespread resistance of P. falciparum to antimalarials emphasizes the urgent need for new therapies, as treatment remains the primary strategy to control the disease. Although combinations of synthetic drugs are used in treatment, medicinal plants are often utilized in folk medicine as a complement and/or alternative to treat human malaria, especially in poor endemic areas. This systematic review evaluates the antiplasmodial and/or antimalarial activities, as well as the ethnopharmacological use of plant species by traditional communities from South America, through a search in the PubMed Central and Science Direct databases. Among 346 articles selected using the keywords “Malaria”, “Plants”, “Traditional”, “Knowledge”, “Antimalarial” and “Amazon”, 27 were considered eligible. Plant species with no activities were used to a new search on Google, PubMed, and Science Direct. Of the 389 species or genera from 88 botanical families evaluated, most studies were conducted in Peru, with leaves being the primary plant part used for treatment and/or prevention. Out of the analyzed species, excluding 30 mentioned only by genus, 185 had their extracts, fractions, or pure substances assessed, and only nine species had both in vitro and in vivo activity. Among the 174 species cited by traditional communities evaluated, with no data for activity, 66 presented results when a new literature search was performed. The Chayahuita ethnicity was the community providing more traditional knowledge about malaria treatment. Most plant species mentioned in the articles indicated for treatment and/or prevention of malaria have not yet been evaluated for antiplasmodial and antimalarial activities. Collecting ethnopharmacology information of plants is important, since their use for malaria treatment significantly increases the chances of finding a plant to be used as antimalarial substitutes.

FullText HTML FullText PDF DOI: 10.37871/jbres1972

Certificate of Publication

Copyright

© 2024 Ceravolo IP, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Ceravolo IP, Arcas RCC, Krettli AU. Plants from South America: A Systematic Review of Their Antiplasmodial and Antimalarial Activities Based on Ethnopharmacological Use. J Biomed Res Environ Sci. 2024 Aug 10; 5(8): 921-948. doi: 10.37871/jbres1972, Article ID: JBRES1972, Available at: https://www.jelsciences.com/articles/jbres1972.pdf

Subject area(s)

Pharmacology

References

  1. WHO: world malaria report. 2023.
  2. Ceravolo IP, Aguiar AC, Adebayo JO, Krettli AU. Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology. Front Pharmacol. 2021 Sep 22;12:734263. doi: 10.3389/fphar.2021.734263. PMID: 34630109; PMCID: PMC8493299.
  3. Valadeau C, Pabon A, Deharo E, Albán-Castillo J, Estevez Y, Lores FA, Rojas R, Gamboa D, Sauvain M, Castillo D, Bourdy G. Medicinal plants from the Yanesha (Peru): evaluation of the leishmanicidal and antimalarial activity of selected extracts. J Ethnopharmacol. 2009 Jun 25;123(3):413-22. doi: 10.1016/j.jep.2009.03.041. PMID: 19514108.
  4. Mueller I, Namuigi P, Kundi J, Ivivi R, Tandrapah T, Bjorge S, Reeder JC. Epidemic malaria in the highlands of Papua New Guinea. Am J Trop Med Hyg. 2005 May;72(5):554-60. PMID: 15891129.
  5. Farnsworth NR. Ethnopharmacology and drug development. Ciba Found Symp. 1994;185:42-51; discussion 51-9. doi: 10.1002/9780470514634.ch4. PMID: 7736861.
  6. WHO: world malaria report. 2018.
  7. WHO: world malaria report. 2021.
  8. Adebayo JO, Krettli AU. Potential antimalarials from Nigerian plants: a review. J Ethnopharmacol. 2011 Jan 27;133(2):289-302. doi: 10.1016/j.jep.2010.11.024. Epub 2010 Nov 18. PMID: 21093570.
  9. Botsaris AS: Plants used traditionally to treat malaria in Brazil: the archives of Flora Medicinal. . Journal of Ethnobiology and Ethnomedicine 2007, 3:18.
  10. Vásquez-Ocmín PG, Gadea A, Cojean S, Marti G, Pomel S, Van Baelen AC, Ruiz-Vásquez L, Ruiz Mesia W, Figadère B, Ruiz Mesia L, Maciuk A. Metabolomic approach of the antiprotozoal activity of medicinal Piper species used in Peruvian Amazon. J Ethnopharmacol. 2021 Jan 10;264:113262. doi: 10.1016/j.jep.2020.113262. Epub 2020 Aug 18. PMID: 32818574.
  11. Liu S, Zhang B, Zhou J, Lei Q, Fang Q, Kennelly EJ, Long C. Herbal plants traded at the Kaili medicinal market, Guizhou, China. J Ethnobiol Ethnomed. 2021 Nov 29;17(1):67. doi: 10.1186/s13002-021-00495-4. PMID: 34844607; PMCID: PMC8628420.
  12. Bora U, Sahu A, Saikia AP, Ryakala VK, Goswami P. Medicinal plants used by the people of Northeast India for curing malaria. Phytother Res. 2007 Aug;21(8):800-4. doi: 10.1002/ptr.2178. PMID: 17533627.
