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SS Sickle Cell Disease and Severe Malaria in Children Aged 0 to 15 Hospitalized in the Pediatric Department of the Donka CHU National Hospital in Conakry, Republic of Guinea

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Camara E*, Diop MM, Kouyate M, Camara SH, Abou Madiane B, Diallo ML, Diallo FB, Tchedre R, Barry IK, Bangoura K, Bangoura MA and Conde I

Dates: Received: 2023-03-02 | Accepted: 2023-03-18 | Published: 2023-03-20
Pages: 458-462


Introduction: The superposition of distribution maps of HbS and plasmodium falciparum is at the origin of several theories on the relationship between sickle cell disease and malaria.

Objective: Determine the sociodemographic aspect and identify the main complications of SS sickle cell disease in children with severe malaria at the Donka Pediatrics Department.

Methods: Prospective, descriptive study, lasting 12 months from January 01 to December 31, 2021 including all children from 0-15 years hospitalized whose diagnoses of severe malaria and SS sickle cell anemia were retained during the study period.

Results: The frequency was 6.65%, The age group of 5-9 years represented 41.93% with a sex ratio (M/F) = 1.3. Frequency peaks were encountered in June, July and August (36.56%). Consanguineous marriage was found in 65.59%. Fever was present in 100% of our patients followed by osteo-articular pain (93.54%). Malaria severity criteria were represented by prostration with 81.7%, followed by anemia (77.42%), hyperparasitaemia (46.23%), respiratory distress (45.16%) and seizures (34.4%).
Complications were dominated by bronchopneumopathy, osteomyelitis, dactylitis and necrosis of the femoral head. The evolution was favorable in 95.70% of cases.

Conclusion: The prevalence of sickle cell disease associated with severe malaria remains high in the department with consanguinity often found.
Reducing these two pathologies will necessarily involve the use of means of prevention against malaria and premarital examinations.

FullText HTML FullText PDF DOI: 10.37871/jbres1697

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© 2023 Camara E, et al. Distributed under Creative Commons CC-BY 4.0

How to cite this article

Camara E, Diop MM, Kouyate M, Camara SH, Abou Madiane B, Diallo ML, Diallo FB, Tchedre R, Barry IK, Bangoura K, Bangoura MA, Conde I. SS Sickle Cell Disease and Severe Malaria in Children Aged 0 to 15 Hospitalized in the Pediatric Department of the Donka CHU National Hospital in Conakry, Republic of Guinea. 2023 Mar 20; 4(3): 458-462. doi: 10.37871/jbres1697, Article ID: JBRES1697, Available at:

