Nerium oleander Lin: A Review of Chemical, Pharmacological and Traditional uses

Siham Ayouaz*; Radia Arab; Khokha Mouhoubi; Khodir Madani

**Siham Ayouaz*, Radia Arab, Khokha Mouhoubi and Khodir Madani**

Volume4-Issue4
Dates: Received: 2023-03-25 | Accepted: 2023-04-03 | Published: 2023-04-07
Pages: 641-650

Abstract

Nerium oleander Lin, which is the only species listed in the genus Nerium and a member of the Apocynaceae family, was frequently employed in traditional medicine to address various pathologies. N. oleander has demonstrated its efficacy in various disease models at a time when pharmaceutical firms are focusing more on plant-based traditional medicines to prevent side-effects and resistance against synthetic drugs. Neriin, oleandrin, cardenolides, gentiobiosyl, and odoroside are just a few of the cardiac glycosides that are present in this plant and are toxic in all sections. Additionally, this plant species creates secondary metabolites with pharmacological value, such as alkaloids, flavonoids, and steroids.

FullText HTML FullText PDF DOI: 10.37871/jbres1720

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How to cite this article

Ayouaz S, Arab R, Mouhoubi K, Madani K. Nerium oleander Lin: A Review of Chemical, Pharmacological and Traditional uses. J Biomed Res Environ Sci. 2023 Apr 07; 4(4): 641-650. doi: 10.37871/jbres1720, Article ID: JBRES1720, Available at: https://www.jelsciences.com/articles/jbres1720.pdf

Subject area(s)

