Patra Charalampaki*, Irini Kakaletri and Stamatia Giannarou
Volume3-Issue12
Dates: Received: 2022-12-18 | Accepted: 2022-12-24 | Published: 2022-12-26
Pages: 1527-1531
Abstract
Confocal Laser Endomicroscopy (CLE) is a new technique that is able to show cell structures during surgery. The interpretation of CLE data for tissue characterisation during brain tumour resection is challenging even among experts and it can lead to considerable inter-observer variability.
Different kinds of deep machine learning programs and models were developed for better interpretation of the cell findings. A few-shot learning framework is proposed to assess the diagnostic value of CLE data and to classify them into healthy tissue and different brain tumour types, namely glioblastoma, meningioma, or astrocytoma.
Performance evaluation on ex vivo and in vivo data shows that the rejection of data with low diagnostic value improves the classification accuracy by 37.5% while the proposed tissue characterisation framework achieves 96.20% classification accuracy.
FullText HTML FullText PDF DOI: 10.37871/jbres1629
Certificate of Publication
Copyright
© 2022 Charalampaki P, et al. Distributed under Creative Commons CC-BY 4.0
How to cite this article
Charalampaki P, Kakaletri I, Giannarou S. Can Endomicroscopic Tissue Characterization be Combined with Deep Machine Learning to Support Neurosurgery? 2022 Dec 26; 3(12): 1527-1531. doi: 10.37871/jbres1629, Article ID: JBRES1629, Available at: https://www.jelsciences.com/articles/jbres1629.pdf
Subject area(s)
References
- http://www.cancerresearchuk.org/cancer-info/cancerstats/
- Burnet NG, Jefferies SJ, Benson RJ, Hunt DP, Treasure FP. Years of life lost (YLL) from cancer is an important measure of population burden--and should be considered when allocating research funds. Br J Cancer. 2005 Jan 31;92(2):241-5. doi: 10.1038/sj.bjc.6602321. PMID: 15655548; PMCID: PMC2361853.
- Tanaka Y, Nariai T, Momose T, Aoyagi M, Maehara T, Tomori T, Yoshino Y, Nagaoka T, Ishiwata K, Ishii K, Ohno K. Glioma surgery using a multimodal navigation system with integrated metabolic images. J Neurosurg. 2009 Jan;110(1):163-72. doi: 10.3171/2008.4.17569. PMID: 18847337.
- Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ; ALA-Glioma Study Group. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol. 2006 May;7(5):392-401. doi: 10.1016/S1470-2045(06)70665-9. PMID: 16648043.
- Charalampaki P, Javed M, Daali S, Heiroth HJ, Igressa A, Weber F. Confocal Laser Endomicroscopy for Real-time Histomorphological Diagnosis: Our Clinical Experience With 150 Brain and Spinal Tumor Cases. Neurosurgery. 2015 Aug;62 Suppl 1:171-6. doi: 10.1227/NEU.0000000000000805. PMID: 26181939.
- Li Y, Charalampaki P, Liu Y, Yang GZ, Giannarou S. Context aware decision support in neurosurgical oncology based on an efficient classification of endomicroscopic data. Int J Comput Assist Radiol Surg. 2018 Aug;13(8):1187-1199. doi: 10.1007/s11548-018-1806-7. Epub 2018 Jun 13. PMID: 29948845; PMCID: PMC6096753.
- Li W, Wang L, Xu J, Huo J, Gao Y, Luo J. Revisiting local descriptor-based image-to-class measure for few-shot learning. IEEE Conference on Computer Vision and Pattern Recognition (CVPR). 2019.
- Charalampaki P, Kakaletri I. Confocal Laser Endomicroscopy in Oncological Surgery. Diagnostics (Basel). 2021 Sep 30;11(10):1813. doi: 10.3390/diagnostics11101813. PMID: 34679511; PMCID: PMC8535042.
- Charalampaki P, Javed M, Daali S, Heiroth HJ, Igressa A, Weber F. Confocal Laser Endomicroscopy for Real-time Histomorphological Diagnosis: Our Clinical Experience With 150 Brain and Spinal Tumor Cases. Neurosurgery. 2015 Aug;62 Suppl 1:171-6. doi: 10.1227/NEU.0000000000000805. PMID: 26181939.
- Sanai N, Eschbacher J, Hattendorf G, Coons SW, Preul MC, Smith KA, Nakaji P, Spetzler RF. Intraoperative confocal microscopy for brain tumors: a feasibility analysis in humans. Neurosurgery. 2011 Jun;68(2 Suppl Operative):282-90; discussion 290. doi: 10.1227/NEU.0b013e318212464e. PMID: 21336204.
- Kakaletri I, Linxweiler M, Ajlouni S, Charalampaki P. Development, Implementation and Application of Confocal Laser Endomicroscopy in Brain, Head and Neck Surgery-A Review. Diagnostics (Basel). 2022 Nov 4;12(11):2697. doi: 10.3390/diagnostics12112697. PMID: 36359540; PMCID: PMC9689276.
- Charalampaki P, Nakamura M, Athanasopoulos D, Heimann A. Confocal-Assisted Multispectral Fluorescent Microscopy for Brain Tumor Surgery. Front Oncol. 2019 Jul 18;9:583. doi: 10.3389/fonc.2019.00583. PMID: 31380264; PMCID: PMC6657348.