Dito Anurogo*
Volume4-Issue9
Dates: Received: 2023-09-11 | Accepted: 2023-09-28 | Published: 2023-09-30
Pages: 1348-1369
Abstract
This comprehensive review provides an exploration of Nanoimmunobiotechnomedicine (NIBTM) within the arenas of stem cells and gene editing. Encompassing the interdisciplinary amalgamation of nanotechnology, immunology, biotechnology, and medicine, the study accentuates the transformative potential of NIBTM in therapeutic innovations. By delving deep into stem cell biology, gene editing intricacies, and nanotechnology applications, the study sheds light on the tools and methodologies that leverage nanoparticles for both stem cell research and gene editing. Real-world case studies are employed to underscore the pragmatic applications and the ensuing benefits. Additionally, the study addresses the ethical, safety, and regulatory aspects tied to this novel approach, offering a balanced view of its promise and challenges. Ultimately, the narrative charts the imminent evolution of NIBTM, underscoring the indispensable role of interdisciplinary collaborations in driving holistic solutions in contemporary medicine.
FullText HTML FullText PDF DOI: 10.37871/jbres1804
Certificate of Publication
Copyright
© 2023 Anurogo D. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Anurogo D. The Art of Nanoimmunobiotechnomedicine in Stem Cells and Gene Editing. J Biomed Res Environ Sci. 2023 Sep 30; 4(9): 1348-1369. doi: 10.37871/jbres1804, Article ID: JBRES1804, Available at: https://www.jelsciences.com/articles/ jbres1804.pdf
Subject area(s)
References
- Pretel-Wilson M. The unification of knowledge. Utopics: The Unification of Human Science; 2020. p.175-180.
- Anurogo D. The art of nanoimmunobiotechnomedicine. JKKI: Jurnal Kedokteran dan Kesehatan Indonesia; 2021. p.206-207.
- Sahu T, Yashwant Kumar R, Chauhan S, Bhaskar LVKS, Nair MP, Henu Kumar V. Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science. Journal of Drug Delivery Science and Technology. 2021;63:102487. doi: 10.1016/j.jddst.2021.102487.
- Demidov VV. DNA Beyond Genes. Springer; 2020.
- Jin Y, Li S, Yu Q, Chen T, Liu D. Application of stem cells in regeneration medicine. MedComm (2020). 2023 Jun 17;4(4):e291. doi: 10.1002/mco2.291. PMID: 37337579; PMCID: PMC10276889.
- Huang J, Zhou Y, Li J, Lu A, Liang C. CRISPR/Cas systems: Delivery and application in gene therapy. Front Bioeng Biotechnol. 2022 Nov 22;10:942325. doi: 10.3389/fbioe.2022.942325. PMID: 36483767; PMCID: PMC9723151.
- Rahman MM, Ghoshal UC, Ragunath K, Jenkins G, Rahman M, Edwards C, Hasan M, Taylor-Robinson SD. Biomedical research in developing countries: Opportunities, methods, and challenges. Indian J Gastroenterol. 2020 Jun;39(3):292-302. doi: 10.1007/s12664-020-01056-5. Epub 2020 Jun 30. PMID: 32607962; PMCID: PMC7325473.
- Vasanthan J, Gurusamy N, Rajasingh S, Sigamani V, Kirankumar S, Thomas EL, Rajasingh J. Role of Human Mesenchymal Stem Cells in Regenerative Therapy. Cells. 2020 Dec 31;10(1):54. doi: 10.3390/cells10010054. PMID: 33396426; PMCID: PMC7823630.
- Omole AE, Fakoya AOJ. Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications. PeerJ. 2018 May 11;6:e4370. doi: 10.7717/peerj.4370. PMID: 29770269; PMCID: PMC5951134.
- Ebrahimi A, Ahmadi H, Pourfraidon Ghasrodashti Z, Tanide N, Shahriarirad R, Erfani A, Ranjbar K, Ashkani-Esfahani S. Therapeutic effects of stem cells in different body systems, a novel method that is yet to gain trust: A comprehensive review. Bosn J Basic Med Sci. 2021 Dec 1;21(6):672-701. doi: 10.17305/bjbms.2021.5508. PMID: 34255619; PMCID: PMC8554700.
- Liu W, Li L, Jiang J, Wu M, Lin P. Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics. Precis Clin Med. 2021 Jul 10;4(3):179-191. doi: 10.1093/pcmedi/pbab014. PMID: 34541453; PMCID: PMC8444435.
- Rasul MF, Hussen BM, Salihi A, Ismael BS, Jalal PJ, Zanichelli A, Jamali E, Baniahmad A, Ghafouri-Fard S, Basiri A, Taheri M. Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy. Mol Cancer. 2022 Mar 3;21(1):64. doi: 10.1186/s12943-021-01487-4. PMID: 35241090; PMCID: PMC8892709.
- Doudna JA, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014 Nov 28;346(6213):1258096. doi: 10.1126/science.1258096. PMID: 25430774.
- Ochiai H, Yamamoto T. Construction and Evaluation of Zinc Finger Nucleases. Methods Mol Biol. 2023;2637:1-25. doi: 10.1007/978-1-0716-3016-7_1. PMID: 36773134.
- Zhang Y, Zhang F, Li X, Baller JA, Qi Y, Starker CG, Bogdanove AJ, Voytas DF. Transcription activator-like effector nucleases enable efficient plant genome engineering. Plant Physiol. 2013 Jan;161(1):20-7. doi: 10.1104/pp.112.205179. Epub 2012 Nov 2. PMID: 23124327; PMCID: PMC3532252.
- Sharma P, Lew TTS. Principles of Nanoparticle Design for Genome Editing in Plants. Front Genome Ed. 2022 Mar 7;4:846624. doi: 10.3389/fgeed.2022.846624. PMID: 35330692; PMCID: PMC8940305.
- Duan L, Ouyang K, Xu X, Xu L, Wen C, Zhou X, Qin Z, Xu Z, Sun W, Liang Y. Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing. Front Genet. 2021 May 12;12:673286. doi: 10.3389/fgene.2021.673286. PMID: 34054927; PMCID: PMC8149999.
