Prevalence, Predictors and Diagnosis of Cardiac Amyloidosis in Patients with Aortic Stenosis

Syed Bukhari*

Syed Bukhari*

Volume4-Issue9
Dates: Received: 2023-08-26 | Accepted: 2023-09-12 | Published: 2023-09-13
Pages: 1277-1280

Abstract

Cardiac amyloidosis and aortic stenosis often share a common clinical phenotype, and are associated with morbidity and mortality if untreated. Cardiac amyloidosis is present in ~15% of patients with aortic stenosis. Clinical suspicion for cardiac amyloidosis in aortic stenosis is often raised based on history (bilateral carpal tunnel syndrome, severe lumbar spinal stenosis, spontaneous biceps rupture), chronic troponin elevation, electrocardiographic features (low-voltage criteria, pseudoinfarct pattern), echocardiogram (bilateral ventricular hypertrophy, abnormal longitudinal strain) and magnetic resonance imaging (late gadolinium enhancement, elevated T1 and T2). Eventual diagnosis of cardiac amyloidosis is based either on pyrophosphate nuclear scintigraphy or tissue biopsy depending on which subtype of cardiac amyloidosis is suspected.

FullText HTML FullText PDF DOI: 10.37871/jbres1796

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How to cite this article

Bukhari S. Prevalence, Predictors and Diagnosis of Cardiac Amyloidosis in Patients with Aortic Stenosis. 2023 Sep 13; 4(9): 1277-1280. doi: 10.37871/jbres1796, Article ID: JBRES1796, Available at: https://www.jelsciences.com/articles/ jbres1796.pdf

Subject area(s)