  13. Budiarti M, Maruzy A, Mujahid R, Sari AN, Jokopriyambodo W, Widayat T, Wahyono S: The use of antimalarial plants as traditional treatment in Papua Island, Indonesia. Heliyon 2020, 6(12):e05562.
  14. WHO: Global report on traditional and complementary medicine. 2019.
  15. Bruce-Chwatt LJ. Qinghaosu: a new antimalarial. Br Med J (Clin Res Ed). 1982 Mar 13;284(6318):767-8. doi: 10.1136/bmj.284.6318.767. PMID: 6802219; PMCID: PMC1496377.
  16. Sen T, Samanta SK. Medicinal plants, human health and biodiversity: a broad review. Adv Biochem Eng Biotechnol. 2015;147:59-110. doi: 10.1007/10_2014_273. PMID: 25001990.
  17. Calixto JB. The role of natural products in modern drug discovery. An Acad Bras Cienc. 2019;91 Suppl 3:e20190105. doi: 10.1590/0001-3765201920190105. Epub 2019 Jun 3. PMID: 31166478.
  18. SVS: Boletim epidemiológico de malária. In: Ministério da Saúde. 2024.
  19. Krettli AU: Antimalarial drug discovery: screening of Brazilian medicinal plants and purified compounds. Expert Opin Drug Dis 2009, 4(2):95-108.
  20. Oliveira DR, Krettli AU, Aguiar AC, Leitão GG, Vieira MN, Martins KS, Leitão SG. Ethnopharmacological evaluation of medicinal plants used against malaria by quilombola communities from Oriximiná, Brazil. J Ethnopharmacol. 2015 Sep 15;173:424-34. doi: 10.1016/j.jep.2015.07.035. Epub 2015 Jul 29. PMID: 26231451.
  21. WHO: Status report: Artemisinin and artemisinin-based combination therapy resistance. 2018.
  22. Mahmoudi N, de Julián-Ortiz JV, Ciceron L, Gálvez J, Mazier D, Danis M, Derouin F, García-Domenech R. Identification of new antimalarial drugs by linear discriminant analysis and topological virtual screening. J Antimicrob Chemother. 2006 Mar;57(3):489-97. doi: 10.1093/jac/dki470. Epub 2006 Jan 13. PMID: 16415127.
  23. Chierrito TP, Aguiar AC, de Andrade IM, Ceravolo IP, Gonçalves RA, de Oliveira AJ, Krettli AU. Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum. Malar J. 2014 Apr 14;13:142. doi: 10.1186/1475-2875-13-142. PMID: 24731256; PMCID: PMC4006081.
  24. Tinto H, Bonkian LN, Nana LA, Yerbanga I, Lingani M, Kazienga A, Valéa I, Sorgho H, Kpoda H, Guiguemdé TR, Ouédraogo JB, Mens PF, Schallig H, D'Alessandro U. Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change. Malar J. 2014 May 31;13:207. doi: 10.1186/1475-2875-13-207. PMID: 24885950; PMCID: PMC4049403.
  25. Carvalho LH, Brandão MG, Santos-Filho D, Lopes JL, Krettli AU. Antimalarial activity of crude extracts from Brazilian plants studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in culture. Braz J Med Biol Res. 1991;24(11):1113-23. PMID: 1823001.
  26. Andrade-Neto VF, Brandão MG, Stehmann JR, Oliveira LA, Krettli AU. Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil. J Ethnopharmacol. 2003 Aug;87(2-3):253-6. doi: 10.1016/s0378-8741(03)00141-7. PMID: 12860318.
  27. Coutinho JP, Aguiar AC, dos Santos PA, Lima JC, Rocha MG, Zani CL, Alves TM, Santana AE, Pereira Mde M, Krettli AU. Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part I: Aspidosperma nitidum (Benth) used as a remedy to treat fever and malaria in the Amazon. Mem Inst Oswaldo Cruz. 2013 Dec;108(8):974-82. doi: 10.1590/0074-0276130246. PMID: 24402150; PMCID: PMC4005553.
  28. Induli M, Gebru M, Abdissa N, Akala H, Wekesa I, Byamukama R, Heydenreich M, Murunga S, Dagne E, Yenesew A. Antiplasmodial quinones from the rhizomes of Kniphofia foliosa. Nat Prod Commun. 2013 Sep;8(9):1261-4. PMID: 24273862.
  29. Musila MF, Dossaji SF, Nguta JM, Lukhoba CW, Munyao JM. In vivo antimalarial activity, toxicity and phytochemical screening of selected antimalarial plants. J Ethnopharmacol. 2013 Mar 27;146(2):557-61. doi: 10.1016/j.jep.2013.01.023. Epub 2013 Jan 29. PMID: 23376043.
  30. Nguta JM, Mbaria JM. Brine shrimp toxicity and antimalarial activity of some plants traditionally used in treatment of malaria in Msambweni district of Kenya. J Ethnopharmacol. 2013 Jul 30;148(3):988-92. doi: 10.1016/j.jep.2013.05.053. Epub 2013 Jun 17. PMID: 23791809.
  31. Bantie L, Assefa S, Teklehaimanot T, Engidawork E. In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice. BMC Complement Altern Med. 2014 Mar 1;14:79. doi: 10.1186/1472-6882-14-79. PMID: 24580778; PMCID: PMC3943266.