- Suresh LG, Indhuprakash ST, Gandhi S, Diraviyam T. Amalgamation of nanotechnology with chicken IgY to enrich therapeutic and diagnostic applications: a systematic review. Immunotherapy. 2023 Aug;15(11):867-884. doi: 10.2217/imt-2022-0304. Epub 2023 May 24. PMID: 37222153.
- Joy B. Particular by the possibilities of the convergence of genetics, nanotechnology, and robotics. Technology and Society: Building Our Sociotechnical Future. 2021;67.
- Bae YH, Park K. Advanced drug delivery 2020 and beyond: Perspectives on the future. Adv Drug Deliv Rev. 2020;158:4-16. doi: 10.1016/j.addr.2020.06.018. Epub 2020 Jun 24. PMID: 32592727; PMCID: PMC7736191.
- Kong X, Gao P, Wang J, Fang Y, Hwang KC. Advances of medical nanorobots for future cancer treatments. J Hematol Oncol. 2023 Jul 14;16(1):74. doi: 10.1186/s13045-023-01463-z. PMID: 37452423; PMCID: PMC10347767.
- Sim S, Wong NK. Nanotechnology and its use in imaging and drug delivery (Review). Biomed Rep. 2021 May;14(5):42. doi: 10.3892/br.2021.1418. Epub 2021 Mar 5. PMID: 33728048; PMCID: PMC7953199.
- Afzal O, Altamimi ASA, Nadeem MS, Alzarea SI, Almalki WH, Tariq A, Mubeen B, Murtaza BN, Iftikhar S, Riaz N, Kazmi I. Nanoparticles in Drug Delivery: From History to Therapeutic Applications. Nanomaterials (Basel). 2022 Dec 19;12(24):4494. doi: 10.3390/nano12244494. PMID: 36558344; PMCID: PMC9781272.
- El-Kharrag R, Berckmueller KE, Madhu R, Cui M, Campoy G, Mack HM, Wolf CB, Perez AM, Humbert O, Kiem HP, Radtke S. Efficient polymer nanoparticle-mediated delivery of gene editing reagents into human hematopoietic stem and progenitor cells. Mol Ther. 2022 Jun 1;30(6):2186-2198. doi: 10.1016/j.ymthe.2022.02.026. Epub 2022 Feb 28. PMID: 35240320; PMCID: PMC9171380.
- Keikha R, Daliri K, Jebali A. The Use of Nanobiotechnology in Immunology and Vaccination. Vaccines (Basel). 2021 Jan 21;9(2):74. doi: 10.3390/vaccines9020074. PMID: 33494441; PMCID: PMC7910821.
- Janeway CA Jr., Travers P, Walport M, Shlomchik MJ. Immunobiology: The immune system in health and disease. 5th ed. New York: Garland Science; 2001.
- Ray P, Haideri N, Haque I, Mohammed O, Chakraborty S, Banerjee S, Quadir M, Brinker AE, Banerjee SK. The impact of nanoparticles on the immune system: A gray zone of nanomedicine. Journal of Immunological Sciences. 2021;5(1). doi: 10.29245/2578-3009/2021/1.1206.
- Liu J, Liu Z, Pang Y, Zhou H. The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases. J Nanobiotechnology. 2022 Mar 12;20(1):127. doi: 10.1186/s12951-022-01343-7. PMID: 35279135; PMCID: PMC8917374.
- Farkas DL. Biomedical Applications of Translational Optical Imaging: From Molecules to Humans. Molecules. 2021 Nov 2;26(21):6651. doi: 10.3390/molecules26216651. PMID: 34771060; PMCID: PMC8587670.
- Ponpandian S. Shenbagamoorthy S, Sudarmani DNP. Nanotechnology-based stem cell therapy: Current status and perspectives, in possibilities and limitations in current translational stem cell research. Diana K, editor. Rijeka: IntechOpen; 2023. p.5.
- Dong Y, Wu X, Chen X, Zhou P, Xu F, Liang W. Nanotechnology shaping stem cell therapy: Recent advances, application, challenges, and future outlook. Biomed Pharmacother. 2021 May;137:111236. doi: 10.1016/j.biopha.2021.111236. Epub 2021 Jan 21. PMID: 33486201.
- Bashor CJ, Hilton IB, Bandukwala H, Smith DM, Veiseh O. Engineering the next generation of cell-based therapeutics. Nat Rev Drug Discov. 2022 Sep;21(9):655-675. doi: 10.1038/s41573-022-00476-6. Epub 2022 May 30. PMID: 35637318; PMCID: PMC9149674.
- Liu S, Yu JM, Gan YC, Qiu XZ, Gao ZC, Wang H, Chen SX, Xiong Y, Liu GH, Lin SE, McCarthy A, John JV, Wei DX, Hou HH. Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications. Mil Med Res. 2023 Mar 28;10(1):16. doi: 10.1186/s40779-023-00448-w. PMID: 36978167; PMCID: PMC10047482.
- Khanmohammadi M. Encapsulation of Stem Cells. In: Principles of Biomaterials Encapsulation. Sefat F, Farzi G, Mozafari M, editors. Woodhead Publishing; 2023. p.481-524.
- Chen BQ, Zhao Y, Zhang Y, Pan YJ, Xia HY, Kankala RK, Wang SB, Liu G, Chen AZ. Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy. Bioact Mater. 2022 Aug 10;21:1-19. doi: 10.1016/j.bioactmat.2022.07.023. PMID: 36017071; PMCID: PMC9382433.
- Liu J, Li R, Yang B. Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications. ACS Cent Sci. 2020 Dec 23;6(12):2179-2195. doi: 10.1021/acscentsci.0c01306. Epub 2020 Dec 14. PMID: 33376780; PMCID: PMC7760469.
- Saleh HM, Hassan AI. Synthesis and characterization of nanomaterials for application in cost-effective electrochemical devices. Sustainability. 2023;15(14):10891. doi: 10.3390/su151410891.
- Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H. Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos. Cell Stem Cell. 2016 Nov 3;19(5):587-592. doi: 10.1016/j.stem.2016.10.013. PMID: 27814480.
- Taylor AC, González CH, Ferretti P, Jackman RB. Spontaneous Differentiation of Human Neural Stem Cells on Nanodiamonds. Adv Biosyst. 2019 Apr;3(4):e1800299. doi: 10.1002/adbi.201800299. Epub 2019 Mar 19. PMID: 32627432.