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  1. Sangare A, Sanogo I, Ebongo E, Meite M, Kple-Faget P, Sawadogo S, Segbena A, Ambofo V, Ohoun J, Assale G. Contribution to the study of the relationship between sickle cell disease and malaria. Black African Medicine. 1990;37(5).
  2. Allison AC. Polymorphism and natural selection in human populations. Cold Spring Harb Symp Quant Biol. 1964;29:137-49. doi: 10.1101/sqb.1964.029.01.018. PMID: 14278460.
  3. Pérignon F, Botterel C, Farrugia F, Foulet D, Bachir F, Galacteros S, Bretagne. Malaria and sickle cell disease. Medicine and Infectious Diseases. 2008;38:S140-S141.
  4. Thiam L, Dramé A, Coly IZ, Diouf FN, Seck N, Boiro D, Ndongo AA, Basse I, Niang B, Deme/Ly I, Sylla A, Diagne I, Ndiaye O. Profils épidemiologiques, cliniques et hématologiques de la drépanocytose homozygote SS en phase inter critique chez l’enfant à Ziguinchor, Sénégal [Epidemiological, clinical and hematological profiles of homozygous sickle cell disease during the intercritical period among children in Ziguinchor, Senegal]. Pan Afr Med J. 2017 Nov 7;28:208. French. doi: 10.11604/pamj.2017.28.208.14006. PMID: 29610646; PMCID: PMC5878839.
  5. Labie D. Les relations complexes entre hémoglobinopathies et paludisme [The complex relations between haemoglobinopathies and malaria]. Med Sci (Paris). 2010 Aug-Sep;26(8-9):685-7. French. doi: 10.1051/medsci/2010268-9685. PMID: 20819698.
  6. Ngasia B, Kazadi G, Loko G, Sica L, Wamba G, Gonzalez JP, Tshilolo L. 2ème symposium international de la drépanocytose en Afrique Centrale, 27-28 mai 2011, Libreville, Gabon [2nd International Symposium on Sickle Cell Disease in Central Africa]. Med Trop (Mars). 2011 Dec;71(6):535-6. French. PMID: 22393614.
  7. Maiga M. Morbidity and mortality due to severe malaria in children aged 0 to 15 in the pediatric department of the cmc of ratoma. Doctoral Thesis in Medicine. 2014.
  8. Diakite M, Kante AS, Dina O, Conde A, Camara T, Sylla M, Diallo IS, Doukoure AS, Camara F, Traore FA, Tolo-Diebkile A. Malaria in major form sickle cell disease: Epidemiological, clinical, therapeutic and evolutionary aspects in the hematology department of the Ignace Deen National Hospital in Conakry. Rev Mali Infect Microbiol. 2021;16(3):36-40.
  9. Mbassi AHD, Dongmo F, Ngo Um S, Mafo FV, Alima YA, Njom Nlend AE. Epidemiological, clinical and therapeutic aspects of vaso-occlusive crises in children with sickle cell disease in hospitals in Yaoundé. Health Sci Say. 2017;18(4).
  10. Mattioni S, Stojanovic KS, Girot R, Lionnet F. Sickle cell disease in France. Francophone Journal of Laboratories. 2016;481:61-66.
  11. Camara E, Barry IK, Kasse D, Ondima LHM. Major sickle cell syndrome in children: Epidemiological and clinical aspects in the Pediatric Department of Donka (Conakry). Rev Int Sc Med Abj-RISM. 2019;21(1):71-75.
  12. Diagne I, Ndiaye O, Moreira C, Signate-Sy H, Camara B, Diouf S, Diack-Mbaye A, Ba M, Sarr M, Sow D, Fall M. Les syndromes drépanocytaires majeurs en pédiatrie à Dakar (Sénégal) [Sickle cell disease in children in Dakar, Senegal]. Arch Pediatr. 2000 Jan;7(1):16-24. French. doi: 10.1016/s0929-693x(00)88912-5. PMID: 10668081.
  13. Barry IK, Camara E, Diallo ML, Ondima LHM, Dia H. Infectious complications of major sickle cell disease in the Pediatric Department of Donka National Hospital in Conakry (Guinea): About 34 cases. Health Sci Say. 2019:20(4).
  14. Douamba S, Nagalo K, Tamini L, Traoré I, Kam M, Kouéta F, Yé D. Syndromes drépanocytaires majeurs et infections associées chez l ’enfant au Burkina Faso [Major sickle cell syndromes and infections associated with this condition in children in Burkina Faso]. Pan Afr Med J. 2017 Jan 4;26:7. French. doi: 10.11604/pamj.2017.26.7.9971. PMID: 28450986; PMCID: PMC5398225.
  15. Deme LI, Ba ID, Thiongane A, Guèye/Tall. Epidemiological and clinical profile of children and adolescents with major sickle cell syndromes admitted in an emergency situation to a sickle cell consultation in Dakar. J Afr Pediatr Genet Med. 2017;3:44-49.
  16. Mbika Cardorelle A, Okoko A, Mouko A. Les crises vaso-occlusives de l'enfant drépanocytaire à Brazzaville [Vaso-occlusive crisis of sickle cell child in Brazzaville drugs news]. Arch Pediatr. 2010 Mar;17(3):295-6. French. doi: 10.1016/j.arcped.2009.11.009. Epub 2010 Jan 19. PMID: 20034770.


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