Covid-19 Research

Research Article

The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil

Journal of Biomedical Research & Environmental Sciences article abstract with citation details, DOI, publication dates, subject areas, full text links, and references.

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Open Access
Article Type Research Article
Subject Medicine Group
OCLC JBRES Record
Gilberto Henrique NL Lopes, Joselene Beatriz S da Silva, Ronian S Carvalho, Marcos Vinicius T Martins, Santiago S Rocha and Stefan V de Oliveira*
Issue: Volume4-Issue10
Pages: 1412-1421
Received: 2023-09-14
Accepted: 2023-09-25
Published: 2023-10-15

Abstract

Background: The novel coronavirus pandemic is an international public health emergency due to the high contagious potential of the virus on a global scale and, similarly to what happened globally, Brazilian authorities took measures to reduce its impact on the healthcare system, including social distancing. In this context of exhaustion of the system, it is worth questioning the situation of patients who need medical care for other diseases, such as the cardiovascular ones.

Objectives: Describe the changes in the epidemiological profile of hospitalizations cardiovascular diseases during the COVID-19 pandemic in Brazil.

Methods: Assessment of relative variations on the number of hospitalizations, associated average time, mortality rate and financial investments.

Results: After the beginning of the pandemic, there was reduction of 21.46% in hospitalizations, more accentuated in females and in the Northern region, and increase of 14.14% in mortality, of greater significance in the Midwestern region. In younger ages, mortality and permanence time presented more accentuated positive variations. In elective admissions, growth in mortality and in hospital expenses were more significant.

Conclusion: The pandemic impacted on cardiovascular diseases in a multifactorial way. The number of hospitalizations decreased, and the mortality rate increased, as efforts concentrated on moderate and severe cases. Therefore, there is a need for policies that minimize mid- and long-term impacts, as well as studies that investigate possible late complications of infections by the novel coronavirus.

FullText HTML FullText PDF DOI: 10.37871/jbres1811 Crossmark

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Copyright

© 2023 Gilberto Henrique NLL, et al. Distributed under Creative Commons CC-BY 4.0 Creative CommonsAttribution

How to cite this article

Gilberto Henrique NLL, da Silva JBS, Carvalho RS, Martins MVT, Rocha SS, de Oliveira SV. The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil. J Biomed Res Environ Sci. 2023 Oct 15; 4(10): 1412-1421. doi: 10.37871/ jbres1811, Article ID: JBRES1811, Available at: https://www.jelsciences.com/articles/jbres1811.pdf

Subject area(s)