- Yang TC, Chang CY, Yarmishyn AA, Mao YS, Yang YP, Wang ML, Hsu CC, Yang HY, Hwang DK, Chen SJ, Tsai ML, Lai YH, Tzeng Y, Chang CC, Chiou SH. Carboxylated nanodiamond-mediated CRISPR-Cas9 delivery of human retinoschisis mutation into human iPSCs and mouse retina. Acta Biomater. 2020 Jan 1;101:484-494. doi: 10.1016/j.actbio.2019.10.037. Epub 2019 Oct 28. PMID: 31672582.
- Penewit K, Holmes EA, McLean K, Ren M, Waalkes A, Salipante SJ. Efficient and Scalable Precision Genome Editing in Staphylococcus aureus through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection. mBio. 2018 Feb 20;9(1):e00067-18. doi: 10.1128/mBio.00067-18. Erratum in: mBio. 2018 Oct 2;9(5): Erratum in: mBio. 2019 Jan 15;10(1): PMID: 29463653; PMCID: PMC5821094.
- Kanaya N, Kitamura Y, Vazquez ML, Franco A, Chen KS, Van Schaik TA, Farzani TA, Borges P, Ichinose T, Seddiq W, Kuroda S, Boland G, Jahan N, Fisher D, Wakimoto H, Shah K. Gene-edited and -engineered stem cell platform drives immunotherapy for brain metastatic melanomas. Sci Transl Med. 2023;15(698). doi: 10.1126/scitranslmed.ade8732.
- Zhou W, Yang J, Zhang Y, Hu X, Wang W. Current landscape of gene-editing technology in biomedicine: Applications, advantages, challenges, and perspectives. MedComm (2020). 2022 Jul 14;3(3):e155. doi: 10.1002/mco2.155. PMID: 35845351; PMCID: PMC9283854.
- Masoudi Asil S, Ahlawat J, Guillama Barroso G, Narayan M. Application of Nanotechnology in Stem-Cell-Based Therapy of Neurodegenerative Diseases. Applied Sciences, 2020;10(14): p. 4852.
- Vissers C, Ming GL, Song H. Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders. Adv Drug Deliv Rev. 2019 Aug;148:239-251. doi: 10.1016/j.addr.2019.02.007. Epub 2019 Feb 21. PMID: 30797953; PMCID: PMC6703981.
- Duan L, Ouyang K, Xu X, Xu L, Wen C, Zhou X, Qin Z, Xu Z, Sun W, Liang Y. Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing. Front Genet. 2021 May 12;12:673286. doi: 10.3389/fgene.2021.673286. PMID: 34054927; PMCID: PMC8149999.
- Sioson VA, Kim M, Joo J. Challenges in delivery systems for CRISPR-based genome editing and opportunities of nanomedicine. Biomed Eng Lett. 2021 Jul 13;11(3):217-233. doi: 10.1007/s13534-021-00199-4. PMID: 34350049; PMCID: PMC8316527.
- Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021 Feb;20(2):101-124. doi: 10.1038/s41573-020-0090-8. Epub 2020 Dec 4. PMID: 33277608; PMCID: PMC7717100.
- Joseph TM, Kar Mahapatra D, Esmaeili A, Piszczyk Ł, Hasanin MS, Kattali M, Haponiuk J, Thomas S. Nanoparticles: Taking a Unique Position in Medicine. Nanomaterials (Basel). 2023 Jan 31;13(3):574. doi: 10.3390/nano13030574. PMID: 36770535; PMCID: PMC9920911.
- Dubey AK, Kumar Gupta V, Kujawska M, Orive G, Kim NY, Li CZ, Kumar Mishra Y, Kaushik A. Exploring nano-enabled CRISPR-Cas-powered strategies for efficient diagnostics and treatment of infectious diseases. J Nanostructure Chem. 2022;12(5):833-864. doi: 10.1007/s40097-022-00472-7. Epub 2022 Feb 14. PMID: 35194511; PMCID: PMC8853211.
- Tenchov R, Bird R, Curtze AE, Zhou Q. Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement. ACS Nano. 2021 Nov 23;15(11):16982-17015. doi: 10.1021/acsnano.1c04996. Epub 2021 Jun 28. PMID: 34181394.
- Wang X, Li C, Wang Y, Chen H, Zhang X, Luo C, Zhou W, Li L, Teng L, Yu H, Wang J. Smart drug delivery systems for precise cancer therapy. Acta Pharm Sin B. 2022 Nov;12(11):4098-4121. doi: 10.1016/j.apsb.2022.08.013. Epub 2022 Aug 22. PMID: 36386470; PMCID: PMC9643298.
- Jia R, Teng L, Gao L, Su T, Fu L, Qiu Z, Bi Y. Advances in Multiple Stimuli-Responsive Drug-Delivery Systems for Cancer Therapy. Int J Nanomedicine. 2021 Feb 25;16:1525-1551. doi: 10.2147/IJN.S293427. PMID: 33658782; PMCID: PMC7920594.
- Kozovska Z, Rajcaniova S, Munteanu P, Dzacovska S, Demkova L. CRISPR: History and perspectives to the future. Biomed Pharmacother. 2021 Sep;141:111917. doi: 10.1016/j.biopha.2021.111917. Epub 2021 Jul 16. PMID: 34328110.
- Ranganathan V, Wahlin K, Maruotti J, Zack DJ. Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide RNAs. Nat Commun. 2014 Aug 8;5:4516. doi: 10.1038/ncomms5516. PMID: 25105359; PMCID: PMC4133144.
- Hejabi F, Abbaszadeh MS, Taji S, O'Neill A, Farjadian F, Doroudian M. Nanocarriers: A novel strategy for the delivery of CRISPR/Cas systems. Front Chem. 2022 Jul 26;10:957572. doi: 10.3389/fchem.2022.957572. PMID: 36092658; PMCID: PMC9450496.
- Duan L, Ouyang K, Xu X, Xu L, Wen C, Zhou X, Qin Z, Xu Z, Sun W, Liang Y. Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing. Front Genet. 2021 May 12;12:673286. doi: 10.3389/fgene.2021.673286. PMID: 34054927; PMCID: PMC8149999.
