Sergio Espana-Cueto, Jose Ramon Santos*, Oscar Blanch-Lombarte, Joan-Ramon Grifols, Gemma Llados, Cristina Lopez, Daniel Molina-Morant, Maria Nevot, Edwards Pradenas, Benjamin Trinite, Esther Jimenez-Moyano, Ruth Pena, Silvia Marfil, Mariona Parera, Francesc Catala, Agueda Hernandez-Rodriguez, Antoni Escalas, Ignacio Blanco, Veronica Saludes, Elisa Martro, Carla Rovirosa, Eva Riveira-Munoz, Teresa Puig, Christelle Ferra, Carmen Fernandez-Arias, Julia Blanco, Ester Ballana, Bonaventura Clotet, Pere J Cardona, Marc Noguera-Julian, Julia Garcia-Prado, Lourdes Mateu, Marta Massanella and Roger Paredes
Volume3-Issue11
Dates: Received: 2022-11-03 | Accepted: 2022-11-07 | Published: 2022-11-08
Pages: 1293-1297
Abstract
We describe a case of a patient who experienced recurrent COVID-19 pneumonia over a period of 123 days. Neither remdesivir nor convalescent plasma were temporally associated with viral clearance or increased plasma neutralization capacity. Antibody levels remained low until day 151 and cellular immunity increased overtime with no viral evolution.
FullText HTML
FullText PDF
DOI: 10.37871/jbres1595
Certificate of Publication
Copyright
© 2022 Espana-Cueto S, et al. Distributed under Creative Commons CC-BY 4.0 
How to cite this article
Espana-Cueto S, Santos JR, Blanch-Lombarte O, Joan-Ramon G, Llados G, Lopez C, Molina-Morant D, Nevot M, Pradenas E, Trinite B, Jimenez-Moyano E, Pena R, Marfil S, Parera M, Catala F, Hernandez-Rodriguez A, Escalas A, Blanco I, Saludes V, Martro E, Rovirosa C, Riveira-Munoz E, Puig T, Ferra C, Fernandez-Arias C, Blanco J, Ballana E, Clotet B, Cardona PJ, Noguera-Julian M, Garcia-Prado J, Mateu L, Massanella M, Paredes R. Prolonged Viral Shedding and Multiple Admissions Due to SARS-CoV-2-Associated Pneumonia in a Patient with Chronic Lymphocytic Leukemia: A Case Report. 2022 Nov 08; 3(11): 1293-1297. doi: 10.37871/jbres1595, Article ID: JBRES1595, Available at: https://www.jelsciences.com/articles/jbres1595.pdf
Subject area(s)
References
- Nakajima Y, Ogai A, Furukawa K, Arai R, Anan R, Nakano Y, Kurihara Y, Shimizu H, Misaki T, Okabe N. Prolonged viral shedding of SARS-CoV-2 in an immunocompromised patient. J Infect Chemother. 2021 Feb;27(2):387-389. doi: 10.1016/j.jiac.2020.12.001. Epub 2020 Dec 4. PMID: 33328135; PMCID: PMC7836222.
- Tarhini H, Recoing A, Bridier-Nahmias A, Rahi M, Lambert C, Martres P, Lucet JC, Rioux C, Bouzid D, Lebourgeois S, Descamps D, Yazdanpanah Y, Le Hingrat Q, Lescure FX, Visseaux B. Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection. J Infect Dis. 2021 May 20;223(9):1522-1527. doi: 10.1093/infdis/jiab075. PMID: 33556961; PMCID: PMC7928754.
- Ferrari S, Caprioli C, Weber A, Rambaldi A, Lussana F. Convalescent hyperimmune plasma for chemo-immunotherapy induced immunodeficiency in COVID-19 patients with hematological malignancies. Leuk Lymphoma. 2021 Jun;62(6):1490-1496. doi: 10.1080/10428194.2021.1872070. Epub 2021 Jan 18. PMID: 33461387; PMCID: PMC7832449.
- Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 2021 Feb 18;184(4):861-880. doi: 10.1016/j.cell.2021.01.007. Epub 2021 Jan 12. PMID: 33497610; PMCID: PMC7803150.
- Ginaldi L, De Martinis M, Matutes E, Farahat N, Morilla R, Catovsky D. Levels of expression of CD19 and CD20 in chronic B cell leukaemias. J Clin Pathol. 1998 May;51(5):364-9. doi: 10.1136/jcp.51.5.364. PMID: 9708202; PMCID: PMC500695.
