Prevalence and Associated Factors of Soil Transmitted Helminths (Sths) and Schistosomes Mansoni Among School-Age Children in West Ethiopia

Habtamu Tadesse Gudeta*; Kifle Woldemichael Hajito; Mamo Nigatu

**Habtamu Tadesse Gudeta*, Kifle Woldemichael Hajito and Mamo Nigatu**

Volume4-Issue5
Dates: Received: 2023-05-06 | Accepted: 2023-05-22 | Published: 2023-05-30
Pages: 917-934

Abstract

Background: Soil-Transmitted Helminths (STHs) and schistosomes have been major public health problems in tropical and sub-tropical developing countries. School-age and preschool children are predominantly affected by soil-transmitted helminths and schistosomes. Parasite infections may cause micronutrient deficiency that results in anemia, growth retardation, and impaired cognitive development among children.

Objective: This study aimed to determine the prevalence and associated factors of soil-transmitted helminths and schistosomes among school-aged children.

Methods: A community-based cross-sectional study was conducted among 307 school-age children in West Ethiopia. Data regarding associated factors was collected through face-to-face interviews using a structured questionnaire. The stool specimen was examined for the existence of parasitic agents according to standard operating procedures. The data was entered into Epi-Data version3.1 and then exported to SPSS version 22 for analysis. Bivariate and multivariable logistic regressions were computed. Variables with a p ≤ 0.25 on the bivariate analysis were candidates for the multivariable analysis. The significance of the association was declared by a 95% confidence interval of AOR and a p < 0.05 in the multivariate model.

Result: A total of 307 stool samples were collected from school-age children who were included in the study. This study's results showed that the prevalence of intestinal parasitic infections was 40.4%. The most predominant intestinal parasitic infections were Ascaris lumbricoid (38.7%), followed by Hookworm (27.4%), and Trichuris trichiura (26.6%). Not handwashing after toilet (AOR = 2.19,95% (1.27-4.63) p = 0.025), eating unwashed fruits (AOR = 2.28,95% CI(1.209-4.29) p = 0.011), unclean fingernails (AOR = 2.38,95% CI(1.20-4.54), p = 0.013), eating street food (AOR = 2.98,95%CI (1.809-6.37, p = 0.001), unprotected water source (AOR = 2.87,95% CI(1.47) p = 5.56) (p = 0.002) and poor knowledge about the ways of transmission of IPIs (AOR = 2.28, 95% CI(1.01-5.12), p = 0.046) were found to be significantly associated with intestinal parasitic infections.

Conclusion: This study findings revealed a high prevalence of multiple parasitic infections that need annual mass deworming. This study called for mass drug administration, the provision of clean water supplies, scaling sanitation and hygiene, and health education.

FullText HTML FullText PDF DOI: 10.37871/jbres1753

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How to cite this article

Gudeta HT, Hajito KW, Nigatu M. Prevalence and Associated Factors of Soil Transmitted Helminths (Sths) and Schistosomes Mansoni Among School-Age Children in West Ethiopia. J Biomed Res Environ Sci. 2023 May 30; 4(5): 917-934. doi: 10.37871/jbres1753, Article ID: JBRES1753, Available at: https://www.jelsciences.com/articles/jbres1753.pdf

Subject area(s)