- Foley RA, Sims RA, Duggan EC, Olmedo JK, Ma R, Jonas SJ. Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation. Front Bioeng Biotechnol. 2022 Sep 26;10:973326. doi: 10.3389/fbioe.2022.973326. PMID: 36225598; PMCID: PMC9549251.
- Pranke I, Golec A, Hinzpeter A, Edelman A, Sermet-Gaudelus I. Emerging Therapeutic Approaches for Cystic Fibrosis. From Gene Editing to Personalized Medicine. Front Pharmacol. 2019 Feb 27;10:121. doi: 10.3389/fphar.2019.00121. PMID: 30873022; PMCID: PMC6400831.
- Wei M, Yang Z, Li S, Le W. Nanotherapeutic and Stem Cell Therapeutic Strategies in Neurodegenerative Diseases: A Promising Therapeutic Approach. Int J Nanomedicine. 2023 Feb 3;18:611-626. doi: 10.2147/IJN.S395010. PMID: 36760756; PMCID: PMC9904216.
- Turocy J, Adashi EY, Egli D. Heritable human genome editing: Research progress, ethical considerations, and hurdles to clinical practice. Cell. 2021 Mar 18;184(6):1561-1574. doi: 10.1016/j.cell.2021.02.036. PMID: 33740453.
- Zhao Y, Li G, Chen Y, Lu Y. Challenges and Advances in Genome Editing Technologies in Streptomyces. Biomolecules. 2020 May 8;10(5):734. doi: 10.3390/biom10050734. PMID: 32397082; PMCID: PMC7278167.
- Anjum S, Ishaque S, Fatima H, Farooq W, Hano C, Abbasi BH, Anjum I. Emerging Applications of Nanotechnology in Healthcare Systems: Grand Challenges and Perspectives. Pharmaceuticals (Basel). 2021 Jul 21;14(8):707. doi: 10.3390/ph14080707. PMID: 34451803; PMCID: PMC8401281.
- Ojha N, Dhamoon AS. Myocardial Infarction. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
- Pala R, Pattnaik S, Busi S, Nauli SM. Nanomaterials as Novel Cardiovascular Theranostics. Pharmaceutics. 2021 Mar 7;13(3):348. doi: 10.3390/pharmaceutics13030348. PMID: 33799932; PMCID: PMC7998597.
- Anselmo AC, Mitragotri S. Nanoparticles in the clinic: An update. Bioeng Transl Med. 2019 Sep 5;4(3):e10143. doi: 10.1002/btm2.10143. PMID: 31572799; PMCID: PMC6764803.
- Jain A, Behera M, Mahapatra C, Sundaresan NR, Chatterjee K. Nanostructured polymer scaffold decorated with cerium oxide nanoparticles toward engineering an antioxidant and anti-hypertrophic cardiac patch. Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111416. doi: 10.1016/j.msec.2020.111416. Epub 2020 Aug 24. PMID: 33255018.
- Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet MF, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ. Defining the Riddle in Order to Solve It: There Is More Than One "Parkinson's Disease". Mov Disord. 2023 Jul;38(7):1127-1142. doi: 10.1002/mds.29419. Epub 2023 May 8. PMID: 37156737.
- Ferrari S, Vavassori V, Canarutto D, Jacob A, Castiello MC, Javed AO, Genovese P. Gene Editing of Hematopoietic Stem Cells: Hopes and Hurdles Toward Clinical Translation. Front Genome Ed. 2021 Mar 31;3:618378. doi: 10.3389/fgeed.2021.618378. PMID: 34713250; PMCID: PMC8525369.
- Anurogo D, Yuli Prasetyo Budi N, Thi Ngo MH, Huang YH, Pawitan JA. Cell and Gene Therapy for Anemia: Hematopoietic Stem Cells and Gene Editing. Int J Mol Sci. 2021 Jun 10;22(12):6275. doi: 10.3390/ijms22126275. PMID: 34200975; PMCID: PMC8230702.
- Khaddour K, Hana CK, Mewawalla P. Hematopoietic Stem Cell Transplantation. [Updated 2023 May 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
- Abdelnour SA, Xie L, Hassanin AA, Zuo E, Lu Y. The Potential of CRISPR/Cas9 Gene Editing as a Treatment Strategy for Inherited Diseases. Front Cell Dev Biol. 2021 Dec 15;9:699597. doi: 10.3389/fcell.2021.699597. PMID: 34977000; PMCID: PMC8715006.
- Li H, Yang Y, Hong W, Huang M, Wu M, Zhao X. Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects. Signal Transduct Target Ther. 2020 Jan 3;5(1):1. doi: 10.1038/s41392-019-0089-y. PMID: 32296011; PMCID: PMC6946647.
- Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ. Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. Nat Commun. 2020 Jun 26;11(1):3232. doi: 10.1038/s41467-020-17029-3. PMID: 32591530; PMCID: PMC7320157.
- Yan J, Kang DD, Dong Y. Harnessing lipid nanoparticles for efficient CRISPR delivery. Biomater Sci. 2021 Sep 14;9(18):6001-6011. doi: 10.1039/d1bm00537e. PMID: 34115079; PMCID: PMC8440433.
- Guo C, Ma X, Gao F, Guo Y. Off-target effects in CRISPR/Cas9 gene editing. Front Bioeng Biotechnol. 2023 Mar 9;11:1143157. doi: 10.3389/fbioe.2023.1143157. PMID: 36970624; PMCID: PMC10034092.
- Li T, Yang Y, Qi H, Cui W, Zhang L, Fu X, He X, Liu M, Li PF, Yu T. CRISPR/Cas9 therapeutics: progress and prospects. Signal Transduct Target Ther. 2023 Jan 16;8(1):36. doi: 10.1038/s41392-023-01309-7. PMID: 36646687; PMCID: PMC9841506.
- Huang J, Zhou Y, Li J, Lu A, Liang C. CRISPR/Cas systems: Delivery and application in gene therapy. Front Bioeng Biotechnol. 2022 Nov 22;10:942325. doi: 10.3389/fbioe.2022.942325. PMID: 36483767; PMCID: PMC9723151.