Biology

References

Omara T, Kiprop AK, Ramkat RC, Cherutoi J, Kagoya S, Moraa Nyangena D, Azeze Tebo T, Nteziyaremye P, Nyambura Karanja L, Jepchirchir A, Maiyo A, Jematia Kiptui B, Mbabazi I, Kiwanuka Nakiguli C, Nakabuye BV, Chepkemoi Koske M. Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies. Evid Based Complement Alternat Med. 2020 Mar 15;2020:3529081. doi: 10.1155/2020/3529081. PMID: 32256639; PMCID: PMC7102457.
Newman DJ, Cragg GM. Natural Products as Sources of New Drugs from 1981 to 2014. J Nat Prod. 2016 Mar 25;79(3):629-61. doi: 10.1021/acs.jnatprod.5b01055. Epub 2016 Feb 7. PMID: 26852623.
Hossen MS, Barek MA, Jahan N, Safiqul Islam M. A Review on Current Repurposing Drugs for the Treatment of COVID-19: Reality and Challenges. SN Compr Clin Med. 2020;2(10):1777-1789. doi: 10.1007/s42399-020-00485-9. Epub 2020 Aug 31. PMID: 32904710; PMCID: PMC7457893.
Akkol EK, Dereli FTG, Sobarzo-Sánchez E, Khan H. Roles of Medicinal Plants and Constituents in Gynecological Cancer Therapy: Current Literature and Future Directions. Curr Top Med Chem. 2020;20(20):1772-1790. doi: 10.2174/1568026620666200416084440. PMID: 32297581.
Mansouri E, Kooti W, Bazvand M, Ghasemi Boroon M, Amirzargar A, Afrisham R, Afzalzadeh MR, Ashtary-Larky D, Jalali N. The Effect of Hydro-Alcoholic Extract of Foeniculum vulgare Mill on Leukocytes and Hematological Tests in Male Rats. Jundishapur J Nat Pharm Prod. 2015 Feb 20;10(1):e18396. doi: 10.17795/jjnpp-18396. PMID: 25866717; PMCID: PMC4379888.
El-Shaibany A, Al-Habori M, Al-Maqtari T, Al-Mahbashi H. The Yemeni Brown Algae Dictyota dichotoma Exhibit High In Vitro Anticancer Activity Independent of Its Antioxidant Capability. Biomed Res Int. 2020 Feb 17;2020:2425693. doi: 10.1155/2020/2425693. PMID: 32149090; PMCID: PMC7048913.
Kuršvietienė L, Mongirdienė A, Bernatonienė J, Šulinskienė J, Stanevičienė I. Selenium Anticancer Properties and Impact on Cellular Redox Status. Antioxidants (Basel). 2020 Jan 17;9(1):80. doi: 10.3390/antiox9010080. PMID: 31963404; PMCID: PMC7023255.
Aboul-Soud MAM, Ashour AE, Challis JK, Ahmed AF, Kumar A, Nassrallah A, Alahmari TA, Saquib Q, Siddiqui MA, Al-Sheikh Y, El-Shemy HA, Aboul-Enein AM, Alghamdi KM, Jones PD, Giesy JP. Biochemical and Molecular Investigation of In Vitro Antioxidant and Anticancer Activity Spectrum of Crude Extracts of Willow Leaves Salix safsaf. Plants (Basel). 2020 Sep 30;9(10):1295. doi: 10.3390/plants9101295. PMID: 33008079; PMCID: PMC7599573.
Asadi-Samani M, Kooti W, Aslani E, Shirzad H. A Systematic Review of Iran's Medicinal Plants With Anticancer Effects. J Evid Based Complementary Altern Med. 2016 Apr;21(2):143-53. doi: 10.1177/2156587215600873. Epub 2015 Aug 21. PMID: 26297173.
Aboud AS. Antimicrobial activities of aqueous and ethanolic extracts from Nerium oleander used in the treatment of burns infections isolates. J Pharm Chem Biol Sci. 2015;2(4):248-258.
Noori Ahmad Abadi M, Mortazavi M, Kalani N, Marzouni HZ, Kooti W, Ali-Akbari S. Effect of Hydroalcoholic Extract of Rosmarinus officinalis L. Leaf on Anxiety in Mice. J Evid Based Complementary Altern Med. 2016 Oct;21(4):NP85-90. doi: 10.1177/2156587216642101. Epub 2016 Apr 6. PMID: 27055822.
Khalighi-Sigaroodi F, Jeddi-Tehrani M, Ahvazi M, Shahnazi S, Bayat AA, Mohajer N, Zarei S. Cytotoxicity evaluation of Taverniera spartea on human cancer cell lines. Journal of Medicinal Plants. 2014;13(50):114-128.
Farkhondeh T, Kianmehr M, Kazemi T, Samarghandian S, Khazdair MR. Toxicity effects of Nerium oleander, basic and clinical evidence: A comprehensive review. Hum Exp Toxicol. 2020 Jun;39(6):773-784. doi: 10.1177/0960327120901571. Epub 2020 Jan 23. PMID: 31971021.
