Strategies for Improving Adherence in Patients with HIVAIDS

Abubakar Yaro*; Edmund Puca; Catherine Johnson

**Abubakar Yaro*, Edmund Puca and Catherine Johnson**

Volume4-Issue12
Dates: Received: 2023-11-24 | Accepted: 2023-12-18 | Published: 2023-12-20
Pages: 1675-1683

Abstract

Human Immunodeficiency Virus (HIV)-1 is the cause of Acquired Immunodeficiency Syndrome (AIDS). Due to advances in clinical management, HIV/AIDS is now regarded a chronic disease instead of terminal disease. However, non-adherence is a challenge in effective management of HIV/AIDS. Non-adherence is classified into intentional and unintentional non-adherence Interactive toxicity belief is now one of the main factors that promotes non-adherence among HIV patients. Detecting non-adherence is an essential component of managing this phenomenon. A number measures has been proposed on how to manage non-adherence Optimum non-adherence-preventing measures should be holistic that involve different strategies. This review suggest MIB+ model for tackling non-adherence among HIV/AIDS patients. We also need to have more understanding on how stigma implicates non-adherence.

FullText HTML FullText PDF DOI: 10.37871/jbres1851

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How to cite this article

Yaro A, Puca E, Johnson C. Strategies for Improving Adherence in Patients with HIVAIDS. J Biomed Res Environ Sci. 2023 Dec 20; 4(12): 1675-1683. doi: 10.37871/jbres1851, Article ID: JBRES1851, Available at: https://www.jelsciences.com/articles/ jbres1851.pdf

Subject area(s)

