Samya A Isa*, Ayman Haq and Mustafa M Husain
Volume4-Issue6
Dates: Received: 2023-04-13 | Accepted: 2023-06-23 | Published: 2023-06-27
Pages: 1083-1091
Abstract
Objective: Anxiety is partly driven by changes in neuroendocrine signaling, which continues to be an area of study. Birds are a useful model to study anxiety disorders due to their unique behaviors and social makeup, leading to several observable behaviors indicative of anxiety.
Methods: Using PRISMA guidelines, a systematic review of studies published from January 2000 to August 2022 in PubMed, PsycINFO and MedLine was conducted. Inclusion criteria included animal studies utilizing an avian model, examining the relationship between a neuroendocrine biomarker and behavioral displays of anxiety. Exclusion criteria included review articles, editorials, studies where anxiolytic drugs were used and studies where anxiety was not the primary studied behavior.
Results: 376 articles were screened. 10 papers met the review criteria. Dopamine, serotonin and glycogen synthase kinase 3β (GSK-3β) were found to be inversely related to anxiety levels. Ghrelin and γ-Aminobutyric acid type A (GABAa) were directly correlated with anxiety levels. Corticosterone correlated in a bidirectional manner depending on when a stress was applied, however, lower levels at baseline were more predictive of less anxious birds. Pituitary adenylate cyclase was shown to increase anxiety but was also time-dependent. Arginine vaso-peptide was found to reduce anxiety, but was also context-dependent. Vasointestinal Peptide had no relation to anxiety.
Conclusion: Birds display similar chemical responses to humans when anxious, and due to anxiety-related behaviors unique to birds, allow for an additional approach to the investigation of different neuroendocrine markers that are not always strongly considered when studying the neurobiology of anxiety in humans.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1771
Certificate of Publication
Copyright
© 2023 Isa SA, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Isa SA, Haq A, Husain MM. Avian Models of the Neurobiology of Anxiety: A Systematic Review. 2023 June 27; 4(6): 1083-1091. doi: 10.37871/jbres1771, Article ID: JBRES1771, Available at: https://www.jelsciences.com/articles/jbres1771.pdf
Subject area(s)
References
- Łoś K, Waszkiewicz N. Biological Markers in Anxiety Disorders. J Clin Med. 2021 Apr 17;10(8):1744. doi: 10.3390/jcm10081744. PMID: 33920547; PMCID: PMC8073190.
- Boulay J, Chaillou E, Bertin A, Constantin P, Arnould C, Leterrier C, Calandreau L. A higher inherent trait for fearfulness is associated with increased anxiety-like behaviours and diazepam sensitivity in Japanese quail. Behav Brain Res. 2013 Jan 15;237:124-8. doi: 10.1016/j.bbr.2012.09.026. Epub 2012 Sep 20. PMID: 23000529.
- Hymel KA, Sufka KJ. Pharmacological reversal of cognitive bias in the chick anxiety-depression model. Neuropharmacology. 2012 Jan;62(1):161-6. doi: 10.1016/j.neuropharm.2011.06.009. Epub 2011 Jun 23. PMID: 21722654.
- Sufka KJ, Warnick JE, Pulaski CN, Slauson SR, Kim YB, Rimoldi JM. Antidepressant efficacy screening of novel targets in the chick anxiety-depression model. Behav Pharmacol. 2009 Mar;20(2):146-54. doi: 10.1097/FBP.0b013e32832a8082. PMID: 19300238.
- Kelly AM, Goodson JL. Functional interactions of dopamine cell groups reflect personality, sex, and social context in highly social finches. Behav Brain Res. 2015 Mar 1;280:101-12. doi: 10.1016/j.bbr.2014.12.004. Epub 2014 Dec 8. PMID: 25496780.
- Lattin CR, Merullo DP, Riters LV, Carson RE. In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird. Sci Rep. 2019 Jul 18;9(1):10407. doi: 10.1038/s41598-019-46845-x. PMID: 31320692; PMCID: PMC6639298.
- Gastón MS, Schiöth HB, De Barioglio SR, Salvatierra NA. Gabaergic control of anxiety-like behavior, but not food intake, induced by ghrelin in the intermediate medial mesopallium of the neonatal chick. Horm Behav. 2015 Jan;67:66-72. doi: 10.1016/j.yhbeh.2014.11.015. Epub 2014 Dec 9. PMID: 25499794.
- Krause ET, Kjaer JB, Lüders C, van LP. A polymorphism in the 5'-flanking region of the serotonin transporter (5-HTT) gene affects fear-related behaviors of adult domestic chickens. Behav Brain Res. 2017 Jul 14;330:92-96. doi: 10.1016/j.bbr.2017.04.051. Epub 2017 Apr 29. PMID: 28465138.
- Carvajal P, Carlini VP, Schiöth HB, de Barioglio SR, Salvatierra NA. Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks. Neurobiol Learn Mem. 2009 May;91(4):402-7. doi: 10.1016/j.nlm.2008.12.008. Epub 2009 Jan 31. PMID: 19146965.
- Kingsbury MA, Miller KM, Goodson JL. VPAC receptor signaling modulates grouping behavior and social responses to contextual novelty in a gregarious finch: a role for a putative prefrontal cortex homologue. Horm Behav. 2013 Aug;64(3):511-8. doi: 10.1016/j.yhbeh.2013.07.004. Epub 2013 Jul 27. PMID: 23899763; PMCID: PMC3864561.
- Goodson JL, Evans AK. Neural responses to territorial challenge and nonsocial stress in male song sparrows: segregation, integration, and modulation by a vasopressin V1 antagonist. Horm Behav. 2004 Nov;46(4):371-81. doi: 10.1016/j.yhbeh.2004.02.008. PMID: 15465522.
- Moaraf S, Rippin I, Terkel J, Eldar-Finkelman H, Barnea A. GSK-3β Inhibition in Birds Affects Social Behavior and Increases Motor Activity. Front Physiol. 2022 Apr 28;13:881174. doi: 10.3389/fphys.2022.881174. PMID: 35574473; PMCID: PMC9095836.
- Hollósy T, Józsa R, Jakab B, Németh J, Lengvári I, Reglodi D. Effects of in ovo treatment with PACAP antagonist on general activity, motor and social behavior of chickens. Regul Pept. 2004 Dec 15;123(1-3):99-106. doi: 10.1016/j.regpep.2004.05.018. PMID: 15518899.
- Gastón MS, Cid MP, Salvatierra NA. Bicuculline, a GABAA-receptor antagonist, blocked HPA axis activation induced by ghrelin under an acute stress. Behav Brain Res. 2017 Mar 1;320:464-472. doi: 10.1016/j.bbr.2016.10.035. Epub 2016 Oct 22. PMID: 27780724.