  32. Upadhyay HC, Sisodia BS, Agrawal J, Pal A, Darokar MP, Srivastava SK. Antimalarial potential of extracts and isolated compounds from four species of genus ammannia. Medicinal Chemistry Research. 2014;23:870-876. doi: 10.1007/s00044-013-0682-5.
  33. Aguiar AC, Cunha AC, Ceravolo IP, Gonçalves RA, Oliveira AJ, Krettli AU. Aspidosperma (Apocynaceae) plant cytotoxicity and activity towards malaria parasites. Part II: experimental studies withAspidosperma ramiflorum in vivo and in vitro. Mem Inst Oswaldo Cruz. 2015 Nov;110(7):906-13. doi: 10.1590/0074-02760150188. PMID: 26560981; PMCID: PMC4660620.
  34. Rocha e Silva LF, Nogueira KL, Pinto AC, Katzin AM, Sussmann RA, Muniz MP, de Andrade Neto VF, Chaves FC, Coutinho JP, Lima ES, Krettli AU, Tadei WP, Pohlit AM. In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives. Antimicrob Agents Chemother. 2015;59(6):3271-80. doi: 10.1128/AAC.05012-14. Epub 2015 Mar 23. PMID: 25801563; PMCID: PMC4432218.
  35. Satish PVV, Sunita K. Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA). BMC Complement Altern Med. 2017 Sep 11;17(1):458. doi: 10.1186/s12906-017-1958-y. Retraction in: BMC Complement Med Ther. 2021 May 10;21(1):139. doi: 10.1186/s12906-021-03312-3. PMID: 28893216; PMCID: PMC5594526.
  36. Odonne G, Valadeau C, Alban-Castillo J, Stien D, Sauvain M, Bourdy G. Medical ethnobotany of the Chayahuita of the Paranapura basin (Peruvian Amazon). J Ethnopharmacol. 2013 Mar 7;146(1):127-53. doi: 10.1016/j.jep.2012.12.014. Epub 2012 Dec 21. PMID: 23266276.
  37. Paniagua Zambrana NY, Bussmann RW, Hart RE, Moya Huanca AL, Ortiz Soria G, Ortiz Vaca M, Ortiz Álvarez D, Soria Morán J, Soria Morán M, Chávez S, Chávez Moreno B, Chávez Moreno G, Roca O, Siripi E. Traditional knowledge hiding in plain sight - twenty-first century ethnobotany of the Chácobo in Beni, Bolivia. J Ethnobiol Ethnomed. 2017 Oct 10;13(1):57. doi: 10.1186/s13002-017-0179-2. PMID: 29017576; PMCID: PMC5634836.
  38. Ruiz L, Ruiz L, Maco M, Cobos M, Gutierrez-Choquevilca AL, Roumy V. Plants used by native Amazonian groups from the Nanay River (Peru) for the treatment of malaria. J Ethnopharmacol. 2011 Jan 27;133(2):917-21. doi: 10.1016/j.jep.2010.10.039. Epub 2010 Oct 30. PMID: 21040768.
  39. Vigneron M, Deparis X, Deharo E, Bourdy G. Antimalarial remedies in French Guiana: a knowledge attitudes and practices study. J Ethnopharmacol. 2005 Apr 26;98(3):351-60. doi: 10.1016/j.jep.2005.01.049. PMID: 15814272.
  40. Luziatelli G, Sørensen M, Theilade I, Mølgaard P. Asháninka medicinal plants: a case study from the native community of Bajo Quimiriki, Junín, Peru. J Ethnobiol Ethnomed. 2010 Aug 13;6:21. doi: 10.1186/1746-4269-6-21. PMID: 20707893; PMCID: PMC2933607.
  41. Weniger B, Robledo S, Arango GJ, Deharo E, Aragón R, Muñoz V, Callapa J, Lobstein A, Anton R. Antiprotozoal activities of Colombian plants. J Ethnopharmacol. 2001 Dec;78(2-3):193-200. doi: 10.1016/s0378-8741(01)00346-4. PMID: 11694364.
  42. Bieski IG, Rios Santos F, de Oliveira RM, Espinosa MM, Macedo M, Albuquerque UP, de Oliveira Martins DT. Ethnopharmacology of medicinal plants of the pantanal region (mato grosso, Brazil). Evid Based Complement Alternat Med. 2012;2012:272749. doi: 10.1155/2012/272749. Epub 2012 Feb 26. PMID: 22474496; PMCID: PMC3303862.
  43. Vásquez-Ocmín P, Cojean S, Rengifo E, Suyyagh-Albouz S, Amasifuen Guerra CA, Pomel S, Cabanillas B, Mejía K, Loiseau PM, Figadère B, Maciuk A. Antiprotozoal activity of medicinal plants used by Iquitos-Nauta road communities in Loreto (Peru). J Ethnopharmacol. 2018 Jan 10;210:372-385. doi: 10.1016/j.jep.2017.08.039. Epub 2017 Sep 5. PMID: 28887215.