Ekalu A, Ayo RG, James HD, Hamisu I. A mini-review on the phytochemistry and biological activities of selected Apocynaceae plants. Preprint. 2019.
Zhang J, Li H, Li Y, Li ZW, Sang CC, Gao MH, Zhang DM, Zhang XQ, Ye WC. Four new corynanthe-type alkaloids from the roots of Alstonia scholaris. Chin J Nat Med. 2019 Dec;17(12):918-923. doi: 10.1016/S1875-5364(19)30113-X. PMID: 31882046.
El-Taher AM, El Gendy AEG, Alkahtani J, Elshamy AI, Abd-ElGawad AM. Taxonomic implication of integrated chemical, morphological, and anatomical attributes of leaves of eight Apocynaceae taxa. Diversity. 2020;12(9):334. doi: 10.3390/d12090334.
Wang CH, Wang GC, Wang Y, Zhang XQ, Huang XJ, Zhang DM, Chen MF, Ye WC. Cytotoxic dimeric indole alkaloids from Catharanthus roseus. Fitoterapia. 2012 Jun;83(4):765-9. doi: 10.1016/j.fitote.2012.03.007. Epub 2012 Mar 13. PMID: 22445552.
Botelho AFM, Santos-Miranda A, Joca HC, Mattoso CRS, de Oliveira MS, Pierezan F, Cruz JS, Soto-Blanco B, Melo MM. Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity. J Ethnopharmacol. 2017 Jul 12;206:170-177. doi: 10.1016/j.jep.2017.05.031. Epub 2017 May 28. PMID: 28564584.
Sharma A, Verma P, Mathur A, Mathur AK. Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus. Protoplasma. 2018 Sep;255(5):1281-1294. doi: 10.1007/s00709-018-1233-1. Epub 2018 Mar 5. PMID: 29508069.
Huang M, Shen S, Luo C, Ren Y. Genus Periploca (Apocynaceae): A Review of Its Classification, Phytochemistry, Biological Activities and Toxicology. Molecules. 2019 Jul 29;24(15):2749. doi: 10.3390/molecules24152749. PMID: 31362394; PMCID: PMC6696197.
Wong A, Greene SL. Successful treatment of Nerium oleander toxicity with titrated Digoxin Fab antibody dosing. Clin Toxicol (Phila). 2018 Jul;56(7):678-680. doi: 10.1080/15563650.2018.1432865. Epub 2018 Jan 30. PMID: 29382214.
Ramesha A, Venkataramana M, Nirmaladevi D, Gupta VK, Chandranayaka S, Srinivas C. Cytotoxic effects of oosporein isolated from endophytic fungus Cochliobolus kusanoi. Front Microbiol. 2015 Sep 1;6:870. doi: 10.3389/fmicb.2015.00870. PMID: 26388840; PMCID: PMC4556033.
Dhinesh B, Annamalai M. A study on performance, combustion and emission behaviour of diesel engine powered by novel nano Nerium oleander biofuel. Journal of Cleaner Production. 2018;196:74-83. doi: 10.1016/j.jclepro.2018.06.002.
Aruna P, Mangaiyarkarasi R, Pavithra V, Rathnaswathy S, Renisha S. Quantification of biopigments from Nerium oleander L. and assessing their antioxidant potential. The Pharma Innovation Journal. 2020;9(3):331-333.
Sinha S, Biswas K. A concise review on Nerium oleander L. An important medicinal plant. Trop Plant Res. 2016;3:408-412.
Farooqui S, Tyagi T. Nerium oleander: It’s application in basic and applied science: A Review. Int J Pharm Pharm Sci. 2018;10(3):1-4. doi: 10.22159/ijpps.2018v10i3.22505.
Garima Z, Amla B. A review on chemistry and pharmacological activity of Nerium oleander L. Journal of Chemical and Pharmaceutical Research. 2010;2(6):351-358.
Hussain M, Gorsi M. Antimicrobial activity of Nerium oleander Linn. Asian Journal of Plant Sciences. 2004;3(2):177-180.
Adome RO, Gachihi JW, Onegi B, Tamale J, Apio SO. The cardiotonic effect of the crude ethanolic extract of Nerium oleander in the isolated guinea pig hearts. Afr Health Sci. 2003 Aug;3(2):77-82. PMID: 12913798; PMCID: PMC2141602.
Hammiche V, Merad R, Azzouz M. Poisonous plants for medicinal use around the Mediterranean. Springer; 2013.
Kiran C, Prasad D. A review on Nerium oleander Linn. (Kaner). International Journal of Pharmacognosy and Phytochemical Research. 2014;6(3):593-597.
