miRNAs as Valuable Diagnostic Biomarkers in Patients with Multiple Sclerosis

Nasim Niki Saeidi; Arezou Dabiri; Reza Mansouri; Alireza Moomivand; Mahdi Goudarzvand*

Nasim Niki Saeidi, Arezou Dabiri, Reza Mansouri, Alireza Moomivand and Mahdi Goudarzvand*

Volume4-Issue4
Dates: Received: 2023-04-19 | Accepted: 2023-04-25 | Published: 2023-04-26
Pages: 773-778

Abstract

Multiple Sclerosis (MS) is an autoimmune condition caused by chronic inflammation of central nervous system and demyelination of neurons. At present, microRNAs (miRNAs) are recognised as a diagnostic and prognostic indicator of the diseases. But they are also a new and innovative goal in gene therapy. Therefore, the aim of this study is to find a simple, non-invasive, and valuable biomarker for early detection and potential treatment of MS. In the present study, 30 serum samples of patients with recurrent MS (recurrecy dettermined with McDonald's criteria) were obtained along with the 30 healthy samples. The qRT-PCR method was performed to evaluate the expression level of miR-155a, miR-146a, miR-34a, miR-143a and miR-373a in both groups. The results revealed that miR-155a and miR-146a were significantly upregulated while miR-34a, miR-143a and miR-373a were significantly downregulated in the patient group in comparison with healthy subjects. These results candidate these microRNAs with altered levels as potential diagnostic and prognostic markers in patients with MS, which may be involved in the therapeutic schedule for MS like microRNA replacement therapy in the near future.

FullText HTML FullText PDF DOI: 10.37871/jbres1735

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How to cite this article

Saeidi NN, Dabiri A, Mansouri R, Moomivand A, Goudarzvand M. miRNAs as Valuable Diagnostic Biomarkers in Patients with Multiple Sclerosis. J Biomed Res Environ Sci. 2023 Apr 26; 4(4): 773-778. doi: 10.37871/jbres1735, Article ID: JBRES1735, Available at: https://www.jelsciences.com/articles/jbres1735.pdf

Subject area(s)

Multiple Sclerosis

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