HIV/AIDS

References

Sharp PM, Bailes E, Chaudhuri RR, Rodenburg CM, Santiago MO, Hahn BH. The origins of acquired immune deficiency syndrome viruses: where and when? Philos Trans R Soc Lond B Biol Sci. 2001 Jun 29;356(1410):867-76. doi: 10.1098/rstb.2001.0863. PMID: 11405934; PMCID: PMC1088480.
HIV.org: The Global HIV and AIDS Epidemic. 2023.
Shafer RW, Vuitton DA. Highly active antiretroviral therapy (HAART) for the treatment of infection with human immunodeficiency virus type 1. Biomed Pharmacother. 1999 Mar;53(2):73-86. doi: 10.1016/s0753-3322(99)80063-8. PMID: 10337461.
Puhan MA, Van Natta ML, Palella FJ, Addessi A, Meinert C; Ocular Complications of AIDS Research Group. Excess mortality in patients with AIDS in the era of highly active antiretroviral therapy: temporal changes and risk factors. Clin Infect Dis. 2010 Oct 15;51(8):947-56. doi: 10.1086/656415. PMID: 20825306; PMCID: PMC2943970.
Sension MG. Long-Term suppression of HIV infection: benefits and limitations of current treatment options. J Assoc Nurses AIDS Care. 2007 Jan-Feb;18(1 Suppl):S2-10. doi: 10.1016/j.jana.2006.11.012. PMID: 17275719.
World Health Organization. Adherence to Long-term Therapies: Evidence for Action. 2010.
Fassinou P, Elenga N, Rouet F, Laguide R, Kouakoussui KA, Timite M, Blanche S, Msellati P. Highly active antiretroviral therapies among HIV-1-infected children in Abidjan, Côte d'Ivoire. AIDS. 2004 Sep 24;18(14):1905-13. doi: 10.1097/00002030-200409240-00006. PMID: 15353976.
Cupsa A, Gheonea C, Bulucea D, Dinescu S. Factors with a negative influence on compliance to antiretroviral therapies. Ann N Y Acad Sci. 2000 Nov;918:351-4. doi: 10.1111/j.1749-6632.2000.tb05504.x. PMID: 11131722.
Haberer JE, Cook A, Walker AS, Ngambi M, Ferrier A, Mulenga V, Kityo C, Thomason M, Kabamba D, Chintu C, Gibb DM, Bangsberg DR. Excellent adherence to antiretrovirals in HIV+ Zambian children is compromised by disrupted routine, HIV nondisclosure, and paradoxical income effects. PLoS One. 2011 Apr 21;6(4):e18505. doi: 10.1371/journal.pone.0018505. PMID: 21533031; PMCID: PMC3080873.
Nabukeera-Barungi N, Kalyesubula I, Kekitiinwa A, Byakika-Tusiime J, Musoke P. Adherence to antiretroviral therapy in children attending Mulago Hospital, Kampala. Ann Trop Paediatr. 2007 Jun;27(2):123-31. doi: 10.1179/146532807X192499. PMID: 17565809.
Katz IT, Ryu AE, Onuegbu AG, Psaros C, Weiser SD, Bangsberg DR, Tsai AC. Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis. J Int AIDS Soc. 2013 Nov 13;16(3 Suppl 2):18640. doi: 10.7448/IAS.16.3.18640. PMID: 24242258; PMCID: PMC3833107.
Williams N, Mayer C, Huser V. A Descriptive Study of HIV Patients Highly Adherent to Antiretroviral. AMIA Annu Symp Proc. 2021 Jan 25;2020:1295-1304. PMID: 33936506; PMCID: PMC8075478.
Gallant J, Hsue PY, Shreay S, Meyer N. Comorbidities Among US Patients With Prevalent HIV Infection-A Trend Analysis. J Infect Dis. 2017 Dec 19;216(12):1525-1533. doi: 10.1093/infdis/jix518. PMID: 29253205.
Caballero J, Ownby RL, Jacobs RJ, Thomas JE, Schweizer MS. Association Between Cognitive Tests and Antiretroviral Medication Adherence in Older Adults With HIV. Ann Pharmacother. 2019 Feb;53(2):151-158. doi: 10.1177/1060028018798327. Epub 2018 Sep 3. PMID: 30175588.
Boretzki J, Wolf E, Wiese C, Noe S, Balogh A, Meurer A, Krznaric I, Zink A, Lersch C, Spinner CD. Highly specific reasons for nonadherence to antiretroviral therapy: results from the German adherence study. Patient Prefer Adherence. 2017 Nov 8;11:1897-1906. doi: 10.2147/PPA.S141762. PMID: 29184394; PMCID: PMC5687417.
