Rodolfo J Gordillo* and Rita Dorantes
Volume3-Issue11
Dates: Received: 2022-10-12 | Accepted: 2022-11-07 | Published: 2022-11-08
Pages: 1302-1306
Abstract
Membranous Glomerulonephritis (GMN) is an autoimmune disease whose etiology has not been defined with precisión, When there is no association with another disease which ocurrs in two thirds of the cases is considered to be idiopathic. It is the most common cause of Nephrotic Syndrome in Adults, primary caucasic and over 60 years of age. It is regarded as a non inflammatory Glomerulonephritis, concept with which I am not completely in agreement because I think as other researchers have taught than in GMN [1] the Complement system contributes to various Glomerulophaties by causing cellular damage by both an inflammation-dependant and inflammation-independent ways. Here I discuss a case of a woman who developed an idiopathic GMN presented with a nephrotic sÃndrome with severe protracted proteinuria also I describe her initial treatment and the changes that I made and discuss her follow up for 7 years, and current medical status.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1597
Certificate of Publication
Copyright
© 2022 Gordillo RJ, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Gordillo RJ, Dorantes R. An Alternative Therapy for Membranous Glomerulonephritis: A Case Report. 2022 Nov 08; 3(11): 1302-1306. doi: 10.37871/jbres1597, Article ID: JBRES1597, Available at: https://www.jelsciences.com/articles/jbres1597.pdf
Subject area(s)
References
- Segawa Y, Hisano S, Matsushita M, Fujita T, Hirose S, Takeshita M, Iwasaki H. IgG subclasses and complement pathway in segmental and global membranous nephropathy. Pediatr Nephrol. 2010 Jun;25(6):1091-9. doi: 10.1007/s00467-009-1439-8. Epub 2010 Feb 12. PMID: 20151159.
- HEYMANN W, HACKEL DB, HARWOOD S, WILSON SG, HUNTER JL. Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med. 1959 Apr;100(4):660-4. doi: 10.3181/00379727-100-24736. PMID: 13645677.
- Ronco P, Debiec H. Molecular Pathogenesis of Membranous Nephropathy. Annu Rev Pathol. 2020 Jan 24;15:287-313. doi: 10.1146/annurev-pathol-020117-043811. Epub 2019 Oct 17. PMID: 31622560.
- Klouda PT, Manos J, Acheson EJ, Dyer PA, Goldby FS, Harris R, Lawler W, Mallick NP, Williams G. Strong association between idiopathic membranous nephropathy and HLA-DRW3. Lancet. 1979 Oct 13;2(8146):770-1. doi: 10.1016/s0140-6736(79)92118-4. PMID: 90863.
- Stanescu HC, Arcos-Burgos M, Medlar A, Bockenhauer D, Kottgen A, Dragomirescu L, Voinescu C, Patel N, Pearce K, Hubank M, Stephens HA, Laundy V, Padmanabhan S, Zawadzka A, Hofstra JM, Coenen MJ, den Heijer M, Kiemeney LA, Bacq-Daian D, Stengel B, Powis SH, Brenchley P, Feehally J, Rees AJ, Debiec H, Wetzels JF, Ronco P, Mathieson PW, Kleta R. Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med. 2011 Feb 17;364(7):616-26. doi: 10.1056/NEJMoa1009742. PMID: 21323541.
- Fresquet M, Jowitt TA, Gummadova J, Collins R, O'Cualain R, McKenzie EA, Lennon R, Brenchley PE. Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy. J Am Soc Nephrol. 2015 Feb;26(2):302-13. doi: 10.1681/ASN.2014050502. Epub 2014 Oct 6. PMID: 25288605; PMCID: PMC4310666.
- Scolari F, Alberici F, Mescia F, Delbarba E, Trujillo H, Praga M, Ponticelli C. Therapies for Membranous Nephropathy: A Tale From the Old and New Millennia. Front Immunol. 2022 Mar 1;13:789713. doi: 10.3389/fimmu.2022.789713. PMID: 35300332; PMCID: PMC8921478.
- Gordillo RJ. A novel therapy to reverse end stage kidney renal diseases in its early stages 1 & 2 to a normal renal function or to stabilize and halt ist progression in moreb advances stages. J of Clinical Nephrology and Research. 2021;8(1):1102-1109. doi: 10.47739/2379-0652/1102.
- Panchapakesan U, Chen XM, Pollock CA. Drug insight: thiazolidinediones and diabetic nephropathy--relevance to renoprotection. Nat Clin Pract Nephrol. 2005 Nov;1(1):33-43. doi: 10.1038/ncpneph0029. PMID: 16932362.
- Seitz-Polski B, Dolla G, Payré C, Girard CA, Polidori J, Zorzi K, Birgy-Barelli E, Jullien P, Courivaud C, Krummel T, Benzaken S, Bernard G, Burtey S, Mariat C, Esnault VL, Lambeau G. Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy. J Am Soc Nephrol. 2016 May;27(5):1517-33. doi: 10.1681/ASN.2014111061. Epub 2015 Nov 13. PMID: 26567246; PMCID: PMC4849812.
- Fiorentino M, Tondolo F, Bruno F, Infante B, Grandaliano G, Gesualdo L, Manno C. Treatment with rituximab in idiopathic membranous nephropathy. Clin Kidney J. 2016 Dec;9(6):788-793. doi: 10.1093/ckj/sfw091. Epub 2016 Oct 13. PMID: 27994855; PMCID: PMC5162414.
