PLGA Nanoparticles with Cannabidiol for Efficient and Durable Antibacterial Applications

Ming Cheng; Qiang Ma; Lu Tang; Bo Wang; Liya Liu; Bei Fan; Liang Zhang*; Fengzhong Wang*

Ming Cheng, Qiang Ma, Lu Tang, Bo Wang, Liya Liu, Bei Fan, Liang Zhang* and Fengzhong Wang*

Volume4-Issue4
Dates: Received: 2023-04-06 | Accepted: 2023-04-14 | Published: 2023-04-17
Pages: 727-735

Abstract

The Cannabidiol (CBD) are extensively used owing to their potent antibacterial effects. We developed CBD-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles using an emulsion process technology, resulting informing the PLGA@CBD nanoparticles. The emulsion parameters were optimized using three-dimensional surface plots. When scaled up under optimal conditions, the corresponding loading content efficiency were 16.51%. Compared with natural cannabidiol, the physically modified PLGA nanoparticles became smooth, round, and solid, improving their water solubility and bioavailability, realizing long-time antibacterial. Therefore, the nanoparticles showed better efficacy against Gram-positive bacteria. Our results confirm that the PLGA@CBD nanoparticles have been achieved as long-acting antibacterial delivery system, which improved the treatment efficiency.

FullText HTML FullText PDF DOI: 10.37871/jbres1730

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How to cite this article

Cheng M, Ma Q, Tang L, Wang B, Liu L, Fan B, Zhang L, Wang F. PLGA Nanoparticles with Cannabidiol for Effi cient and Durable Antibacterial Applications. J Biomed Res Environ Sci. 2023 Apr 17; 4(4): 727-735. doi: 10.37871/jbres1730, Article ID: JBRES1730, Available at: https://www.jelsciences.com/articles/jbres1730.pdf

Subject area(s)

Pharmaceutica Analytica Acta

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