Tuller DM, Bangsberg DR, Senkungu J, Ware NC, Emenyonu N, Weiser SD. Transportation costs impede sustained adherence and access to HAART in a clinic population in southwestern Uganda: a qualitative study. AIDS Behav. 2010 Aug;14(4):778-84. doi: 10.1007/s10461-009-9533-2. Epub 2009 Mar 13. PMID: 19283464; PMCID: PMC2888948.
Barnett PG, Chow A, Joyce VR, Bayoumi AM, Griffin SC, Nosyk B, Holodniy M, Brown ST, Sculpher M, Anis AH, Owens DK. Determinants of the cost of health services used by veterans with HIV. Med Care. 2011 Sep;49(9):848-56. doi: 10.1097/MLR.0b013e31821b34c0. PMID: 21610542.
Pruitt Z, Robst J, Langland-Orban B, Brooks RG. Healthcare costs associated with antiretroviral adherence among medicaid patients. Appl Health Econ Health Policy. 2015 Feb;13(1):69-80. doi: 10.1007/s40258-014-0138-1. PMID: 25403718.
Castelan A, Nellen JF, van der Valk M, Nieuwkerk PT. Intentional- but not Unintentional Medication Non-adherence was Related with Beliefs about Medicines Among a Multi-Ethnic Sample of People with HIV. AIDS Behav. 2023 Apr;27(4):1045-1054. doi: 10.1007/s10461-022-03842-y. Epub 2022 Sep 3. PMID: 36056998; PMCID: PMC9440648.
Kalichman SC, Amaral CM, White D, Swetsze C, Pope H, Kalichman MO, Cherry C, Eaton L. Prevalence and clinical implications of interactive toxicity beliefs regarding mixing alcohol and antiretroviral therapies among people living with HIV/AIDS. AIDS Patient Care STDS. 2009 Jun;23(6):449-54. doi: 10.1089/apc.2008.0184. PMID: 19413503; PMCID: PMC2856434.
Altice FL, Mostashari F, Friedland GH. Trust and the acceptance of and adherence to antiretroviral therapy. J Acquir Immune Defic Syndr. 2001 Sep 1;28(1):47-58. doi: 10.1097/00042560-200109010-00008. PMID: 11579277.
Kalichman SC, Kalichman MO, Cherry C, Hoyt G, Washington C, Grebler T, Welles B, Merely C. Intentional Medication Nonadherence Because of Interactive Toxicity Beliefs Among HIV-Positive Active Drug Users. J Acquir Immune Defic Syndr. 2015 Dec 15;70(5):503-9. doi: 10.1097/QAI.0000000000000776. PMID: 26226250; PMCID: PMC4648658.
El-Krab R, Kalichman SC. Alcohol-Antiretroviral Therapy Interactive Toxicity Beliefs and Intentional Medication Nonadherence: Review of Research with Implications for Interventions. AIDS Behav. 2021 Dec;25(Suppl 3):251-264. doi: 10.1007/s10461-021-03285-x. Epub 2021 May 5. PMID: 33950339.
Sankar A, Wunderlich T, Neufeld S, Luborsky M. Sero-positive African Americans' beliefs about alcohol and their impact on anti-retroviral adherence. AIDS Behav. 2007 Mar;11(2):195-203. doi: 10.1007/s10461-006-9144-0. PMID: 16799842; PMCID: PMC4216565.
Kalichman SC, Eaton LA, Kalichman MO. Substance Use-Related Intentional Nonadherence to Antiretroviral Therapy Among Young Adults Living with HIV. AIDS Patient Care STDS. 2022 Jan;36(1):26-33. doi: 10.1089/apc.2021.0137. Epub 2021 Dec 14. PMID: 34905404; PMCID: PMC8905232.
Gard TL, Hoover DR, Shi Q, Cohen MH, Mutimura E, Adedimeji AA, Anastos K. The impact of HIV status, HIV disease progression, and post-traumatic stress symptoms on the health-related quality of life of Rwandan women genocide survivors. Qual Life Res. 2013 Oct;22(8):2073-84. doi: 10.1007/s11136-012-0328-y. Epub 2012 Dec 28. PMID: 23271207; PMCID: PMC4084826.
Heath KV, Singer J, O'Shaughnessy MV, Montaner JS, Hogg RS. Intentional nonadherence due to adverse symptoms associated with antiretroviral therapy. J Acquir Immune Defic Syndr. 2002 Oct 1;31(2):211-7. doi: 10.1097/00126334-200210010-00012. PMID: 12394800.
