Factors Associated with the Death of Children Aged 0 to 15 Years with Bacterial Meningitis in the Pediatric Department of Donka National Hospital

Camara E*; Diallo ML; Diop MM; Kouyate M; Barry IK; Camara SH; Bangoura K; Diallo FB; Bangoura MA; Barry A; Camara DD; Abou Madiane B

**Camara E*, Diallo ML, Diop MM, Kouyate M, Barry IK, Camara SH, Bangoura K, Diallo FB, Bangoura MA, Barry A, Camara DD and Abou Madiane B**

Volume4-Issue2
Dates: Received: 2023-02-08 | Accepted: 2023-02-17 | Published: 2023-02-22
Pages: 273-280

Abstract

Introduction: Bacterial meningitis is a serious, life-threatening infection; its diagnosis must be early and its management must be rapid. Bacteria commonly implicated in children are Neisseria meningitidis, Streptococcus pneumonia and Haemophilus influenzae type b. The specific etiology is a function of age, immune function, vaccination status, genetics, and geographic location.

Objective: To identify the factors associated with death in children aged 0 to 15 with bacterial meningitis in the pediatric department of Donka National Hospital.
Methods: Prospective, descriptive and analytical study of 6 months (April 12 to October 12, 2022) including children aged 0-15 years with bacterial meningitis confirmed by cyto-bacteriological analysis of CSF.

Results: From of a total of 766 children, we collected 118 cases of bacterial meningitis, either frequency of 15.4%. The average age was 3.97 ± 4.06 years with extremes of 1 month and 15 years. The sex ratio was 1.5 in favor of boys. Altered consciousness (p < 0.001), delay in consultation > 3 days (p = 0.01), poor nutritional status (p = 0.0000063904), cloudy appearance of the CSF (p = 0.003) and presence of serious signs (p = 0.0000050753) such as shock, generalized hypertonia, signs of decortication and decerebration were poor prognostic factors. The mortality rate observed in this work was 23.7%.

Conclusion: Child hood bacterial meningitis often leads to death in children admitted to the pediatric ward of Donka National Hospital. Children who received this diagnosis and who also had an alteration of consciousness a consultation delay of more than 3 days with signs of severity had an increased risk of dying.

FullText HTML FullText PDF DOI: 10.37871/jbres1672

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How to cite this article

Camara E, Diallo ML, Diop MM, Kouyate M, Barry IK, Camara SH, Bangoura K, Diallo FB, Bangoura MA, Barry A, Camara DD, Abou Madiane B. Factors Associated with the Death of Children Aged 0 to 15 Years with Bacterial Meningitis in the Pediatric Department of Donka National Hospital. 2023 Feb 22; 4(2): 273-280. doi: 10.37871/jbres1672, Article ID: JBRES1672, Available at: https://www.jelsciences.com/articles/jbres1672.pdf

Subject area(s)