Cardiovascular Diseases

References

  1. Bezerra ACV, Silva CEMD, Soares FRG, Silva JAMD. Factors associated with people's behavior in social isolation during the COVID-19 pandemic. Cien Saude Colet. 2020 Jun;25(suppl 1):2411-2421. Portuguese, English. doi: 10.1590/1413-81232020256.1.10792020. Epub 2020 Apr 23. PMID: 32520286.
  2. Aquino EML, Silveira IH, Pescarini JM, Aquino R, Souza-Filho JA, Rocha AS, Ferreira A, Victor A, Teixeira C, Machado DB, Paixão E, Alves FJO, Pilecco F, Menezes G, Gabrielli L, Leite L, Almeida MCC, Ortelan N, Fernandes QHRF, Ortiz RJF, Palmeira RN, Junior EPP, Aragão E, Souza LEPF, Netto MB, Teixeira MG, Barreto ML, Ichihara MY, Lima RTRS. Social distancing measures to control the COVID-19 pandemic: potential impacts and challenges in Brazil. Cien Saude Colet. 2020 Jun;25(suppl 1):2423-2446. English, Portuguese. doi: 10.1590/1413-81232020256.1.10502020. Epub 2020 Apr 22. PMID: 32520287.
  3. Coronavírus Brasil. Painel Coronavírus. 2020.
  4. Ornell F, Schuch JB, Sordi AO, Kessler FHP. "Pandemic fear" and COVID-19: mental health burden and strategies. Braz J Psychiatry. 2020;42(3):232-235. doi: 10.1590/1516-4446-2020-0008. Epub 2020 Apr 3. Erratum in: Braz J Psychiatry. 2020;42(3):333. PMID: 32267343; PMCID: PMC7236170.
  5. Ministério da Saúde (BR). DATASUS. Morbidade hospitalar do SUS - por local de residência - Brasil: óbitos segundo ano/mês processamento capítulo cid-10: ix. doenças do aparelho circulatório período: 2019. Óbitos segundo Ano/mês processamento Capítulo CID-10: IX. Doenças do aparelho circulatório. Brasília: Ministério da Saúde. 2020.
  6. Figueiredo ET, Azevedo L, Rezende ML, Alves CG. Rheumatic Fever: A Disease without Color. Arq Bras Cardiol. 2019 Jul 29;113(3):345-354. doi: 10.5935/abc.20190141. PMID: 31365604; PMCID: PMC6882402.
  7. Bitar H, Alismail S. The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: A rapid systematic review. Digit Health. 2021 Apr 19;7:20552076211009396. doi: 10.1177/20552076211009396. PMID: 33959378; PMCID: PMC8060773.
  8. Ministério da Saúde (BR). DATASUS: Informações de Saúde, Epidemiológicas e Morbidade: Banco de dados. Brasília. In: Ministério da Saúde; 2020.
  9. WHO. ICD-10 Version. 2016.
  10. Ministério da Saúde (BR). Resolução nº 466, de 12 de dezembro de 2012. Diretrizes e normas regulamentadoras de pesquisa envolvendo seres humanos. Diário Oficial da União. 2012.
  11. Zuin M, Mugnai G, Zamboni A, Zakja E, Valle R, Turiano G, Themistoclakis S, Scarpa D, Saccà S, Roncon L, Rizzetto F, Purita P, Polo A, Pantano I, Mugnolo A, Molon G, Meneghin S, Mancuso D, Lia M, Grassi G, Cutolo A, Chirillo F, Bozzini P, Bonapace S, Anselmi M, Rigatelli G, Bilato C. Decline of Admission for Acute Coronary Syndromes and Acute Cardiovascular Conditions during COVID-19 Pandemic in Veneto Region. Viruses. 2022 Aug 30;14(9):1925. doi: 10.3390/v14091925. PMID: 36146731; PMCID: PMC9502380.
  12. Metzler B, Siostrzonek P, Binder RK, Bauer A, Reinstadler SJ. Decline of acute coronary syndrome admissions in Austria since the outbreak of COVID-19: the pandemic response causes cardiac collateral damage. Eur Heart J. 2020 May 14;41(19):1852-1853. doi: 10.1093/eurheartj/ehaa314. PMID: 32297932; PMCID: PMC7184486.
  13. Ministério da Saúde (BR). Centro de operações de emergência em saúde pública| doença pelo Coronavírus 2019 (COE-COVID19). Boletim 17. Brasília: Ministério da Saúde. 2020.
  14. Emanuel EJ, Persad G, Upshur R, Thome B, Parker M, Glickman A, Zhang C, Boyle C, Smith M, Phillips JP. Fair Allocation of Scarce Medical Resources in the Time of Covid-19. N Engl J Med. 2020 May 21;382(21):2049-2055. doi: 10.1056/NEJMsb2005114. Epub 2020 Mar 23. PMID: 32202722.