Sinha D, Sarkar N, Biswas J, Bishayee A. Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Semin Cancer Biol. 2016 Oct;40-41:209-232. doi: 10.1016/j.semcancer.2015.11.001. Epub 2016 Jan 13. PMID: 26774195.
Bnouham M, Mekhfi H, Abdelkhaleq L, Ziyyat A. Medicinal plants used in the treatment of diabetes in Morocco. International Journal of Diabetes and Metabolism. 2002;10(1):33-50.
Erdemoglu N, Küpeli E, Yeşilada E. Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. J Ethnopharmacol. 2003 Nov;89(1):123-9. doi: 10.1016/s0378-8741(03)00282-4. PMID: 14522443.
Zibbu G, Batra A. In an ornamental plant: Thevetia peruviana (PERS.) schum. International Journal of Pharma and Bio Sciences. 2010;1:2.
Chan EW, Wong SK, Chan HT. Apocynaceae species with antiproliferative and/or antiplasmodial properties: a review of ten genera. J Integr Med. 2016 Jul;14(4):269-84. doi: 10.1016/S2095-4964(16)60261-3. PMID: 27417173.
Chaudhary K, Prasad D, Sandhu B. Preliminary pharmacognostic and phytochemical studies on Nerium oleander Linn. (White cultivar). Journal of Pharmacognosy and Phytochemistry. 2015;4(1):185-188.
Balkan IA, Doğan H, Zengin G, Colak N, Ayaz FA, Gören A, Kırmızıbekmez H, Yeşilada E. Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components. Industrial Crops and Products. 2018;112:24-31. doi: 10.1016/j.indcrop.2017.10.058.
Tayoub G, Sulaiman H, Alorfi M. Analysis of oleandrin in oleander extract (Nerium oleander) by HPLC. Journal of Natural Products. 2014;7:73-78.
Santhi R, Lakshmi G, Priyadharshini AM, Anandaraj L. Phytochemical screening of Nerium oleander leaves and Momordica charantia leaves. International Research Journal of Pharmacy. 2011;2(1):131-135.
Hameed HI, Jasim H, Kareem MA, Hussein OA. Alkaloid constitution of Nerium oleander using Gas Chromatography-Mass Spectroscopy (GC-MS). Journal of Medicinal Plants Research. 2015;9(9):326-334. doi:10.5897/JMPR2015.5746.
Atay BI, Gören AC, Kırmızıbekmez H, Yesilada E. Evaluation of the in vitro anti-inflammatory activity of Nerium oleander L. flower extracts and activity-guided isolation of the active constituents. Records of Natural Products. 2018;12(2):128-141. doi: 10.25135/rnp.15.17.05.100.
Hussain M, Chorvatova A, Singh J. Physiological effects and biochemical properties of a serum protein that produces positive inotropic and chronotropic effects on isolated guinea pig atria. Mol Cell Biochem. 2004 Jun;261(1-2):201-7. doi: 10.1023/b:mcbi.0000028757.98334.5a. PMID: 15362505.
Calderón-Montaño JM, Burgos-Morón E, Orta ML, Mateos S, López-Lázaro M. A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells. Planta Med. 2013 Aug;79(12):1017-23. doi: 10.1055/s-0032-1328715. Epub 2013 Jul 3. PMID: 23824549.
Cao X, Nie X, Xiong S, Cao L, Wu Z, Moore PK, Bian JS. Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity. Redox Biol. 2018 May;15:513-521. doi: 10.1016/j.redox.2018.01.012. Epub 2018 Feb 2. PMID: 29413963; PMCID: PMC5881418.
Minnat TR. In vivo and in vitro antibacterial assessment of Nerium oleander aqueous leaf extract against bacterial pathogens and its effect in treatment of wounds. Al-Qadisiyah Journal of Veterinary Medicine Sciences. 2016;15(2):31-39.
Siddiqui I, Bokhari N, Perveen K. Antifungal ability of Nerium oleander against Fusarium oxysporum, Sclerotium rolfsii and Macrophomina phaseolina. The Journal of Animal & Plant Sciences. 2016;26(1):269-274.
Namian P, Talebi T, Germi GK, Shabani F. Screening of biological activities (antioxidant, antibacterial and antitumor) of Nerium oleander leaf and flower extracts. American Journal of Phytomedicine and Clinical Therapeutics. 2013;10(11):378-384.