Community Health

References

Negussu N, Mengistu B, Kebede B, Deribe K, Ejigu E, Tadesse G, Mekete K, Sileshi M. Ethiopia Schistosomiasis and Soil-Transmitted Helminthes Control Programme: Progress and Prospects. Ethiop Med J. 2017;55(Suppl 1):75-80. PMID: 28878432; PMCID: PMC5582635.
Organization WH. Soil-transmitted helminthiases: eliminating as public health problem soil-transmitted helminthiases in children: progress report 2001-2010 and strategic plan 2011-2020. 2012.
Hotez PJ, Alvarado M, Basáñez MG, Bolliger I, Bourne R, Boussinesq M, Brooker SJ, Brown AS, Buckle G, Budke CM, Carabin H, Coffeng LE, Fèvre EM, Fürst T, Halasa YA, Jasrasaria R, Johns NE, Keiser J, King CH, Lozano R, Murdoch ME, O'Hanlon S, Pion SD, Pullan RL, Ramaiah KD, Roberts T, Shepard DS, Smith JL, Stolk WA, Undurraga EA, Utzinger J, Wang M, Murray CJ, Naghavi M. The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases. PLoS Negl Trop Dis. 2014 Jul 24;8(7):e2865. doi: 10.1371/journal.pntd.0002865. PMID: 25058013; PMCID: PMC4109880.
Hotez PJ, Kamath A. Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis. 2009 Aug 25;3(8):e412. doi: 10.1371/journal.pntd.0000412. PMID: 19707588; PMCID: PMC2727001.
Hotez PJ, Fenwick A, Savioli L, Molyneux DH. Rescuing the bottom billion through control of neglected tropical diseases. Lancet. 2009 May 2;373(9674):1570-5. doi: 10.1016/S0140-6736(09)60233-6. PMID: 19410718.
Norris J, Adelman C, Spantchak Y, Marano K. Social and economic impact review on neglected tropical diseases. Economic Policy/Briefing Paper Washington DC: Hudson Institute. 2012.
Mather W, Hutchings P, Budge S, Jeffrey P. Association between water and sanitation service levels and soil-transmitted helminth infection risk factors: a cross-sectional study in rural Rwanda. Trans R Soc Trop Med Hyg. 2020 May 7;114(5):332-338. doi: 10.1093/trstmh/trz119. PMID: 32052038.
Karshima SN. Prevalence and distribution of soil-transmitted helminth infections in Nigerian children: a systematic review and meta-analysis. Infect Dis Poverty. 2018 Jul 9;7(1):69. doi: 10.1186/s40249-018-0451-2. PMID: 29983115; PMCID: PMC6036687.
Strunz EC, Addiss DG, Stocks ME, Ogden S, Utzinger J, Freeman MC. Water, sanitation, hygiene, and soil-transmitted helminth infection: a systematic review and meta-analysis. PLoS Med. 2014 Mar 25;11(3):e1001620. doi: 10.1371/journal.pmed.1001620. PMID: 24667810; PMCID: PMC3965411.
Organization WH. Soil-transmitted helminthiases: eliminating as public health problem soil-transmitted helminthiases in children: progress report 2001-2010 and strategic plan 2011-2020: World Health Organization; 2012.
WHO Expert Committee. Prevention and control of schistosomiasis and soil-transmitted helminthiasis. World Health Organ Tech Rep Ser. 2002;912:i-vi, 1-57, back cover. PMID: 12592987.
Chelkeba L, Mekonnen Z, Emana D, Jimma W, Melaku T. Prevalence of soil-transmitted helminths infections among preschool and school-age children in Ethiopia: a systematic review and meta-analysis. Glob Health Res Policy. 2022 Mar 21;7(1):9. doi: 10.1186/s41256-022-00239-1. PMID: 35307028; PMCID: PMC8935818.
Hotez PJ, Molyneux DH, Fenwick A, Savioli L, Takeuchi T. A Global Fund to Fight Neglected Tropical Diseases: is the G8 Hokkaido Toyako 2008 Summit ready? PLoS Negl Trop Dis. 2008 Mar 26;2(3):e220. doi: 10.1371/journal.pntd.0000220. PMID: 18365038; PMCID: PMC2268747.
Edelduok E, Eyo J, Ekpe E. Soil-transmitted helminth infections in relation to the knowledge and practice of preventive measures among school children in rural communities in South-Eastern Nigeria. IOSR Journal of Pharmacy and Biological Sciences. 2013;5(6):33-7.