Cardiovascular Diseases

References

Bukhari S, Kasi A, Khan B. Bradyarrhythmias in Cardiac Amyloidosis and Role of Pacemaker. Curr Probl Cardiol. 2023 Jun 30;48(11):101912. doi: 10.1016/j.cpcardiol.2023.101912. Epub ahead of print. PMID: 37392977.
Masri A, Bukhari S, Eisele YS, Soman P. Molecular Imaging of Cardiac Amyloidosis. J Nucl Med. 2020 Jul;61(7):965-970. doi: 10.2967/jnumed.120.245381. Epub 2020 Jun 1. PMID: 32482792; PMCID: PMC9374028.
Bukhari S, Barakat AF, Eisele YS, Nieves R, Jain S, Saba S, Follansbee WP, Brownell A, Soman P. Prevalence of Atrial Fibrillation and Thromboembolic Risk in Wild-Type Transthyretin Amyloid Cardiomyopathy. Circulation. 2021 Mar 30;143(13):1335-1337. doi: 10.1161/CIRCULATIONAHA.120.052136. Epub 2021 Mar 29. PMID: 33779268.
Bukhari S, Oliveros E, Parekh H, Farmakis D. Epidemiology, Mechanisms, and Management of Atrial Fibrillation in Cardiac Amyloidosis. Curr Probl Cardiol. 2023 Apr;48(4):101571. doi: 10.1016/j.cpcardiol.2022.101571. Epub 2022 Dec 28. PMID: 36584731.
Bukhari S, Fatima S, Nieves R, Ibrahim J, Brownell A, Soman P. Bleeding risk associated with transthyretin cardiac amyloidosis. Journal of the American College of Cardiology. 2021;77(18_Supplement_1):530.
Bukhari S, Fatima S, Elgendy IY. Cardiogenic shock in the setting of acute myocardial infarction: Another area of sex disparity? World J Cardiol. 2021 Jun 26;13(6):170-176. doi: 10.4330/wjc.v13.i6.170. PMID: 34194635; PMCID: PMC8223697.
Bukhari S. Cardiac amyloidosis: state-of-the-art review. J Geriatr Cardiol. 2023 May 28;20(5):361-375. doi: 10.26599/1671-5411.2023.05.006. PMID: 37397865; PMCID: PMC10308177.
Bukhari S, Bashir Z, Shpilsky D, Eisele YS, Soman P. Reduced ejection fraction at diagnosis is an independent predictor of mortality in transthyretin amyloid cardiomyopathy. Circulation. 2020;142(Suppl_3):A16145.
Bukhari S, Khan B. Prevalence of ventricular arrhythmias and role of implantable cardioverter-defibrillator in cardiac amyloidosis. J Cardiol. 2023 May;81(5):429-433. doi: 10.1016/j.jjcc.2023.02.009. Epub 2023 Mar 7. PMID: 36894119.
Ternacle J, Krapf L, Mohty D, Magne J, Nguyen A, Galat A, Gallet R, Teiger E, Côté N, Clavel MA, Tournoux F, Pibarot P, Damy T. Aortic Stenosis and Cardiac Amyloidosis: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 Nov 26;74(21):2638-2651. doi: 10.1016/j.jacc.2019.09.056. PMID: 31753206.
Nitsche C, Scully PR, Patel KP, Kammerlander AA, Koschutnik M, Dona C, Wollenweber T, Ahmed N, Thornton GD, Kelion AD, Sabharwal N, Newton JD, Ozkor M, Kennon S, Mullen M, Lloyd G, Fontana M, Hawkins PN, Pugliese F, Menezes LJ, Moon JC, Mascherbauer J, Treibel TA. Prevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis. J Am Coll Cardiol. 2021 Jan 19;77(2):128-139. doi: 10.1016/j.jacc.2020.11.006. Epub 2020 Nov 9. PMID: 33181246
Scully PR, Patel KP, Treibel TA, Thornton GD, Hughes RK, Chadalavada S, Katsoulis M, Hartman N, Fontana M, Pugliese F, Sabharwal N, Newton JD, Kelion A, Ozkor M, Kennon S, Mullen M, Lloyd G, Menezes LJ, Hawkins PN, Moon JC. Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation. Eur Heart J. 2020 Aug 1;41(29):2759-2767. doi: 10.1093/eurheartj/ehaa170. PMID: 32267922
Treibel TA, Fontana M, Gilbertson JA, Castelletti S, White SK, Scully PR, Roberts N, Hutt DF, Rowczenio DM, Whelan CJ, Ashworth MA, Gillmore JD, Hawkins PN, Moon JC. Occult Transthyretin Cardiac Amyloid in Severe Calcific Aortic Stenosis: Prevalence and Prognosis in Patients Undergoing Surgical Aortic Valve Replacement. Circ Cardiovasc Imaging. 2016 Aug;9(8):e005066. doi: 10.1161/CIRCIMAGING.116.005066. PMID: 27511979.
Bukhari S. Musculoskeletal manifestations of transthyretin cardiac amyloidosis. J Biomed Res Environ Sci. 2023;4(8): 1233-1235. doi: 10.37871/jbres1789.
Bukhari S, Barakat A, Mulukutla S, Thoma F, Eisele YS, Nieves R, Shpilsky D, Soman P. Faster progression of left ventricular thickness in men compared to women in wild-type transthyretin cardiac amyloidosis. Journal of the American College of Cardiology. 2020;75(11_Supplement_1):812.
