Maria Teresa Audicana*, Paula Ollo, Natividad Longo, Marta Velasco, Ariadna Besga and Eduardo Fernandez
Volume4-Issue6
Dates: Received: 2023-05-22 | Accepted: 2023-06-06 | Published: 2023-06-10
Pages: 993-998
Abstract
The prevalence of fish, seafood and Anisakis allergy varies greatly depending on country-specific eating habits, assuming that the highest consumption corresponds to the highest prevalence. Mediterranean countries are particularly affected.
Hereditary Alpha-Tryptasemia (HaT) is a common autosomal dominant genetic trait recently identified. Although it is estimated to affect approximately 1 in 20 individuals of white European origin, a diagnostic method is not routinely available.
Here by we present the cases of two families with different allergic reaction phenotypes to fish and seafood, IgE and no IgE mediated reactions. The current review focused on the impact of the diagnosis of HaT in families, particularly when the mutation is symptomatic and the affectation from an early age and in both sexes and finally this review tried to warn about the possible involvement of Anisakis in allergic reactions in patients with HaT.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1759
Certificate of Publication

Copyright
© 2023 Audicana MT, et al. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Audicana MT, Ollo P, Longo N, Velasco M, Besga A, Fernández E. Is Anisakis simplex a Trigger for Anaphylactic Reactions in Hereditary Alpha-Tryptasemia?. 2023 June 10; 4(6): 993-998. doi: 10.37871/jbres1759, Article ID: JBRES1759, Available at: https://www.jelsciences.com/articles/jbres1759.pdf
Subject area(s)
References
- Audicana MT, Fernández de Corres L, Muñoz D, Fernández E, Navarro JA, del Pozo MD. Recurrent anaphylaxis caused by Anisakis simplex parasitizing fish. J Allergy Clin Immunol. 1995 Oct;96(4):558-60. doi: 10.1016/s0091-6749(95)70301-2. PMID: 7560669.
- Audicana MT, Kennedy MW. Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity. Clin Microbiol Rev. 2008 Apr;21(2):360-79, table of contents. doi: 10.1128/CMR.00012-07. PMID: 18400801; PMCID: PMC2292572.
- Audicana MT. Anisakis, Something Is Moving inside the Fish. Pathogens. 2022 Mar 7;11(3):326. doi: 10.3390/pathogens11030326. PMID: 35335650; PMCID: PMC8950136.
- EFSA BIOHAZ Panel, 2010. Scientific opinion on risk assessment of parasites in fishery products. EFSA Journal 2010;8(4):1543. doi: 10.2903/j.efsa.2010.1543.
- Lyons JJ. Hereditary alpha-tryptasemia. 2022.
- Hamilton MJ, Zhao M, Giannetti MP, Weller E, Hufdhi R, Novak P, Mendoza-Alvarez LB, Hornick J, Lyons JJ, Glover SC, Castells MC, Pozdnyakova O. Distinct Small Intestine Mast Cell Histologic Changes in Patients With Hereditary Alpha-tryptasemia and Mast Cell Activation Syndrome. Am J Surg Pathol. 2021 Jul 1;45(7):997-1004. doi: 10.1097/PAS.0000000000001676. PMID: 33481382; PMCID: PMC8192345.
- Le QT, Lyons JJ, Naranjo AN, Olivera A, Lazarus RA, Metcalfe DD, Milner JD, Schwartz LB. Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia. J Exp Med. 2019 Oct 7;216(10):2348-2361. doi: 10.1084/jem.20190701. Epub 2019 Jul 23. PMID: 31337736; PMCID: PMC6780998.
- Lyons JJ, Greiner G, Hoermann G, Metcalfe DD. Incorporating Tryptase Genotyping Into the Workup and Diagnosis of Mast Cell Diseases and Reactions. J Allergy Clin Immunol Pract. 2022 Aug;10(8):1964-1973. doi: 10.1016/j.jaip.2022.05.003. Epub 2022 May 18. PMID: 35597543.
- Sordi B, Vanderwert F, Crupi F, Gesullo F, Zanotti R, Bonadonna P, Crosera L, Elena C, Fiorelli N, Ferrari J, Grifoni F, Sciumè M, Parente R, Triggiani M, Palterer B, Mecheri V, Almerigogna F, Santi R, Di Medio L, Brandi ML, Iorno ML, Ciardetti I, Bencini S, Annunziato F, Mannarelli C, Pieri L, Guglielmelli P, Mannelli F, Vannucchi AM. Disease correlates and clinical relevance of hereditary α-tryptasemia in patients with systemic mastocytosis. J Allergy Clin Immunol. 2023 Feb;151(2):485-493.e11. doi: 10.1016/j.jaci.2022.09.038. Epub 2022 Oct 27. PMID: 36309122.
- Pyatilova P, Akin C, Alvarez-Twose I, Arock M, Bonadonna P, Brockow K, Butterfield JH, Broesby-Olsen S, Carter MC, Castells M, George TI, Gotlib J, Greiner G, Gülen T, Hartmann K, Hermine O, Horny HP, Jawhar M, Lange M, Lyons JJ, Maurer M, Metcalfe DD, Nedoszytko B, Niedoszytko M, Orfao A, Reiter A, Schwaab J, Sotlar K, Sperr WR, Triggiani M, Valent P, Siebenhaar F. Refined Treatment Response Criteria for Indolent Systemic Mastocytosis Proposed by the ECNM-AIM Consortium. J Allergy Clin Immunol Pract. 2022 Aug;10(8):2015-2024. doi: 10.1016/j.jaip.2022.05.037. Epub 2022 Jun 18. PMID: 35724950.