Strunz EC, Suchdev PS, Addiss DG. Soil-Transmitted Helminthiasis and Vitamin A Deficiency: Two Problems, One Policy. Trends Parasitol. 2016 Jan;32(1):10-18. doi: 10.1016/j.pt.2015.11.007. Epub 2015 Dec 24. PMID: 26724966.
Lo NC, Addiss DG, Hotez PJ, King CH, Stothard JR, Evans DS, Colley DG, Lin W, Coulibaly JT, Bustinduy AL, Raso G, Bendavid E, Bogoch II, Fenwick A, Savioli L, Molyneux D, Utzinger J, Andrews JR. A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now. Lancet Infect Dis. 2017 Feb;17(2):e64-e69. doi: 10.1016/S1473-3099(16)30535-7. Epub 2016 Nov 30. PMID: 27914852; PMCID: PMC5280090.
Karagiannis-Voules DA, Biedermann P, Ekpo UF, Garba A, Langer E, Mathieu E, Midzi N, Mwinzi P, Polderman AM, Raso G, Sacko M, Talla I, Tchuenté LA, Touré S, Winkler MS, Utzinger J, Vounatsou P. Spatial and temporal distribution of soil-transmitted helminth infection in sub-Saharan Africa: a systematic review and geostatistical meta-analysis. Lancet Infect Dis. 2015 Jan;15(1):74-84. doi: 10.1016/S1473-3099(14)71004-7. Epub 2014 Dec 3. PMID: 25486852.
Pullan RL, Brooker SJ. The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit Vectors. 2012 Apr 26;5:81. doi: 10.1186/1756-3305-5-81. PMID: 22537799; PMCID: PMC3419672.
Hotez PJ, Kamath A. Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl Trop Dis. 2009 Aug 25;3(8):e412. doi: 10.1371/journal.pntd.0000412. PMID: 19707588; PMCID: PMC2727001.
Warunee N, Choomanee L, Sataporn P, Rapeeporn Y, Nuttapong W, Sompong S, Thongdee S, Bang-On S, Rachada K. Intestinal parasitic infections among school children in Thailand. Trop Biomed. 2007 Dec;24(2):83-8. PMID: 18209713.
Rivero MR, De Angelo C, Nuñez P, Salas M, Liang S. Intestinal parasitism and nutritional status among indigenous children from the Argentinian Atlantic Forest: Determinants of enteroparasites infections in minority populations. Acta tropica. 2018;187:248-56.
Osman M, El Safadi D, Cian A, Benamrouz S, Nourrisson C, Poirier P, Pereira B, Razakandrainibe R, Pinon A, Lambert C, Wawrzyniak I, Dabboussi F, Delbac F, Favennec L, Hamze M, Viscogliosi E, Certad G. Prevalence and Risk Factors for Intestinal Protozoan Infections with Cryptosporidium, Giardia, Blastocystis and Dientamoeba among Schoolchildren in Tripoli, Lebanon. PLoS Negl Trop Dis. 2016 Mar 14;10(3):e0004496. doi: 10.1371/journal.pntd.0004496. Erratum in: PLoS Negl Trop Dis. 2016 Apr;10(4):e0004643. PMID: 26974335; PMCID: PMC4790957.
Tanner M, Burnier E, Mayombana C, Betschart B, de Savigny D, Marti HP, Suter R, Aellen M, Lüdin E, Degrémont AA. Longitudinal study on the health status of children in a rural Tanzanian community: parasitoses and nutrition following control measures against intestinal parasites. Acta Trop. 1987 Jun;44(2):137-74. PMID: 2891267.
Abdel-Aziz MA, Afifi AA, Malik EM, Adam I. Intestinal protozoa and intestinal helminthic infections among schoolchildren in Central Sudan. Asian Pacific Journal of Tropical Medicine. 2010;3(4):292-3.
Erismann S, Diagbouga S, Odermatt P, Knoblauch AM, Gerold J, Shrestha A, Grissoum T, Kaboré A, Schindler C, Utzinger J, Cissé G. Prevalence of intestinal parasitic infections and associated risk factors among schoolchildren in the Plateau Central and Centre-Ouest regions of Burkina Faso. Parasit Vectors. 2016 Oct 18;9(1):554. doi: 10.1186/s13071-016-1835-4. PMID: 27756339; PMCID: PMC5069922.
Gyang VP, Chuang TW, Liao CW, Lee YL, Akinwale OP, Orok A, Ajibaye O, Babasola AJ, Cheng PC, Chou CM, Huang YC, Sonko P, Fan CK. Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. J Microbiol Immunol Infect. 2019 Feb;52(1):106-113. doi: 10.1016/j.jmii.2016.09.005. Epub 2017 Jun 22. PMID: 28711437.