  44. Krettli AU, Andrade-Neto VF, Brandão MG, Ferrari WM. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Mem Inst Oswaldo Cruz. 2001 Nov;96(8):1033-42. doi: 10.1590/s0074-02762001000800002. PMID: 11784919.
  45. Nogueira F, Rosário VED. Methods for assessment of antimalarial activity in the different phases of the plasmodium life cycle. Revista Pan-Amazônica de Saúde. 2010;1(3):109-124. Doi: 0.5123/S2176-62232010000300015.
  46. Farnesworth NR, Soejarto DD. Potential consequences of plant extinction in the United States in the current and future availability of prescription drugs. Econ Bot. 1991;39:231-240.
  47. Lima RB, Rocha e Silva LF, Melo MR, Costa JS, Picanço NS, Lima ES, Vasconcellos MC, Boleti AP, Santos JM, Amorim RC, Chaves FC, Coutinho JP, Tadei WP, Krettli AU, Pohlit AM. In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon. Malar J. 2015 Dec 18;14:508. doi: 10.1186/s12936-015-0999-2. PMID: 26682750; PMCID: PMC4683771.
  48. Ceravolo IP, Zani CL, Figueiredo FJB, Kohlhoff M, Santana AEG, Krettli AU. Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity. Malar J. 2018 Nov 26;17(1):436. doi: 10.1186/s12936-018-2568-y. PMID: 30477525; PMCID: PMC6257952.
  49. Montoia A, Rocha E Silva LF, Torres ZE, Costa DS, Henrique MC, Lima ES, Vasconcellos MC, Souza RC, Costa MR, Grafov A, Grafova I, Eberlin MN, Tadei WP, Amorim RC, Pohlit AM. Antiplasmodial activity of synthetic ellipticine derivatives and an isolated analog. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2631-4. doi: 10.1016/j.bmcl.2014.04.070. Epub 2014 Apr 28. PMID: 24813729.
  50. Vale VV, Vilhena TC, Trindade RC, Ferreira MR, Percário S, Soares LF, Pereira WL, Brandão GC, Oliveira AB, Dolabela MF, De Vasconcelos F. Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a plant used to treat malaria in the Brazilian Amazon. Malar J. 2015 Mar 27;14:132. doi: 10.1186/s12936-015-0643-1. PMID: 25888719; PMCID: PMC4379762.
  51. Ferreira LT, Venancio VP, Kawano T, Abrão LCC, Tavella TA, Almeida LD, Pires GS, Bilsland E, Sunnerhagen P, Azevedo L, Talcott ST, Mertens-Talcott SU, Costa FTM. Chemical Genomic Profiling Unveils the in Vitro and in Vivo Antiplasmodial Mechanism of Açaí (Euterpe oleracea Mart.) Polyphenols. ACS Omega. 2019 Sep 13;4(13):15628-15635. doi: 10.1021/acsomega.9b02127. PMID: 31572864; PMCID: PMC6761757.
  52. da Cruz Filho IJ, Duarte DMFA, da Conceição Alves de Lima D, Marques DSC, Dos Santos FAB, Alves LC, de Lima Aires A, Nogueira F, do Carmo Alves de Lima M. In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole. Int J Biol Macromol. 2023 Mar 15;231:123339. doi: 10.1016/j.ijbiomac.2023.123339. Epub 2023 Jan 20. PMID: 36682648.
  53. Araújo DMF, da Cruz Filho IJ, Santos T, Pereira DTM, Marques DSC, da Conceição Alves de Lima A, de Aquino TM, de Moraes Rocha GJ, do Carmo Alves de Lima M, Nogueira F. Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications. Int J Biol Macromol. 2022 Oct 31;219:224-245. doi: 10.1016/j.ijbiomac.2022.07.225. Epub 2022 Aug 1. PMID: 35926677.
  54. Assis FFV, Almeida Junior JS, Moraes TMP, Varotti FP, Moraes CC, Sartoratto A, Moraes WP, Minervino AHH. Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods. Pharmaceutics. 2023 Apr 6;15(4):1162. doi: 10.3390/pharmaceutics15041162. PMID: 37111647; PMCID: PMC10145024.
  55. Roumy V, Gutierrez-Choquevilca AL, Lopez Mesia JP, Ruiz L, Ruiz Macedo JC, Abedini A, Landoulsi A, Samaillie J, Hennebelle T, Rivière C, Neut C. In vitro Antimicrobial Activity of Traditional Plant Used in Mestizo Shamanism from the Peruvian Amazon in Case of Infectious Diseases. Pharmacogn Mag. 2015 Oct;11(Suppl 4):S625-33. doi: 10.4103/0973-1296.172975. PMID: 27013805; PMCID: PMC4787099.
  56. Rodríguez YV, Arias MH, García JO, Deharo E, Garavito G. Pharmacological activity of Curarea toxicofera in combination with classical antimalarial treatments. J Ethnopharmacol. 2018 Aug 10;222:288-294. doi: 10.1016/j.jep.2018.04.008. Epub 2018 Apr 4. PMID: 29626674.