- Lux CT, Scharenberg AM. Therapeutic Gene Editing Safety and Specificity. Hematol Oncol Clin North Am. 2017 Oct;31(5):787-795. doi: 10.1016/j.hoc.2017.05.002. Epub 2017 Jun 29. PMID: 28895847; PMCID: PMC5653273.
- Kavanagh EW, Green JJ. Toward Gene Transfer Nanoparticles as Therapeutics. Adv Healthc Mater. 2022 Apr;11(7):e2102145. doi: 10.1002/adhm.202102145. Epub 2022 Jan 17. PMID: 35006646.
- Betz, U.A.K, Arora L, Assal RA, Azevedo H, Baldwin J, Becker MS, Bostock S, Cheng V, Egle T, Ferrari N, Schneider-Futschik EK, Gerhardy S Hammes A, Harzheim C, Herget T, Jauset C, Kretschmer S, Lammie C, Kloss N, Fernandes SM, Zhao G. Game changers in science and technology - now and beyond. Technological Forecasting and Social Change. 2023;193:122588. doi: 10.1016/j.techfore.2023.122588.
- Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 2019 Mar;18(3):175-196. doi: 10.1038/s41573-018-0006-z. PMID: 30622344; PMCID: PMC6410566.
- Katti A, Diaz BJ, Caragine CM, Sanjana NE, Dow LE. CRISPR in cancer biology and therapy. Nat Rev Cancer. 2022 May;22(5):259-279. doi: 10.1038/s41568-022-00441-w. Epub 2022 Feb 22. PMID: 35194172.
- Chandran SS, Klebanoff CA. T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance. Immunol Rev. 2019 Jul;290(1):127-147. doi: 10.1111/imr.12772. PMID: 31355495; PMCID: PMC7027847.
- Malachowski, T. and A. Hassel, Engineering nanoparticles to overcome immunological barriers for enhanced drug delivery. Engineered Regeneration. 2020;1:35-50.doi: 10.1016/j.engreg.2020.06.001.
- Shah D, Soper B, Shopland L. Cytokine release syndrome and cancer immunotherapies - historical challenges and promising futures. Front Immunol. 2023 May 25;14:1190379. doi: 10.3389/fimmu.2023.1190379. PMID: 37304291; PMCID: PMC10248525.
- Balagopal S, Sasaki K, Kaur P, Nikolaidi M, Ishihara J. Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy. J Mater Chem B. 2022 Sep 28;10(37):7491-7511. doi: 10.1039/d2tb00592a. PMID: 35912720; PMCID: PMC9518648.
- Zhang XH, Tee LY, Wang XG, Huang QS, Yang SH. Off-target Effects in CRISPR/Cas9-mediated Genome Engineering. Mol Ther Nucleic Acids. 2015 Nov 17;4(11):e264. doi: 10.1038/mtna.2015.37. PMID: 26575098; PMCID: PMC4877446.
- Naeem M, Majeed S, Hoque MZ, Ahmad I. Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing. Cells. 2020 Jul 2;9(7):1608. doi: 10.3390/cells9071608. PMID: 32630835; PMCID: PMC7407193.
- Simeonov DR, Marson A. CRISPR-Based Tools in Immunity. Annu Rev Immunol. 2019 Apr 26;37:571-597. doi: 10.1146/annurev-immunol-042718-041522. Epub 2019 Jan 30. PMID: 30698999.
- Zhang D, Hussain A, Manghwar H, Xie K, Xie S, Zhao S, Larkin RM, Qing P, Jin S, Ding F. Genome editing with the CRISPR-Cas system: an art, ethics and global regulatory perspective. Plant Biotechnol J. 2020 Aug;18(8):1651-1669. doi: 10.1111/pbi.13383. Epub 2020 Apr 30. PMID: 32271968; PMCID: PMC7336378.
- Hryhorowicz M, Lipiński D, Zeyland J, Słomski R. CRISPR/Cas9 Immune System as a Tool for Genome Engineering. Arch Immunol Ther Exp (Warsz). 2017 Jun;65(3):233-240. doi: 10.1007/s00005-016-0427-5. Epub 2016 Oct 3. PMID: 27699445; PMCID: PMC5434172.
- Chen S, Chen D, Liu B, Haisma HJ. Modulating CRISPR/Cas9 genome-editing activity by small molecules. Drug Discov Today. 2022 Apr;27(4):951-966. doi: 10.1016/j.drudis.2021.11.018. Epub 2021 Nov 22. PMID: 34823004.
- Doerflinger M, Forsyth W, Ebert G, Pellegrini M, Herold MJ. CRISPR/Cas9-The ultimate weapon to battle infectious diseases? Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12693. Epub 2016 Dec 6. PMID: 27860197.
- Cornel AM, van Til NP, Boelens JJ, Nierkens S. Strategies to Genetically Modulate Dendritic Cells to Potentiate Anti-Tumor Responses in Hematologic Malignancies. Front Immunol. 2018 May 18;9:982. doi: 10.3389/fimmu.2018.00982. PMID: 29867960; PMCID: PMC5968097.
- Azangou-Khyavy M, Ghasemi M, Khanali J, Boroomand-Saboor M, Jamalkhah M, Soleimani M, Kiani J. CRISPR/Cas: From Tumor Gene Editing to T Cell-Based Immunotherapy of Cancer. Front Immunol. 2020 Sep 29;11:2062. doi: 10.3389/fimmu.2020.02062. PMID: 33117331; PMCID: PMC7553049.
- Wasti S, Lee IH, Kim S, Lee JH, Kim H. Ethical and legal challenges in nanomedical innovations: a scoping review. Front Genet. 2023 May 12;14:1163392. doi: 10.3389/fgene.2023.1163392. PMID: 37252668; PMCID: PMC10213273.
- Kyriakides TR, Raj A, Tseng TH, Xiao H, Nguyen R, Mohammed FS, Halder S, Xu M, Wu MJ, Bao S, Sheu WC. Biocompatibility of nanomaterials and their immunological properties. Biomed Mater. 2021 Mar 11;16(4):10.1088/1748-605X/abe5fa. doi: 10.1088/1748-605X/abe5fa. PMID: 33578402; PMCID: PMC8357854.