Pediatrics

References

Ramgopal S, Walker LW, Vitale MA, Nowalk AJ. Factors associated with serious bacterial infections in infants ≤60 days with hypothermia in the emergency department. Am J Emerg Med. 2019 Jun;37(6):1139-1143. doi: 10.1016/j.ajem.2019.04.015. Epub 2019 Apr 11. PMID: 31006603.
Lien CY, Lee JJ, Tsai WC, Chen SY, Huang CR, Chien CC, Lu CH, Chang WN. The clinical characteristics of spontaneous Gram-negative bacterial meningitis in adults: A hospital-based study. J Clin Neurosci. 2019 Jun;64:101-105. doi: 10.1016/j.jocn.2019.03.047. Epub 2019 Apr 17. PMID: 31005474.
Fuentes-Antrás J, Ramírez-Torres M, Osorio-Martínez E, Lorente M, Lorenzo-Almorós A, Lorenzo O, Górgolas M. Acute Community-Acquired Bacterial Meningitis: Update on Clinical Presentation and Prognostic factors. New Microbiol. 2019 Apr;41(4):81-87. Epub 2019 Apr 17. PMID: 30994177.
Kim KS. Acute bacterial meningitis in infants and children. Lancet Infect Dis. 2010 Jan;10(1):32-42. doi: 10.1016/S1473-3099(09)70306-8. PMID: 20129147.
Scheld WM, Koedel U, Nathan B, Pfister HW. Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury. J Infect Dis. 2002 Dec 1;186 Suppl 2:S225-33. doi: 10.1086/344939. PMID: 12424702.
Neuman HB, Wald ER. Bacterial meningitis in childhood at the Children's Hospital of Pittsburgh: 1988-1998. Clin Pediatr (Phila). 2001 Nov;40(11):595-600. doi: 10.1177/000992280104001102. PMID: 11758958.
Bakayoko MM. Meningitis in children admitted to the pediatric department of the Regional Hospital of Faranah, Aspects: epidemiological, diagnostic and therapeutic. Medical doctoral thesis. Gamal Abdel Nasser University. 2018.
Berthe IM. Epidemiological, clinical, bacteriological and therapeutic study of bacterial meningitis in children aged 0 to 15 at the CSREF&MSF in Koutiala. Medical doctoral thesis. University of Bamako. 2020.
Coulibaly MM. Causes of bacterial meningitis in children aged 1 month to 15 years from 2012 to 2018 in the pediatric department of Mali hospital. Medical doctoral thesis. University of Bamako. 2018.
Amare AT, Kebede ZT, Welch HD. Epidemiology of bacterial meningitis in children admitted to Gondar University Hospital in the post pneumococcal vaccine era. Pan Afr Med J. 2018 Nov 20;31:193. doi: 10.11604/pamj.2018.31.193.10254. PMID: 31086637; PMCID: PMC6488968.
Tfifha M, Mallouli M, Sahli J. Bacterial meningitis in infants and children: assessment of 11 years in a pediatric service in Tunisia. JIMSfax. 2016;29:54-63.
Sougou NM, Diouf JB, Bassoum O, Diop M, Kane Leye M, Leye MMM, Tal-Dia A. Epidemiological aspects of acute respiratory infections in pediatric hospitals in Dakar. Senegal, African and Malagasy Review for Scientific Research. Health Sciences. 2019;1.
Camara E, Kouyaté M, Barry IK, Diallo ML, Camara SH, Bangoura K. Acute respiratory viral infections in children under 15 years in Conakry: Etiologies and management. Health Sci. 2022;23:15-19.
Coulibaly H. Epidemiological and clinical aspects of acute respiratory infections in children aged 0-59 months in the pediatric department of Sikasso hospital, University of Sciences, Techniques and Technologies of Bamako, thesis. Med: Sikasso. 2017;60.
El Fakiri K, Bourrous M, Diffo C, Rada N, Draiss G, Bouskraoui M. Meningitis in infants and children at the University Hospital of Marrakech: experience of a Moroccan pediatric unit. J Pediatric Daycare. 2016;29:237-243.
Soeters HM, Diallo AO, Bicaba BW, Kadadé G, Dembélé AY, Acyl MA, Nikiema C, Sadji AY, Poy AN, Lingani C, Tall H, Sakandé S, Tarbangdo F, Aké F, Mbaeyi SA, Moïsi J, Paye MF, Sanogo YO, Vuong JT, Wang X, Ronveaux O, Novak RT; MenAfriNet Consortium. Bacterial Meningitis Epidemiology in Five Countries in the Meningitis Belt of Sub-Saharan Africa, 2015-2017. J Infect Dis. 2019 Oct 31;220(220 Suppl 4):S165-S174. doi: 10.1093/infdis/jiz358. PMID: 31671441; PMCID: PMC6853282.
Pelkonen T, Roine I, Monteiro L, Correia M, Pitkäranta A, Bernardino L, Peltola H. Risk factors for death and severe neurological sequelae in childhood bacterial meningitis in sub-Saharan Africa. Clin Infect Dis. 2009 Apr 15;48(8):1107-10. doi: 10.1086/597463. PMID: 19275501.
Shrestha RG, Tandukar S, Ansari S, Subedi A, Shrestha A, Poudel R, Adhikari N, Basnyat SR, Sherchand JB. Bacterial meningitis in children under 15 years of age in Nepal. BMC Pediatr. 2015 Aug 19;15:94. doi: 10.1186/s12887-015-0416-6. PMID: 26286573; PMCID: PMC4541735.
Alamarat Z, Hasbun R. Management of Acute Bacterial Meningitis in Children. Infect Drug Resist. 2020 Nov 11;13:4077-4089. doi: 10.2147/IDR.S240162. PMID: 33204125; PMCID: PMC7667001.
Roine I, Peltola H, Fernández J, Zavala I, González Mata A, González Ayala S, Arbo A, Bologna R, Miño G, Goyo J, López E, Dourado de Andrade S, Sarna S. Influence of admission findings on death and neurological outcome from childhood bacterial meningitis. Clin Infect Dis. 2008 Apr 15;46(8):1248-52. doi: 10.1086/533448. PMID: 18444863.
Rahimi BA, Ishaq N, Mudaser GM, Taylor WR. Outcome of acute bacterial meningitis among children in Kandahar, Afghanistan: A prospective observational cohort study. PLoS One. 2022 Apr 11;17(4):e0265487. doi: 10.1371/journal.pone.0265487. PMID: 35404980; PMCID: PMC9000062.
Kuti BP, Bello EO, Jegede TO, Olubosede O. Epidemiological, clinical and prognostic profile of childhood acute bacterial meningitis in a resource poor setting. J Neurosci Rural Pract. 2015 Oct-Dec;6(4):549-57. doi: 10.4103/0976-3147.165424. PMID: 26752902; PMCID: PMC4692015.
Peltola H, Roine I, Kallio M, Pelkonen T. Outcome of childhood bacterial meningitis on three continents. Sci Rep. 2021 Nov 3;11(1):21593. doi: 10.1038/s41598-021-01085-w. PMID: 34732790; PMCID: PMC8566566.
Mioramalala SA, Ramasy Razafindratovo RM, Rakotozanany A, Miarimbola R, Weldegebriel G, Mwenda JM, Robinson AL. Analysis of Death and Survival Factors Associated with Childhood Bacterial Meningitis at a Reference Pediatric Hospital in Antananarivo, Madagascar. J Immunol Sci. 2018 Jul 2;Suppl(2):8-14. PMID: 30843000; PMCID: PMC6398577.
Olson D, Lamb MM, Gaensbauer JT, Todd JK, Halsey NA, Asturias EJ; Guatemala Pediatric Bacterial Surveillance Working Group. Risk Factors for Death and Major Morbidity in Guatemalan Children with Acute Bacterial Meningitis. Pediatr Infect Dis J. 2015 Jul;34(7):724-8. doi: 10.1097/INF.0000000000000720. PMID: 26069947; PMCID: PMC4467373.
de Jonge RC, van Furth AM, Wassenaar M, Gemke RJ, Terwee CB. Predicting sequelae and death after bacterial meningitis in childhood: a systematic review of prognostic studies. BMC Infect Dis. 2010 Aug 5;10:232. doi: 10.1186/1471-2334-10-232. PMID: 20684796; PMCID: PMC2921388.