  57. Houël E, Fleury M, Odonne G, Nardella F, Bourdy G, Vonthron-Sénécheau C, Villa P, Obrecht A, Eparvier V, Deharo E, Stien D. Antiplasmodial and anti-inflammatory effects of an antimalarial remedy from the Wayana Amerindians, French Guiana: takamalaimë (Psidium acutangulum Mart. ex DC., Myrtaceae). J Ethnopharmacol. 2015 May 26;166:279-85. doi: 10.1016/j.jep.2015.03.015. Epub 2015 Mar 16. PMID: 25792015.
  58. Vásquez-Ocmín PG, Cojean S, Roumy V, Marti G, Pomel S, Gadea A, Leblanc K, Dennemont I, Ruiz-Vásquez L, Ricopa Cotrina H, Ruiz Mesia W, Bertani S, Ruiz Mesia L, Maciuk A. Deciphering anti-infectious compounds from Peruvian medicinal Cordoncillos extract library through multiplexed assays and chemical profiling. Front Pharmacol. 2023 Jun 5;14:1100542. doi: 10.3389/fphar.2023.1100542. PMID: 37342590; PMCID: PMC10278888.
  59. Dolabela MF, Oliveira SG, Nascimento JM, Peres JM, Wagner H, Póvoa MM, de Oliveira AB. In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon. Phytomedicine. 2008 May;15(5):367-72. doi: 10.1016/j.phymed.2008.02.001. Epub 2008 Mar 11. PMID: 18337075.
  60. López C, Pastrana M, Ríos A, Cogollo A, Pabón A. Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi. Molecules. 2018 Apr 17;23(4):934. doi: 10.3390/molecules23040934. PMID: 29673229; PMCID: PMC6017910.
  61. Coppi A, Cabinian M, Mirelman D, Sinnis P. Antimalarial activity of allicin, a biologically active compound from garlic cloves. Antimicrob Agents Chemother. 2006 May;50(5):1731-7. doi: 10.1128/AAC.50.5.1731-1737.2006. PMID: 16641443; PMCID: PMC1472199.
  62. Bravo JA, Sauvain M, Gimenez T. A., Victoria Muñoz O, Callapa J, Le Men-Olivier L, Massiot G, Lavaud C. Bioactive phenolic glycosides from Amburana cearensis. Phytochemistry 1999;50(1):71-74. doi: 10.1016/S0031-9422(98)00497-X.
  63. Gachet MS, Schühly W. Jacaranda -an ethnopharmacological and phytochemical review. J Ethnopharmacol. 2009;121(1):14-27.
  64. Zhai B, Clark J, Ling T, Connelly M, Medina-Bolivar F, Rivas F. Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L. Molecules. 2014 Jan 8;19(1):756-66. doi: 10.3390/molecules19010756. PMID: 24406786; PMCID: PMC6271036.
  65. Sandoval A, Patricia M, Suaréz C, Enrique L. Identificación de metabolitos secundarios de Brosimum rubescens (MORACEAE), determinación de actividad antimalárica. Universidad Tecnológica de Pereira, Colombia. 2007;13(33):129-131.
  66. Tran QL, Tezuka Y, Ueda JY, Nguyen NT, Maruyama Y, Begum K, Kim HS, Wataya Y, Tran QK, Kadota S. In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. J Ethnopharmacol. 2003 Jun;86(2-3):249-52. doi: 10.1016/s0378-8741(03)00045-x. PMID: 12738095.
  67. Cysne DN, Fortes TS, Reis AS, de Paulo Ribeiro B, Dos Santos Ferreira A, do Amaral FM, Guerra RN, Marinho CR, Nicolete R, Nascimento FR. Antimalarial potential of leaves of Chenopodium ambrosioides L. Parasitol Res. 2016 Nov;115(11):4327-4334. doi: 10.1007/s00436-016-5216-x. Epub 2016 Aug 5. PMID: 27492200.
  68. Batiha GE, Beshbishy AM, Guswanto A, Nugraha A, Munkhjargal T, M Abdel-Daim M, Mosqueda J, Igarashi I. Phytochemical Characterization and Chemotherapeutic Potential of Cinnamomum verum Extracts on the Multiplication of Protozoan Parasites In Vitro and In Vivo. Molecules. 2020 Feb 24;25(4):996. doi: 10.3390/molecules25040996. PMID: 32102270; PMCID: PMC7070835.
  69. Ettebong EO, Inyang GB, Bassey AIL, Udobang JA, Thomas PS, Essien EG, Ubulom PE, Obot DN. In vivo antiplasmodial evaluation of methanol mesocarp extract of Citrillus lanatus in Plasmodium berghei berghei infected mice. The Journal of Phytopharmacology. 2021;10(2):84-88. doi: 10.31254/phyto.2021.10203.
  70. Mohanty S, Maurya AK, Jyotshna, Saxena A, Shanker K, Pal A, Bawankule DU. Flavonoids rich fraction of Citrus limetta fruit peels reduces proinflammatory cytokine production and attenuates malaria pathogenesis. Curr Pharm Biotechnol. 2015;16(6):544-52. doi: 10.2174/138920101606150407114023. PMID: 25860065.
  71. Tayler NM, De Jesús R, Spadafora R, Coronado LM, Spadafora C. Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice. J Parasit Dis. 2020 Jun;44(2):305-313. doi: 10.1007/s12639-020-01207-7. Epub 2020 Mar 9. PMID: 32499668; PMCID: PMC7244650.