- Egbuna C, Parmar VK, Jeevanandam J, Ezzat SM, Patrick-Iwuanyanwu KC, Adetunji CO, Khan J, Onyeike EN, Uche CZ, Akram M, Ibrahim MS, El Mahdy NM, Awuchi CG, Saravanan K, Tijjani H, Odoh UE, Messaoudi M, Ifemeje JC, Olisah MC, Ezeofor NJ, Chikwendu CJ, Ibeabuchi CG. Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology. J Toxicol. 2021 Jul 30;2021:9954443. doi: 10.1155/2021/9954443. PMID: 34422042; PMCID: PMC8376461.
- Soldner F, Jaenisch R. Stem Cells, Genome Editing, and the Path to Translational Medicine. Cell. 2018 Oct 18;175(3):615-632. doi: 10.1016/j.cell.2018.09.010. PMID: 30340033; PMCID: PMC6461399.
- Li G, Li X, Zhuang S, Wang L, Zhu Y, Chen Y, Sun W, Wu Z, Zhou Z, Chen J, Huang X, Wang J, Li D, Li W, Wang H, Wei W. Gene editing and its applications in biomedicine. Sci China Life Sci. 2022 Apr;65(4):660-700. doi: 10.1007/s11427-021-2057-0. Epub 2022 Feb 18. PMID: 35235150; PMCID: PMC8889061.
- Rothschild J. Ethical considerations of gene editing and genetic selection. J Gen Fam Med. 2020 May 29;21(3):37-47. doi: 10.1002/jgf2.321. PMID: 32489755; PMCID: PMC7260159.
- Joseph AM, Karas M, Ramadan Y, Joubran E, Jacobs RJ. Ethical Perspectives of Therapeutic Human Genome Editing From Multiple and Diverse Viewpoints: A Scoping Review. Cureus. 2022 Nov 27;14(11):e31927. doi: 10.7759/cureus.31927. PMID: 36582559; PMCID: PMC9793437.
- Moradi S, Mahdizadeh H, Šarić T, Kim J, Harati J, Shahsavarani H, Greber B, Moore JB 4th. Research and therapy with induced pluripotent stem cells (iPSCs): social, legal, and ethical considerations. Stem Cell Res Ther. 2019 Nov 21;10(1):341. doi: 10.1186/s13287-019-1455-y. PMID: 31753034; PMCID: PMC6873767.
- Gyngell C, Douglas T, Savulescu J. The Ethics of Germline Gene Editing. J Appl Philos. 2017 Aug;34(4):498-513. doi: 10.1111/japp.12249. Epub 2016 Nov 9. PMID: 28919655; PMCID: PMC5573992.
- Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle D, Tong L, Tong W, Eijnden-van-Raaij JVD, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W Jr. Emerging technologies and their impact on regulatory science. Exp Biol Med (Maywood). 2022 Jan;247(1):1-75. doi: 10.1177/15353702211052280. Epub 2021 Nov 16. PMID: 34783606; PMCID: PMC8749227.
- Atkins A, Chung CH, Allen AG, Dampier W, Gurrola TE, Sariyer IK, Nonnemacher MR, Wigdahl B. Off-Target Analysis in Gene Editing and Applications for Clinical Translation of CRISPR/Cas9 in HIV-1 Therapy. Front Genome Ed. 2021 Aug 17;3:673022. doi: 10.3389/fgeed.2021.673022. PMID: 34713260; PMCID: PMC8525399.
- Boateng F, Ngwa W. Delivery of Nanoparticle-Based Radiosensitizers for Radiotherapy Applications. Int J Mol Sci. 2019 Dec 31;21(1):273. doi: 10.3390/ijms21010273. PMID: 31906108; PMCID: PMC6981554.
- Filippova J, Matveeva A, Zhuravlev E, Stepanov G. Guide RNA modification as a way to improve CRISPR/Cas9-based genome-editing systems. Biochimie. 2019 Dec;167:49-60. doi: 10.1016/j.biochi.2019.09.003. Epub 2019 Sep 4. PMID: 31493470.
- Paliwal R, Babu RJ, Palakurthi S. Nanomedicine scale-up technologies: feasibilities and challenges. AAPS PharmSciTech. 2014 Dec;15(6):1527-34. doi: 10.1208/s12249-014-0177-9. Epub 2014 Jul 22. PMID: 25047256; PMCID: PMC4245446.
- Robertson JD, Rizzello L, Avila-Olias M, Gaitzsch J, Contini C, Magoń MS, Renshaw SA, Battaglia G. Purification of Nanoparticles by Size and Shape. Sci Rep. 2016 Jun 8;6:27494. doi: 10.1038/srep27494. PMID: 27271538; PMCID: PMC4897710.
- Aghababai Beni A, Jabbari H. Nanomaterials for environmental applications. Results in Engineering. 2022; 15:100467. doi: 10.1016/j.rineng.2022.100467.
- Harish V, Tewari D, Gaur M, Yadav AB, Swaroop S, Bechelany M, Barhoum A. Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications. Nanomaterials (Basel). 2022 Jan 28;12(3):457. doi: 10.3390/nano12030457. PMID: 35159802; PMCID: PMC8839643.
- Dobrowsky T, Gianni D, Pieracci J, Suh J. AAV manufacturing for clinical use: Insights on current challenges from the upstream process perspective. Current Opinion in Biomedical Engineering. 2021;20:100353. doi: 10.1016/j.cobme.2021.100353.
- Lamb JR, Jennings LL, Gudmundsdottir V, Gudnason V, Emilsson V. It's in Our Blood: A Glimpse of Personalized Medicine. Trends Mol Med. 2021 Jan;27(1):20-30. doi: 10.1016/j.molmed.2020.09.003. Epub 2020 Sep 25. PMID: 32988739.
- Shrestha B, Wang L, Brey EM, Uribe GR, Tang L. Smart Nanoparticles for Chemo-Based Combinational Therapy. Pharmaceutics. 2021 Jun 8;13(6):853. doi: 10.3390/pharmaceutics13060853. PMID: 34201333; PMCID: PMC8227511.
- Cook AB, Decuzzi P. Harnessing Endogenous Stimuli for Responsive Materials in Theranostics. ACS Nano. 2021 Feb 23;15(2):2068-2098. doi: 10.1021/acsnano.0c09115. Epub 2021 Feb 8. PMID: 33555171; PMCID: PMC7905878.
