Zhe Chuan Feng*, Kwok To Yue, Weijie Lu, Jeffrey Yiin, Benjamin Klein and Ian T Ferguson
Volume4-Issue5
Dates: Received: 2023-04-23 | Accepted: 2023-05-06 | Published: 2023-05-08
Pages: 860-863
Abstract
Raman spectroscopy was utilized to study surgical excision specimens of human breast and lymph node tissues from patients with leaking silicone bag-gel breast implants. This may offer a simple and effective method of detection to evaluate tissues.
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DOI: 10.37871/jbres1745
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© 2023 Feng ZC, et al. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Feng ZC, Yue KT, Lu W, Yiin J, Klein B, Ferguson IT. Raman Spectroscopic Detection of Silicone Leakage in Human Breast and Lymph Node Tissues. J Biomed Res Environ Sci. 2023 May 08; 4(5): 860-863. doi: 10.37871/jbres1745, Article ID: JBRES1745, Available at: https://www.jelsciences.com/articles/jbres1745.pdf
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References
- Paidi SK, Troncoso JR, Harper MG, Liu Z, Nguyen KG, Ravindranathan S, Rebello L, Lee DE, Ivers JD, Zaharoff DA, Rajaram N, Barman I. Raman spectroscopy reveals phenotype switches in breast cancer metastasis. Theranostics. 2022 Jul 11;12(12):5351-5363. doi: 10.7150/thno.74002. PMID: 35910801; PMCID: PMC9330538.
- Hanna K, Krzoska E, Shaaban AM, Muirhead D, Abu-Eid R, Speirs V. Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospects. Br J Cancer. 2022 May;126(8):1125-1139. doi: 10.1038/s41416-021-01659-5. Epub 2021 Dec 10. PMID: 34893761; PMCID: PMC8661339.
- Ragusa A, Notarstefano V, Svelato A, Belloni A, Gioacchini G, Blondeel C, Zucchelli E, De Luca C, D'Avino S, Gulotta A, Carnevali O, Giorgini E. Raman Microspectroscopy Detection and Characterisation of Microplastics in Human Breastmilk. Polymers (Basel). 2022 Jun 30;14(13):2700. doi: 10.3390/polym14132700. PMID: 35808745; PMCID: PMC9269371.
- Ci YX, Gao TY, Feng J, Guo JQ. Fourier transform infrared spectroscopic characterization of human breast tissue: Implications for breast cancer diagnosis. Applied Spectroscopy. 1999;53:312-315.
- Cubeddu R, Pifferi A, Taroni P, Torricelli A, Valentini G. Noninvasive absorption and scattering spectroscopy of bulk diffusive media: An application to the optical characterization of human breast. Appl Phys Lett. 1999;74:874.
- Heffer E, Pera V, Schütz O, Siebold H, Fantini S. Near-infrared imaging of the human breast: complementing hemoglobin concentration maps with oxygenation images. J Biomed Opt. 2004 Nov-Dec;9(6):1152-60. doi: 10.1117/1.1805552. PMID: 15568935.
- Redd DCB, Feng ZC, Yue KT, Gansler TS. Raman spectroscopic characterization of human breast tissues: implications for breast malignancy monitoring. Appl Spectroscopy. 1993;47:788.
- Cater RAB, Martine AA, Netto MM, Soares FA. FT-Raman spectroscopy study of human breast tissue, in Proceedings of SPIE -- Volume 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, eds. Anita Mahadevan-Jansen, Michael G. Sowa, Gerwin J. Puppels, Zygmunt Gryczynski, Tuan Vo-Dinh, Joseph R. Lakowicz. 2004;190-197.
- Varga J, Schumacher HR, Jimenez SA. Systemic sclerosis after augmentation mammoplasty with silicone implants. Ann Intern Med. 1989 Sep 1;111(5):377-83. doi: 10.7326/0003-4819-111-5-377. PMID: 2669593.
- Tabatowski K, Elson CE, Johnston WW. Silicone lymphadenopathy in a patient with a mammary prosthesis. Fine needle aspiration cytology, histology and analytical electron microscopy. Acta Cytol. 1990 Jan-Feb;34(1):10-4. PMID: 2296832.
- Truong LD, Cartwright J Jr, Goodman MD, Woznicki D. Silicone lymphadenopathy associated with augmentation mammaplasty. Morphologic features of nine cases. Am J Surg Pathol. 1988 Jun;12(6):484-91. doi: 10.1097/00000478-198806000-00009. PMID: 3377110.
- Klang E, Yosepovich A, Krosser A, Soffer S, Halshtok Neiman O, Shalmon A, Gotlieb M, Sklair-Levy M. Detection of Pathologically Proven Silicone Lymphadenopathy: Ultrasonography Versus Magnetic Resonance Imaging. J Ultrasound Med. 2018 Apr;37(4):969-975. doi: 10.1002/jum.14434. Epub 2017 Sep 29. PMID: 28960388.
- Rukanskienė D, Bytautaitė G, Česnauskaitė A, Pilipaitytė L, Aštrauskas T, Jonaitienė E. The Value of Ultrasound in the Evaluation of the Integrity of Silicone Breast Implants. Medicina (Kaunas). 2021 May 3;57(5):440. doi: 10.3390/medicina57050440. PMID: 34063687; PMCID: PMC8147634.
- Abraham JL, Etz ES. Molecular microanalysis of pathological specimens in situ with a laser-Raman microprobe. Science. 1979 Nov 9;206(4419):716-8. doi: 10.1126/science.493979. PMID: 493979.
- Pellenbarg RE, Tevault DE. Silicone as a trace contaminant in laboratory solvents. Total Environ Sci. 1988;73:23.
- Frank CJ, McCreery RL, Red DCB, Gansler TS. Detection of silicone in lumph mode biopsy specimens by near-infrared Raman spectroscopy. Appl Spectroscopy. 1993;47:387.
- Zúñiga WC, Jones V, Anderson SM, Echevarria A, Miller NL, Stashko C, Schmolze D, Cha PD, Kothari R, Fong Y, Storrie-Lombardi MC. Raman Spectroscopy for Rapid Evaluation of Surgical Margins during Breast Cancer Lumpectomy. Sci Rep. 2019 Oct 10;9(1):14639. doi: 10.1038/s41598-019-51112-0. PMID: 31601985; PMCID: PMC6787043.
- Vanna R, Morasso C, Marcinnò B, Piccotti F, Torti E, Altamura D, Albasini S, Agozzino M, Villani L, Sorrentino L, Bunk O, Leporati F, Giannini C, Corsi F. Raman Spectroscopy Reveals That Biochemical Composition of Breast Microcalcifications Correlates with Histopathologic Features. Cancer Res. 2020 Apr 15;80(8):1762-1772. doi: 10.1158/0008-5472.CAN-19-3204. Epub 2020 Feb 24. PMID: 32094303.