Rees G, Leong O, Crowston JG, Lamoureux EL. Intentional and unintentional nonadherence to ocular hypotensive treatment in patients with glaucoma. Ophthalmology. 2010 May;117(5):903-8. doi: 10.1016/j.ophtha.2009.10.038. Epub 2010 Feb 13. PMID: 20153902.
Iihara N, Kurosaki Y, Miyoshi C, Takabatake K, Morita S, Hori K. Comparison of individual perceptions of medication costs and benefits between intentional and unintentional medication non-adherence among Japanese patients. Patient Educ Couns. 2008 Feb;70(2):292-9. doi: 10.1016/j.pec.2007.10.016. PMID: 18068938.
Unni EJ, Farris KB. Unintentional non-adherence and belief in medicines in older adults. Patient Educ Couns. 2011 May;83(2):265-8. doi: 10.1016/j.pec.2010.05.006. Epub 2010 Jun 12. PMID: 20542401.
Saratsiotou I, Kordoni M, Bakogiannis C, Livadarou E, Skarlos D, Kosmidis PA, Razis E. Treatment adherence of cancer patients to orally administered chemotherapy: insights from a Greek study using a self-reported questionnaire. J Oncol Pharm Pract. 2011 Dec;17(4):304-11. doi: 10.1177/1078155210380292. Epub 2010 Aug 10. PMID: 20699330.
Gadkari AS, McHorney CA. Unintentional non-adherence to chronic prescription medications: how unintentional is it really? BMC Health Serv Res. 2012 Jun 14;12:98. doi: 10.1186/1472-6963-12-98. PMID: 22510235; PMCID: PMC3375198.
Kalichman SC, Grebler T, Amaral CM, McNerey M, White D, Kalichman MO, Cherry C, Eaton L. Intentional non-adherence to medications among HIV positive alcohol drinkers: prospective study of interactive toxicity beliefs. J Gen Intern Med. 2013 Mar;28(3):399-405. doi: 10.1007/s11606-012-2231-1. Epub 2012 Oct 12. PMID: 23065532; PMCID: PMC3579979.
Fatch R, Emenyonu NI, Muyindike W, Kekibiina A, Woolf-King S, Hahn JA. Alcohol Interactive Toxicity Beliefs and ART Non-adherence Among HIV-Infected Current Drinkers in Mbarara, Uganda. AIDS Behav. 2017 Jul;21(7):1812-1824. doi: 10.1007/s10461-016-1429-3. PMID: 27198557; PMCID: PMC5116271.
Chesney MA. The elusive gold standard. Future perspectives for HIV adherence assessment and intervention. J Acquir Immune Defic Syndr. 2006 Dec 1;43 Suppl 1:S149-55. doi: 10.1097/01.qai.0000243112.91293.26. PMID: 17133199.
Garfield S, Clifford S, Eliasson L, Barber N, Willson A. Suitability of measures of self-reported medication adherence for routine clinical use: a systematic review. BMC Med Res Methodol. 2011 Nov 3;11:149. doi: 10.1186/1471-2288-11-149. PMID: 22050830; PMCID: PMC3219622.
Gaifer Z, Boulassel MR. Comparative Analysis of two Methods of Measuring Antiretroviral Therapy Adherence in HIV-Infected Omani Patients. J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958219867316. doi: 10.1177/2325958219867316. PMID: 31389287; PMCID: PMC6900587.
Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, Wu AW. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care. 2000 Jun;12(3):255-66. doi: 10.1080/09540120050042891. PMID: 10928201.
Morisky DE, Green LW, Levine DM. Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care. 1986 Jan;24(1):67-74. doi: 10.1097/00005650-198601000-00007. PMID: 3945130.
Marrazzo J, Ramjee G, Nair G. Pre-exposure prophylaxis for HIV women: Daily tenofovir, oral tenofovir/emtricitabine or vaginal tenofovir gel in the VOICE study (MTN 003) 20th conference on retroviruses and opportunistic infections. Atlanta GA USA Abstract 26LB. 2013.
Stone VE, Hogan JW, Schuman P, Rompalo AM, Howard AA, Korkontzelou C, Smith DK; HERS STUDY. Antiretroviral regimen complexity, self-reported adherence, and HIV patients' understanding of their regimens: survey of women in the her study. J Acquir Immune Defic Syndr. 2001 Oct 1;28(2):124-31. doi: 10.1097/00042560-200110010-00003. PMID: 11588505.
