Saeed Karimi, Morteza Naderan*, Salar Bahrami, Masomeh Sabzevary and Mohammad Naderan
Volume4-Issue11
Dates: Received: 2023-10-30 | Accepted: 2023-11-19 | Published: 2023-11-23
Pages: 1601-1606
Abstract
The ocular manifestations of the differentiation syndrome (DS) are rarely reported in the literature with only six cases published until now. Patients with acute promyelocytic leukemia (APL) who undergo treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are especially susceptible to developing DS. This is a serious diagnosis with a life-threatening impact on some patients, however, amenable to prophylaxis and treatment by systemic corticosteroids. An exudative retinal detachment (ERD) may either complicate or herald the development of DS. In this article, we present a case of APL who developed ERD in advance of DS symptoms, its multimodal imaging characteristics, and review the published articles concerning this rare disease manifestation.
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DOI: 10.37871/jbres1836
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© 2023 Karimi S, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Karimi S, Naderan M, Bahrami S, Sabzevary M, Naderan M. Exudative Retinal Detachment as a Prodromal Manifestation of Differentiation Syndrome in Acute Promyelocytic Leukemia: A Case Report and Review of Literature. J Biomed Res Environ Sci. 2023 Nov 23; 4(11): 1601-1606. doi: 10.37871/jbres1836, Article ID: JBRES1836, Available at: https://www.jelsciences.com/ articles/jbres1836.pdf
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