Abdi M, Nibret E, Munshea A. Prevalence of intestinal helminthic infections and malnutrition among schoolchildren of the Zegie Peninsula, northwestern Ethiopia. J Infect Public Health. 2017 Jan-Feb;10(1):84-92. doi: 10.1016/j.jiph.2016.02.009. Epub 2016 Mar 26. PMID: 27026133.
Emana D, Jemal K, Bajiro M, Mekonnen Z. Prevalence and intensity of soil-transmitted helminths among school-aged children in Sigmo Primary School, Jimma Zone, South-Western Ethiopia. Clinical Medicine Research. 2015;4(4):98-103.
Tefera E, Belay T, Mekonnen SK, Zeynudin A, Belachew T. Prevalence and intensity of soil transmitted helminths among school children of Mendera Elementary School, Jimma, Southwest Ethiopia. The Pan African Medical Journal. 2017;27.
Kidane E, Menkir S, Kebede A, Desta M. Prevalence of intestinal parasitic infections and their associations with anthropometric measurements of school children in selected primary schools, Wukro Town, Eastern Tigray, Ethiopia. Int J Curr Microbiol Appl Sci. 2014;3(3):11-29.
Gebretsadik G. Prevalence of intestinal parasites and associated risk factors among schoolchildren of Homesha district (Woreda) in Benishangul-Gumuz regional state, western Ethiopia. J Fam Med Health Care. 2016;2(4):57-64.
Hailegebriel T. Prevalence of intestinal parasitic infections and associated risk factors among students at Dona Berber primary school, Bahir Dar, Ethiopia. BMC Infect Dis. 2017 May 23;17(1):362. doi: 10.1186/s12879-017-2466-x. PMID: 28535750; PMCID: PMC5442677.
Gizaw Z, Adane T, Azanaw J, Addisu A, Haile D. Childhood intestinal parasitic infection and sanitation predictors in rural Dembiya, northwest Ethiopia. Environ Health Prev Med. 2018 Jun 22;23(1):26. doi: 10.1186/s12199-018-0714-3. PMID: 29933747; PMCID: PMC6015452.
Merid Y, Hegazy M, Mekete G, Teklemariam S. Intestinal helminthic infection among children at Lake Awassa area, South Ethiopia. The Ethiopian Journal of Health Development (EJHD). 2001;15(1).
Chelkeba L, Mekonnen Z, Alemu Y, Emana D. Epidemiology of intestinal parasitic infections in preschool and school-aged Ethiopian children: a systematic review and meta-analysis. BMC Public Health. 2020 Jan 28;20(1):117. doi: 10.1186/s12889-020-8222-y. PMID: 31992252; PMCID: PMC6988312.
Sitotaw B, Mekuriaw H, Damtie D. Prevalence of intestinal parasitic infections and associated risk factors among Jawi primary school children, Jawi town, north-west Ethiopia. BMC Infect Dis. 2019 Apr 25;19(1):341. doi: 10.1186/s12879-019-3971-x. PMID: 31023271; PMCID: PMC6485161.
Workneh T, Esmael A, Ayichiluhm M. Prevalence of intestinal parasitic infections and associated factors among Debre Elias primary schools children, East Gojjam Zone, Amhara Region, North West Ethiopia. J Bacteriol Parasitol. 2014;15(1):1-5.
Reji P, Belay G, Erko B, Legesse M, Belay M. Intestinal parasitic infections and malnutrition amongst first-cycle primary schoolchildren in Adama, Ethiopia. African journal of primary health care & family medicine. 2011;3(1).
Girma M, Agedew E, Gedeamu G, Haftu D, Yohanes T. Prevalence of Schistosoma mansoni infection and associated factors in irrigation workers in Gamo Gofa and South Omo Zone, 2017: A Community based parasitological survey. 2018.
Mengitsu B, Shafi O, Kebede B, Kebede F, Worku DT, Herero M, French M, Kebede B, Mackenzie C, Martindale S, Kebede Z, Hirpa T, Frawley H, Crowley K, O'Neil M, McPherson S. Ethiopia and its steps to mobilize resources to achieve 2020 elimination and control goals for neglected tropical diseases webs joined can tie a lion. Int Health. 2016 Mar;8 Suppl 1:i34-52. doi: 10.1093/inthealth/ihw007. PMID: 26940308.