  72. Zibi RDN, Tala VRS, Mbopi PY, Bayaga NH, Tcheuffa GMT, Ngoupayo J. Comparative Antiplasmodial and Cytotoxic Activities of Coffea arabica and Coffea canephora alkaloids extracts. International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR). 2022;12(1):54-59. doi: 10.51847/md2J5bMnQF.
  73. Al-Musayeib NM, Mothana RA, Matheeussen A, Cos P, Maes L. In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region. BMC Complement Altern Med. 2012 Apr 20;12:49. doi: 10.1186/1472-6882-12-49. PMID: 22520595; PMCID: PMC3493369.
  74. Ibukunoluwa MR. In vivo anti-plasmodial activity and histopathological analysis of water and ethanol extracts of a polyherbal antimalarial recipe. Journal of Pharmacognosy and Phytotherapy Research 2017, 9(6):87-100. doi: 10.5897/JPP2017.0449.
  75. Souza AA. Princípios Antimaláricos de Croton cajucara Benth. (Euphorbiaceae). Manaus: Universidade Federal do Amazonas; 2016.
  76. Yapu DG, Mozombite DS, Salgado ER, Turba AG. Evaluación de la actividad antiplasmódica in vitro de extractos de Euterpe oleracea, Myrciaria dubia y Croton lechleri. BIOFARBO. 2008;16(1):16-20.
  77. Kienen JLP. Atividade antiplasmódica e composição química de óleos essenciais e extratos fixos de Croton sacaquinha Croizat. Manaus: Universidade Federal do Amazonas; 2022.
  78. Kvist LP, Christensen SB, Rasmussen HB, Mejia K, Gonzalez A. Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. J Ethnopharmacol. 2006 Jul 19;106(3):390-402. doi: 10.1016/j.jep.2006.01.020. Epub 2006 Mar 3. PMID: 16517108.
  79. Gachet MS, Lecaro JS, Kaiser M, Brun R, Navarrete H, Muñoz RA, Bauer R, Schühly W. Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis. J Ethnopharmacol. 2010 Mar 2;128(1):184-97. doi: 10.1016/j.jep.2010.01.007. Epub 2010 Jan 11. PMID: 20064594.
  80. Herlina T, Aloanis AA, Kurnia D, Harneti D, Maharani R, ,, Supratman U. Prenylated Isoflavanonesfrom the Stem Bark of Erythrina poeppigiana (Leguminosae) and its Antimalarial Properties. Natural Product Communications. 2017;12(8):1249-1250. doi: 10.1177/1934578X1701200825.
  81. Clarkson C, Maharaj VJ, Crouch NR, Grace OM, Pillay P, Matsabisa MG, Bhagwandin N, Smith PJ, Folb PI. In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. J Ethnopharmacol. 2004 Jun;92(2-3):177-91. doi: 10.1016/j.jep.2004.02.011. PMID: 15137999.
  82. Muñoz V, Sauvain M, Bourdy G, Callapa J, Bergeron S, Rojas I, Bravo JA, Balderrama L, Ortiz B, Gimenez A, Deharo E. A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians. J Ethnopharmacol. 2000 Feb;69(2):127-37. doi: 10.1016/s0378-8741(99)00148-8. PMID: 10687869.
  83. Bihonegn T, Giday M, Yimer G, Animut A, Sisay M. Antimalarial activity of hydromethanolic extract and its solvent fractions of Vernonia amygdalina leaves in mice infected with Plasmodium berghei. SAGE Open Med. 2019 May 13;7:2050312119849766. doi: 10.1177/2050312119849766. PMID: 31205692; PMCID: PMC6537240.
  84. Anjos DBd. Composição química e atividade antimalárica in vitro de endopleura uchi (huber) cuatrec e himatanthus sucuuba (spruce) wood. Manaus: Universidade Federal do Amazonas; 2021.
  85. Valdés BA. Estudio fitoquímico bio dirigido de Socratea exorrhiza (Mart.) Wendl.: University of Panama; 2005.
  86. Suzery M, Cahyono B, Amalina ND, Budiman C, Bayu I, Asy'ari M, Widayat W. Antiplasmodial activity of Hyptis pectinata extract and its analog against 3D7 Plasmodium falciparum through caseinolytic protease proteolytic (ClpP) inhibition. Thai Journal Pharmaceutical Sciences. 2021;45(6).
  87. Ankrah NA, Nyarko AK, Addo PG, Ofosuhene M, Dzokoto C, Marley E, Addae MM, Ekuban FA. Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria. Phytother Res. 2003 Jun;17(6):697-701. doi: 10.1002/ptr.1196. PMID: 12820245.
  88. Onyegbule FA, Bruce SO, Onyekwe ON, Onyealisi OL, Okoye PC. Evaluation of the in vivo antiplasmodial activity of ethanol leaf extract and fractions of Jatropha gossypifolia in Plasmodium berghei infected mice. Journal of Medicinal Plants Research 2019;13(11):269-279. doi: 10.5897/JMPR2019.6766.