  15. Diaz A, Sarac BA, Schoenbrunner AR, Janis JE, Pawlik TM. Elective surgery in the time of COVID-19. Am J Surg. 2020 Jun;219(6):900-902. doi: 10.1016/j.amjsurg.2020.04.014. Epub 2020 Apr 16. PMID: 32312477; PMCID: PMC7161516.
  16. Moroni F, Gramegna M, Ajello S, Beneduce A, Baldetti L, Vilca LM, Cappelletti A, Scandroglio AM, Azzalini L. Collateral Damage: Medical Care Avoidance Behavior Among Patients With Myocardial Infarction During the COVID-19 Pandemic. JACC Case Rep. 2020 Aug;2(10):1620-1624. doi: 10.1016/j.jaccas.2020.04.010. Epub 2020 Apr 23. PMID: 32835261; PMCID: PMC7252183.
  17. Camilo VC de O, Souto YS, Zavan N de O, Cardoso FR de O, Santos VA, Martins Machado A, Oda JY. Telemedicina e fatores limitantes para seu exercício no Brasil e no mundo durante a pandemia de Covid-19. In: Uma revisão integrativa. CONJ. 2021;21(6):866-82.
  18. Zhu J, Pang J, Ji P, Zhong Z, Li H, Li B, Zhang J, Lu J. Coagulation dysfunction is associated with severity of COVID-19: A meta-analysis. J Med Virol. 2021 Feb;93(2):962-972. doi: 10.1002/jmv.26336. Epub 2020 Oct 14. PMID: 32706396; PMCID: PMC7404826.
  19. Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 2020 Jun;127:104362. doi: 10.1016/j.jcv.2020.104362. Epub 2020 Apr 9. PMID: 32305883; PMCID: PMC7195278.
  20. Elkazzaz M, Ahmed A, Abo-Amer YE, Hydara T, Haikal A, Razek DNAE, Eltayb WA, Wang X, Karpiński TM, Hamza D, Jabbar B, Shamkh IM. In Silico Discovery of GPCRs and GnRHRs as Novel Binding Receptors of SARS-CoV-2 Spike Protein Could Explain Neuroendocrine Disorders in COVID-19. Vaccines (Basel). 2022 Sep 8;10(9):1500. doi: 10.3390/vaccines10091500. PMID: 36146578; PMCID: PMC9504287.
  21. Belani P, Schefflein J, Kihira S, Rigney B, Delman BN, Mahmoudi K, Mocco J, Majidi S, Yeckley J, Aggarwal A, Lefton D, Doshi AH. COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke. AJNR Am J Neuroradiol. 2020 Aug;41(8):1361-1364. doi: 10.3174/ajnr.A6650. Epub 2020 Jun 25. PMID: 32586968; PMCID: PMC7658882.
  22. Majidi S, Fifi JT, Ladner TR, Lara-Reyna J, Yaeger KA, Yim B, Dangayach N, Oxley TJ, Shigematsu T, Kummer BR, Stein LK, Weinberger J, Fara MG, De Leacy R, Dhamoon MS, Tuhrim S, Mocco J. Emergent Large Vessel Occlusion Stroke During New York City's COVID-19 Outbreak: Clinical Characteristics and Paraclinical Findings. Stroke. 2020 Sep;51(9):2656-2663. doi: 10.1161/STROKEAHA.120.030397. Epub 2020 Jul 31. PMID: 32755349; PMCID: PMC7434004.
  23. Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Syndr. 2020 May-Jun;14(3):247-250. doi: 10.1016/j.dsx.2020.03.013. Epub 2020 Mar 25. PMID: 32247212; PMCID: PMC7102662.
  24. Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, Jain SS, Burkhoff D, Kumaraiah D, Rabbani L, Schwartz A, Uriel N. COVID-19 and Cardiovascular Disease. Circulation. 2020 May 19;141(20):1648-1655. doi: 10.1161/CIRCULATIONAHA.120.046941. Epub 2020 Mar 21. PMID: 32200663.
  25. Sabatino J, Di Salvo G, Calcaterra G, Bassareo PP, Oreto L, Cazzoli I, Calabrò MP, Guccione P, Gatzoulis MA; Congenital Heart Disease Working Group of the Italian Society of Cardiology (SIC). Adult congenital heart disease: Special considerations for COVID-19 and vaccine allocation/prioritization. Int J Cardiol Congenit Heart Dis. 2021 Aug;4:100186. doi: 10.1016/j.ijcchd.2021.100186. Epub 2021 Jun 16. PMID: 35360449; PMCID: PMC8206548.
  26. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020 Apr;8(4):e21. doi: 10.1016/S2213-2600(20)30116-8. Epub 2020 Mar 11. Erratum in: Lancet Respir Med. 2020 Jun;8(6):e54. PMID: 32171062; PMCID: PMC7118626.