- Juárez-Salcedo LM, Desai V, Dalia S. Venetoclax: evidence to date and clinical potential. Drugs Context. 2019 Oct 9;8:212574. doi: 10.7573/dic.212574. PMID: 31645879; PMCID: PMC6788387.
- Djaldetti M, Leibovitch C, Ganelin-Cohen E, Bessler H. Rituximab modifies peripheral blood mononuclear cells immune responses. Int J Immunol Immunother. 2019;6:037. doi: 10.23937/2378-3672/1410037.
- Martín-Moro F, Marquet J, Piris M, Michael BM, Sáez AJ, Corona M, Jiménez C, Astibia B, García I, Rodríguez E, García-Hoz C, Fortún-Abete J, Herrera P, López-Jiménez J. Survival study of hospitalised patients with concurrent COVID-19 and haematological malignancies. Br J Haematol. 2020 Jul;190(1):e16-e20. doi: 10.1111/bjh.16801. Epub 2020 May 27. PMID: 32379921; PMCID: PMC7267398.
- Beigel JH, Tomashek KM, Dodd LE. Remdesivir for the Treatment of Covid-19 - Preliminary Report. Reply. N Engl J Med. 2020 Sep 3;383(10):994. doi: 10.1056/NEJMc2022236. Epub 2020 Jul 10. PMID: 32649078.
- RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. PMID: 32678530; PMCID: PMC7383595.
- Cogliati Dezza F, Oliva A, Cancelli F, Savelloni G, Valeri S, Mauro V, Calabretto M, Russo G, Venditti M, Turriziani O, Mastroianni CM. Determinants of prolonged viral RNA shedding in hospitalized patients with SARS-CoV-2 infection. Diagn Microbiol Infect Dis. 2021 Jun;100(2):115347. doi: 10.1016/j.diagmicrobio.2021.115347. Epub 2021 Feb 12. PMID: 33639375; PMCID: PMC7879029.
- Clark E, Guilpain P, Filip IL, Pansu N, Le Bihan C, Cartron G, Tchernonog E, Roubille C, Morquin D, Makinson A, Tuaillon E, Le Moing V. Convalescent plasma for persisting COVID-19 following therapeutic lymphocyte depletion: a report of rapid recovery. Br J Haematol. 2020 Aug;190(3):e154-e156. doi: 10.1111/bjh.16981. Epub 2020 Jul 16. PMID: 32593180; PMCID: PMC7361823.
- RECOVERY Collaborative Group. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet. 2021 May 29;397(10289):2049-2059. doi: 10.1016/S0140-6736(21)00897-7. Epub 2021 May 14. PMID: 34000257; PMCID: PMC8121538.
- Tan AT, Linster M, Tan CW, Le Bert N, Chia WN, Kunasegaran K, Zhuang Y, Tham CYL, Chia A, Smith GJD, Young B, Kalimuddin S, Low JGH, Lye D, Wang LF, Bertoletti A. Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients. Cell Rep. 2021 Feb 9;34(6):108728. doi: 10.1016/j.celrep.2021.108728. Epub 2021 Jan 21. PMID: 33516277; PMCID: PMC7826084.
- Avanzato VA, Matson MJ, Seifert SN, Pryce R, Williamson BN, Anzick SL, Barbian K, Judson SD, Fischer ER, Martens C, Bowden TA, de Wit E, Riedo FX, Munster VJ. Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer. Cell. 2020 Dec 23;183(7):1901-1912.e9. doi: 10.1016/j.cell.2020.10.049. Epub 2020 Nov 4. PMID: 33248470; PMCID: PMC7640888.
- Tegally H, Wilkinson E, Giovanetti M, Iranzadeh A, Fonseca V, Giandhari J, Doolabh D, Pillay S, San EJ, Msomi N, Mlisana K, von Gottberg A, Walaza S, Allam M, Ismail A, Mohale T, Glass AJ, Engelbrecht S, Van Zyl G, Preiser W, Petruccione F, Sigal A, Hardie D, Marais G, Hsiao NY, Korsman S, Davies MA, Tyers L, Mudau I, York D, Maslo C, Goedhals D, Abrahams S, Laguda-Akingba O, Alisoltani-Dehkordi A, Godzik A, Wibmer CK, Sewell BT, Lourenço J, Alcantara LCJ, Kosakovsky Pond SL, Weaver S, Martin D, Lessells RJ, Bhiman JN, Williamson C, de Oliveira T. Detection of a SARS-CoV-2 variant of concern in South Africa. Nature. 2021 Apr;592(7854):438-443. doi: 10.1038/s41586-021-03402-9. Epub 2021 Mar 9. PMID: 33690265.