  89. Okunade AL, Lewis WH. Oleanene constituents of Lantana cujabensis. Fitoterapia. 2004 Jun;75(3-4):327-31. doi: 10.1016/j.fitote.2004.02.005. PMID: 15158990.
  90. Seyfe S, Toma A, Etisso AA, Debela E, Fikru A, Eyado A. Phytochemical screening and in vivo antimalarial activities of crude extracts of Lantana trifolia root and Premna oligotricha leaves in plasmodium berghei infected mice. Journal of Medicinal Plants Research.2017;11(47):763-769. doi: 10.5897/JMPR2017.6519.
  91. Antoun MD, Ramos Z, Vazques J, Oquendo I, Proctor GR, Gerena L, Franzblau SG. Evaluation of the flora of Puerto Rico for in vitro antiplasmodial and antimycobacterial activities. Phytother Res. 2001 Nov;15(7):638-42. doi: 10.1002/ptr.880. PMID: 11746852.
  92. Adewale O, Oyeniyi T, Famodimu M, Adejoba A, Orubima C, Adeleke M. In vivo anti-plasmodial screening of Nicotiana tabacum and its effects on hepatic and renal function in swiss albino mice. Journal of Microbiology, Biotechnology and Food Sciences. 2013;3(2).
  93. Akono Ntonga P, Baldovini N, Mouray E, Mambu L, Belong P, Grellier P. Activity of Ocimum basilicum, Ocimum canum, and Cymbopogon citratus essential oils against Plasmodium falciparum and mature-stage larvae of Anopheles funestus s.s. Parasite. 2014;21:33. doi: 10.1051/parasite/2014033. Epub 2014 Jul 7. PMID: 24995776; PMCID: PMC4082313.
  94. Silva A. Estudo fitoquímico, avaliação da toxicidade oral aguda e da atividade antimalárica in vitro e in vivo das cascas de Parahancornia fasciculata (Poir.) Benoist (Apocynaceae). Belém: Universidade Federal do Pará; 2013.
  95. Aliyu K, Mohammed Y, Abdullahi IN, Umar AA, Bashir F, Sani MN, Kabuga AI, Adamu AY, Akande AO. In vitro antiplasmodial activity of Phyllanthus amarus against Plasmodium falciparum and evaluation of its acute toxicity effect in mouse model. Trop Parasitol. 2021 Jan-Jun;11(1):31-37. doi: 10.4103/tp.TP_78_20. Epub 2021 May 14. PMID: 34195058; PMCID: PMC8213120.
  96. Subeki S, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, Katakura K, Kobayashi S, Trimurningsih T, Chairul C, Yoshihara T. Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri. J Nat Prod. 2005 Apr;68(4):537-9. doi: 10.1021/np0497245. PMID: 15844943.
  97. Fandeur T, Moretti C, Polonsky J. In vitro and in vivo assessement of the antimalarial activity of sergeolide. Planta Med. 1985 Feb;51(1):20-3. doi: 10.1055/s-2007-969382. PMID: 17340392.
  98. Moraes JC. Atividade antiplasmódica in vitro dos óleos essenciais de folhas e galhos de Piper marginatum jacq. (Piperaceae). Santarém: Universidade Federal do Oeste do Pará; 2018.
  99. Chalco N. Estudio fitoquímico preliminar de las hojas de Pouteria caimito y actividad antimalárica de su extracto clorofórmico. Lima: Universidad Nacional Mayor de San Marcos; 2017.
  100. Calderon AI, Angerhofer CK, Pezzuto JM, Farnsworth NR, Foster R, Condit R, Gupta MP, Soejarto DD. Forest plot as a tool to demonstrate the pharmaceutical potential of plants in a tropical forest of Panama. Econ Bot. 2000;54:278-294. doi: 10.1007/BF02864782.
  101. Gontijo DC, do Nascimento MFA, Rody HVS, Magalhães RA, Margalho LF, Brandão GC, de Oliveira AB. In vitro antiplasmodial activity, targeted LC-MS metabolite profiling, and identification of major natural products in the bioactive extracts of Palicourea and Psychotria species from the Amazonia and Atlantic Forest biomes, Brazil. Metabolomics. 2021 Sep 4;17(9):81. doi: 10.1007/s11306-021-01833-z. PMID: 34480651.
  102. Rajendran C, Begam M, Kumar D, Baruah I, Gogoi HK, Srivastava RB, Veer V. Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice. J Parasit Dis. 2014 Jun;38(2):148-52. doi: 10.1007/s12639-013-0252-2. Epub 2013 Feb 3. PMID: 24808642; PMCID: PMC4000368.
  103. Mishra K, Chakraborty D, Pal A, Dey N. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp Parasitol. 2010 Apr;124(4):421-7. doi: 10.1016/j.exppara.2009.12.007. Epub 2009 Dec 29. PMID: 20036657.
  104. Okokon JE, Mobley R, Edem UA, Bassey AI, Fadayomi I, Drijfhout F, Horrocks P, Li WW. In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves. Sci Rep. 2022 Jun 17;12(1):10250. doi: 10.1038/s41598-022-14391-8. PMID: 35715548; PMCID: PMC9205285.