Gebretsadik G. Prevalence of intestinal Parasites and associated risk factors among schoolchildren of Homesha District (Woreda) in Benishangul-Gumuz regional State, western Ethiopia. Journal of Family Medicine and Health Care. 2016;2(4):57-64.
Haftu D, Deyessa N, Agedew E. Prevalence and determinant factors of intestinal parasites among school children in Arba Minch town, Southern Ethiopia. Am J Health Res. 2014;2(5):247-4.
Organization WH. Bench aids for the diagnosis of intestinal parasites. 2019.
Alemu G, Abossie A, Yohannes Z. Current status of intestinal parasitic infections and associated factors among primary school children in Birbir town, Southern Ethiopia. BMC infectious diseases. 2019;19(1):270.
Gadisa E, Jote K. Prevalence and factors associated with intestinal parasitic infection among under-five children in and around Haro Dumal Town, Bale Zone, Ethiopia. BMC pediatrics. 2019;19(1):385.
Getachew M, Yewhalaw D, Tafess K, Getachew Y, Zeynudin A. Anaemia and associated risk factors among pregnant women in Gilgel Gibe dam area, Southwest Ethiopia. Parasit Vectors. 2012 Dec 17;5:296. doi: 10.1186/1756-3305-5-296. PMID: 23244514; PMCID: PMC3533966.
Butera E, Mukabutera A, Nsereko E, Munyanshongore C, Rujeni N, Mwikarago IE, Moreland PJ, Manasse MN. Prevalence and risk factors of intestinal parasites among children under two years of age in a rural area of Rutsiro district, Rwanda - a cross-sectional study. Pan Afr Med J. 2019 Jan 7;32:11. doi: 10.11604/pamj.2019.32.11.15949. PMID: 31143316; PMCID: PMC6522168.
Sitotaw B, Shiferaw W. Prevalence of Intestinal Parasitic Infections and Associated Risk Factors among the First-Cycle Primary Schoolchildren in Sasiga District, Southwest Ethiopia. J Parasitol Res. 2020 Mar 13;2020:8681247. doi: 10.1155/2020/8681247. PMID: 32231795; PMCID: PMC7093910.
Eyamo T, Girma M, Alemayehu T, Bedewi Z. Soil-Transmitted Helminths And Other Intestinal Parasites Among Schoolchildren In Southern Ethiopia. Research and reports in tropical medicine. 2019;10:137.
Ayalew A, Debebe T, Worku A. Prevalence and risk factors of intestinal parasites among Delgi school children, North Gondar, Ethiopia. J Parasitol Vector Biol. 2011;3(5):75-81.
Abossie A, Seid M. Assessment of the prevalence of intestinal parasitosis and associated risk factors among primary school children in Chencha town, Southern Ethiopia. BMC Public Health. 2014 Feb 14;14:166. doi: 10.1186/1471-2458-14-166. PMID: 24528627; PMCID: PMC3933408.
Workneh T, Esmael A, Ayichiluhm M. Prevalence of intestinal parasitic infections and associated factors among Debre Elias primary schools children, East Gojjam Zone, Amhara Region, North West Ethiopia. J Bacteriol Parasitol. 2014;5(1):1.
Gyang VP, Chuang TW, Liao CW, Lee YL, Akinwale OP, Orok A, Ajibaye O, Babasola AJ, Cheng PC, Chou CM, Huang YC, Sonko P, Fan CK. Intestinal parasitic infections: Current status and associated risk factors among school aged children in an archetypal African urban slum in Nigeria. J Microbiol Immunol Infect. 2019 Feb;52(1):106-113. doi: 10.1016/j.jmii.2016.09.005. Epub 2017 Jun 22. PMID: 28711437.
Workineh L, Kiros T, Damtie S, Andualem T, Dessie B. Prevalence of Soil-Transmitted Helminth and Schistosoma mansoni Infection and Their Associated Factors among Hiruy Abaregawi Primary School Children, Rural Debre Tabor, North West Ethiopia: A Cross-Sectional Study. J Parasitol Res. 2020 Jan 29;2020:2521750. doi: 10.1155/2020/2521750. PMID: 32411418; PMCID: PMC7204315.
