Pipitsa Valsamaki*, Konstantinos Liapis, Vasileios Tsalkanis, Georgios Chalikias and Athanassios Zissimopoulos
Volume4-Issue1
Dates: Received: 2022-12-27 | Accepted: 2023-01-03 | Published: 2023-01-05
Pages: 008-013
Abstract
Suspicion for Cardiac Amyloidosis (CA) led a 75-year-old male patient with fatigue, dyspnea, and palpitations to be subjected to scintigraphic myocardial investigation with technetium-99m-pyrophosphate (99mTc-PYP, or PYP scan) in order to distinguish transthyretin-related CA (ATTR) from the light-chain Amyloidosis (AL) form. A characteristic anamnesis of bilateral carpal tunnel syndrome, vertebral canal stenosis, and senile cataract, as well as laboratory, Electrocardiographic (ECG), and echocardiographic exploration was compatible with a positive for ATTR PYP scan. Specific features on PYP scan, namely Apical Sparing, more marked Septal Uptake and an associated Equivalent cardiac retention, particularly heart-to-contralateral (H/CL) Ratio from 1 h to 3 h pi (“ASSUMER”) were coupled with a negative genetic analysis, verifying wild-type ATTR. The herein introduced “ASSUMER” on PYP scan could be a hallmark not only of the amyloid fibril subtype but also origin.
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DOI: 10.37871/jbres1643
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© 2023 Valsamaki P, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Valsamaki P, Liapis K, Tsalkanis V, Chalikias G, Zissimopoulos A. “ASSUMER” on PYP Scan for Cardiac Amyloid Typing and Origin: Case-Specific Corroborating Clinical Background and Genetic Analysis. 2022 Jan 05; 4(1): 008-0013. doi: 10.37871/jbres1643, Article ID: JBRES1643, Available at: https://www.jelsciences.com/articles/jbres1643.pdf
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