Bukhari S, Malhotra S, Shpilsky D, Nieves R, Soman P. Amyloidosis prediction score: A clinical model for diagnosing transthyretin cardiac amyloidosis. Journal of Cardiac Failure. 2020;26(10):S33. doi: 10.1016/j.cardfail.2020.09.100.
Nieves RA, Bukhari S, Harinstein ME. Adding value to myocardial perfusion scintigraphy: A prediction tool to predict adverse cardiac outcomes and risk stratify. J Nucl Cardiol. 2021 Oct;28(5):2283-2285. doi: 10.1007/s12350-021-02670-2. Epub 2021 Jun 24. PMID: 34169472.
Bukhari S, Brownell A, Nieves R, Eisele Y, Follansbee W, Soman P. Clinical Predictors of positive Tc-99m pyrophosphate scan in patients hospitalized for decompensated heart failure. Journal of Nuclear Medicine. 2020;659.
Elgendy IY, Bukhari S, Barakat AF, Pepine CJ, Lindley KJ, Miller EC; American College of Cardiology Cardiovascular Disease in Women Committee. Maternal Stroke: A Call for Action. Circulation. 2021 Feb 16;143(7):727-738. doi: 10.1161/CIRCULATIONAHA.120.051460. Epub 2021 Feb 15. PMID: 33587666; PMCID: PMC8049095.
Bukhari S, Yaghi S, Bashir Z. Stroke in Young Adults. J Clin Med. 2023 Jul 29;12(15):4999. doi: 10.3390/jcm12154999. PMID: 37568401; PMCID: PMC10420127.
Bukhari S, Fatima S, Barakat AF, Fogerty AE, Weinberg I, Elgendy IY. Venous thromboembolism during pregnancy and postpartum period. Eur J Intern Med. 2022 Mar;97:8-17. doi: 10.1016/j.ejim.2021.12.013. Epub 2021 Dec 20. PMID: 34949492.
Bukhari S, Brownell A, Nieves R, Eisele YS, Follansbee W, Soman P. Prevalence and characteristics of wild type transthyretin amyloid cardiomyopathy in hospitalized patients referred for TC-99M pyrophosphate (PYP) scan. Journal of the American College of Cardiology. 2020;75(11_Supplement_1):811.
Bukhari S, Nieves R, Fatima S, Iyer A, Soman P. Hypertrophic cardiomyopathy mimicking amyloid cardiomyopathy. Journal of the American College of Cardiology. 2021;77(18_Supplement_1):1921.
Bukhari S, Fatima S, Brownell A, Eisele YS, Soman P. Race-specific phenotypic and genotypic comparison of patients with transthyretin cardiac amyloidosis. Journal of the American College of Cardiology. 2021;77(18_Supplement_1):675.
Bukhari S, Masri A, Ahmad S, Eisele Y, Brownell A, Soman P. Discrepant Tc-99m PYP planar grade and H/CL ratio: Which correlates better with diffuse tracer uptake on SPECT? Journal of Nuclear Medicine. 2020;61(supplement 1):1633.
Masri A, Bukhari S, Ahmad S, Nieves R, Eisele YS, Follansbee W, Brownell A, Wong TC, Schelbert E, Soman P. Efficient 1-Hour Technetium-99 m Pyrophosphate Imaging Protocol for the Diagnosis of Transthyretin Cardiac Amyloidosis. Circ Cardiovasc Imaging. 2020 Feb;13(2):e010249. doi: 10.1161/CIRCIMAGING.119.010249. Epub 2020 Feb 17. PMID: 32063053; PMCID: PMC7032611.
Fatima S, Bukhari S, Pacella J. The cardiovascular implications of COVID-19: A comprehensive review. Medical Research Archives. 2020;8(5). doi: 10.18103/mra.v8i5.2140.
Brazile T, Barakat AF, Bukhari S, Schelbert EB, Soman P. A 25-Year-Old Man with Refractory Schizophrenia and Clozapine-Induced Myocarditis Diagnosed by Non-Invasive Cardiovascular Magnetic Resonance. Am J Case Rep. 2021 May 15;22:e930103. doi: 10.12659/AJCR.930103. PMID: 33990535; PMCID: PMC8130977.
Malayala SV, Bukhari S, Vanaparthy R, Raza A, Akella R. A Case of COVID-19 Induced Descending Aortic Thrombus and Splenic Infarctions. J Community Hosp Intern Med Perspect. 2022 Sep 9;12(5):88-92. doi: 10.55729/2000-9666.1100. PMID: 36262483; PMCID: PMC9529656.
Nitsche C, Mascherbauer J. Double trouble: severe aortic stenosis and cardiac amyloidosis. Wien Klin Wochenschr. 2020 Dec;132(23-24):705-707. doi: 10.1007/s00508-020-01787-7. PMID: 33306134.
Sud K, Narula N, Aikawa E, Arbustini E, Pibarot P, Merlini G, Rosenson RS, Seshan SV, Argulian E, Ahmadi A, Zhou F, Moreira AL, Côté N, Tsimikas S, Fuster V, Gandy S, Bonow RO, Gursky O, Narula J. The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis. Nat Rev Cardiol. 2023 Jun;20(6):418-428. doi: 10.1038/s41569-022-00818-2. Epub 2023 Jan 9. Erratum in: Nat Rev Cardiol. 2023 Feb 17;: PMID: 36624274; PMCID: PMC10199673.