Sahiledengle B, Beker S, Girum Y. Prevalence and risk factors of intestinal parasites among primary school children in Shashamane town, southern Ethiopia. MOJ Public Health. 2020;9(3):55-61.
Living-Jamala U, Eze N, Nduka FO. Prevalence and intensity of intestinal helminth infections and associated risk factors among school-aged children in Abua/Odual local government area, Rivers state. Journal of Applied Life Sciences International. 2018:1-7.
Alamir M, Awoke W, Feleke A. Intestinal parasites infection and associated factors among school children in Dagi primary school, Amhara National Regional State, Ethiopia. Health. 2013;2013.
Afework Bitew A, Abera B, Seyoum W, Endale B, Kiber T, Goshu G, Admass A. Soil-Transmitted Helminths and Schistosoma mansoni Infections in Ethiopian Orthodox Church Students around Lake Tana, Northwest Ethiopia. PLoS One. 2016 May 20;11(5):e0155915. doi: 10.1371/journal.pone.0155915. PMID: 27203749; PMCID: PMC4874599.
Asemahagn MA. Parasitic infection and associated factors among the primary school children in Motta town, western Amhara, Ethiopia. Am J Public Health Res. 2014;2(6):248-54.
Alemu G, Aschalew Z, Zerihun E. Burden of intestinal helminths and associated factors three years after initiation of mass drug administration in Arbaminch Zuria district, southern Ethiopia. BMC infectious diseases. 2018;18(1):435.
Quihui-Cota L, Valencia ME, Crompton DW, Phillips S, Hagan P, Diaz-Camacho SP, Triana Tejas A. Prevalence and intensity of intestinal parasitic infections in relation to nutritional status in Mexican schoolchildren. Trans R Soc Trop Med Hyg. 2004 Nov;98(11):653-9. doi: 10.1016/j.trstmh.2003.12.017. PMID: 15363645.
Gelaw A, Anagaw B, Nigussie B, Silesh B, Yirga A, Alem M, Endris M, Gelaw B. Prevalence of intestinal parasitic infections and risk factors among schoolchildren at the University of Gondar Community School, Northwest Ethiopia: a cross-sectional study. BMC Public Health. 2013 Apr 5;13:304. doi: 10.1186/1471-2458-13-304. PMID: 23560704; PMCID: PMC3621079.
Tadesse G. The prevalence of intestinal helminthic infections and associated risk factors among school children in Babile town, eastern Ethiopia. Ethiopian Journal of Health Development. 2005;19(2):140-7.
Mehraj V, Hatcher J, Akhtar S, Rafique G, Beg MA. Prevalence and factors associated with intestinal parasitic infection among children in an urban slum of Karachi. PLoS One. 2008;3(11):e3680. doi: 10.1371/journal.pone.0003680. Epub 2008 Nov 10. PMID: 18997865; PMCID: PMC2577067.
Ahmed KS, Siraj NM, Fitsumberhan H, Isaac S, Yohannes S, Eman D, et al. Knowledge, Attitude and Practice (KAP) Assessment of Intestinal Parasitic Infection among School Children in Asmara, Eritrea. Health. 2016;9(1):57-68.
Tulu B, Taye S, Amsalu E. Prevalence and its associated risk factors of intestinal parasitic infections among Yadot primary school children of South Eastern Ethiopia: a cross-sectional study. BMC Res Notes. 2014 Nov 26;7:848. doi: 10.1186/1756-0500-7-848. PMID: 25425173; PMCID: PMC4289289.
Ngonjo T, Kihara J, Gicheru M, Wanzala P, Njenga S, Mwandawiro C. Prevalence and intensity of intestinal parasites in school age children in Thika District, Kenya. African Journal of Health Sciences. 2012;21(3-4):153-60.
Gyorkos TW, Maheu-Giroux M, Blouin B, Casapia M. Impact of health education on soil-transmitted helminth infections in schoolchildren of the Peruvian Amazon: a cluster-randomized controlled trial. PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2397. doi: 10.1371/journal.pntd.0002397. PMID: 24069469; PMCID: PMC3772033.