Hong SY, Jerger L, Jonas A, Badi A, Cohen S, Nachega JB, Parienti JJ, Tang AM, Wanke C, Terrin N, Pereko D, Blom A, Trotter AB, Jordan MR. Medication possession ratio associated with short-term virologic response in individuals initiating antiretroviral therapy in Namibia. PLoS One. 2013;8(2):e56307. doi: 10.1371/journal.pone.0056307. Epub 2013 Feb 28. PMID: 23509605; PMCID: PMC3585291.
Evans D, Fox MP. When and how should we be measuring adherence to antiretroviral therapy in resource-limited settings? J Clinical Research in HIV AIDS and Prevention. 2013;1:24-30. doi:10.14302/issn.2324-7339.jcrhap-13-edt.1.2.
Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, Singh S, Rachlis B, Wu P, Cooper C, Thabane L, Wilson K, Guyatt GH, Bangsberg DR. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006 Aug 9;296(6):679-90. doi: 10.1001/jama.296.6.679. PMID: 16896111.
Ajose O, Mookerjee S, Mills EJ, Boulle A, Ford N. Treatment outcomes of patients on second-line antiretroviral therapy in resource-limited settings: a systematic review and meta-analysis. AIDS. 2012 May 15;26(8):929-38. doi: 10.1097/QAD.0b013e328351f5b2. PMID: 22313953.
Drain PK, Bardon AR, Simoni JM, Cressey TR, Anderson P, Sevenler D, Olanrewaju AO, Gandhi M, Celum C. Point-of-care and Near Real-time Testing for Antiretroviral Adherence Monitoring to HIV Treatment and Prevention. Curr HIV/AIDS Rep. 2020 Oct;17(5):487-498. doi: 10.1007/s11904-020-00512-3. PMID: 32627120; PMCID: PMC7492442.
Rutsaert S, De Spiegelaere W, De Clercq L, Vandekerckhove L. Evaluation of HIV-1 reservoir levels as possible markers for virological failure during boosted darunavir monotherapy. J Antimicrob Chemother. 2019 Oct 1;74(10):3030-3034. doi: 10.1093/jac/dkz269. PMID: 31314108.
Schüpbach J. Viral RNA and p24 antigen as markers of HIV disease and antiretroviral treatment success. Int Arch Allergy Immunol. 2003 Nov;132(3):196-209. doi: 10.1159/000074552. PMID: 14646380.
Giron LB, Tenore SB, Janini LMR, Sucupira MCA, Diaz RS. Laboratory surrogate markers of residual HIV replication among distinct groups of individuals under antiretroviral therapy. PLoS One. 2019 Jun 17;14(6):e0217502. doi: 10.1371/journal.pone.0217502. PMID: 31206536; PMCID: PMC6576780.
Ferreyra C, Yun O, Eisenberg N, Alonso E, Khamadi AS, Mwau M, Mugendi MK, Alvarez A, Velilla E, Flevaud L, Arnedo M, Dalmau D, Roddy P, Bernasconi A, Palma PP. Evaluation of clinical and immunological markers for predicting virological failure in a HIV/AIDS treatment cohort in Busia, Kenya. PLoS One. 2012;7(11):e49834. doi: 10.1371/journal.pone.0049834. Epub 2012 Nov 21. PMID: 23185450; PMCID: PMC3504110.
Haberer JE, Kiwanuka J, Nansera D, Ragland K, Mellins C, Bangsberg DR. Multiple measures reveal antiretroviral adherence successes and challenges in HIV-infected Ugandan children. PLoS One. 2012;7(5):e36737. doi: 10.1371/journal.pone.0036737. Epub 2012 May 9. PMID: 22590600; PMCID: PMC3348916.
Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach: 2010 Revision. Geneva: World Health Organization; 2010. PMID: 23741771.
Hamers RL, Sigaloff KC, Wensing AM, Wallis CL, Kityo C, Siwale M, Mandaliya K, Ive P, Botes ME, Wellington M, Osibogun A, Stevens WS, Rinke de Wit TF, Schuurman R; PharmAccess African Studies to Evaluate Resistance (PASER). Patterns of HIV-1 drug resistance after first-line antiretroviral therapy (ART) failure in 6 sub-Saharan African countries: implications for second-line ART strategies. Clin Infect Dis. 2012 Jun;54(11):1660-9. doi: 10.1093/cid/cis254. Epub 2012 Apr 3. PMID: 22474222.