Dey P, Chaudhuri TK. Pharmacological aspects of Nerium indicum Mill: A comprehensive review. Pharmacogn Rev. 2014 Jul;8(16):156-62. doi: 10.4103/0973-7847.134250. PMID: 25125887; PMCID: PMC4127823.
Wong SK, Lim YY, Abdullah NR, Nordin FJ. Assessment of antiproliferative and antiplasmodial activities of five selected Apocynaceae species. BMC Complement Altern Med. 2011 Jan 14;11:3. doi: 10.1186/1472-6882-11-3. PMID: 21232161; PMCID: PMC3032759.
Sikarwar MS, Patil MB, Kokate CK, Sharma S, Bhat V. Antidiabetic activity of Nerium indicum leaf extract in alloxan-induced diabetic rats. Journal of Young Pharmacists. 2009;1(4):330. doi: 10.4103/0975-1483.59323.
Saranya S, Vijayarani K, Pavithra S. Green synthesis of iron nanoparticles using aqueous extract of Musa ornata flower sheath against pathogenic bacteria. Indian Journal of Pharmaceutical Sciences. 2017;79(5):688-694. doi: 10.4172/pharmaceutical-sciences.1000280.
Raveen R, Kamakshi KT, Deepa M, Subramanian A. Larvicidal activity of Nerium oleander L. (Apocynaceae) flower extracts against Culex quinquefasciatus Say (Diptera: Culicidae). Int J Mosq Res. 2014;1(1):38-42.
Mohadjerani M. Antioxidant Activity and Total Phenolic Content of Nerium oleander L. Grown in North of Iran. Iran J Pharm Res. 2012 Fall;11(4):1121-6. PMID: 24250545; PMCID: PMC3813149.
Al-Snai A. Pharmacological and therapeutic effects of Lippia nodiflora (Phyla nodiflora). IOSR Journal of Pharmacy. 2019;9(8):15-25.
Mary YS, Mary YS, Bielenica A, Armaković S, Armaković SJ, Chandramohan V, Dammalli M. Investigation of the reactivity properties of a thiourea derivative with anticancer activity by DFT and MD simulations. J Mol Model. 2021 Jul 3;27(8):217. doi: 10.1007/s00894-021-04835-9. PMID: 34218339.
Ali FH, Kassem GM, Atta-Alla OA. Propolis as a natural decontaminant and antioxidant in fresh oriental sausage. Vet Ital. 2010 Apr-Jun;46(2):167-72. PMID: 20560126.
Singhal KG, Gupta GD. Hepatoprotective and antioxidant activity of methanolic extract of flowers of Nerium oleander against CCl4-induced liver injury in rats. Asian Pac J Trop Med. 2012 Sep;5(9):677-85. doi: 10.1016/S1995-7645(12)60106-0. PMID: 22805717.
Zitouni GT, Ozkay Y, Ozdemir A, Kaplancikli ZA, Mehlika. Synthesis of some benzothiazole based piperazine-dithiocarbamate derivatives and evaluation of their anticancer activities. Letters in Drug Design & Discovery. 2011;8(9):830-837. doi: 10.2174/157018011797200786.
Sanna G, Madeddu S, Serreli G, Nguyen HT, Le NT, Usai D, Carta A, Cappuccinelli P, Zanetti S, Donadu MG. Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV). Nat Prod Res. 2021 Dec;35(24):5674-5680. doi: 10.1080/14786419.2020.1824228. Epub 2020 Sep 25. PMID: 32975126; PMCID: PMC9491107.
Ibrahim IAA, Abdulla MA, Abdelwahab SI, Al-Bayaty F, Majid NA. Leaves extract of Muntingia calabura protects against gastric ulcer induced by ethanol in Sprague-dawley rats. Clinical and Experimental Pharmacology. 2012;5. doi: 10.4172/2161-1459.S5-004.
Nimish LP, Sanjay BK, Nayna MB, Jaimik DR. Phytopharmacological properties of Coriander sativum as a potential medicinal tree: An overview. J Appl Pharm Sci. 2011;1(4):20-25.
Singh S, Shenoy S, Nehete PN, Yang P, Nehete B, Fontenot D, Yang G, Newman RA, Sastry KJ. Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity. Fitoterapia. 2013 Jan;84:32-9. doi: 10.1016/j.fitote.2012.10.017. Epub 2012 Nov 2. PMID: 23127567.
Roni M, Murugan K, Panneerselvam C, Subramaniam J, Hwang JS. Evaluation of leaf aqueous extract and synthesized silver nanoparticles using Nerium oleander against Anopheles stephensi (Diptera: Culicidae). Parasitol Res. 2013 Mar;112(3):981-90. doi: 10.1007/s00436-012-3220-3. Epub 2012 Dec 13. PMID: 23239092.