- Yang J, Zhang X, Zhang X, Wang L, Feng W, Li Q. Beyond the Visible: Bioinspired Infrared Adaptive Materials. Adv Mater. 2021 Apr;33(14):e2004754. doi: 10.1002/adma.202004754. Epub 2021 Feb 24. PMID: 33624900.
- Koh DM, Papanikolaou N, Bick U, Illing R, Kahn CE Jr, Kalpathi-Cramer J, Matos C, Martí-Bonmatí L, Miles A, Mun SK, Napel S, Rockall A, Sala E, Strickland N, Prior F. Artificial intelligence and machine learning in cancer imaging. Commun Med (Lond). 2022 Oct 27;2:133. doi: 10.1038/s43856-022-00199-0. PMID: 36310650; PMCID: PMC9613681.
- Sahu M, Gupta R, Ambasta RK, Kumar P. Artificial intelligence and machine learning in precision medicine: A paradigm shift in big data analysis. Prog Mol Biol Transl Sci. 2022;190(1):57-100. doi: 10.1016/bs.pmbts.2022.03.002. Epub 2022 Apr 8. PMID: 36008002.
- Van Calster B, Wynants L, Timmerman D, Steyerberg EW, Collins GS. Predictive analytics in health care: how can we know it works? J Am Med Inform Assoc. 2019 Dec 1;26(12):1651-1654. doi: 10.1093/jamia/ocz130. PMID: 31373357; PMCID: PMC6857503.
- Athanasopoulou K, Daneva NG, Adamopoulos PG, Scorilas A. Artificial intelligence: The milestone in modern biomedical research. Bio Med Informatics. 2022;2(4):727-744. doi: 10.3390/biomedinformatics2040049.
- Deng Z, Guo L, Chen X, Wu W. Smart Wearable Systems for Health Monitoring. Sensors (Basel). 2023 Feb 23;23(5):2479. doi: 10.3390/s23052479. PMID: 36904682; PMCID: PMC10007426.
- Guk K, Han G, Lim J, Jeong K, Kang T, Lim EK, Jung J. Evolution of Wearable Devices with Real-Time Disease Monitoring for Personalized Healthcare. Nanomaterials (Basel). 2019 May 29;9(6):813. doi: 10.3390/nano9060813. PMID: 31146479; PMCID: PMC6631918.
- Venkatesan M, Mohan H, Ryan JR, Schürch CM, Nolan GP, Frakes DH, Coskun AF. Virtual and augmented reality for biomedical applications. Cell Rep Med. 2021 Jul 21;2(7):100348. doi: 10.1016/j.xcrm.2021.100348. PMID: 34337564; PMCID: PMC8324499.
- Dhar P, Rocks T, Samarasinghe RM, Stephenson G, Smith C. Augmented reality in medical education: students' experiences and learning outcomes. Med Educ Online. 2021 Dec;26(1):1953953. doi: 10.1080/10872981.2021.1953953. PMID: 34259122; PMCID: PMC8281102.
- Ellwanger JH, Chies JAB. Zoonotic spillover: Understanding basic aspects for better prevention. Genet Mol Biol. 2021 Jun 4;44(1 Suppl 1):e20200355. doi: 10.1590/1678-4685-GMB-2020-0355. PMID: 34096963; PMCID: PMC8182890.
- Seal S, Dharmarajan G, Khan I. Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm. Elife. 2021 Sep 21;10:e68874. doi: 10.7554/eLife.68874. PMID: 34544548; PMCID: PMC8455132.
- Fifel K, Videnovic A. Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update. Front Neurosci. 2021 Jan 18;14:627330. doi: 10.3389/fnins.2020.627330. PMID: 33536872; PMCID: PMC7848154.
- Malhotra RK. Neurodegenerative Disorders and Sleep. Sleep Med Clin. 2022 Jun;17(2):307-314. doi: 10.1016/j.jsmc.2022.02.009. Epub 2022 Apr 22. PMID: 35659082.
- Khan MF, Wang H. Environmental Exposures and Autoimmune Diseases: Contribution of Gut Microbiome. Front Immunol. 2020 Jan 10;10:3094. doi: 10.3389/fimmu.2019.03094. PMID: 31998327; PMCID: PMC6970196.
- Faenza I, Blalock WL. Innate Immunity: A Balance between Disease and Adaption to Stress. Biomolecules. 2022 May 23;12(5):737. doi: 10.3390/biom12050737. PMID: 35625664; PMCID: PMC9138980.
- Hofer S, Hofstätter N, Punz B, Hasenkopf I, Johnson L, Himly M. Immunotoxicity of nanomaterials in health and disease: Current challenges and emerging approaches for identifying immune modifiers in susceptible populations. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022 Nov;14(6):e1804. doi: 10.1002/wnan.1804. PMID: 36416020; PMCID: PMC9787548.
- Baral B. Phages against killer superbugs: An enticing strategy against antibiotics-resistant pathogens. Front Pharmacol. 2023 Jan 24;14:1036051. doi: 10.3389/fphar.2023.1036051. PMID: 36762109; PMCID: PMC9902939.
- Parmanik A, Das S, Kar B, Bose A, Dwivedi GR, Pandey MM. Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review. Curr Microbiol. 2022 Nov 3;79(12):388. doi: 10.1007/s00284-022-03061-7. PMID: 36329256; PMCID: PMC9633024.
- Gyngell C. Gene editing and the health of future generations. J R Soc Med. 2017 Jul;110(7):276-279. doi: 10.1177/0141076817705616. Epub 2017 Apr 26. PMID: 28445654; PMCID: PMC5524257.
- Sirisena ND, Dissanayake VHW. Genetics and genomic medicine in Sri Lanka. Mol Genet Genomic Med. 2019 Jun;7(6):e744. doi: 10.1002/mgg3.744. Epub 2019 May 20. PMID: 31106988; PMCID: PMC6565544.
- Krittanawong C, Singh NK, Scheuring RA, Urquieta E, Bershad EM, Macaulay TR, Kaplin S, Dunn C, Kry SF, Russomano T, Shepanek M, Stowe RP, Kirkpatrick AW, Broderick TJ, Sibonga JD, Lee AG, Crucian BE. Human Health during Space Travel: State-of-the-Art Review. Cells. 2022 Dec 22;12(1):40. doi: 10.3390/cells12010040. PMID: 36611835; PMCID: PMC9818606.