Li L, Eron JJ, Ribaudo H, Gulick RM, Johnson BA. Evaluating the Effect of Early Versus Late ARV Regimen Change if Failure on an Initial Regimen: Results From the AIDS Clinical Trials Group Study A5095. J Am Stat Assoc. 2012;107(498):542-554. doi: 10.1080/01621459.2011.646932. Epub 2012 Jul 24. PMID: 23329858; PMCID: PMC3545451.
Fisher JD, Fisher WA, Amico KR, Harman JJ. An information-motivation-behavioral skills model of adherence to antiretroviral therapy. Health Psychol. 2006 Jul;25(4):462-73. doi: 10.1037/0278-6133.25.4.462. PMID: 16846321.
Fisher JD, Amico KR, Fisher WA, Harman JJ. The information-motivation-behavioral skills model of antiretroviral adherence and its applications. Curr HIV/AIDS Rep. 2008 Nov;5(4):193-203. doi: 10.1007/s11904-008-0028-y. PMID: 18838059.
Shubber Z, Mills EJ, Nachega JB, Vreeman R, Freitas M, Bock P, Nsanzimana S, Penazzato M, Appolo T, Doherty M, Ford N. Patient-Reported Barriers to Adherence to Antiretroviral Therapy: A Systematic Review and Meta-Analysis. PLoS Med. 2016 Nov 29;13(11):e1002183. doi: 10.1371/journal.pmed.1002183. PMID: 27898679; PMCID: PMC5127502.
Sileo KM, Simbayi LC, Abrams A, Cloete A, Kiene SM. The role of alcohol use in antiretroviral adherence among individuals living with HIV in South Africa: Event-level findings from a daily diary study. Drug Alcohol Depend. 2016 Oct 1;167:103-11. doi: 10.1016/j.drugalcdep.2016.07.028. Epub 2016 Aug 10. PMID: 27567968; PMCID: PMC5037036.
Satinsky EN, Myers B, Andersen LS, Kagee A, Joska J, Magidson JF. "Now We Are Told That We Can Mix": Messages and Beliefs Around Simultaneous Use of Alcohol and ART. AIDS Behav. 2020 Sep;24(9):2680-2690. doi: 10.1007/s10461-020-02825-1. PMID: 32162093.
Norton WE, Amico KR, Fisher WA, Shuper PA, Ferrer RA, Cornman DH, Trayling CA, Redding C, Fisher JD. Information-motivation-behavioral skills barriers associated with intentional versus unintentional ARV non-adherence behavior among HIV+ patients in clinical care. AIDS Care. 2010 Aug;22(8):979-87. doi: 10.1080/09540121003758630. PMID: 20552469; PMCID: PMC4286200.
Safren SA, Bedoya CA, O'Cleirigh C, Biello KB, Pinkston MM, Stein MD, Traeger L, Kojic E, Robbins GK, Lerner JA, Herman DS, Mimiaga MJ, Mayer KH. Cognitive behavioural therapy for adherence and depression in patients with HIV: a three-arm randomised controlled trial. Lancet HIV. 2016 Nov;3(11):e529-e538. doi: 10.1016/S2352-3018(16)30053-4. Epub 2016 Sep 19. PMID: 27658881; PMCID: PMC5321546.
Magidson JF, Belus JM, Seitz-Brown CJ, Tralka H, Safren SA, Daughters SB. Act Healthy: A Randomized Clinical Trial Evaluating a Behavioral Activation Intervention to Address Substance Use and Medication Adherence Among Low-Income, Black/African American Individuals Living with HIV/AIDS. AIDS Behav. 2022 Jan;26(1):102-115. doi: 10.1007/s10461-021-03354-1. Epub 2021 Jun 26. PMID: 34173895; PMCID: PMC8808422.
Herrmann S, McKinnon E, John M, Hyland N, Martinez OP, Cain A, Turner K, Coombs A, Manolikos C, Mallal S. Evidence-based, multifactorial approach to addressing non-adherence to antiretroviral therapy and improving standards of care. Intern Med J. 2008 Jan;38(1):8-15. doi: 10.1111/j.1445-5994.2007.01477.x. Epub 2007 Oct 3. PMID: 17916167.
Lee JL, Dy SM, Gurses AP, Kim JM, Suarez-Cuervo C, Berger ZD, Brown R, Xiao Y. Towards a More Patient-Centered Approach to Medication Safety. J Patient Exp. 2018 Jun;5(2):83-87. doi: 10.1177/2374373517727532. Epub 2017 Sep 19. PMID: 29978022; PMCID: PMC6022941.