  27. Brito VP, Carrijo AMM, Oliveira SV. Associação da diabetes mellitus com a gravidade da COVID-19 e seus potenciais fatores mediadores: Uma revisão sistemática. Revista Thema. 2020; 18:204-217. doi: 10.15536/thema.V18.Especial.2020.204-217.1820.
  28. Li J, Wang X, Chen J, Zhang H, Deng A. Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China. JAMA Cardiol. 2020 Jul 1;5(7):825-830. doi: 10.1001/jamacardio.2020.1624. Erratum in: JAMA Cardiol. 2020 Aug 1;5(8):968. PMID: 32324209; PMCID: PMC7180726.
  29. Guimarães RM, Andrade SS, Machado EL, Bahia CA, Oliveira MM, Jacques FV. Diferenças regionais na transição da mortalidade por doenças cardiovasculares no Brasil, 1980 a 2012 [Regional differences in cardiovascular mortality transition in Brazil, 1980 to 2012]. Rev Panam Salud Publica. 2015 Feb;37(2):83-9. Portuguese. PMID: 25915012.
  30. Malta DC, Teixeira R, Oliveira GMM, Ribeiro ALP. Cardiovascular Disease Mortality According to the Brazilian Information System on Mortality and the Global Burden of Disease Study Estimates in Brazil, 2000-2017. Arq Bras Cardiol. 2020 Aug 28;115(2):152-160. English, Portuguese. doi: 10.36660/abc.20190867. PMID: 32696855; PMCID: PMC8384283.
  31. Figueiredo FSF, Rodrigues TFCDS, Rêgo ADS, Andrade L, Oliveira RR, Radovanovic CAT. Distribution and spatial autocorrelation of the hospitalizations for cardiovascular diseases in adults in Brazil. Rev Gaucha Enferm. 2020 Jun 12;41:e20190314. English, Portuguese. doi: 10.1590/1983-1447.2020.20190314. PMID: 32555957.
  32. Mendonça FD, Rocha SS, Pinheiro DLP, Pimenta DL, Oliveira SV. Região norte do Brasil e a pandemia de COVID-19: Análise socioeconômica e epidemiológica: J Health NPEPS. 2020;5(1):20-37.
  33. Instituto Brasileiro de Geografia e Estatística (IBGE). Pesquisa nacional por amostra de domicílios. Rio de Janeiro: IBGE. 2016.
  34. Kragholm K, Andersen MP, Gerds TA, Butt JH, Østergaard L, Polcwiartek C, Phelps M, Andersson C, Gislason GH, Torp-Pedersen C, Køber L, Schou M, Fosbøl EL. Association Between Male Sex and Outcomes of Coronavirus Disease 2019 (COVID-19)-A Danish Nationwide, Register-based Study. Clin Infect Dis. 2021 Dec 6;73(11):e4025-e4030. doi: 10.1093/cid/ciaa924. PMID: 32634827; PMCID: PMC7454435.
  35. Siqueira ASE, Siqueira-Filho AG, Land MGP. Analysis of the Economic Impact of Cardiovascular Diseases in the Last Five Years in Brazil. Arq Bras Cardiol. 2017 Jul;109(1):39-46. doi: 10.5935/abc.20170068. Epub 2017 Jun 1. PMID: 28591251; PMCID: PMC5524474.
  36. Papadopoulos V, Li L, Samplaski M. Why does COVID-19 kill more elderly men than women? Is there a role for testosterone? Andrology. 2021 Jan;9(1):65-72. doi: 10.1111/andr.12868. Epub 2020 Aug 5. PMID: 32681716; PMCID: PMC7404939.
  37. Berhan Y. What immunological and hormonal protective factors lower the risk of COVID-19 related deaths in pregnant women? J Reprod Immunol. 2020 Nov;142:103180. doi: 10.1016/j.jri.2020.103180. Epub 2020 Jul 18. PMID: 32739645; PMCID: PMC7368414.
  38. Rosa MFP, Silva WNT, Baccega TM, Castro IB, Oliveira SV. Síndrome respiratória aguda grave em pacientes pediátricos no contexto da pandemia: Uma análise epidemiológica do Brasil. Rev Ped SOPERJ. 2021;21(2):62-67. doi:10.31365/issn.2595-1769.v21i2p62-67.
  39. Mattioli AV, Sciomer S, Cocchi C, Maffei S, Gallina S. Quarantine during COVID-19 outbreak: Changes in diet and physical activity increase the risk of cardiovascular disease. Nutr Metab Cardiovasc Dis. 2020 Aug 28;30(9):1409-1417. doi: 10.1016/j.numecd.2020.05.020. Epub 2020 May 30. PMID: 32571612; PMCID: PMC7260516.
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