- Drago-Ferrante R, Di Fiore R, Karouia F, Subbannayya Y, Das S, Aydogan Mathyk B, Arif S, Guevara-Cerdán AP, Seylani A, Galsinh AS, Kukulska W, Borg J, Suleiman S, Porterfield DM, Camera A, Christenson LK, Ronca AE, Steller JG, Beheshti A, Calleja-Agius J. Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review. Int J Mol Sci. 2022 Jul 5;23(13):7465. doi: 10.3390/ijms23137465. PMID: 35806469; PMCID: PMC9267413.
- Chriki S, Hocquette JF. The Myth of Cultured Meat: A Review. Front Nutr. 2020 Feb 7;7:7. doi: 10.3389/fnut.2020.00007. PMID: 32118026; PMCID: PMC7020248.
- Kumar P, Sharma N, Sharma S, Mehta N, Verma AK, Chemmalar S, Sazili AQ. In-vitro meat: a promising solution for sustainability of meat sector. J Anim Sci Technol. 2021 Jul;63(4):693-724. doi: 10.5187/jast.2021.e85. Epub 2021 Jul 31. PMID: 34447949; PMCID: PMC8367411.
- Chriki S, Ellies-Oury MP, Hocquette JF. Is "cultured meat" a viable alternative to slaughtering animals and a good comprise between animal welfare and human expectations? Anim Front. 2022 Mar 17;12(1):35-42. doi: 10.1093/af/vfac002. PMID: 35311183; PMCID: PMC8929989.
- Nancarrow SA, Booth A, Ariss S, Smith T, Enderby P, Roots A. Ten principles of good interdisciplinary team work. Hum Resour Health. 2013 May 10;11:19. doi: 10.1186/1478-4491-11-19. PMID: 23663329; PMCID: PMC3662612.
- Yadav A, Yadav K, Ahmad R, Abd-Elsalam AK. Emerging frontiers in nanotechnology for precision agriculture: Advancements, hurdles and prospects. Agrochemicals. 2023;2(2):220-256. doi: 10.3390/agrochemicals2020016.
- Liu Y, Hardie J, Zhang X, Rotello VM. Effects of engineered nanoparticles on the innate immune system. Semin Immunol. 2017 Dec;34:25-32. doi: 10.1016/j.smim.2017.09.011. Epub 2017 Oct 4. PMID: 28985993; PMCID: PMC5705289.
- Chauhan DS, Dhasmana A, Laskar P, Prasad R, Jain NK, Srivastava R, Jaggi M, Chauhan SC, Yallapu MM. Nanotechnology synergized immunoengineering for cancer. Eur J Pharm Biopharm. 2021 Jun;163:72-101. doi: 10.1016/j.ejpb.2021.03.010. Epub 2021 Mar 24. PMID: 33774162; PMCID: PMC8170847.
- Sarathkumar E, Victor M, Menon JA, Jibin K, Padmini S, Jayasree RS. Nanotechnology in cardiac stem cell therapy: cell modulation, imaging and gene delivery. RSC Adv. 2021 Oct 26;11(55):34572-34588. doi: 10.1039/d1ra06404e. PMID: 35494731; PMCID: PMC9043027.
- Kyriakopoulou E, Monnikhof T, van Rooij E. Gene editing innovations and their applications in cardiomyopathy research. Dis Model Mech. 2023 May 1;16(5):dmm050088. doi: 10.1242/dmm.050088. Epub 2023 May 24. PMID: 37222281; PMCID: PMC10233723.
- Li H, Yang Y, Hong W, Huang M, Wu M, Zhao X. Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects. Signal Transduct Target Ther. 2020 Jan 3;5(1):1. doi: 10.1038/s41392-019-0089-y. PMID: 32296011; PMCID: PMC6946647.
- Nie D, Guo T, Yue M, Li W, Zong X, Zhu Y, Huang J, Lin M. Research Progress on Nanoparticles-Based CRISPR/Cas9 System for Targeted Therapy of Tumors. Biomolecules. 2022 Sep 5;12(9):1239. doi: 10.3390/biom12091239. PMID: 36139078; PMCID: PMC9496048.
- Johansen KH. How CRISPR/Cas9 Gene Editing Is Revolutionizing T Cell Research. DNA Cell Biol. 2022 Jan;41(1):53-57. doi: 10.1089/dna.2021.0579. Epub 2021 Dec 22. PMID: 34939826; PMCID: PMC8787706.
- Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin HS. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018 Sep 19;16(1):71. doi: 10.1186/s12951-018-0392-8. PMID: 30231877; PMCID: PMC6145203.
- Goetz LH, Schork NJ. Personalized medicine: motivation, challenges, and progress. Fertil Steril. 2018 Jun;109(6):952-963. doi: 10.1016/j.fertnstert.2018.05.006. PMID: 29935653; PMCID: PMC6366451.
- Strianese O, Rizzo F, Ciccarelli M, Galasso G, D'Agostino Y, Salvati A, Del Giudice C, Tesorio P, Rusciano MR. Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease. Genes (Basel). 2020 Jul 6;11(7):747. doi: 10.3390/genes11070747. PMID: 32640513; PMCID: PMC7397223.
- Debela DT, Muzazu SG, Heraro KD, Ndalama MT, Mesele BW, Haile DC, Kitui SK, Manyazewal T. New approaches and procedures for cancer treatment: Current perspectives. SAGE Open Med. 2021 Aug 12;9:20503121211034366. doi: 10.1177/20503121211034366. PMID: 34408877; PMCID: PMC8366192.
- Samal L, Fu HN, Camara DS, Wang J, Bierman AS, Dorr DA. Health information technology to improve care for people with multiple chronic conditions. Health Serv Res. 2021 Oct;56 Suppl 1(Suppl 1):1006-1036. doi: 10.1111/1475-6773.13860. Epub 2021 Oct 5. PMID: 34363220; PMCID: PMC8515226.
- Gibbs P, Beavis A. Contemporary thinking on transdisciplinary knowledge: What those who know, know. Springer Nature; 2020.