  105. Atanu FO, Rotimi D, Ilesanmi OB, Al Malki JS, Batiha GE, Idakwoji PA. Hydroethanolic Extracts of Senna alata Leaves Possess Antimalarial Effects and Reverses Haematological and Biochemical Pertubation in Plasmodium berghei-infected Mice. J Evid Based Integr Med. 2022 Jan-Dec;27:2515690X221116407. doi: 10.1177/2515690X221116407. PMID: 35929106; PMCID: PMC9358563.
  106. Agbafor KN. Glucose-6-phosphate dehydrogenase Activity in albino rats treated with aqueous extract of fresh leaves of Senna hirsuta. International Journal of Pharmacy & Life Sciences. 2015;6(10/11):4755-4759. doi: 10.5829/idosi.abr.2015.9.6.1019
  107. Girmaw F, Ashagrie G. Evaluation of the Anti-Malarial Activity of the Crude Root Extract and Solvent Fraction of Sesamum indicum (Fabaceae). J Exp Pharmacol. 2023 Mar 28;15:163-175. doi: 10.2147/JEP.S407557. PMID: 37013163; PMCID: PMC10066629.
  108. Fischer DC, de Amorim Gualda NC, Bachiega D, Carvalho CS, Lupo FN, Bonotto SV, Alves Mde O, Yogi A, Santi SM, Avila PE, Kirchgatter K, Moreno PR. In vitro screening for antiplasmodial activity of isoquinoline alkaloids from Brazilian plant species. Acta Trop. 2004 Nov-Dec;92(3):261-6. doi: 10.1016/j.actatropica.2004.08.009. PMID: 15533296.
  109. dos Santos DAP, Vieira PC, da Silva MFGF, Fernandes JB, Rattray L, Croft SL. Antiparasitic activities of acridone alkaloids from Swinglea glutinosa (Bl.) Merr. Journal of the Brazilian Chemical Society. 2009;20(4). doi: 10.1590/S0103-50532009000400008.
  110. Gupta P, Vasudeva N. In vitro antiplasmodial and antimicrobial potential of Tagetes erecta roots. Pharm Biol. 2010 Nov;48(11):1218-23. doi: 10.3109/13880201003695142. Epub 2010 Sep 6. PMID: 20818936.
  111. Nutham N, Sakulmettatham S, Klongthalay S, Chutoam P, Somsak V. Protective Effects of Tinospora crispa Stem Extract on Renal Damage and Hemolysis during Plasmodium berghei Infection in Mice. J Pathog. 2015;2015:738608. doi: 10.1155/2015/738608. Epub 2015 Oct 27. PMID: 26600953; PMCID: PMC4639667.
  112. Jullian V, Bourdy G, Georges S, Maurel S, Sauvain M. Validation of use of a traditional antimalarial remedy from French Guiana, Zanthoxylum rhoifolium Lam. J Ethnopharmacol. 2006 Jul 19;106(3):348-52. doi: 10.1016/j.jep.2006.01.011. Epub 2006 Feb 28. PMID: 16504432.
  113. Biruksew A, Zeynudin A, Alemu Y, Golassa L, Yohannes M, Debella A, Urge G, De Spiegeleer B, Suleman S. Zingiber Officinale Roscoe and Echinops Kebericho Mesfin Showed Antiplasmodial Activities against Plasmodium Berghei in a Dose-dependent Manner in Ethiopia. Ethiop J Health Sci. 2018 Sep;28(5):655-664. doi: 10.4314/ejhs.v28i5.17. PMID: 30607081; PMCID: PMC6308778.

Comments

Swift, Reliable, and studious. We aim to cherish the world by publishing precise knowledge.

  • Brown University Library
  • University of Glasgow Library
  • University of Pennsylvania, Penn Library
  • University of Amsterdam Library
  • The University of British Columbia Library
  • UC Berkeley’s Library
  • MIT Libraries
  • Kings College London University
  • University of Texas Libraries
  • UNSW Sidney Library
  • The University of Hong Kong Libraries
  • UC Santa Barbara Library
  • University of Toronto Libraries
  • University of Oxford Library
  • Australian National University
  • ScienceOpen
  • UIC Library
  • KAUST University Library
  • Cardiff University Library
  • Ball State University Library
  • Duke University Library
  • Rutgers University Library
  • Air University Library
  • UNT University of North Texas
  • Washington Research Library Consortium
  • Penn State University Library
  • Georgetown Library
  • Princeton University Library
  • Science Gate
  • Internet Archive
  • WashingTon State University Library
  • Dimensions
  • Zenodo
  • OpenAire
  • Index Copernicus International
  • icmje
  • International Scientific Indexing (ISI)
  • Sherpa Romeo
  • ResearchGate
  • Universidad De Lima
  • WorldCat
  • JCU Discovery
  • McGill
  • National University of Singepore Libraries
  • SearchIT
  • Scilit
  • SemantiScholar
  • Base Search
  • VU
  • KB
  • Publons
  • oaji
  • Harvard University
  • sjsu-library
  • UWLSearch
  • Florida Institute of Technology
  • CrossRef
  • LUBsearch
  • Universitat de Paris
  • Technical University of Denmark
  • ResearchBIB
  • Google Scholar
  • Microsoft Academic Search